Jonathan Hall: Catalogue data in Autumn Semester 2016

Award: The Golden Owl
Name Prof. Dr. Jonathan Hall
FieldPharmazeutische Chemie
Address
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 437
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telephone+41 44 633 74 35
Fax+41 44 633 13 69
E-mailjonathan.hall@pharma.ethz.ch
DepartmentChemistry and Applied Biosciences
RelationshipFull Professor

NumberTitleECTSHoursLecturers
535-0001-00LIntroduction to Pharmaceutical Sciences I2 credits3VC. Halin Winter, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, J. Hall, J.‑C. Leroux, D. Neri, U. Quitterer, R. Schibli, G. Schneider, H. U. Zeilhofer
AbstractFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ObjectiveFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ContentIntroduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields.
Lecture notesHandouts for individual lectures.
Prerequisites / NoticeInteractive teaching
535-0230-00LMedicinal Chemistry I2 credits2VJ. Hall
AbstractThe lectures give an overview of selected drugs and the molecular mechanisms underlying their therapeutic effects in disease. The historical and modern-day methods by which these drugs were discovered and developed are described. Structure-function relationships and the biophysical rules underlying ligand-target interactions will be discussed and illustrated with examples.
ObjectiveBasic understanding of therapeutic agents with respect to molecular, pharmacological and pharmaceutical properties.
ContentMolecular mechanisms of action of drugs. Structure function and biophysical basis of ligand-target interactions
Lecture notesWill be provided in parts before each individual lecture.
Literature- G.L. Patrick, "An Introduction to Medicinal Chemistry", 5th edition, Oxford University Press
- D. Steinhilber, M. Schubert-Zsilavecz, H.J. Roth, "Medizinische Chemie", Deutscher Apotheker Verlag Stuttgart (2005)
- J.H. Block, J.M. Beale, "Organic Medicinal and Pharmaceutical Chemistry", 11th edition, Lippincott, Williams, Wilkins (2002)
- A. Gringauz, "How Drugs Act and Why", Wiley (1997)
Prerequisites / NoticeRequirements: Knowledge of physical and organic chemistry, biochemistry and biology.
Attendance of Medicinal Chemistry II in the spring semester.
535-0239-00LPractical Course in Medicinal Chemistry Restricted registration - show details 3 credits7PJ. Hall, M. Detmar, C. Halin Winter, D. Neri
AbstractThe course comprises experiments relating to concepts of medicinal chemistry including statistical processing, fitting of experimental data, computer modeling of protein structures, experimental measurement of affinity constants and kinetic dissociation constants for protein ligands. The chemical stability of a drug will be studied. Basic gene cloning and protein expression will be introduced.
ObjectiveKnowledge of experimental methods in drug discovery and development
ContentCharacterisation of the biophysical and biological properties of drugs.
Lecture notesScripts
LiteratureOriginal literature
Prerequisites / NoticeRequirements:
Laboratory course in Pharmaceutical Anaytics;
Lecture Medicinal Chemistry I in the same semester or earlier.
535-0900-00LSeminars on Drug Discovery and Development1 credit1KJ.‑C. Leroux, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, D. Neri, U. Quitterer, R. Schibli, G. Schneider, H. U. Zeilhofer
AbstractState-of-the-art information on drug discovery and development by experts from academia and industry.
ObjectiveState-of-the-art information on drug discovery and development.
ContentSeminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics.
535-1001-00LLaboratory Course General Chemistry (for Biology and Pharmacy) Information Restricted registration - show details
Information about the practical course will be given on the first day.
6 credits8PR. O. Kissner, K.‑H. Altmann, J. Hall, D. Neri, G. Schneider, M. D. Wörle
AbstractIntroduction to the practical work in a chemistry laboratory. The most important manipulations and techniques are treated, as well as the the most fundamental chemical reaction types.
Objective- Knowledge of the basic chemical laboratory methods.
- Basic knowledge of the scientific approach in experimenting.
- Observation and interpretation of real-world chemical processes.
- Keeping of a reliable laboratory journal.
Content- Simple chemical methods and calculations.
- Separation techniques.
- Physical measurements: mass, volume, pH, optical spectra.
- Ionic solids (salts).
- Acid/base chemistry, buffers.
- Redox reactions.
- Metal complexes.
- Titration methods and quantitative spectrometry.
- Introduction to qualitative analysis.
Lecture notesCourse manual in German (is handed out to the students at the begin of the lessons).
Language: German, English upon request.

PDF files available at
http://acac1.ethz.ch/praktikum/docs.html
LiteratureBasic Concepts of Chemistry, International Student Version, 8th Edition, Leo J. Malone, Theodore Dolter
Wiley

is a suitable textbook.
Prerequisites / NoticeThis practical course causes costs for materials and chemicals. The costs are charged to the students at the end of semester.
551-1309-00LRNA-Biology Restricted registration - show details
Number of participants limited to 20.
6 credits7GC. Beyer, F. Allain, J. Hall, H. L. Lightfoot, B. Mateescu, O. Voinnet, K. Weis, A. Wutz
AbstractIntroduction to the diversity of current RNA-research at all levels from structural biology to systems biology using mainly model systems like S. cerevisiae (yeast), mammalian cells.
ObjectiveThe students will obtain an overview about the diversity of current RNA-research. They will learn to design experiments and use techniques necessary to analyze different aspects of RNA biology. Through lectures and literature seminars, they will learn about the burning questions of RNA research and discuss approaches to address these questions experimentally. In practical lab projects the students will work in one of the participating laboratories. Finally, they will learn how to present and discuss their data in an appropriate manner. Student assessment is a graded semester performance based on individual performance in the laboratory, the written exam and the poster presentation.
LiteratureDocumentation and recommended literature will be provided at the beginning and during the course.
Prerequisites / NoticeThe course will be taught in English.