Name | Prof. Stefanie-Dorothea Krämer |
Field | Biopharmacy |
Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 409 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
Telephone | +41 44 633 74 03 |
Fax | +41 44 633 14 57 |
stefanie.kraemer@pharma.ethz.ch | |
URL | http://www.biopharmacy.ethz.ch/ |
Department | Chemistry and Applied Biosciences |
Relationship | Adjunct Professor and Privatdozentin |
Number | Title | ECTS | Hours | Lecturers | |
---|---|---|---|---|---|
535-0241-AAL | Biopharmacy Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 3 credits | 6R | S.‑D. Krämer | |
Abstract | Introduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential. | ||||
Objective | Introduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential. | ||||
Content | Introduction to pharmacokinetics; definition of the most important pharmacokinetic parameters and their calculation from clinical data (compartment model, statistical model); kinetics of absorption (absorption profiles); distribution of drugs and role of protein binding; kinetics of elimination: excretion and biotransformation (physiological model); pharmacokinetic profiling of drugs for therapy optimization and for the analysis of the interaction potential; dosage regimen design. | ||||
535-0250-00L | Biotransformation of Drugs and Xenobiotics | 1 credit | 1V | S.‑D. Krämer | |
Abstract | Knowledge of the major reactions of biotransformation in drug therapy, prediction of possible metabolites of drugs and xenobiotics, recognition of structure elements and reactions which can lead to toxic metabolites. Knowledge of inter- and intraindividual factors influencing metabolism. | ||||
Objective | Goals: knowledge of the major reactions of biotransformation in drug therapy, prediction of possible metabolites of drugs and xenobiotics, recognition of structure elements and reactions which can lead to toxic metabolites. Knowledge of inter- and intraindividual factors influencing metabolism. | ||||
Content | Major reactions of biotransformation. Major enzymes and reaction partners involved in the biotransformation of drugs and xenobiotics. Toxic reactions of metabolites. Factors which affect the biotransformation. | ||||
Lecture notes | Biotransformation of drugs and xenobiotics | ||||
Literature | B. Testa and S.D. Krämer. The Biochemistry of Drug Metabolism: Volumes 1 and 2, VHCA, Zürich, 2008 and 2010. B. Testa and S.D. Krämer. The Biochemistry of Drug Metabolism: Parts 1 to 7. Published in Chemistry & Biodiversity, 2006-2009. |