The spring semester 2021 will certainly take place online until Easter. Exceptions: Courses that can only be carried out with on-site presence. Please note the information provided by the lecturers.

Rudolf Aebersold: Catalogue data in Autumn Semester 2016

Name Prof. Dr. Rudolf Aebersold
Inst. f. Molekulare Systembiologie
ETH Zürich, HPM H 25
Otto-Stern-Weg 3
8093 Zürich
Telephone+41 44 633 31 70
RelationshipFull Professor

551-0002-AALGeneral Biology II
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
4 credits6RU. Sauer, R. Aebersold, H.‑M. Fischer, W. Gruissem
AbstractMolecular biology approach to teach the basic principles of biochemistry, cell biology, cgenetics, evolutionary biology and form and function of vacular plants.

This is a virtual self-study lecture for non-German speakers of the "Allgemeine Biology II (551-0002-00L) lecture. The exam will be written jointly with the participants of this lecture.
ObjectiveThe understanding basic concepts of biology: the hierarchy of the structural levels of biological organisation, with particular emphasis on the cell and its molecular functions, the fundamentals of metabolism and molecular genetics, as well as form and function of vascular plants.
ContentThe structure and function of biomacromolecules; basics of metabolism; tour of the cell; membrane structure and function; basic energetics of cellular processes; respiration, photosynthesis; cell cycle, from gene to protein; structure and growth of vascular plants, resource acquisition and transport, soil and plant nutrition.

Specifically the following Campbell chapters will be covered:
3 Biochemistry Chemistry of water
4 Biochemistry Carbon: the basis of molecular diversity
5 Biochemistry Biological macromolecules and lipids
7 Cell biology Cell structure and function
8 Cell biology Cell membranes
10 Cell biology Respiration: introduction to metabolism
10 Cell biology Cell respiration
11 Cell biology Photosynthetic processes
16 Genetics Nucleic acids and inheritance
17 Genetics Expression of genes
18 Genetics Control of gene expression
19 Genetics DNA Technology
35 Plant structure&function Plant Structure and Growth
36 Plant structure&function Transport in vascular plants
37 Plant structure&function Plant nutrition
38 Plant structure&function Reproduction of flowering plants
39 Plant structure&function Plants signal and behavior
Lecture notesNo script
LiteratureCampbell et al. (2015) Biology - A Global Approach. 10th Edition (Global Edition)
Prerequisites / NoticeBasic general and organic chemistry

PLEASE NOTE This lecture is newly conceived and will be held for the first time in the spring semester 2017.
551-1003-00LMethods of Biological Analysis Information 3 credits3GR. Aebersold, M. Badertscher, K. Weis
Principles of the most important separation techniques and the interpretation of molecular spectra.

The course will teach the basis and typical applications of methods for the analysis of nucleic acid sequences, mass spectrometric analysis of proteins and proteomes and advanced light and fluorescent imaging methods.
Knowledge of the necessary basics and the possibilities of application of the relevant spectroscopical and separation methods in analytical chermistry.

Knowledge of the theoretical basis of the methods for nucleic acid sequence analysis, mass spectrometry based protein and proteome analysis and advanced light and fluorescent imaging methods, and an understanding of the application of these principles in experimental biology.
Application oriented basics of instrumental analysis in organic chemistry and the empirical employment of the methods of structure elucidation (mass spectrometry, NMR-, IR-, UV/VIS spectroscopy). Basics and application of chromatographic and electrophoretic separation methods. Application of the knowledge by practising.

The course will consist of lectures covering the theoretical and technical base of the respective analytical methods and of exercises where typical applications of the methods in modern experimental biology are discussed.
Lecture notes529-1042-00
A comprehensive script is available in the HCI-Shop. A summary of the part "Spektroskopie" defines the relevant material for the exam.

Materials supporting the lectures and exercises will be made available via Moodle.
- Pretsch E., Bühlmann P., Badertscher M. Structure Determination of Organic Compounds, 5th revised and enlarged English edition, Springer-Verlag, Berlin 2009;
- Pretsch E., Bühlmann P., Badertscher M., Spektroskopische Daten zur Strukturaufklärung organischer Verbindungen, fünfte Auflage, Springer-Verlag, Berlin 2010;
- D.A. Skoog, J.J. Leary, Instrumentelle Analytik, Grundlagen, Geräte, Anwendungen, Springer, Berlin, 1996;
- K. Cammann, Instrumentelle Analytische Chemie, Verfahren, Anwendungen, Qualitätssicherung, Spektrum Akademischer Verlag, Heidelberg, 2001;
- R. Kellner, J.-M. Mermet, M. Otto, H.M. Widmer, Analytical Chemistry, Wiley-VCH Verlag, Weinheim, 1998;
- K. Robards, P.R.Haddad, P.E. Jackson, Principles and practice of modern chromatographic methods, Academic Press, London, 1994;
Prerequisites / Notice529-1042-00
- 529-1001-01 V "Allgemeine Chemie I (für Biol./Pharm.Wiss.)"
- 529-1001-00 P "Allgemeine Chemie I (für Biol./Pharm.Wiss.)"
- 529-1011-00 G "Organische Chemie I (für Biol./Pharm.Wiss.)"
551-1159-00LMolecular Systems Biology0 credits1KU. Sauer, R. Aebersold
AbstractSeminar series on current research topics in systems biology
ObjectiveAn overview of systesm biology research
ContentSeminar series on current research topics in systems biology
Lecture notesnone