Christian Frei: Catalogue data in Autumn Semester 2017

Name Dr. Christian Frei
Address
Inst. f. Biomedizinische Technik
ETH Zürich, ETZ F 83
Gloriastrasse 35
8092 Zürich
SWITZERLAND
Telephone+41 44 632 45 85
E-mailfrei@biomed.ee.ethz.ch
DepartmentInformation Technology and Electrical Engineering
RelationshipLecturer

NumberTitleECTSHoursLecturers
227-0945-00LCell and Molecular Biology for Engineers I
This course is part I of a two-semester course.
3 credits3GC. Frei
AbstractThe course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology.
ObjectiveAfter completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested.
ContentLectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells.

In addition, three journal clubs will be held, where one/two publictions will be discussed (part I: 1 Journal club, part II: 2 Journal Clubs). For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded and count as 25% for the final grade.
Lecture notesScripts of all lectures will be available.
Literature"Molecular Biology of the Cell" (6th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter.
227-0949-00LBiological Methods for Engineers (Basic Lab) Information Restricted registration - show details
Number of participants limited to 10.
2 credits4PC. Frei
AbstractThe course during 4 afternoons (13h to 18h) covers basic laboratory skills and safety, cell culture, protein analysis, RNA/DNA Isolation and RT-PCR. Each topic will be introduced, followed by practical work at the bench. Presence during the course is mandatory.
ObjectiveThe goal of this laboratory course is to give students practical exposure to basic techniques of cell and molecular biology.
ContentThe goal of this laboratory course is to give students practical exposure to basic techniques of cell and molecular biology.
Prerequisites / NoticeEnrollment is limited and students from the Master's programme in Biomedical Engineering (BME) have priority.
752-0100-AALBiochemistry
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
2 credits4RC. Frei
AbstractBasic knowledge of enzymology, in particular the structure, kinetics and chemistry of enzyme-catalysed reaction in vitro and in vivo. Biochemistry of metabolism: Those completing the course are able to describe and understand fundamental cellular metabolic processes.
ObjectiveBased on the biology and chemistry courses in the 1. and 2. semester more detailed biochemical knowledge about enzymology, membrane biochemistry, and central metabolism will be presented
ContentProgram

Introduction, basics, composition of cells, biochemical units, repetition of relevant organic chemistry
Structure and function of proteins
Carbohydrates, structure of DNA
Lipids an biological membranes
Enzymes and enzyme kinetics
Catalytic strategies
Metabolism: Basic concepts and design. Repetition of basic thermodynamics
Glycolysis
The citric acid cycle
Oxidative phosphorylation
Fatty acid metabolism
Lecture notesPrinciples of Biochemistry (5th Edition) 5th Edition
by Laurence A. Moran (Author), Robert A Horton (Author), Gray Scrimgeour (Author), Marc Perry (Author)
LiteraturePrinciples of Biochemistry (5th Edition) 5th Edition
by Laurence A. Moran (Author), Robert A Horton (Author), Gray Scrimgeour (Author), Marc Perry (Author)
Prerequisites / NoticeBasic knowledge in biology and chemistry is a precondition.
752-0100-00LBiochemistry2 credits2VC. Frei
AbstractBasic knowledge of enzymology, in particular the structure, kinetics and chemistry of enzyme-catalysed reaction in vitro and in vivo. Biochemistry of metabolism: Those completing the course are able to describe and understand fundamental cellular metabolic processes.
ObjectiveStudents are able to understand
- the structure and function of biological macromolecules
- the kinetic bases of enzyme reactions
- thermodynamic and mechanistic basics of relevant metabolic processes
Students are able to describe the relevant metabolic reactions in detail
ContentProgram

Introduction, basics, composition of cells, biochemical units, repetition of relevant organic chemistry
Structure and function of proteins
Carbohydrates
Lipids an biological membranes
Enzymes and enzyme kinetics
Catalytic strategies
Metabolism: Basic concepts and design. Repetition of basic thermodynamics
Glycolysis, fermentation
The citric acid cycle
Oxidative phosphorylation
Fatty acid metabolism
Lecture notesHorton et al. (Pearson) serves as lecture notes.
Prerequisites / NoticeBasic knowledge in biology and chemistry is a precondition.