Autumn Semester 2020 takes place in a mixed form of online and classroom teaching.
Please read the published information on the individual courses carefully.

Ernst Hafen: Catalogue data in Autumn Semester 2016

Name Prof. Dr. Ernst Hafen
FieldMolekulare Entwicklungsbiologie
Address
Inst. f. Molekulare Systembiologie
ETH Zürich, HPM H 29
Otto-Stern-Weg 3
8093 Zürich
SWITZERLAND
Telephone+41 44 633 36 88
E-mailhafen@imsb.biol.ethz.ch
URLhttp://www.imsb.ethz.ch/researchgroup/hafene
DepartmentBiology
RelationshipFull Professor

NumberTitleECTSHoursLecturers
551-0015-00LBiology I2 credits2VR. Glockshuber, E. Hafen
AbstractThe lecture Biology I, together with the lecture Biology II in the following summer semester, is a basic, introductory course into Biology for Students of Materials Sciences and other students with biology as subsidiary subject.
ObjectiveThe goal of this course is to give the students a basic understanding of the molecules that build a cell and make it function, and the basic principles of metabolism and molecular genetics.
ContentDie folgenden Kapitelnummern beziehen sich auf das der Vorlesung zugrundeliegende Lehrbuch "Biology" (Campbell & Rees, 10th edition, 2015)
Kapitel 1-4 des Lehrbuchs werden als Grundwissen vorausgesetzt

1. Aufbau der Zelle

Kapitel 5: Struktur und Funktion biologischer Makromoleküle
Kapitel 6: Eine Tour durch die Zelle
Kaptiel 7: Membranstruktur und-funktion
Kapitel 8: Einführung in den Stoffwechsel
Kapitel 9: Zelluläre Atmung und Speicherung chemischer Energie
Kapitel 10: Photosynthese
Kapitel 12: Der Zellzyklus
Kapitel 17: Vom Gen zum Protein

2. Allgemeine Genetik

Kapitel 13: Meiose und Reproduktionszyklen
Kapitel 14: Mendel'sche Genetik
Kapitel 15: Die chromosomale Basis der Vererbung
Kapitel 16: Die molekulare Grundlage der Vererbung
Kapitel 18: Genetik von Bakterien und Viren
Kapitel 46: Tierische Reproduktion

Grundlagen des Stoffwechsels und eines Überblicks über molekulare Genetik
Lecture notesDer Vorlesungsstoff ist sehr nahe am Lehrbuch gehalten, Skripte werden ggf. durch die Dozenten zur Verfügung gestellt.
LiteratureDas folgende Lehrbuch ist Grundlage für die Vorlesungen Biologie I und II:

„Biology“, Campbell and Rees, 10th Edition, 2015, Pearson/Benjamin Cummings, ISBN 978-3-8632-6725-4
Prerequisites / NoticeZur Vorlesung Biologie I gibt es während der Prüfungssessionen eine einstündige, schriftliche Prüfung. Die Vorlesung Biologie II wird separat geprüft.
551-0016-AALBiology II Information
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
2 credits4RM. Stoffel, E. Hafen
AbstractThe lecture course Biology II is a basic introductory course into biology for students who need to pass this course for admission to their MSc curriculum.
ObjectiveThe objective of the lecture course Biology II is the understanding of form, function, and development of animals and of the basic underlying mechanisms.
ContentThe following numbers of chapters refer to the text-book "Biology" (Campbell & Reece, 7th edition, 2005) on which the course is based. Chapters 1-4 are a basic prerequisite. The sections "Structure of the Cell" (Chapters 5-10, 12, 17) and "General Genetics" (Chapters 13-16, 18, 46) are covered by the lecture Biology I.

1. Genomes, DNA Technology, Genetic Basis of Development

Chapter 19: Eukaryotic Genomes: Organization, Regulation, and Evolution
Chapter 20: DNA Technology and Genomics
Chapter 21: The Genetic Basis of Development

2. Form, Function, and Development of Animals I

Chapter 40: Basic Principles of Animal Form and Function
Chapter 41: Animal Nutrition
Chapter 44: Osmoregulation and Excretion
Chapter 47: Animal Development

3. Form, Function, and Develeopment of Animals II

Chapter 42: Circulation and Gas Exchange
Chapter 43: The Immune System
Chapter 45: Hormones and the Endocrine System
Chapter 48: Nervous Systems
Chapter 49: Sensory and Motor Mechanisms
LiteratureThe following text-book is the basis for the courses Biology I and II:

„Biology“, Campbell and Reece, 7th Edition, 2005, Pearson/Benjamin Cummings, ISBN 0-8053-7166-4
Prerequisites / NoticePrerequisite: Lecture course Biology I of winter semester
551-0103-AALFundamentals of Biology II: Cell Biology Information
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
5 credits11RE. Hafen, J. Fernandes de Matos, U. Kutay, G. Schertler, U. Suter, S. Werner
AbstractThe goal of this course is to provide students with a wide general understanding in cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.
ObjectiveThe goal of this course is to provide students with a wide general understanding cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.
ContentThe focus is animal cells and the development of multicellular organisms with a clear emphasis on the molecular basis of cellular structures and phenomena. The topics include biological membranes, the cytoskeleton, protein sorting, energy metabolism, cell cycle and division, viruses, extracellular matrix, cell signaling, embryonic development and cancer research.
LiteratureAlberts et al. 'Molecular Biology of the Cell' 6th edition, 2014, ISBN 9780815344322 (hard cover) and ISBN 9780815345244 (paperback).

Topic/Lecturer/Chapter/Pages:

Analyzing cells & molecules / Gebhard Schertler/8/ 439-463;
Membrane structure / Gebhard Schertler/ 10/ 565-595;
Compartments and Sorting/ Ulrike Kutay/12+14+6/641-694/755-758/782-783/315-320/325 -333/Table 6-2/Figure6-20, 6-21, 6-32, 6-34;
Intracellular Membrane Traffic/ Ulrike Kutay/13/695-752;
The Cytoskeleton/ Ulrike Kutay/ 16/889 - 948 (only the essentials);
Membrane Transport of Small Molecules and the Electrical Properties of Membranes /Sabine Werner/11/597 - 633;
Mechanisms of Cell Communication / Sabine Werner/15/813-876;
Cancer/ Sabine Werner/20/1091-1141;
Cell Junctions and Extracellular Matrix/Ueli Suter / 1035-1081;
Stem Cells and Tissue Renewal/Ueli Suter /1217-1262;
Development of Multicellular organisms/ Ernst Hafen/ 21/ 1145-1179 /1184-1198/1198-1213;
Cell Migration/Joao Matos/951-960;
Cell Death/Joao Matos/1021-1032;
Cell Cycle/chromosome segregation/Cell division/Meiosis/Joao Matos/ 963-1018.
Prerequisites / Noticenone
551-0103-00LFundamentals of Biology II: Cell Biology5 credits5VE. Hafen, J. Fernandes de Matos, U. Kutay, G. Schertler, U. Suter, S. Werner
AbstractThe goal of this course is to provide students with a wide general understanding in cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.
ObjectiveThe goal of this course is to provide students with a wide general understanding cell biology. With this material as a foundation, students have enough of a cell biological basis to begin their specialization not only in cell biology but also in related fields such as biochemistry, microbiology, pharmacological sciences, molecular biology, and others.
ContentThe focus is animal cells and the development of multicellular organisms with a clear emphasis on the molecular basis of cellular structures and phenomena. The topics include biological membranes, the cytoskeleton, protein sorting, energy metabolism, cell cycle and division, viruses, extracellular matrix, cell signaling, embryonic development and cancer research.
Lecture notesThe lectures are presented in the Powerpoint format. These are available on the WEB for ETH students over the nethz (Moodle). Some lectures are available on the ETH WEB site in a live format (Livestream) at the above WEB site.
LiteratureThe lectures follow Alberts et al. `Molecular Biology of the Cell' 6th edition, 2014, ISBN 9780815344322 (hard cover) and ISBN 9780815345244
(paperback).
Prerequisites / NoticeSome of the lectures are given in the English language. Certain sections of the text-book must be studied by self-instruction.
551-0105-00LFundamentals of Biology IA5 credits5GM. Aebi, E. Hafen
AbstractThe course provides an introduction to the basics of molecular- and cell biology and genetics.
ObjectiveIntroduction to modern biology and to principal biological concepts.
ContentThe course is divided into several chapters:
1. Basic principles of Evolution.
2. Chemistry of Life: Water; Carbon and molecular diversity; biomolecules
3. The cell: structure; membrane structure and function, cell cycle
4. Metabolism: Respiration; Photosynthesis; Fermentation
5. Inheritance: meiosis and sexual reproduction; Mendelian genetics, chromosomal basis of inheritance, molecular basis of inheritance, from gene to protein, regulation of gene expression; genomes and their evolution
Lecture notesNone.
LiteratureThe text-book "Biology" (Campbell, Reece) (10th edition) is the basis of the course.
The structure of the course is largely identical with that of the text-book.
Prerequisites / NoticeCertain sections of the text-book must be studied by self-instruction.
551-0371-00LGrowth Control: Insights from Yeast and Flies Information Restricted registration - show details
Number of participants limited to 8.
6 credits7GH. Stocker, R. C. Dechant, E. Hafen, M. Peter
AbstractAll organisms have to control their growth in accordance with environmental conditions. This course focuses on the analysis of growth regulation in the model organisms yeast and Drosophila. The participants will perform experiments in small teams to study insulin/TOR signaling as a key regulator of cellular growth. A particular focus will be the discussion of current research.
ObjectiveThe aims of the block course are that participants

(I) understand the function and evolution of insulin/TOR signaling

(II) learn how genetic approaches in different organisms contribute to the understanding of human diseases such as cancer

(III) will get familiarized with reading and discussing research articles

(IV) get a first exposure to current research.
ContentThe block course consists of

(I) experiments:

Teams of two students each will join research labs to work on current projects focusing on growth regulation in both single-cell eukaryotes (yeast) and multicellular animals (Drosophila). The students will present their projects and results to their colleagues.

(II) lectures on growth regulation in yeast and Drosophila.

(III) journal clubs to discuss recent literature.
Lecture notesLecture handouts
LiteratureOriginal research articles will be discussed during the course.
551-0571-00LFrom DNA to Diversity (University of Zurich)
No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH.
UZH Module Code: BIO336

Mind the enrolment deadlines at UZH:
http://www.uzh.ch/studies/application/mobilitaet_en.html
2 credits2VA. Hajnal, D. Bopp, E. Hafen
AbstractThe evolution of the various body-plans is investigated by means of comparison of developmentally essential control genes of molecularly analysed model organisms.
ObjectiveBy the end of this module, each student should be able to
- recognize the universal principles underlying the development of
different animal body plans.
- explain how the genes encoding the molecular toolkit have evolved
to create animal diversity.
- relate changes in gene structure or function to evolutionary
changes in animal development.
Key skills:
By the end of this module, each student should be able to
- present and discuss a relevant evolutionary topic in an oral
presentation
- select and integrate key concepts in animal evolution from
primary literature
- participate in discussions on topics presented by others
551-0916-00LLearning and Teaching Biology Information Restricted registration - show details
Does not take place this semester.
Number of participants limited to 20
The block course will only take place with a minimum of 10 participants.
6 credits7GE. Hafen
AbstractThis course represents an introduction to recent research into student learning on the conceptual foundations of modern biology, together with pedagogical methods associated with effective instruction and its valuation. Students will be involved in active research into conceptual and practical issues involved in biology education and methods to discover student preconceptions.
ObjectiveProvides an overview on student's learning and shows ways to make the classroom experience more engaging and effective for students. Students will learn to produce a research-based paper on a project they work on during the course.
LiteratureThe course is not taught by a particular book, but recommended literature (review articles and selected primary literature) will be provided during the course.

See the introductory video to the course here: http://youtu.be/GFJuNncSsdE
551-0963-00LSpecialized Biology Course with an Educational Focus: Teaching Diploma Information Restricted registration - show details
Specialised Courses in the Respective Subject with an Educational Focus in Biology for Teaching Diploma.
12 credits26AE. Hafen, J. Egli, W.‑D. Hardt, M. Zwicky
AbstractSpecialist aspects of biology are covered from the angle of imparting these to pupils, their historical development, and their significance for the subject, the individual and society.
ObjectiveAfter successfully completing the module, students should be in a position:
- to call up more in-depth specialist knowledge of biology, covering a wide range of topics, and to impart this to others.
- to explain biological concepts and principles, as well as the way they fit together.
- to analyse controversial topics and to give factual explanations for these.
- to conduct more in-depth work on a research topic and to compile a tuition unit based on this topic
- to prepare tuition units involving complex learning matter at a high specialist level which are suitably tailored to the recipients, and to teach these in a manner conducive to learning.
ContentDemanding biological topics are dealt with under consideration of the special needs of persons involved in teaching. The module comprises the parts:

1) Lecture (Tues. 08.00-09.45 hrs)
2) Colloquium (every second Tues. 10.15-12.00 hrs., begins on first lecture day)
3) Seminar with presentation (every second Tues. 10.15-12.00 hrs., begins in second lecture week)
4) Semester thesis in a research group (7 weeks)
Lecture notesUnterlagen für den Unterricht werden online mit Hilfe der e-learning Platform OLAT abgegeben.
LiteratureLiteratur und Literaturhinweise werden mit der e-learning Platform OLAT abgegeben.
Prerequisites / NoticeThis Course lasts for two semesters. It can be started in autumn or in spring. Booking is only required once.

Performance Assessment:
Performance is assessed during the course of the entire modul, with a final test. Active participation in the colloquia and group seminars is required. The thesis report and an oral presentation have to be completed.

The Specialized Biology Course with an Educational Focus (12 CP) can be acknowledged, in agreement with the advisor of the respective elective major, as one of the two obligatory research projects (each 15 CP). In such a case, additional 3 CP must be obtained in another course.

In case of overbooking of the course, students enrolled in the Teaching Diploma in Biology will have priority for registration.

The course is organized jointly with the University of Zurich (Fachbereich Biologie) and is held at the Life Science Zurich Learning Center of the ETH Zurich and the University of Zurich.
551-0963-02LSpecialized Biology Course with an Educational Focus II: Teaching Diploma Information Restricted registration - show details
Specialised Courses in the Respective Subject with an Educational Focus in Biology ONLY for students upgrading TC to Teaching Diploma.
6 credits13AE. Hafen, J. Egli, M. Zwicky
AbstractSpecialized aspects of biology are dealt with under the viewpoint of their presentation, their historical development, their significance for the field, the individual and society.
ObjectiveThe goal is to promote the ability to understand biological concepts, principles and their interrelationships and to communicate specialist knoweldge to various groups of recipients in an understandable manner.
ContentDemanding biological topics are dealt with under consideration of the special needs of persons involved in teaching. The module:

1) Lecture (Tues. 08.00-09.45 hrs)
2) Colloquium (every second Tues. 10.15-12.00 hrs., begins on first lecture day)
3) Seminar with presentation (every second Tues. 10.15-12.00 hrs., begins in second lecture week)
4) Semester thesis in a research group (3.5 weeks)
Lecture notesNone.
LiteratureSpecific references will be made available for the individual projects.
Prerequisites / NoticeThe program of this course represents one half (6 CP) of that of the Specialized Biology Course with an Educational Focus (551-0963-00, 12 CP).