Stefanie-Dorothea Krämer: Catalogue data in Autumn Semester 2016

Award: The Golden Owl
Name Prof. Stefanie-Dorothea Krämer
FieldBiopharmacy
Address
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 409
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 74 03
Fax+41 44 633 14 57
E-mailstefanie.kraemer@pharma.ethz.ch
URLhttp://www.biopharmacy.ethz.ch/
DepartmentChemistry and Applied Biosciences
RelationshipAdjunct Professor and Privatdozentin

NumberTitleECTSHoursLecturers
535-0241-AALBiopharmacy
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
3 credits6RS.‑D. Krämer
AbstractIntroduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential.
ObjectiveIntroduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential.
ContentIntroduction to pharmacokinetics; definition of the most important pharmacokinetic parameters and their calculation from clinical data (compartment model, statistical model); kinetics of absorption (absorption profiles); distribution of drugs and role of protein binding; kinetics of elimination: excretion and biotransformation (physiological model); pharmacokinetic profiling of drugs for therapy optimization and for the analysis of the interaction potential; dosage regimen design.
535-0250-00LBiotransformation of Drugs and Xenobiotics1 credit1VS.‑D. Krämer
AbstractKnowledge of the major reactions of biotransformation in drug therapy, prediction of possible metabolites of drugs and xenobiotics, recognition of structure elements and reactions which can lead to toxic metabolites. Knowledge of inter- and intraindividual factors influencing metabolism.
ObjectiveGoals: knowledge of the major reactions of biotransformation in drug therapy, prediction of possible metabolites of drugs and xenobiotics, recognition of structure elements and reactions which can lead to toxic metabolites. Knowledge of inter- and intraindividual factors influencing metabolism.
ContentMajor reactions of biotransformation. Major enzymes and reaction partners involved in the biotransformation of drugs and xenobiotics. Toxic reactions of metabolites. Factors which affect the biotransformation.
Lecture notesBiotransformation of drugs and xenobiotics
LiteratureB. Testa and S.D. Krämer. The Biochemistry of Drug Metabolism: Volumes 1 and 2, VHCA, Zürich, 2008 and 2010.

B. Testa and S.D. Krämer. The Biochemistry of Drug Metabolism: Parts 1 to 7. Published in Chemistry & Biodiversity, 2006-2009.