Dario Neri: Catalogue data in Autumn Semester 2017

Name Prof. Dr. Dario Neri
FieldBiomakromoleküle
Address
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI G 392.4
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 74 01
Fax+41 44 633 13 58
E-maildario.neri@pharma.ethz.ch
DepartmentChemistry and Applied Biosciences
RelationshipFull Professor

NumberTitleECTSHoursLecturers
535-0001-00LIntroduction to Pharmaceutical Sciences I2 credits2VC. Halin Winter, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, J. Hall, J.‑C. Leroux, C. Müller, D. Neri, U. Quitterer, R. Schibli, G. Schneider, H. U. Zeilhofer
AbstractFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ObjectiveFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ContentIntroduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields.
Lecture notesHandouts for individual lectures.
Prerequisites / NoticeInteractive teaching
535-0011-00LDrug Seminar Restricted registration - show details
The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences
5 credits9SC. Halin Winter, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, D. Neri, V. I. Otto, U. Quitterer, R. Schibli, G. Schneider, C. Steuer, H. U. Zeilhofer
AbstractThe course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium.
ObjectiveThe main objectives of this course are:

- students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic
- students gain in-depth knowledge of the topic investigated
- students train their scientific writing and presentation skills
- students train their ability to plan a project and work in a team
ContentThe Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences.

The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences.

During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester.
Prerequisites / NoticeOnly for students of MSc Pharmacy and MSc Pharmaceutical Sciences.
535-0030-00LTherapeutic Proteins3 credits3GC. Halin Winter, D. Neri
AbstractIn this course, various topics related to the development, GMP production and application of therapeutic proteins will be discussed. Furthermore, students will expand their training in pharmaceutical immunology and will be introduced to the basic concepts of pharmaceutical product quality management.
ObjectiveStudents know and understand:
- basic mechanisms and regulation of the immune response
- the pathogenic mechanisms of the most important immune-mediated disorders
- the most frequently used expression systems for the production of therapeutic proteins
- the use of protein engineering tools for modifying different features of therapeutic proteins
- the mechanism of action of selected therapeutic proteins and their application
- basic concepts in the GMP production of therapeutic proteins
ContentThe course consists of two parts:
In a first part, students will complete their training of pharmaceutical immunology (Chapter 13 - 16 Immunobiology VIII textbook). This part particularly focuses on the pathogenic mechanisms of immune-mediated diseases. Deepened knowledge of immunology will be relevant for understanding the mechanism of action of many therapeutic proteins, as well as for understanding one major concern related to the use of protein-based drugs, namely, immunogenicity.
The second part focuses on topics related to the development and application of therapeutic proteins, such as protein expression, protein engineering, reducing immunogenicity, and GMP production of therapeutic proteins. Furthermore, selected examples of approved therapeutic proteins will be discussed.
Lecture notesHandouts to the lectures will be available for downloading under http://www.pharma.ethz.ch/scripts/index
Literature- Janeway's ImmunoBiology, by Kenneth Murphy (9th Edition), Chapters 12-16
- Lecture Handouts
- Paper References provided in the Scripts
- EMEA Dossier for Humira
535-0239-00LPractical Course in Medicinal Chemistry Restricted registration - show details 3 credits7PJ. Hall, M. Detmar, C. Halin Winter, D. Neri
AbstractThe course comprises experiments relating to concepts of medicinal chemistry including statistical processing, fitting of experimental data, computer modeling of protein structures, experimental measurement of affinity constants and kinetic dissociation constants for protein ligands. The chemical stability of a drug will be studied. Basic gene cloning and protein expression will be introduced.
ObjectiveKnowledge of experimental methods in drug discovery and development
ContentCharacterisation of the biophysical and biological properties of drugs.
Lecture notesScripts
LiteratureOriginal literature
Prerequisites / NoticeRequirements:
Laboratory course in Pharmaceutical Anaytics;
Lecture Medicinal Chemistry I in the same semester or earlier.
535-0810-00LGene Technology Information 2 credits2GD. Neri
AbstractThe course will provide a solid overview of the science and issues in gene technology and its pharmaceutical applications.
ObjectiveThe aim of the lecture course is to provide a solid overview of gene technology, with a special focus on drug development. Topics: Antibody phage technology, DNA-encoded chemistry, protein modification technology, genome sequencing, transcriptomics, proteomics, functional genomics, principle of drug discovery. The course is suited for advanced undergraduate and early graduate students in pharmaceutical sciences or related fields.
Content1. Antibody phage technology
The antibody molecule
V genes, CDRs, basics of antibody engineering
Principles of phage display
Phagemid and phage vectors
Antibody libraries
Phage display selection methodologies
Other phage libraries (peptides, globular proteins, enzymes)
Alternative screening/selection methodologies
DNA-encoded chemical libraries

2. Proteins: chemical modification and detection of biomolecular interactions
Homo- and hetero-dimerization of proteins
Chemical modifications of proteins
Antibody-drug conjugates
Radioactive labeling of proteins
Kinetic association and dissociation constants
Affinity constant: definition and its experimental measurement

3. Genomics: Applications to Human Biology
Protein cloning and expression
DNA sequencing
Some foundations of genetic analysis
Knock-out technologies
Transcriptomics
Proteomics
Recombinant vaccines

4: Pharmaceuticals: Focus on Discovery
Ligand Discovery
Half-life extension
Cancer therapy
Gene therapy
Lecture notesSkript "Gene Technology" by Prof. Dario Neri and slides of the lecture
535-0830-00LPharmaceutical Immunology Information 2 credits2GD. Neri, C. Halin Winter
AbstractGet Students familiar with basic Immunological concepts of pharmaceutical relevance.
ObjectiveGet Students familiar with basic Immunological concepts of pharmaceutical relevance.
ContentChapters 1 - 11 of the Janeway's ImmunoBiology, by Kenneth Murphy (9th Edition; Garland).
LiteratureJaneway's ImmunoBiology, by Kenneth Murphy (9th Edition).

Paperback
[www.garlandscience.com]
535-0900-00LSeminars on Drug Discovery and Development1 credit1KJ.‑C. Leroux, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, D. Neri, U. Quitterer, R. Schibli, G. Schneider, H. U. Zeilhofer
AbstractState-of-the-art information on drug discovery and development by experts from academia and industry.
ObjectiveState-of-the-art information on drug discovery and development.
ContentSeminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics.
535-1001-00LLaboratory Course General Chemistry (for Biology and Pharmacy) Information Restricted registration - show details
Information about the practical course will be given on the first day.
6 credits8PR. O. Kissner, K.‑H. Altmann, J. Hall, D. Neri, G. Schneider, M. D. Wörle
AbstractIntroduction to the practical work in a chemistry laboratory. The most important manipulations and techniques are treated, as well as the the most fundamental chemical reaction types.
Objective- Knowledge of the basic chemical laboratory methods.
- Basic knowledge of the scientific approach in experimenting.
- Observation and interpretation of real-world chemical processes.
- Keeping of a reliable laboratory journal.
Content- Simple chemical methods and calculations.
- Separation techniques.
- Physical measurements: mass, volume, pH, optical spectra.
- Ionic solids (salts).
- Acid/base chemistry, buffers.
- Redox reactions.
- Metal complexes.
- Titration methods and quantitative spectrometry.
- Introduction to qualitative analysis.
Lecture notesCourse manual in German (is handed out to the students at the begin of the lessons).
Language: German, English upon request.

PDF files available at
http://acac1.ethz.ch/praktikum/docs.html
LiteratureBasic Concepts of Chemistry, International Student Version, 8th Edition, Leo J. Malone, Theodore Dolter
Wiley

is a suitable textbook.
Prerequisites / NoticeThis practical course causes costs for materials and chemicals. The costs are charged to the students at the end of semester.