Gunnar Jeschke: Katalogdaten im Frühjahrssemester 2019

NameHerr Prof. Dr. Gunnar Jeschke
LehrgebietElektronenspinresonanz
Adresse
Lab. für Physikalische Chemie
ETH Zürich, HCI F 227
Vladimir-Prelog-Weg 1-5/10
8093 Zürich
SWITZERLAND
Telefon+41 44 632 57 02
E-Mailgunnar.jeschke@phys.chem.ethz.ch
DepartementChemie und Angewandte Biowissenschaften
BeziehungOrdentlicher Professor

NummerTitelECTSUmfangDozierende
529-0499-00LPhysical Chemistry1 KP1KB. H. Meier, M. Ernst, P. H. Hünenberger, G. Jeschke, F. Merkt, M. Reiher, J. Richardson, R. Riek, S. Riniker, T. Schmidt, R. Signorell, H. J. Wörner
KurzbeschreibungSeminarreihe über aktuelle Probleme in der Physikalischen Chemie
Lernziel
551-1414-00LMolecular and Structural Biology V: Studying Macromolecules by NMR and EPR4 KP2VF. Allain, A. D. Gossert, G. Jeschke, K. Wüthrich
KurzbeschreibungThe course provides an overview of experimental methods for studying function and structure of macromolecules at atomic resolution in solution. The two main methods used are Nuclear Magnetic Resonance (NMR) spectroscopy and Electron Paramagnetic Resonance (EPR) spectroscopy.
LernzielInsight into the methodology, areas of application and limitations of these two methods for studying biological macromolecules. Practical exercises with spectra to have hands on understanding of the methodology.
InhaltPart I: Historical overview of structural biology.
Part II: Basic concepts of NMR and initial examples of applications.
2D NMR and isotope labeling for studying protein function and molecular interactions at atomic level.
Studies of dynamic processes of proteins in solution.
Approaches to study large particles.
Methods for determination of protein structures in solution.
Part III: NMR methods for structurally characterizing RNA and protein-RNA complexes.
Part IV: EPR of biomolecules
Literatur1) Wüthrich, K. NMR of Proteins and Nucleic Acids, Wiley-Interscience.
2) Dominguez et al, Prog Nucl Magn Reson Spectrosc. 2011 Feb;58(1-2):1-61.
3) Duss O et al, Methods Enzymol. 2015;558:279-331.