Janos Vörös: Catalogue data in Autumn Semester 2020

Name Prof. Dr. Janos Vörös
Inst. f. Biomedizinische Technik
ETH Zürich, ETZ F 82
Gloriastrasse 35
8092 Zürich
Telephone+41 44 632 59 03
Fax+41 44 632 11 93
DepartmentInformation Technology and Electrical Engineering
RelationshipFull Professor

227-0085-13LProjects & Seminars: Let’s Build and Control our own Atomic Force Microscope... Restricted registration - show details
Only for Electrical Engineering and Information Technology BSc.

The course unit can only be taken once. Repeated enrollment in a later semester is not creditable.
3.5 credits3.5PJ. Vörös
AbstractThe category of "Laboratory Courses, Projects, Seminars" includes courses and laboratories in various formats designed to impart practical knowledge and skills. Moreover, these classes encourage independent experimentation and design, allow for explorative learning and teach the methodology of project work.
ObjectiveInvented in the 1980s in Zurich and awarded with a Nobel price, the atomic force microscope (AFM) has enabled us to visualize surfaces at the single atom level, and to measure single molecule and cell-cell interactions, deepening our understanding of material science and biology. This is enabled by controlling micromechanical piezo actuators with nanometer precision and processing noisy signals in order to achieve meaningful data.

In order to introduce you to the capabilities of modern AFMs in biomedical sensing, you will build your own setups in groups of two. You will be introduced to an AFM’s functionality, control, and signal read-out using LabView. A tuning fork signal will be used as the feedback for the self-built AFM. In order to better understand the working principle of a tuning fork, you will also build your own frequency sweeper and analyze it with self-built low-pass filters.
After you have implemented your own setup, you will have the chance to characterize different biomedical samples on state-of-the-art setups. This data will then be analyzed using Matlab.
The focus of this P&S seminar is to enable you to transfer your theoretical knowledge into practice and at the same time get to know how electrical engineering can be used in biomedical research.

The course requires active participation during the practical sessions, a 10-15 min presentation and a short written report on the acquired results. The course will be given in English.

05.10, 08.10, 12.10, 15.10, , 26.10, 29.10, 9.11, 12.11
227-0386-00LBiomedical Engineering Information 4 credits3GJ. Vörös, S. J. Ferguson, S. Kozerke, M. P. Wolf, M. Zenobi-Wong
AbstractIntroduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined.
ObjectiveIntroduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations.
ContentIntroduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism.
Practical and theoretical exercises in small groups in the laboratory.
Lecture notesIntroduction to Biomedical Engineering
by Enderle, Banchard, and Bronzino


227-0393-10LBioelectronics and Biosensors Information 6 credits2V + 2UJ. Vörös, M. F. Yanik, T. Zambelli
AbstractThe course introduces the concepts of bioelectricity and biosensing. The sources and use of electrical fields and currents in the context of biological systems and problems are discussed. The fundamental challenges of measuring biological signals are introduced. The most important biosensing techniques and their physical concepts are introduced in a quantitative fashion.
ObjectiveDuring this course the students will:
- learn the basic concepts in biosensing and bioelectronics
- be able to solve typical problems in biosensing and bioelectronics
- learn about the remaining challenges in this field
ContentL1. Bioelectronics history, its applications and overview of the field
- Volta and Galvani dispute
- BMI, pacemaker, cochlear implant, retinal implant, limb replacement devices
- Fundamentals of biosensing
- Glucometer and ELISA

L2. Fundamentals of quantum and classical noise in measuring biological signals

L3. Biomeasurement techniques with photons

L4. Acoustics sensors
- Differential equation for quartz crystal resonance
- Acoustic sensors and their applications

L5. Engineering principles of optical probes for measuring and manipulating molecular and cellular processes

L6. Optical biosensors
- Differential equation for optical waveguides
- Optical sensors and their applications
- Plasmonic sensing

L7. Basic notions of molecular adsorption and electron transfer
- Quantum mechanics: Schrödinger equation energy levels from H atom to crystals, energy bands
- Electron transfer: Marcus theory, Gerischer theory

L8. Potentiometric sensors
- Fundamentals of the electrochemical cell at equilibrium (Nernst equation)
- Principles of operation of ion-selective electrodes

L9. Amperometric sensors and bioelectric potentials
- Fundamentals of the electrochemical cell with an applied overpotential to generate a faraday current
- Principles of operation of amperometric sensors
- Ion flow through a membrane (Fick equation, Nernst equation, Donnan equilibrium, Goldman equation)

L10. Channels, amplification, signal gating, and patch clamp Y4

L11. Action potentials and impulse propagation

L12. Functional electric stimulation and recording
- MEA and CMOS based recording
- Applying potential in liquid - simulation of fields and relevance to electric stimulation

L13. Neural networks memory and learning
LiteraturePlonsey and Barr, Bioelectricity: A Quantitative Approach (Third edition)
Prerequisites / NoticeThe course requires an open attitude to the interdisciplinary approach of bioelectronics.
In addition, it requires undergraduate entry-level familiarity with electric & magnetic fields/forces, resistors, capacitors, electric circuits, differential equations, calculus, probability calculus, Fourier transformation & frequency domain, lenses / light propagation / refractive index, Michaelis-Menten equation, pressure, diffusion AND basic knowledge of biology and chemistry (e.g. understanding the concepts of concentration, valence, reactants-products, etc.).
227-0970-00LResearch Topics in Biomedical Engineering0 credits2KK. P. Prüssmann, S. Kozerke, M. Stampanoni, K. Stephan, J. Vörös
AbstractCurrent topics in Biomedical Engineering presented by speakers from academia and industry.
ObjectiveGetting insight into actual areas and problems of Biomedical Engineering an Health Care.