Autumn Semester 2020 takes place in a mixed form of online and classroom teaching.
Please read the published information on the individual courses carefully.

Markus Stoffel: Catalogue data in Autumn Semester 2019

Name Prof. Dr. Markus Stoffel
FieldMetabolic Diseases
Inst. f. Molecular Health Sciences
ETH Zürich, HPL H 36
Otto-Stern-Weg 7
8093 Zürich
Telephone+41 44 633 45 60
Fax+41 44 633 13 62
RelationshipFull Professor

377-0301-03LEndocrinology, Metabolism Restricted registration - show details
Only for Human Medicine BSc
5 credits5VM. Stoffel, F. Beuschlein, A. Hall, C. Wolfrum
AbstractDiscussion of normal structure and function of the endocrine systems, their interaction with the autonomic nervous system and their role in metabolism. In addition, pathophysiological and clinical aspects, diagnostics and therapeutic concepts of the most important endocrine diseases and related metabolic disorders as well as respective preventive measures are adressed.
ObjectiveDie Studierenden sollen nach erfolgreichem Abschluss dieses Moduls zu Folgendem befähigt sein:
1. Systematik des endokrinen Systems erklären.
2. Aufbau und Funktion des Hypothalamus, Hypophyse, Nebenniere, endokrinen Pankreas, Schilddrüse, Eierstöcke, Hoden
3. Prinzipien und Regulation des Knochen, Kalzium und Phosphat-Stoffwechsels, Energiehaushaltes, Glukosestoffwechsel, Lipidstoffwechsel, Blutdruck.
4. Kenntnisse von hormonell regulierten Stoffwechselprozessen (Kohlenhydrate, Eiweiss und Fett).
5. Die wichtigsten endokrinen Krankheitsbilder und Tumoren, deren Entstehung, Klinik, Diagnostik und Therapie, kennen.
6. Die wichtigsten Massnahmen zur Prävention von Stoffwechselerkrankungen und die zugrunde liegenden Mechanismen kennen.
ContentDie Studierenden lernen in diesem Modul Anatomie, Physiologie, und Pathophysiologie der endokrinen Drüsen, sowie die Klinik, Diagnostik, Therapie und Prävention der wichtigsten Krankheitsbilder des Hormonsystems kennen. Dies beinhaltet:

• Systematik des endokrinen Systems: Aufbau und anatomische Lage der verschiedenen Hormondrüsen.
• Neuronale Innervation und vaskuläres Versorgungsgebiet der Hormondrüsen.
• Hormonklassen: Protein- und Polypeptidhormone , Amino- und Aminosäurederivate Steroidhormone, Biosynthese von Protein- und Polypeptidhormonen, Biosynthese von Amino- und Aminosäuren-derivathormonen, Biosynthese von Steroidhormonen, Speicherung von Hormonen, Sekretion von Hormonen, Transport von Hormonen, Halbwertszeiten, Abbau und Ausscheidung von Hormonen.
Übertragung von Informationen durch Hormone: Hormonwirkung an Rezeptoren, Struktur und Funktionsweise von membranassoziierten Hormonrezeptoren, Struktur und Funktion von Zellkernrezeptoren, Regulation der Hormonsekretion.
• Aufbau und Funktion des Hypothalamus, Aufbau und Funktion der Hypophyse.
• Aufbau und Funktion der Schilddrüse, Unter- und Überfunktion der Schilddrüse, Prinzipien der Diagnostik und Therapie von Schilddrüsenerkrankungen. Symptome, Anamnese und klinische Untersuchung bei Schilddrüsenerkrankungen,
• Knochen, Kalzium und Phosphatstoffwechsel.
• Regulation des Glukose-, Lipid- und Protein-Stoffwechsels, Essstörungen, Etiologie, Diagnostik, Therapie und Prävention der Adpositas.
• Aufbau und Funktion des endokrinen Pankreas, Pathogenese verschiedener Typen des Diabetes mellitus. Prinzipien der Diagnostik und Therapie und Prävention des Typ1 und Typ 2 Diabetes, Risikofaktoren und Komplikationen. Symptome, Anamnese und klinische Untersuchung bei Diabetes mellitus,
• Aufbau und Funktion der Nebenniere, Pathogenese, Prinzipien der Diagnostik und Therapie von Erkrankungen mit Über- und Unterfunktion der Nebenniere. Symptome, Anamnese und klinische Untersuchung bei Über- und Unterfunktion der Nebenniere.
• Aufbau und Funktion der Ovarien und Testes, Prinzipien der Reproduktionsphysiologie.
Lecture notesThere is no traditional script for this course. Instead the course is supported by a Moodle page through which students have access to all necessary texts, exercises, videos and activities.
LiteratureThe essential course material will be available on the course's Moodle Page in the form of scripts and lesson handouts.
The course does not have an "official" textbook, but students may find a general reference book on the topic interesting. For this purpose the text "Endokrinologie und Stoffwechsel” von Stefan Fischli und Giatgen A. Spinas (Herausgeber), Thieme Verlag, may be helpful.
Prerequisites / NoticeThe course builds on the content of the "Chemie für Mediziner", "Biochemie", “Pathobiochemie”, "Pharmakologie für Mediziner" and "Molekulare Genetik und Zellbiologie" course and “Nutrition and Digestion”.
551-0016-AALBiology II
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
2 credits4RM. Stoffel, E. Hafen
AbstractThe lecture course Biology II is a basic introductory course into biology for students who need to pass this course for admission to their MSc curriculum.
ObjectiveThe objective of the lecture course Biology II is the understanding of form, function, and development of animals and of the basic underlying mechanisms.
ContentThe following numbers of chapters refer to the text-book "Biology" (Campbell & Reece, 7th edition, 2005) on which the course is based. Chapters 1-4 are a basic prerequisite. The sections "Structure of the Cell" (Chapters 5-10, 12, 17) and "General Genetics" (Chapters 13-16, 18, 46) are covered by the lecture Biology I.

1. Genomes, DNA Technology, Genetic Basis of Development

Chapter 19: Eukaryotic Genomes: Organization, Regulation, and Evolution
Chapter 20: DNA Technology and Genomics
Chapter 21: The Genetic Basis of Development

2. Form, Function, and Development of Animals I

Chapter 40: Basic Principles of Animal Form and Function
Chapter 41: Animal Nutrition
Chapter 44: Osmoregulation and Excretion
Chapter 47: Animal Development

3. Form, Function, and Develeopment of Animals II

Chapter 42: Circulation and Gas Exchange
Chapter 43: The Immune System
Chapter 45: Hormones and the Endocrine System
Chapter 48: Nervous Systems
Chapter 49: Sensory and Motor Mechanisms
LiteratureThe following text-book is the basis for the courses Biology I and II:

„Biology“, Campbell and Reece, 7th Edition, 2005, Pearson/Benjamin Cummings, ISBN 0-8053-7166-4
Prerequisites / NoticePrerequisite: Lecture course Biology I of winter semester
551-1409-00LRNA Biology Lecture Series II: Non-coding RNAs: Biology and Therapeutics4 credits2VJ. Hall, M. Stoffel, further lecturers
AbstractThis course covers aspects of RNA biology related to the functions of non-coding RNAs as well as their use as drugs to treat diseases.
ObjectiveThe students should get familiar with the wide array of roles, which non-coding RNAs play in cellular functions.
ContentMicro RNAs; computational approaches to miRNAs; micro RNA function in metabolism; viruses and viral RNAs; nucleic acid-based drugs; ncRNA-mediated genome regulation; epigenetic programming of genome remodelling in ciliates; telomerase and telomeres; tRNA biology.
Prerequisites / NoticeBasic knowledge of cell and molecular biology.
551-1423-00LCurrent Topics in Metabolism and Disease Restricted registration - show details
Number of participants limited to 8.
2 credits1SM. Stoffel, E. Araldi, I. Guccini
AbstractThe course is a literature seminar or "journal club". Each Friday a student, or a member of the Stoffel Lab in the Institute of Molecular Health Sciences, will present a comprehensive presentation of a recent paper published in a top ranking international peer reviewed journal that relates to metabolism and disease.
ObjectiveThe course introduces the students to recent developments in the fields of metabolism and disease. It also supports the development of analytical skills, including critical reading of scientific literature, being able to present and critically discuss scientific experiments, point out technical limitations, and placing recent discoveries in the broader context of biology, physiology and medicine. The student should be able to grasp what the authors wanted to learn i.e. their hypothesis and their goals, why the authors chose the experimental approach and methods used, the strengths and weaknesses of the experiments, the quality of the data presented, the conclusions drawn, and how the work fits into the wider literature in the field. Furthermore, the student should discuss alternative approaches and future experiments. Each student will present one paper during the course, which provides him/her with practice in public speaking.
ContentEach student will present at least once during the semester. The presentation includes an introduction to the field of the paper, a critical description of the main results, a summary of the main points and a discussion of their significance.
Every participant is expected to take part in the discussion and to ask questions. At each meeting, all students are expected to read and prepare the paper beforehand. Each paper presented will be announced one week in advance of the presentation.
Lecture notesPresentations will be made available after the seminars.
LiteratureStudents will be guided to choose their papers base on recent literature published less than 1 year prior in a relevant journal.
551-1515-00LInsulin Signaling Information Restricted registration - show details
Number of participants limited to 15.

The enrolment is done by the D-BIOL study administration.
6 credits7GM. Stoffel, E. Araldi
AbstractIntroduction to the physiological and biochemical action of insulin signaling and its role in the fasted/feeding response and in obesity and diabetes.
ObjectiveThe students will obtain an overview about the current topics of research in insulin signaling and how it impacts on growth, metabolism and cell differentiation. They will learn to design experiments and use techniques necessary to analyze different aspects of insulin signaling,including physiological actions in whole animals as well as in tissue culture. Through lectures and literature seminars, they will learn about the open questions of insulin signaling research and discuss approaches to address these questions experimentally.

In practical lab projects the students will perform physiological in vivo studies as well as biochemical experiments. Finally, they will learn how to present and discuss their data. Student assessment is a graded semester performance based on individual performance in the laboratory, a written exam and the lab data presentation.