Frédéric Allain: Catalogue data in Autumn Semester 2019
|Name||Prof. Dr. Frédéric Allain|
Institut für Biochemie
ETH Zürich, HPP L 14.1
|Telephone||+41 44 633 39 40|
|Fax||+41 44 633 12 94|
Number of participants limited to 20.
The enrolment is done by the D-BIOL study administration.
|6 credits||7G||F. Allain, C. Ciaudo, J. Corn, J. Hall, M. Jinek, S. Jonas, R. Santoro, O. Voinnet, K. Weis, A. Wutz|
|Abstract||Introduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells.|
|Objective||The students will obtain an overview about the diversity of current RNA-research. They will learn to design experiments and use techniques necessary to analyze different aspects of RNA biology. Through lectures and literature seminars, they will learn about the burning questions of RNA research and discuss approaches to address these questions experimentally. In practical lab projects the students will work in one of the participating laboratories. Finally, they will learn how to present and discuss their data in an appropriate manner. Student assessment is a graded semester performance based on individual performance in the laboratory, the written exam and the poster presentation.|
|Literature||Documentation and recommended literature will be provided at the beginning and during the course.|
|Prerequisites / Notice||The course will be taught in English.|
|551-1407-00L||RNA Biology Lecture Series I: Transcription & Processing & Translation|
Does not take place this semester.
|4 credits||2V||F. Allain, N. Ban, U. Kutay, further lecturers|
|Abstract||This course covers aspects of RNA biology related to gene expression at the posttranscriptional level. These include RNA transcription, processing, alternative splicing, editing, export and translation.|
|Objective||The students should obtain an understanding of these processes, which are at work during gene expression.|
|Content||Transcription & 3'end formation ; splicing, alternative splicing, RNA editing; the ribosome & translation, translation regulation, RNP biogenesis & nuclear export, mRNA surveillance & mRNA turnover; signal transduction & RNA.|
|Prerequisites / Notice||Basic knowledge of cell and molecular biology.|
|551-1411-00L||Molecular and Structural Biology III: Current Topics |
The course will only take place with a minimum of 6 participants.
|2 credits||1V||K. Locher, F. Allain, N. Ban, R. Glockshuber, M. Pilhofer, E. Weber-Ban|
|Abstract||The course discusses current topics and cutting edge research in the structural, molecular, and biochemical study of cellular macromolecules. Student participation is an essential component of the course and will contribute to the exam grade|
|Objective||The goal is to discuss cutting edge research in the structural, molecular, and biochemical study of cellular macromolecules. Students will also have an opportunity to present and discuss recent breakthroughs relevant to the research fields presented by the faculty teaching the course (see http://www.mol.biol.ethz.ch/research.html for details on the topics).|
|Literature||Will be distributed by the instructors|
|551-1601-00L||Biophysics of Biological Macromolecules|
The course will only take place with a minimum of 6 participants
|6 credits||2V + 1U||A. D. Gossert, F. Allain, A. Cléry, S. Jonas|
|Abstract||This lecture course targets physics students and students of interdisciplinary sciences (major physics) for their education in biophysics. In this course the basics of molecular biology are presented bearing in mind the special interests of the physics students.|
|Objective||Basics of molecular biology and biophysics in in view of the special interest of students in physics.|
|Content||This lecture course targets physics students and students of interdisciplinary sciences (major physics) for their education in biophysics. In this course the basics of molecular biology are presented bearing in mind the special interests of the physics students. |
The topics include: The molecules of life - properties of biological macromolecules. Discussion of structure and function of proteins, quantitative description molecular interactions and of enzyme function.
Introduction to methods to study biological macromolecules: purification techniques, optical spectroscopy, X-ray crystallography, electron microscopy (EM) and nuclear magnetic resonance (NMR) spectroscopy.
Introduction to the genetic system of E.coli bacteria: DNA, RNA and protein biosynthesis (transcription and translation) and biotechnological applications.
|Lecture notes||Additional documentation in support of text book|
|Prerequisites / Notice||Small classes with active participation of students|
|551-1619-00L||Structural Biology||1 credit||1K||R. Glockshuber, F. Allain, N. Ban, K. Locher, M. Pilhofer, E. Weber-Ban, K. Wüthrich|
|Abstract||The course consists of a series of research seminars on Structural Biology, Biochemistry and Biophysics, given by both scientists of the National Center of Competence in Research (NCCR) in Structural Biology and external speakers. Information on the individual seminars is provided on the following websites:|
|Objective||The goal of this course is to provide doctoral and postdoctoral students with a broad overview on the most recent developments in biochemistry, structural biology and biophysics.|