Randall Platt: Katalogdaten im Frühjahrssemester 2018

NameHerr Prof. Dr. Randall Platt
LehrgebietBiologisches Engineering
Adresse
Professur Biologisches Engineering
ETH Zürich, D-BSSE, BSA M 754
Mattenstrasse 26
4058 Basel
SWITZERLAND
Auszeichnung: Die Goldene Eule
Telefon+41 61 387 33 50
E-Mailrandall.platt@bsse.ethz.ch
DepartementBiosysteme
BeziehungAusserordentlicher Professor

NummerTitelECTSUmfangDozierende
636-0113-00LGenome Engineering4 KP3VR. Platt
KurzbeschreibungThis course is an introduction to genome engineering and an examination of recent advancements and future challenges. It covers the discovery and development of gene editing technologies and their applications in basic and applied research. The focus is on gaining an in-depth molecular and cellular understanding of the technologies and also insight into how these tools can be used and further deve
LernzielThe objective of this course is to learn how gene editing technologies function at the molecular and cellular level, and how they are leveraged to understand the role of genetic elements in biological processes. Students will be introduced to the history and motivation behind the discovery and development of transformative genome engineering technologies, and also gain insight into the ethical, safety, and regulatory facets shaping the field.
InhaltThe course content is comprised of lectures, discussions of important literature in the field, and a project. Lectures in Genome Engineering will be technology-focused and incorporate: 1) historical context to motivate the need for developing the technology, 2) development of the technology from concept to robust tool, 3) methods to discover, characterize, and evaluate the technology, and 4) applications of the technology in basic and applied research. Discussions of important literature in the field will be conducted in class, one course meeting following a lecture covering the topic material and assignment of the reading. The project will be team-based and entail devising a solution to a critical need in the field.

Main topics:
--Discovery and development of genome editing technologies
--The prokaryotic adaptive immune system CRISPR-Cas
--Genome engineering methods for generating genetically engineered model systems
--Genotype-phenotype linkage via genetic screens
--Massively paralleled perturbation and phenotyping
--Gene editing tools as genetic recording devices
--Gene editing tools as diagnostics and therapeutics
--Ethics, safety, and regulatory facets of genome engineering
SkriptHandout during the course.
LiteraturPeer-reviewed scientific publications will be assigned to complement lecture content.
636-0301-00LCurrent Topics in Biosystems Science and Engineering2 KP1ST. Stadler, N. Beerenwinkel, Y. Benenson, K. M. Borgwardt, P. S. Dittrich, M. Fussenegger, A. Hierlemann, D. Iber, M. H. Khammash, D. J. Müller, S. Panke, R. Paro, R. Platt, S. Reddy, T. Schroeder, J. Stelling
KurzbeschreibungThis seminar will feature invited lectures about recent advances and developments in systems biology, including topics from biology, bioengineering, and computational biology.
LernzielTo provide an overview of current systems biology research.
InhaltThe final list of topics will be available at http://www.bsse.ethz.ch/education/.
636-1004-AALBio IV: Genetics
Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben.

Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen.
5 KP7RR. Platt
Kurzbeschreibung
Lernziel
LiteraturLewin, Genes XI, chapters: 3,15, 16, 19-23, 26-30
636-1008-AALBio Lab III: Molecular Biology I
Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben.

Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen.
1 KP3RR. Platt
Kurzbeschreibung
Lernziel
InhaltPCR, restriction digest, ligation, transformation, gel analysis, Sanger sequencing, Gibson assembly