Name | Prof. Dr. Annette Oxenius |
Field | Immunology |
Address | Institut für Mikrobiologie ETH Zürich, HCI G 401 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
Telephone | +41 44 632 33 17 |
aoxenius@micro.biol.ethz.ch | |
Department | Biology |
Relationship | Full Professor |
Number | Title | ECTS | Hours | Lecturers | |
---|---|---|---|---|---|
551-0033-00L | Molecular Genetics and Cell Biology Only for Health Sciences and Technology BSc and Human Medicine BSc. | 5 credits | 5G | E. Hafen, K. Köhler, A. Oxenius | |
Abstract | Dieser Kurs vermittelt die Grundprinzipien der Evolution, Zellbiologie, Molekularbiologie, Genetik und Entwicklungsbiologie am Beispiel Mensch. | ||||
Objective | 1.Die Studierenden können die Bedeutung der Evolution für die Entstehung des Menschen und von Krankheiten erklären. 2. Die Studierenden kennen die Zelle als kleinste Einheit des Körpers. Sie können erklären, wie die Funktionen der Zelle in bestimmten Krankheiten gestört sind und wo Therapien eingreifen. Sie können die Vervielfältigung von Zellen im Körper beschreiben und aufzeigen, wie Fehler bei dieser Vervielfältigung zu Krankheiten führen können. 3. Die Studierenden kennen die DNA als Grundlage des Lebens. Sie können erklären, wie die DNA Information speichert und wie diese Information vervielfältigt und vor Schäden geschützt werden kann. Sie können beschreiben, wie die Information abgelesen und in Proteine übersetzt wird. Sie können erklären, durch welche Mechanismen auf der Ebene der DNA, der RNA und der Proteine Krankheiten entstehen können. 4. Die Studierenden können erklären, welche Technologien zur Diagnostik und Therapie von Krankheiten eingesetzt werden können. 5. Die Studierenden können erklären, wie sich Menschen genetisch voneinander unterscheiden und kennen die molekularen Grundlagen dieser Unterschiede. Sie können erklären, wie diese Unterscheide zu Krankheiten führen können und warum manche dieser Unterschiede sich nicht auf Krankheiten auswirken. 6. Die Studierenden kennen die molekularen Ursachen der häufigsten Erbkrankheiten und können die Wahrscheinlichkeit des Auftretens und der Weitergabe an Nachkommen bestimmen. 7. Die Studierenden können die biochemischen und molekularen Grundlagen der menschlichen Fortpflanzung erklären und kennen die Grundprinzipien der Embyronalentwicklung des Menschen. Die Studierenden können erklären, welche Mechanismen bei einer fehlerhaften Entwicklung gestört sein können. 8. Die Studierenden kennen die geschichtliche Entwicklung der Biologie und ihre Auswirkungen auf die Medizin und die Gesellschaft. | ||||
551-0223-00L | Immunology III | 4 credits | 2V | M. Kopf, M. Bachmann, S. B. Freigang, J. Kisielow, S. R. Leibundgut, A. Oxenius, R. Spörri | |
Abstract | This course provides a detailed understanding of - development of T and B cells - the dynamics of a immune response during acute and chronic infection - mechanisms of immunopathology - modern vaccination strategies Key experimental results will be shown to help understanding how immunological text book knowledge has evolved. | ||||
Objective | Obtain a detailed understanding of - the development, activation, and differentiation of different types of T cells and their effectormechanisms during immune responses, - Recognition of pathogenic microorganisms by the host cells and molecular events thereafter, - events and signals for maturation of naive B cells to antibody producing plasma cells and memory B cells. - Optimization of B cell responses by intelligent design of new vaccines | ||||
Content | o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg) o NK T cells and responses to lipid antigens o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17 o Overview of cytokines and their effector function o Co-stimulation (signals 1-3) o Dendritic cells o Evolution of the "Danger" concept o Cells expressing Pattern Recognition Receptors and their downstream signals o T cell function and dysfunction in acute and chronic viral infections | ||||
Literature | Documents of the lectures are available for download at: https://moodle-app2.let.ethz.ch/course/view.php?id=2581¬ifyeditingon=1 | ||||
Prerequisites / Notice | Immunology I and II recommended but not compulsory | ||||
551-0317-00L | Immunology I | 3 credits | 2V | A. Oxenius, M. Kopf | |
Abstract | Introduction into structural and functional aspects of the immune system. Basic knowledge of the mechanisms and the regulation of an immune response. | ||||
Objective | Introduction into structural and functional aspects of the immune system. Basic knowledge of the mechanisms and the regulation of an immune response. | ||||
Content | - Introduction and historical background - Innate and adaptive immunity, Cells and organs of the immune system - B cells and antibodies - Generation of diversity - Antigen presentation and Major Histoincompatibility (MHC) antigens - Thymus and T cell selection - Autoimmunity - Cytotoxic T cells and NK cells - Th1 and Th2 cells, regulatory T cells - Allergies - Hypersensitivities - Vaccines, immune-therapeutic interventions | ||||
Lecture notes | Electronic access to the documentation will be provided. The link can be found at "Lernmaterialien" | ||||
Literature | - Kuby, Immunology, 7th edition, Freemen + Co., New York, 2009 | ||||
Prerequisites / Notice | Immunology I (WS) and Immunology II (SS) will be examined as one learning entity in a "Sessionsprüfung". | ||||
551-0509-00L | Current Immunological Research in Zürich | 0 credits | 1K | R. Spörri, M. Detmar, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers | |
Abstract | This monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion. | ||||
Objective | The aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups. | ||||
Content | Presentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich. | ||||
Lecture notes | none | ||||
551-1106-00L | Progress Reports in Microbiology and Immunology Students must sign up via secr.micro.biol.ethz.ch | 0 credits | 5S | J. Piel, M. Aebi, H.‑M. Fischer, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli | |
Abstract | Presentation and discussion of current research results in the field of Microbiology and Infection Immunology | ||||
Objective | Precise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims | ||||
551-1117-00L | Cutting Edge Topics: Immunology and Infection Biology | 2 credits | 1S | A. Oxenius, B. Becher, C. Halin Winter, M. Kopf, S. R. Leibundgut, C. Münz, A. Trkola, M. van den Broek | |
Abstract | Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion. | ||||
Objective | Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion. The aim of this course is to confront students with current research topics and with scientific presentation. The course offers the opportunity to gain in depth knowledge about diverse topics which are often only briefly touched in the concept courses and to engage in discussion with experts in the field. | ||||
Content | Immunology and infection biology. The specific topics are variable and depend each semester on the list of invited experts. | ||||
551-1171-00L | Immunology: from Milestones to Current Topics | 4 credits | 2S | B. Ludewig, J. Kisielow, M. Kopf, A. Oxenius, University lecturers | |
Abstract | Milestones in Immunology: on old concepts and modern experiments | ||||
Objective | The course will cover six grand topics in immunology (B cells, innate immunity, antigen presentation, tumor immunity, thymus and T cells, cytotoxic T cells and NK cells) and for each grand topic four hours will be allocated. During the first double hour, historical milestone papers will be presented by the supervisor providing an overview on the development of the conceptional framework and critical technological advances. The students will also prepare themselves for this double lecture by reading the historical milestone papers and contributing to the discussion. In the following lecture up to four students will present each a recent high impact research paper which emerged from the landmark achievements of the previously discussed milestone concepts. | ||||
Content | Milestones and current topics of innate immunity, antigen presentatino, B cells, thymus and T cells, cytotoxic T cells and NK cells, and tumor immunology. | ||||
Lecture notes | Original and review articles will be distributed by the lecturer. | ||||
Literature | Literaturunterlagen werden vor Beginn des Kurses auf folgender website zugänglich sein: Moodle Course https://moodle-app2.let.ethz.ch/course/view.php?id=3450 |