Randall Platt: Catalogue data in Spring Semester 2019

Name Prof. Dr. Randall Platt
FieldBiological Engineering
Address
Professur Biologisches Engineering
ETH Zürich, D-BSSE, BSA M 754
Mattenstrasse 26
4058 Basel
SWITZERLAND
Award: The Golden Owl
Telephone+41 61 387 33 50
E-mailrandall.platt@bsse.ethz.ch
DepartmentBiosystems Science and Engineering
RelationshipAssociate Professor

NumberTitleECTSHoursLecturers
636-0113-00LGenome Engineering4 credits3VR. Platt
AbstractThis course is both an introduction to genome engineering and also a highly interactive practical training on effectively reading, writing, and presenting in an academic context.
ObjectiveThe objective of this course is to learn how gene editing technologies function at the molecular and cellular level and how they are applied in research and clinical settings. Students will be introduced to the history and motivation behind the discovery and development of transformative genome engineering technologies, and also gain insight into the ethical, safety, and regulatory facets shaping the field. This content will be explored by critically examining and discussing current literature in the field and devising a technology development plan.
ContentThe course content is comprised of lectures, discussions, and a project. Lectures in Genome Engineering will be technology-focused and incorporate: 1) historical context to motivate the need for developing the technology, 2) development of the technology from concept to robust tool, 3) methods to discover, characterize, and evaluate the technology, and 4) applications of the technology in basic and applied research. Primary research articles will be assigned each week, which will be followed by an in-class lecture and discussion. The course project will be team-based and entail devising a solution to a critical need in the field.

Main topics:
--Discovery and development of genome editing technologies
--The prokaryotic adaptive immune system CRISPR-Cas
--Genome engineering methods for generating genetically engineered model systems
--Genotype-phenotype linkage via genetic screens
--Massively paralleled perturbation and phenotyping
--Gene editing tools as molecular recording devices
--Gene editing tools as diagnostics and therapeutics
Lecture notesMade available through the course website.
LiteratureAssigned each week. Made available through the course website.
636-0301-00LCurrent Topics in Biosystems Science and Engineering2 credits1SR. Platt, N. Beerenwinkel, Y. Benenson, K. M. Borgwardt, P. S. Dittrich, M. Fussenegger, A. Hierlemann, D. Iber, M. H. Khammash, D. J. Müller, S. Panke, R. Paro, S. Reddy, T. Schroeder, T. Stadler, J. Stelling
AbstractThis seminar will feature invited lectures about recent advances and developments in systems biology, including topics from biology, bioengineering, and computational biology.
ObjectiveTo provide an overview of current systems biology research.
ContentThe final list of topics will be available at http://www.bsse.ethz.ch/education/.
636-1004-AALBio IV: Genetics
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
5 credits7RR. Platt
Abstract
Objective
LiteratureLewin, Genes XI, chapters: 3,15, 16, 19-23, 26-30
636-1008-AALBio Lab III: Molecular Biology I
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
1 credit3RR. Platt
Abstract
Objective
ContentPCR, restriction digest, ligation, transformation, gel analysis, Sanger sequencing, Gibson assembly