Yves Barral: Catalogue data in Autumn Semester 2016
|Name||Prof. Dr. Yves Barral|
Institut für Biochemie
ETH Zürich, HPM D 8.3
|Telephone||+41 44 632 06 78|
|Fax||+41 44 632 15 91|
|551-0309-00L||Concepts in Modern Genetics||6 credits||4V||Y. Barral, D. Bopp, A. Hajnal, M. Stoffel, O. Voinnet|
|Abstract||Concepts of modern genetics and genomics, including principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference.|
|Objective||This course focuses on the concepts of classical and modern genetics and genomics.|
|Content||The topics include principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference.|
|Lecture notes||Scripts and additional material will be provided during the semester.|
|Prerequisites / Notice||This course is a co-production of the University of Zurich and ETH Zurich, and will be taught in English. The course takes place on Monday afternoon at ETH Hoenggerberg, and on Tuesday morning at UZH Irchel.|
|551-0347-00L||Molecular Mechanisms of Cell Growth and Polarity |
Number of participants limited to 12.
|6 credits||7G||R. Kroschewski, Y. Barral, S. Jessberger, M. Peter|
|Abstract||Introduction to the principles and molecular mechanisms of cell polarity, using animal cells and fungi as model systems.|
|Objective||The students learn to describe the principles and molecular mechanisms of cell polarity, using different model systems as examples: |
- Animal cells during epithelial and neuronal differentiation
- Fungi during morphogenesis and aging.
Based on lectures, literature reading, discussions, presentations and practical lab work the students will be able to compare experimental strategies in different model systems, and to develop open questions in the field of cell polarity. Students will also know about the mechanisms and consequences of asymmetric cell division such as those performed by stem cells and asymmetric protein functions during morphogenesis and aging.
|Content||During this Block-Course, the students will learn to |
(1) describe and compare the principles and molecular mechanisms of cell polarity in fungi and animal cells,
(2) apply, evaluate and compare experimental strategies in the different model systems, and
(3) select the best model system to answer a particular question.
Students - in groups of 2 or max 3- will be integrated into a research project connected to the subject of the course, within one of the participating research groups.
Lectures and technical notes will be given and informal discussions held to provide you with the theoretical background.
|Lecture notes||There will be optional papers to be read before the course start. They serve as framework orientation for the practical parts of this block course and will be made accessible to you shortly before the course starts on the relevant Moodle site.|
|Literature||Documentation and recommended literature (review articles) will be provided during the course.|
|551-0351-00L||Membrane Biology |
Number of participants limited to 21.
|6 credits||7G||V. Korkhov, Y. Barral, B. Kornmann, U. Kutay, A. Rodriguez-Villalon, G. Schertler|
|Abstract||The course will introduce the students to the key concepts in membrane biology and will allow them to be involved in laboratory projects related to that broad field. The course will consist of lectures, literature discussions, and practical laboratory work in small groups. Results of the practical projects will be presented during the poster session at the end of the course.|
|Objective||The aim of the course is to expose the students to a wide range of modern research areas encompassed by the field of membrane biology.|
|Content||Students will be engaged in research projects aimed at understanding the biological membranes at the molecular, organellar and cellular levels. Students will design and perform experiments, evaluate experimental results, analyze the current scientific literature and understand the relevance of their work in the context of the current state of the membrane biology field.|
|Lecture notes||No script|
|Literature||The recommended literature, including reviews and primary research articles, will be provided during the course|
|Prerequisites / Notice||The course will be taught in English. All general lectures will be held at ETH Hoenggerberg; special lectures will be organized by individual participating groups. Students will be divided into small groups to carry out experiments at ETH or at the Paul Scherrer Institute. Travel to the Paul Scherrer Insitute will be organized by car rental or public transportation.|
|551-1303-00L||Cellular Biochemistry of Health and Disease |
Number of participants limited to 15.
|4 credits||2S||P. Picotti, Y. Barral, J. Fernandes de Matos, V. Korkhov, B. Kornmann, R. Kroschewski, M. Peter, A. E. Smith, K. Weis|
|Abstract||During this Masters level seminar style course, students will explore current research topics in cellular biochemistry focused on the structure, function and regulation of selected cell components, and the consequences of dysregulation for pathologies.|
|Objective||Students will work with experts toward a critical analysis of cutting-edge research in the domain of cellular biochemistry, with emphasis on normal cellular processes and the consequences of their dysregulation. At the end of the course, students will be able to introduce, present, evaluate, critically discuss and write about recent scientific articles in the research area of cellular biochemistry.|
|Content||Guided by an expert in the field, students will engage in classical round-table style discussions of current literature with occasional frontal presentations. Students will alternate as discussion leaders throughout the semester, with the student leader responsible to briefly summarize key general knowledge and context of the assigned primary research paper. Together with the faculty expert, all students will participate in discussion of the primary paper, including the foundation of the biological question, specific questions addressed, key methods, key results, remaining gaps and research implications.|
|Literature||The literature will be provided during the course|
|Prerequisites / Notice||The course will be taught in English.|