Vivianne Irene Otto: Catalogue data in Autumn Semester 2019
|Name||PD Dr. Vivianne Irene Otto|
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 415
|Telephone||+41 44 633 73 20|
|Fax||+41 44 633 13 64|
|Department||Chemistry and Applied Biosciences|
|535-0011-00L||Drug Seminar |
The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences
|5 credits||9S||U. Quitterer, K.‑H. Altmann, S. M. Ametamey, A. Burden, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, D. Neri, V. I. Otto, R. Schibli, G. Schneider, C. Steuer|
|Abstract||The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium.|
|Objective||The main objectives of this course are: |
- students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic
- students gain in-depth knowledge of the topic investigated
- students train their scientific writing and presentation skills
- students train their ability to plan a project and work in a team
|Content||The Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences. |
The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences.
During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester.
|Prerequisites / Notice||Only for students of MSc Pharmacy and MSc Pharmaceutical Sciences.|
|535-0310-00L||Glycobiology in Drug Development||1 credit||1V||V. I. Otto|
|Abstract||Protein-based drugs constitute around 25% of new approvals and most of them are glycoproteins. Using selected examples of prominent glycoprotein drugs, the course aims at providing insight into glycosylation-activity relationships and into biotechnological production and analytics.|
|Objective||Students gain insight into the glycobiology of therapeutically used glycoproteins. This implies knowing and understanding|
- the major types of protein-linked glycans and their biosynthesis
- the most important expression systems for production of recombinant glycoproteins
- methods used to control and/or alter glycosylation
- the most prominent clinically used glycoproteins and how glycosylation influences their therapeutic profile.
- Current methods for the qualitative and quantitative characterization of glycoproteins
Students are able to apply this knowledge and propose solutions to biotechnological problems that involve protein glycosylation.
1. Glycans - information carriers in biology and pharmacotherapy
2. Glucocerebrosidase and the biosynthesis of N-glycans
3. Glyocerebrosidase - production and quality control
4. Improving the therapeutic profile of monoclonal antibodies by glycoengineering
5. Sialylation and mucin-type O-glycans as critical quality attributes of glycoprotein hormones and drugs
6. EPO "the same but different"
The lectures will include some exercises in which students apply their knowledge to solve simple biotechnological problems related to protein glycosylation.
|Lecture notes||The slides used for the lectures will be provided online|
|Literature||- Essentials of Glycobiology 3rd edition, A. Varki, R.D. Cummings et al., Cold Spring Harbor Laboratory Press, New York 2017.|
- recent publications as cited/proposed on the lecture slides
|Prerequisites / Notice||Requirements: Basic knowledge in immunology, molecular biology, protein and carbohydrate chemistry, analytical techniques. Basic knowledge in pharmacology.|