Ernst Hafen: Catalogue data in Autumn Semester 2014

Name Prof. em. Dr. Ernst Hafen
FieldMolekulare Entwicklungsbiologie
Address
Inst. f. Molekulare Systembiologie
ETH Zürich, HPM H 29
Otto-Stern-Weg 3
8093 Zürich
SWITZERLAND
E-mailhafen@imsb.biol.ethz.ch
URLhttp://www.imsb.ethz.ch/researchgroup/hafene
DepartmentBiology
RelationshipProfessor emeritus

NumberTitleECTSHoursLecturers
551-0016-AALBiology II Information
Enrolment only for MSc students who need this course as additional requirement.
2 credits4RM. Stoffel, E. Hafen
AbstractThe lecture course Biology II is a basic introductory course into biology for students who need to pass this course for admission to their MSc curriculum.
ObjectiveThe objective of the lecture course Biology II is the understanding of form, function, and development of animals and of the basic underlying mechanisms.
ContentThe following numbers of chapters refer to the text-book "Biology" (Campbell & Reece, 7th edition, 2005) on which the course is based. Chapters 1-4 are a basic prerequisite. The sections "Structure of the Cell" (Chapters 5-10, 12, 17) and "General Genetics" (Chapters 13-16, 18, 46) are covered by the lecture Biology I.

1. Genomes, DNA Technology, Genetic Basis of Development

Chapter 19: Eukaryotic Genomes: Organization, Regulation, and Evolution
Chapter 20: DNA Technology and Genomics
Chapter 21: The Genetic Basis of Development

2. Form, Function, and Development of Animals I

Chapter 40: Basic Principles of Animal Form and Function
Chapter 41: Animal Nutrition
Chapter 44: Osmoregulation and Excretion
Chapter 47: Animal Development

3. Form, Function, and Develeopment of Animals II

Chapter 42: Circulation and Gas Exchange
Chapter 43: The Immune System
Chapter 45: Hormones and the Endocrine System
Chapter 48: Nervous Systems
Chapter 49: Sensory and Motor Mechanisms
LiteratureThe following text-book is the basis for the courses Biology I and II:

„Biology“, Campbell and Reece, 7th Edition, 2005, Pearson/Benjamin Cummings, ISBN 0-8053-7166-4
Prerequisites / NoticePrerequisite: Lecture course Biology I of winter semester
551-0103-AALFundamentals of Biology II: Cell Biology Information
Enrolment only for MSc students who need this course as additional requirement.
5 credits11RU. Kutay, Y. Barral, E. Hafen, G. Schertler, U. Suter, S. Werner
AbstractThe goal of this course is to provide students with a wide general understanding in cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.
ObjectiveThe goal of this course is to provide students with a wide general understanding cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.
ContentThe focus is animal cells and the development of multicellular organisms with a clear emphasis on the molecular basis of cellular structures and phenomena. The topics include biological membranes, the cytoskeleton, protein sorting, energy metabolism, cell cycle and division, viruses, extracellular matrix, cell signaling, embryonic development and cancer research.
LiteratureAlberts et al. ‘Molecular Biology of the Cell’ Fifth edition, 2008 ISBN 978-0-8153-4105-5 (hard cover) and ISBN 978-0-8153-4106-2 (paperback).

Topic/Lecturer/Chapter/Pages: Introduction to Cell Biology/Gebhard Schertler/1+2+3+4/1-193; Cellular compartments/Gebhard Schertler/12/695-748; Membrane lipids/Gebhard Schertler/10/617-629; Working with cells/Ulrike Kutay/9/579-613; Mitochondria/Ulrike Kutay/12+14/695-703/713-723/815-818/856-860; Chloroplasts, peroxisomes/Ulrike Kutay/12+14/695-703/713-723/840-844/856-860; Structure and dynamics of the nucleus/Ulrike Kutay/6+12/362-366/704-706/710-712; Membrane proteins/Gebhard Schertler/10/629-650; Working with membranes/Gebhard Schertler/9/579-615; Nuclear transport of proteins/Ulrike Kutay/12/706-711; RNA processing and nuclear export/Ulrike Kutay/6/345-353/357-366/369; Endoplasmic reticulum/Ulrike Kutay/12/723-745; Vesicular transport/Ulrike Kutay/13/749-766; From the ER through the Golgi/Ulrike Kutay/13/766-779; From the TGN to Lysosomes and the plasma membrane/Ulrike Kutay/13/779-787/799-809; The plasma membrane and endocytosis/Ulrike Kutay/13/787-799; Introduction to the cytoskeleton/Ulrike Kutay/16/965-1035; Microtubules/Ulrike Kutay/16/965-1035; Actin/Muscle/Ulrike Kutay/16/965-1035; Cell polarization and migration/Yves Barral/16/1036-1052; Introduction to the cell cycle/Yves Barral/17/1053-1070; MPF and the cell cycle control machinery/Yves Barral/17/1053-1070; Mechanisms of chromosome segregation/Yves Barral/17/1070-1090; Cell division/Yves Barral/17/1090-1101; Apoptosis/Yves Barral/18/1115-1127; Membrane transport passive and active/Sabine Werner/11/651-667; Ion channels, action potential/Sabine Werner/11/667-687; General principles of signalling/Sabine Werner/15/879-903; Nuclear receptors, G-protein coupled receptors/Sabine Werner/15/879-921; Cell signalling; G-protein coupled receptors/Sabine Werner/15/904-921; Cell signalling; Receptor tyrosine kinases/Sabine Werner/15/921-938; Cell signalling; Tyrosine kinase associated receptors/Sabine Werner/15/921-938; Cell signalling; Receptor serine threonine kinases/Sabine Werner/15/939-944; Signalling through proteolysis/Sabine Werner/15/946-954; Cancer Biology/Sabine Werner/20/1205-1267; Cell-Cell Interactions/Ueli Suter/19/1131-1195; Extracellular Matrix/Ueli Suter/19/1131-1195; Regeneration / Stem Cells/Ueli Suter/23/1417-1484; Germ Cells and Sex Determination/Ernst Hafen/21/1269-1304; Development/Ernst Hafen/22/1305-1417
Prerequisites / Noticenone
551-0103-00LFundamentals of Biology II: Cell Biology Information 5 credits5VU. Kutay, Y. Barral, E. Hafen, G. Schertler, U. Suter, S. Werner
AbstractThe goal of this course is to provide students with a wide general understanding in cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.
ObjectiveThe goal of this course is to provide students with a wide general understanding cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.
ContentThe focus is animal cells and the development of multicellular organisms with a clear emphasis on the molecular basis of cellular structures and phenomena. The topics include biological membranes, the cytoskeleton, protein sorting, energy metabolism, cell cycle and division, viruses, extracellular matrix, cell signaling, embryonic development and cancer research.
Lecture notesThe lectures are presented in the Powerpoint format. These are available on the WEB for ETH students over the nethz (https://sharepoint.biol.ethz.ch/sites/e-learn/551-0103-00L-H13/default.aspx). Some lectures are available on the ETH WEB site in a live format (Livestream) at the above WEB site.
LiteratureThe lectures follow Alberts et al. ‘Molecular Biology of the Cell’ Fifth edition, 2008 ISBN 978-0-8153-4105-5 (hard cover) and ISBN 978-0-8153-4106-2 (paperback).
Prerequisites / NoticeSome of the lectures are given in the English language.
551-0105-00LFundamentals of Biology IA Information 5 credits5GM. Aebi, E. Hafen, M. Peter
AbstractThe course provides an introduction to the basics of molecular- and cell biology and genetics.
ObjectiveIntroduction to modern biology and to principal biological concepts.
ContentThe course is divided into several chapters:
1. Basic principles of Evolution.
2. Chemistry of Life: Water; Carbon and molecular diversity; biomolecules
3. The cell: structure; membrane structure and function, cell cycle
4. Metabolism: Respiration; Photosynthesis; Fermentation
5. Inheritance: meiosis and sexual reproduction; Mendelian genetics, chromosomal basis of inheritance, molecular basis of inheritance, from gene to protein, regulation of gene expression; genomes and their evolution
Lecture notesNone.
LiteratureThe text-book "Biology" (Campbell, Reece) (9th edition) is the basis of the course.
The structure of the course is largely identical with that of the text-book.
Prerequisites / NoticeCertain sections of the text-book must be studied by self-instruction.
551-0371-00LGrowth Control: Insights from Yeast and Flies Information Restricted registration - show details 6 credits7GH. Stocker, R. C. Dechant, E. Hafen, M. Peter
AbstractAll organisms have to control their growth in accordance with environmental conditions. This course focuses on the analysis of growth regulation in the model organisms yeast and Drosophila. The participants will perform experiments in small teams to study insulin/TOR signaling as a key regulator of cellular growth. A particular focus will be the discussion of current research.
ObjectiveThe aims of the block course are that students

(I) understand the function and evolution of insulin/TOR signaling

(II) learn how genetic approaches in different organisms contribute to the understanding of human diseases such as cancer

(III) will get familiarized with reading and discussing research articles

(IV) get a first exposure to current research.
Lecture notesLecture handouts
LiteratureOriginal research articles will be discussed during the course.
551-0571-00LFrom DNA to Diversity (University of Zurich)
No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH.
UZH Module Code: BIO336

Mind the enrolment deadlines at UZH:
Link
2 credits2VA. Hajnal, D. Bopp, E. Hafen
AbstractThe evolution of the various body-plans is investigated by means of comparison of developmentally essential control genes of molecularly analysed model organisms.
ObjectiveBy the end of this module, each student should be able to
- recognize the universal principles underlying the development of
different animal body plans.
- explain how the genes encoding the molecular toolkit have evolved
to create animal diversity.
- relate changes in gene structure or function to evolutionary
changes in animal development.
Key skills:
By the end of this module, each student should be able to
- present and discuss a relevant evolutionary topic in an oral
presentation
- select and integrate key concepts in animal evolution from
primary literature
- participate in discussions on topics presented by others
551-0963-00LSpecialized Biology Course with an Educational Focus: Teaching Diploma Information Restricted registration - show details
Specialised Courses in the Respective Subject with an Educational Focus in Biology for Teaching Diploma.
12 credits26AE. Hafen, J. Egli, W.‑D. Hardt, H.‑J. Zopfi, M. Zwicky
AbstractSpecialist aspects of biology are covered from the angle of imparting these to pupils, their historical development, and their significance for the subject, the individual and society.
ObjectiveAfter successfully completing the module, students should be in a position:
- to call up more in-depth specialist knowledge of biology, covering a wide range of topics, and to impart this to others.
- to explain biological concepts and principles, as well as the way they fit together.
- to analyse controversial topics and to give factual explanations for these.
- to conduct more in-depth work on a research topic and to compile a tuition unit based on this topic
- to prepare tuition units involving complex learning matter at a high specialist level which are suitably tailored to the recipients, and to teach these in a manner conducive to learning.
ContentDemanding biological topics are dealt with under consideration of the special needs of persons involved in teaching. The module comprises the parts:

1) Lecture (Tues. 08.00-09.45 hrs)
2) Colloquium (every second Tues. 10.15-12.00 hrs., begins on first lecture day)
3) Seminar with presentation (every second Tues. 10.15-12.00 hrs., begins in second lecture week)
4) Semester thesis in a research group (7 weeks)
Lecture notesUnterlagen für den Unterricht werden online mit Hilfe der e-learning Platform OLAT abgegeben.
LiteratureLiteratur und Literaturhinweise werden mit der e-learning Platform OLAT abgegeben.
Prerequisites / NoticeThis Course lasts for two semesters. It can be started in autumn or in spring. Booking is only required once.

Performance Assessment:
Performance is assessed during the course of the entire modul, with a final test. Active participation in the colloquia and group seminars is required. The thesis report and an oral presentation have to be completed.

The Specialized Biology Course with an Educational Focus (12 CP) can be acknowledged, in agreement with the advisor of the respective elective major, as one of the two obligatory research projects (each 15 CP). In such a case, additional 3 CP must be obtained in another course.

In case of overbooking of the course, students enrolled in the Teaching Diploma in Biology will have priority for registration.

The course is organized jointly with the University of Zurich (Fachbereich Biologie) and is held at the Life Science Zurich Learning Center of the ETH Zurich and the University of Zurich.
551-0963-02LSpecialized Biology Course with an Educational Focus II: Teaching Diploma Information Restricted registration - show details
Specialised Courses in the Respective Subject with an Educational Focus in Biology ONLY for students upgrading TC to Teaching Diploma.
6 credits13AE. Hafen, J. Egli, H.‑J. Zopfi, M. Zwicky
AbstractSpecialized aspects of biology are dealt with under the viewpoint of their presentation, their historical development, their significance for the field, the individual and society.
ObjectiveThe goal is to promote the ability to understand biological concepts, principles and their interrelationships and to communicate specialist knoweldge to various groups of recipients in an understandable manner.
ContentDemanding biological topics are dealt with under consideration of the special needs of persons involved in teaching. The module:

1) Lecture (Tues. 08.00-09.45 hrs)
2) Colloquium (every second Tues. 10.15-12.00 hrs., begins on first lecture day)
3) Seminar with presentation (every second Tues. 10.15-12.00 hrs., begins in second lecture week)
4) Semester thesis in a research group (3.5 weeks)
Lecture notesNone.
LiteratureSpecific references will be made available for the individual projects.
Prerequisites / NoticeThe program of this course represents one half (6 CP) of that of the Specialized Biology Course with an Educational Focus (551-0963-00, 12 CP).
851-0240-16LCurrent Research on MINT Learning1 credit1KE. Stern, E. Hafen, J. Hromkovic, N. Hungerbühler, A. Togni, A. Vaterlaus
AbstractThis colloquium focusses on the presentation of research projects conducted by the professorships participating in the competence center EducETH which concern learning in the STEM subjects. STEM stands for science, technology, engineering, and mathematics. Doctoral students and postdoctoral researchers will present their current projects and theoretical and methodological aspects will be discussed
ObjectiveParticipants are exemplarily introduced to different research methods used in research on learning and instruction and learn to weigh advantages and disadvantages of these approaches.