Name | Prof. Dr. Jonathan Hall |
Field | Pharmazeutische Chemie |
Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI H 437 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
Telephone | +41 44 633 74 35 |
Fax | +41 44 633 13 69 |
jonathan.hall@pharma.ethz.ch | |
Department | Chemistry and Applied Biosciences |
Relationship | Full Professor |
Number | Title | ECTS | Hours | Lecturers | |
---|---|---|---|---|---|
535-0002-00L | Introduction to Pharmaceutical Sciences II | 2 credits | 2V | J. Hall, A. Burden, S. Erni, K. Eyer, C. Halin Winter, S.‑D. Krämer, C. Müller, C. Steuer | |
Abstract | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
Objective | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | ||||
Content | Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences, which is focused on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields. | ||||
Lecture notes | Handouts for individual lectures. | ||||
Prerequisites / Notice | Interactive teaching Prerequisites: Einführung in die Pharmazeutischen Wissenschaften I | ||||
535-0231-00L | Medicinal Chemistry II | 2 credits | 2V | J. Hall | |
Abstract | The lectures give an overview of selected drugs and the molecular mechanisms underlying their therapeutic effects in disease. The historical and modern-day methods by which these drugs were discovered and developed are described. Structure-function relationships and the biophysical rules underlying ligand-target interactions will be discussed and illustrated with examples. | ||||
Objective | Basic understanding of therapeutic agents with respect to molecular, pharmacological and pharmaceutical properties. | ||||
Content | Molecular mechanisms of action of drugs. Structure function and biophysical basis of ligand-target interactions. | ||||
Lecture notes | Will be provided electronically in parts before each individual lecture. | ||||
Literature | - G.L. Patrick, "An Introduction to Medicinal Chemistry", 5th edition, Oxford University Press (2013) - D. Steinhilber, M. Schubert-Zsilavecz, H.J. Roth, "Medizinische Chemie", Deutscher Apotheker Verlag Stuttgart (2005) - J.H. Block, J.M. Beale, "Organic Medicinal and Pharmaceutical Chemistry", 11th edition, Lippincott, Williams, Wilkins (2002) - A. Gringauz, "How Drugs Act and Why", Wiley (1997) - R. Silverman and M. Holladay, "The Organic Chemistry of Drug Design and Drug Action" 3rd Edition, Academic Press, (2014) | ||||
Prerequisites / Notice | Requirements: Knowledge of physical and organic chemistry, biochemistry and biology; Medicinal Chemistry I. | ||||
535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K.‑H. Altmann, M. Detmar, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer | |
Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | ||||
Objective | State-of-the-art information on drug discovery and development. | ||||
Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | ||||
535-0901-00L | From A to Z in Drug Discovery and Development Does not take place this semester. | 2 credits | 2S | J. Hall, K.‑H. Altmann, M. Detmar, R. Schibli, H. U. Zeilhofer | |
Abstract | The lecture series takes place at the ETH Hönggerberg and covers a variety of major activities involved in drug discovery: selecting drug targets, technologies used in drug discovery, small, medium and large drugs, objectives of the medicinal chemist, assessing drug safety, principles of personalized medicine, designing clinical trials, how intellectual property is protected, as well as others. | ||||
Objective | The objective of the course is to gain a global understanding of most of the important phases in the discovery and development of modern synthetic and biological drugs, from the first activities to clinical trials. The lecture is intended for students that have an interest in the area and/or may consider a career working in drug discovery. This lecture course complements knowledge and experience gained in the research project performed by the PhD student. | ||||
Content | Fifteen two hour lectures for life-science PhD students, given by experts from the ETH, UZH, USZ and the pharmaceutical industry. Introduction to the modern drug discovery process - Principles of drug pharmacokinetics and drug metabolism - Computer sciences in drug discovery - Drug targets - In vitro methods in drug discovery - Natural products in drug discovery - Medicinal chemistry: Chemical lead selection/optimization - Nucleic acid-based drugs - Antibodies and therapeutic proteins: Targets and drugs - In vivo molecular imaging in drug discovery - Personalized medicine in drug discovery and development - Drug formulation: Key development consideration, Current new APIs challenges and FDA rising standards - Preclinical safety, adverse drug events and drug-drug interactions - Clinical development steps including trial design - Intellectual property in drug discovery and development | ||||
Lecture notes | Scripts to be uploaded into ILIAS | ||||
Literature | To be distributed during the lecture | ||||
Prerequisites / Notice | Formally none, but a basic understanding in biochemistry, physiology and chemistry is highly desirable as it will certainly help to get the most from the lectures. |