Stefanie-Dorothea Krämer: Catalogue data in Autumn Semester 2017

Name Prof. Stefanie-Dorothea Krämer
FieldBiopharmacy
Address
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 409
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 74 03
Fax+41 44 633 14 57
E-mailstefanie.kraemer@pharma.ethz.ch
URLhttp://www.biopharmacy.ethz.ch/
DepartmentChemistry and Applied Biosciences
RelationshipAdjunct Professor and Privatdozentin

NumberTitleECTSHoursLecturers
511-1001-00LBiopharmacy (Crash Course) Restricted registration - show details
Obligatory course if assigned by the Admission committee.
2 credits1SS.‑D. Krämer
AbstractThis course provides the basic concepts of biopharmacy (ADMET, absorption, distribution, metabolism, excretion, toxicity of drugs) and pharmacokinetics. After an introduction to the fundamental parameters and concepts, the participants will study independently and apply and consolidate their knowledge in tutorials.
Objective- Knowledge of the ADMET processes and the respective pharmacokinetic parameters.
- Interpretation of pharmacokinetic parameters.
- Analysis of drug plasma concentration-time curves.
- Prediction of pharmacokinetic parameters based on in vitro assays and physicochemical drug properties.
- Knowledge of the effects of physiological factors on the pharmacokinetic parameters and on drug plasma and tissue concentrations.
- Design of dosage regimens, based on pharmacokinetic parameters.
- Prediction of drug-drug interaction potentials based on in vitro assays and pharmacokinetic parameters.
Content- Introduction to biopharmacy (ADMET) and pharmacokinetics.
- Definition of the most important pharmacokinetic parameters and their calculation from plasma concentration-time curves.
- Introduction to compartment models, statistical models, physiological models.
- Pharmacokinetic profiling of drugs for therapy optimization and for the analysis of the interaction potential.
- Design of dosage regimens. In vitro assays to predict pharmacokinetic parameters.
Lecture notesSlides, see documents repository.
LiteratureDennis A. Smith, Charlotte Allerton, Amit S. Kalgutkar, Han van de Waterbeemd, Don K. Walker (Eds.) Pharmacokinetics and Metabolism in Drug Design. 3rd edition, 2012. Wiley online library.
DOI: 10.1002/9783527645763
http://onlinelibrary.wiley.com/book/10.1002/9783527645763
Prerequisites / Notice***
535-0011-00LDrug Seminar Restricted registration - show details
The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences
5 credits9SC. Halin Winter, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, D. Neri, V. I. Otto, U. Quitterer, R. Schibli, G. Schneider, C. Steuer, H. U. Zeilhofer
AbstractThe course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium.
ObjectiveThe main objectives of this course are:

- students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic
- students gain in-depth knowledge of the topic investigated
- students train their scientific writing and presentation skills
- students train their ability to plan a project and work in a team
ContentThe Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences.

The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences.

During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester.
Prerequisites / NoticeOnly for students of MSc Pharmacy and MSc Pharmaceutical Sciences.
535-0250-00LBiotransformation of Drugs and Xenobiotics1 credit1VS.‑D. Krämer
AbstractKnowledge of the major reactions of biotransformation in drug therapy, prediction of possible metabolites of drugs and xenobiotics, recognition of structure elements and reactions which can lead to toxic metabolites. Knowledge of inter- and intraindividual factors influencing metabolism.
ObjectiveGoals: knowledge of the major reactions of biotransformation in drug therapy, prediction of possible metabolites of drugs and xenobiotics, recognition of structure elements and reactions which can lead to toxic metabolites. Knowledge of inter- and intraindividual factors influencing metabolism.
ContentMajor reactions of biotransformation. Major enzymes and reaction partners involved in the biotransformation of drugs and xenobiotics. Toxic reactions of metabolites. Factors which affect the biotransformation.
Lecture notesBiotransformation of drugs and xenobiotics
LiteratureB. Testa and S.D. Krämer. The Biochemistry of Drug Metabolism: Volumes 1 and 2, VHCA, Zürich, 2008 and 2010.

B. Testa and S.D. Krämer. The Biochemistry of Drug Metabolism: Parts 1 to 7. Published in Chemistry & Biodiversity, 2006-2009.