Gisbert Schneider: Catalogue data in Autumn Semester 2017
|Name||Prof. Dr. Gisbert Schneider|
|Field||Computer-Assisted Drug Design|
Inst. f. Pharmazeutische Wiss.
ETH Zürich, HCI H 411
|Telephone||+41 44 633 73 27|
|Fax||+41 44 633 13 79|
|Department||Chemistry and Applied Biosciences|
|511-0007-00L||Scientific Writing and Presenting |
Number of participants limited to 24.
|2 credits||2G||G. Schneider, J. Dolenc, J. A. Hiss, J.‑C. Leroux, O. Renn, J. Schnabl|
|Abstract||This introductory class provides an overview of the basic scientific writing techniques and a guideline to presenting scientific data, together with guided exercises and hands-on training. It is devised to accompany the research projects within the curriculum of the MSc in Pharmaceutical Sciences.|
|Objective||The class enables the participants to prepare their own scientific texts and oral presentations, and critically assess the quality of the presentation of scientific data.|
|Content||The participants receive an introduction to basic formal aspects of scientific writing and the design of graphical elements. Lectures and topical seminars alternate with practical task for the participants, which will be evaluated in a peer-to-peer setting. Performance feedback is provided by both the teachers and the peers.|
|535-0001-00L||Introduction to Pharmaceutical Sciences I||2 credits||2V||C. Halin Winter, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, J. Hall, J.‑C. Leroux, C. Müller, D. Neri, U. Quitterer, R. Schibli, G. Schneider, H. U. Zeilhofer|
|Abstract||First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.|
|Objective||First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.|
|Content||Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields.|
|Lecture notes||Handouts for individual lectures.|
|Prerequisites / Notice||Interactive teaching|
|535-0011-00L||Drug Seminar |
The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences
|5 credits||9S||C. Halin Winter, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, D. Neri, V. I. Otto, U. Quitterer, R. Schibli, G. Schneider, C. Steuer, H. U. Zeilhofer|
|Abstract||The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium.|
|Objective||The main objectives of this course are: |
- students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic
- students gain in-depth knowledge of the topic investigated
- students train their scientific writing and presentation skills
- students train their ability to plan a project and work in a team
|Content||The Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences. |
The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences.
During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester.
|Prerequisites / Notice||Only for students of MSc Pharmacy and MSc Pharmaceutical Sciences.|
|535-0022-00L||Computer-Assisted Drug Design||1 credit||1V||G. Schneider|
|Abstract||The lecture series provides an introduction to computer applications in medicinal chemistry. A focus is on molecular representations, property predictions, molecular similarity concepts, virtual screening techniques, and de novo drug design. All theoretical concepts and algorithms presented are illustrated by practical applications and case studies|
|Objective||The students will learn how computer simulation generates ideas for drug design and development, understand the theoretical principles of property prediction and computer-generated compound generation, and understand possibilities and limitations of computer-assisted drug design in pharmaceutical chemistry. As a result, they are prepared for professional assessment of computer-assisted drug design studies in medicinal chemistry projects.|
|Literature||Recommended textbooks: |
1) G. Schneider, K.-H. Baringhaus (2008) "Molecular Design - Concepts and Applications", Wiley-VCH: Weinheim, New York.
2) H.-D. Höltje, W. Sippl, D. Rognan, G. Folkers (2008) "Molecular Modeling: Basic Principles and Applications", Wiley-VCH: Weinheim, New York.
3) G. Klebe (2009) "Wirkstoffdesign", Spektrum Akademischer Verlag: Heidelberg.
|Prerequisites / Notice||Successful participation in this course is required for a research project ("Forschungspraktikum") in the CADD group.|
|535-0023-00L||Computer-Assisted Drug Design (Practical Course) |
Limited number of participants.
|4 credits||6P||G. Schneider, J. A. Hiss|
|Abstract||The practical course is open for master and graduate students to get an introduction into hands-on computer-assisted drug design. The class includes an introduction to computer-based screening of a virtual compound library, subsequent synthesis of candidate ligands, and biochemically testing for activity on pharmacologically important drug targets.|
|Objective||Participants become familiar with state-of-the-art methodologies in a real-life computer-aided medicinal chemistry project. Participants work as small teams, perform literature research and discuss recent research findings. A seminar talk is to be given presenting the molecular design strategy chosen and the results obtained during the course.|
|Content||The course offers the possibility for people with and without computational and or laboratory background to get an introduction into computer-assisted drug design, as well as practical training in a modern chemical laboratory. Using various software suites, the participants will computationally create and screen a virtual compound library for potential active small molecules. The process will involve an introduction to screening a virtual compound library, synthesizing candidate inhibitors, and biophysical testing against a pharmacologically important drug target.|
|Lecture notes||Detailed information will be handed out during the course.|
Schneider, G. and Baringhaus, K.-H. (2008) Molecular Design - Concepts and Applications. Wiley-VCH, Weinheim, New York.
|Prerequisites / Notice||The class is organized as a two-week block course.|
The number of participants is limited.
Kick-off meeting and confirmation of registration (Vorbesprechung und Platzvergabe): During the last lecture of the class "Computer-Assisted Drug Design" (535-0022-00)
Ideally, students interested in the course participated and successfully passed the lecture "Computer-Assisted Drug Design" (535-0022-00).
|535-0024-00L||Methods in Drug Design |
Complementary to the practical course "Computer-Assisted Drug Design (Practical Course)" 535-0023-00L . Compulsory for the students of the practical course, open for other interested students.
|1 credit||1V||G. Schneider|
|Abstract||The lecture is organized as a two-week block during the practical course "Computer-Assisted Drug Design" (535-0023-00 P), totalling 10 two-hour lectures. It provides an introduction to advanced drug design techniques and approaches emphasizing computer-assisted molecular design.|
|Objective||Participants will learn about computational algorithms and advanced experimental approaches to drug discovery and design, including selected actual topics and practical applications. The contents of the lecture will allow for a deeper understanding of modern computer-assisted drug design methods and how they are linked to experimental applications. The main focus is on computational medicinal chemistry, so that participants will be able to use relevant computer-based methods in own research projects.|
|Literature||Schneider, G. and Baringhaus, K.-H. (2008) Molecular Design - Concepts and Applications. Wiley-VCH, Weinheim, New York.|
Additional selected literature will be provided during the lecture.
|Prerequisites / Notice||The lecture is mandatory for all participants of the course "Computer-Assisted Drug Design" (535-0023-00 P).|
|535-0900-00L||Seminars on Drug Discovery and Development||1 credit||1K||J.‑C. Leroux, K.‑H. Altmann, S. M. Ametamey, M. Detmar, B. A. Gander, C. Halin Winter, J. Hall, D. Neri, U. Quitterer, R. Schibli, G. Schneider, H. U. Zeilhofer|
|Abstract||State-of-the-art information on drug discovery and development by experts from academia and industry.|
|Objective||State-of-the-art information on drug discovery and development.|
|Content||Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics.|
|535-1001-00L||Laboratory Course General Chemistry (for Biology and Pharmacy) |
Information about the practical course will be given on the first day.
|6 credits||8P||R. O. Kissner, K.‑H. Altmann, J. Hall, D. Neri, G. Schneider, M. D. Wörle|
|Abstract||Introduction to the practical work in a chemistry laboratory. The most important manipulations and techniques are treated, as well as the the most fundamental chemical reaction types.|
|Objective||- Knowledge of the basic chemical laboratory methods.|
- Basic knowledge of the scientific approach in experimenting.
- Observation and interpretation of real-world chemical processes.
- Keeping of a reliable laboratory journal.
|Content||- Simple chemical methods and calculations.|
- Separation techniques.
- Physical measurements: mass, volume, pH, optical spectra.
- Ionic solids (salts).
- Acid/base chemistry, buffers.
- Redox reactions.
- Metal complexes.
- Titration methods and quantitative spectrometry.
- Introduction to qualitative analysis.
|Lecture notes||Course manual in German (is handed out to the students at the begin of the lessons).|
Language: German, English upon request.
PDF files available at
|Literature||Basic Concepts of Chemistry, International Student Version, 8th Edition, Leo J. Malone, Theodore Dolter|
is a suitable textbook.
|Prerequisites / Notice||This practical course causes costs for materials and chemicals. The costs are charged to the students at the end of semester.|
|535-2000-00L||Seminar for Group Members||0 credits||2S||G. Schneider|
|Abstract||Weekly group seminar, in which members of the research team present and discuss the results of their projects and selected reports from the current scientific literature.|
|Objective||Participants learn to present scientific studies and discuss own results in greater context.|