From 2 November 2020, the autumn semester 2020 will take place online. Exceptions: Courses that can only be carried out with on-site presence.
Please note the information provided by the lecturers via e-mail.

Manfred Kopf: Catalogue data in Spring Semester 2019

Name Prof. Dr. Manfred Kopf
FieldMolekulare Biomedizin
Inst. f. Molecular Health Sciences
ETH Zürich, HPL G 12
Otto-Stern-Weg 7
8093 Zürich
Telephone+41 44 633 64 70
Fax+41 44 633 13 50
RelationshipFull Professor

376-0152-00LAnatomy and Physiology II Information 5 credits4VM. Ristow, K. De Bock, M. Kopf, L. Slomianka, C. Spengler
AbstractBasic knowledge of the anatomy and physiology of the gastrointestinal tract, endocrine organs, urinary system and the reproductive system. Knowlewdge of the basic mechanisms of pathobiology. Study of all human tissues and selected organs by examining slides under the light microscope.
ObjectiveFoundations of human anatomy and physiology and basics of clinical pathophysiology
ContentShort overview of human anatomy, physiology and general pathology.
3rd semester:
Principles of histology and embryology. Anatomy and physiology: nervous system, muscle, sensory organs, circulatory system, respiratory system.
4rd semester:
Anatomy and physiology: gastrointestinal tract, endocrine system, metabolism and thermoregulation, integumentary system, blood and immune system, urinary system, circadian rhythm, reproductive system, pregnancy and birth.
LiteratureAnatomie: Martini, Timmons, Tallitsch, "Anatomie", Pearson; oder Schiebler, Korf, "Anatomie", Steinkopff / Springer; oder Spornitz, "Anatomie und Physiologie, Lehrbuch und Atlas für Pflege-und Gesundheitsfachberufe", Springer

Physiologie: Thews/Mutschler/Vaupel: Anatomie, Physiologie, Pathophysiologie des Menschen,
Wissenschaftliche Verlagsgesellschaft, Stuttgart


Schmidt/Lang/Thews: Physiologie des Menschen, Springer-Verlag, Heidelberg
Prerequisites / NoticeDer Besuch der Anatomie und Physiologie I - Vorlesung ist Voraussetzung, da die Anatomie und Physiologie II - Vorlesung auf dem Wissen der im vorangegangenen Semester gelesenen Anatomie und Physiologie I - Vorlesung aufbaut.
376-0209-00LMolecular Disease Mechanisms6 credits4VC. Wolfrum, H. Gahlon, M. Kopf
AbstractIn this course the mechanisms of disease development will be studied. Main topics will be:

1. Influence of environmental factors with an emphasis on inflammation and the immune response.
2. Mechanisms underlying disease progression in metabolic disorders, integrating genetic and environmental factors.
3. Mechanisms underlying disease progression in cancer, integrating genetic and environment
ObjectiveTo understand the mechanisms governing disease development with a special emphasis on genetic and environmental associated components
Lecture notesAll information can be found at:

The enrollment key will be provided by email
551-0102-01LFundamentals of Biology I Information Restricted registration - show details
Registrations via myStudies until 30.1.2019 at the latest. Subsequent registrations will not be considered.
6 credits8PM. Gstaiger, T. A. Beyer, M. Kopf, R. Kroschewski, M. Künzler, D. Ramseier, M. Stoffel, E. B. Truernit, A. Wutz
AbstractThis 1st year Laboratory course introduces the student to the entire range of classical and modern molecular biosciences. During this course (Praktikum GL BioI) the students will do three praktikum days in:
- Biochemistry
- Cell Biology I
- Microbiology
- Plant Anantomy & Ecology
(total of 12 experiments)

Each experiment takes one full day.
ObjectiveIntroduction to theoretical and experimental biology

General Praktikum-information and course material can be obtained from Moodle

The general Praktikum information (Assignment list, Instructions and Schedule & Performance Sheet) will also be sent to the students directly (E-mail).
ContentThe class is divided into four blocks: Biochemistry, Microbiology, Plant biology & Ecology and Cell Biology I.

- TAQ Analysis (part 1): Protein purification
- TAQ Analysis (part 2): SDS-Gelelektrophoresis
- TAQ Analysis (part 3): Activity test of the purified protein

Day 1: Basics for the work with microorganisms & Isolation of microorganisms from the environment
Day 2: Morphology and diagnostics of bacteria & Antimicrobial agents
Day 3: Morphology of fungi & Microbial physiology and interactions

- Microscopy and plant cell anatomy
- Plant organ anatomy and gene expression
- Ecology

- Anatomy of mouse & Blood cell determination
- Histology
- Chromosome preparation and analysis
Lecture notesLaboratory manuals

- The protocols can be downloaded from: Moodle

- The protocols can be found from: Moodle
- You HAVE TO print the pdf-file, which is also used as the lab manual during the experiments. Therefore, you have to have the Script always with you, when doing the experiments in Microbiology.

- The protocols can be found from: Moodle

- The handouts of the experiments entitled "Histology" will be provided
- The protocols of "Anatomy of mouse & Blood cell determination" and "Chromosome preparation and analysis" can be found from: Moodle

Your attendance is obligatory and you have to attend all 12 Praktikum days of GL BioI. Absences are only acceptable if you are able to provide a Doctor’s certificate. The original Dr's certificate has to be given to Dr. M. Gstaiger (HPM F43) within five days of the absence of the Praktikum day.

If there will be any exceptional or important situations then you should directly contact the Director of Studies of D-Biol, who will decide if you are allowed to miss a Praktikum day or not.


1. Due to the increased number of students, the official Praktikum registration has to be done, using myStudies, preferably at the end of HS18 but not later than Wednesday January 30, 2019.

2. Later registration is NOT possible and can NOT be accepted!

3. The course registration for FS2019 is usually possible at the end of Autumn semester 2018 and you will obtain an E-mail from the Rectorate when the course registration using myStudies is possible.

Students can register for a practice group via myStudies. As soon as the course unit is registered in myStudies, a text box appears indicating that a group can be selected. Accordingly, students can select a group in the next step. If more than 240 students register, the surplus students will be placed on a waiting list and then allocated by the course responsible.

Extra Praktikum days have to be organized if more than 220 - 240 students will attend the Praktikum. The group division is random and the reserved Extra Praktikum days are:

3.6 / 4.6 / 6.6

The Praktikum GL BioI will take place during the following days and therefore, you have to make sure already now that you will not have any other activities / commitments during these days:

PRAKTIKUM DAYS FS18 (Thursdays):

21.2 / 28.2 / 7.3 / 14.3 / 21.3 / 28.3 / 4.4 / 11.4 / 2.5 / 9.5 / 16.5 / 23.5

No Praktikum during the Easter vacation: 19.4.-26.4. 2019


3.6 / 4.6 / 6.6
551-0318-00LImmunology II3 credits2VA. Oxenius, M. Kopf, S. R. Leibundgut, E. Wetter Slack, further lecturers
AbstractIntroduction into the cellular and molecular basis of the immune system and immune responses against diverse pathogens, tumors, transplants, and self (autoimmunity)
ObjectiveThe lectures will provide a detailed understanding:
- how innate and adaptive immune responses interact at the cellular and molecular level.
- how the immune system recognizes and fights against pathogenic microorganisms including viruses, bacteria, and parasites.
- why lymphocytes tolerate self molecules.
- about function and dysfunction the intestinal immune system.
- immunopathology and inflammatory diseases.
ContentThe aim of lecture is to understand:
> How pathogens are recognized by the innate immune system
> Immune defense against various pathogens
> Immunology of the skin, lung and intestines
> Tumor immunology
> Migration and homing of immune cells
> tolerance and autoimmunity
> T cell memory
Lecture notesPresentations of the lecturers are available at the Moodle link
LiteratureRecommended: Kuby Immunology (Freeman)
551-0396-01LImmunology I Restricted registration - show details
Number of participants limited to 30.

Prerequisites: Attendance of the concept courses Immunology I (551-0317-00L) and Immunology II (551-0318-00L)

The enrolment is done by the D-BIOL study administration.
6 credits7GA. Oxenius, B. Becher, M. Groettrup, M. Kopf, B. Ludewig, C. Münz, R. Spörri, M. van den Broek
AbstractThis block course teaches a wide selection of practical immunological techniques and offers advanced lectures in selected topics in immunology.
ObjectiveThe aim of this block course is the acquaintance with a wide spectrum of immunological techniques involving practical experimental work following analysis and interpretation of the experimental data. Along the practical work, advanced lectures in selected topics in immunology, based on the knowledge from the immunology concept course, will be offered. Furthermore, students will have the opportunity to read, interpret and present current papers followed scientific discussions.
ContentThe aim of this block course is the acquaintance with a wide spectrum of immunological techniques involving practical experimental work following analysis and interpretation of the experimental data. Along the practical work, advanced lectures in selected topics in immunology, based on the knowledge from the immunology concept course, will be offered. Furthermore, students will have the opportunity to read, interpret and present current papers followed scientific discussions.
Lecture notesA script for the course will be available online (the link will be provided in the immunology concept lecture, 551-0318-00L).
Prerequisites / NoticeRequirement for the registration for this block course is the attendance of the immunology concept courses 551-0317-00L and 551-0318-00L.
Evaluation of achievements is done on an individual basis by each participating lecturer.
551-0509-00LCurrent Immunological Research in Zürich0 credits1KR. Spörri, M. Detmar, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers
AbstractThis monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion.
ObjectiveThe aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups.
ContentPresentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich.
Lecture notesnone
551-1100-00LInfectious Agents: From Molecular Biology to Disease
Number of participants limited to 22.
Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures.
(if you missed the deadline, please come to the first date to see, if there are any slots left)
4 credits2SW.‑D. Hardt, L. Eberl, U. F. Greber, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander
AbstractLiterature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.
ObjectiveWorking with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.
Contentfor each model pathogen (or key technology):
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
Lecture notesTeachers will provide the research papers to be discussed.
Students will prepare handouts for the rest of the group for their assigned seminar.
LiteratureTeachers will provide the research papers to be discussed.
Prerequisites / NoticeRestricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.
The first seminar date will serve to form groups of students and assign a paper to each group.
551-1118-00LCutting Edge Topics: Immunology and Infection Biology II Information 2 credits1SA. Oxenius, B. Becher, C. Halin Winter, N. C. Joller, M. Kopf, S. R. Leibundgut, C. Münz, F. Sallusto, R. Spörri, M. van den Broek, University lecturers
AbstractWeekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion.
ObjectiveWeekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion.
The aim of this course is to confront students with current research topics and with scientific presentation. The course offers the opportunity to gain in depth knowledge about diverse topics which are often only briefly touched in the concept courses and to engage in discussion with experts in the field.
ContentImmunology and infection biology.
The specific topics are variable and depend each semester on the list of invited experts.