Jonathan Hall: Catalogue data in Spring Semester 2019

Award: The Golden Owl
Name Prof. Dr. Jonathan Hall
FieldPharmazeutische Chemie
Address
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 437
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 74 35
Fax+41 44 633 13 69
E-mailjonathan.hall@pharma.ethz.ch
DepartmentChemistry and Applied Biosciences
RelationshipFull Professor

NumberTitleECTSHoursLecturers
535-0002-00LIntroduction to Pharmaceutical Sciences II3 credits2VC. Halin Winter, K.‑H. Altmann, S. M. Ametamey, J. Hall, S.‑D. Krämer, J.‑C. Leroux, D. Neri, U. Quitterer, R. Schibli, C. Steuer
AbstractFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ObjectiveFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ContentIntroduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences, which is focused on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields.
Lecture notesHandouts for individual lectures.
Prerequisites / NoticeInteractive teaching
535-0231-00LMedicinal Chemistry II2 credits2VJ. Hall
AbstractThe lectures give an overview of selected drugs and the molecular mechanisms underlying their therapeutic effects in disease. The historical and modern-day methods by which these drugs were discovered and developed are described. Structure-function relationships and the biophysical rules underlying ligand-target interactions will be discussed and illustrated with examples.
ObjectiveBasic understanding of therapeutic agents with respect to molecular, pharmacological and pharmaceutical properties.
ContentMolecular mechanisms of action of drugs. Structure function and biophysical basis of ligand-target interactions.
Lecture notesWill be provided electronically in parts before each individual lecture.
Literature- G.L. Patrick, "An Introduction to Medicinal Chemistry", 5th edition, Oxford University Press (2013)
- D. Steinhilber, M. Schubert-Zsilavecz, H.J. Roth, "Medizinische Chemie", Deutscher Apotheker Verlag Stuttgart (2005)
- J.H. Block, J.M. Beale, "Organic Medicinal and Pharmaceutical Chemistry", 11th edition, Lippincott, Williams, Wilkins (2002)
- A. Gringauz, "How Drugs Act and Why", Wiley (1997)
- R. Silverman and M. Holladay, "The Organic Chemistry of Drug Design and Drug Action" 3rd Edition, Academic Press, (2014)
Prerequisites / NoticeRequirements: Knowledge of physical and organic chemistry, biochemistry and biology; Medicinal Chemistry I.
535-0900-00LSeminars on Drug Discovery and Development1 credit1KR. Schibli, K.‑H. Altmann, M. Detmar, C. Halin Winter, J. Hall, J.‑C. Leroux, D. Neri, U. Quitterer, G. Schneider, H. U. Zeilhofer
AbstractState-of-the-art information on drug discovery and development by experts from academia and industry.
ObjectiveState-of-the-art information on drug discovery and development.
ContentSeminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics.
535-0901-00LFrom A to Z in Drug Discovery and Development2 credits2SJ. Hall, K.‑H. Altmann, M. Arand, M. Detmar, D. Neri, R. Schibli, H. U. Zeilhofer
AbstractThe lecture series takes place at the ETH Hönggerberg and covers a variety of major activities involved in drug discovery: selecting drug targets, technologies used in drug discovery, small, medium and large drugs, objectives of the medicinal chemist, assessing drug safety, principles of personalized medicine, designing clinical trials, how intellectual property is protected, as well as others.
ObjectiveThe objective of the course is to gain a global understanding of most of the important phases in the discovery and development of modern synthetic and biological drugs, from the first activities to clinical trials. The lecture is intended for students that have an interest in the area and/or may consider a career working in drug discovery. This lecture course complements knowledge and experience gained in the research project performed by the PhD student.
ContentFifteen two hour lectures for life-science PhD students, given by experts from the ETH, UZH, USZ and the pharmaceutical industry.
Introduction to the modern drug discovery process - Principles of drug pharmacokinetics and drug metabolism - Computer sciences in drug discovery - Drug targets - In vitro methods in drug discovery - Natural products in drug discovery - Medicinal chemistry: Chemical lead selection/optimization - Nucleic acid-based drugs - Antibodies and therapeutic proteins: Targets and drugs - In vivo molecular imaging in drug discovery - Personalized medicine in drug discovery and development - Drug formulation: Key development consideration, Current new APIs challenges and FDA rising standards - Preclinical safety, adverse drug events and drug-drug interactions - Clinical development steps including trial design - Intellectual property in drug discovery and development
Lecture notesScripts to be uploaded into ILIAS
LiteratureTo be distributed during the lecture
Prerequisites / NoticeFormally none, but a basic understanding in biochemistry, physiology and chemistry is highly desirable as it will certainly help to get the most from the lectures.