Randall Platt: Katalogdaten im Frühjahrssemester 2020

NameHerr Prof. Dr. Randall Platt
LehrgebietBiologisches Engineering
Adresse
Professur Biologisches Engineering
ETH Zürich, D-BSSE, BSA M 754
Mattenstrasse 26
4058 Basel
SWITZERLAND
Auszeichnung: Die Goldene Eule
Telefon+41 61 387 33 50
E-Mailrandall.platt@bsse.ethz.ch
DepartementBiosysteme
BeziehungAusserordentlicher Professor

NummerTitelECTSUmfangDozierende
636-0113-00LGenome Engineering
No longer accepting registrations. Course is fully booked.
4 KP3VR. Platt
KurzbeschreibungThis course is both an introduction to genome engineering and also a highly interactive practical training on effectively reading, writing, and presenting in an academic context.
LernzielThe objective of this course is to learn how gene editing technologies function at the molecular and cellular level and how they are applied in research and clinical settings. Students will be introduced to the history and motivation behind the discovery and development of transformative genome engineering technologies, and also gain insight into the ethical, safety, and regulatory facets shaping the field. This content will be explored by critically examining and discussing current literature in the field and devising a technology development plan.
InhaltThe course content is comprised of lectures, discussions, and a project. Lectures in Genome Engineering will be technology-focused and incorporate: 1) historical context to motivate the need for developing the technology, 2) development of the technology from concept to robust tool, 3) methods to discover, characterize, and evaluate the technology, and 4) applications of the technology in basic and applied research. Primary research articles will be assigned each week, which will be followed by an in-class lecture and discussion. The course project will be team-based and entail devising a solution to a critical need in the field.

Main topics:
--Discovery and development of genome editing technologies
--The prokaryotic adaptive immune system CRISPR-Cas
--Genome engineering methods for generating genetically engineered model systems
--Genotype-phenotype linkage via genetic screens
--Massively paralleled perturbation and phenotyping
--Gene editing tools as molecular recording devices
--Gene editing tools as diagnostics and therapeutics
SkriptMade available through the course website.
LiteraturAssigned each week. Made available through the course website.
636-0301-00LCurrent Topics in Biosystems Science and Engineering2 KP1SR. Platt, N. Beerenwinkel, Y. Benenson, K. M. Borgwardt, P. S. Dittrich, M. Fussenegger, A. Hierlemann, D. Iber, M. H. Khammash, D. J. Müller, S. Panke, S. Reddy, T. Schroeder, T. Stadler, J. Stelling, B. Treutlein, C. Uhler
KurzbeschreibungThis seminar will feature invited lectures about recent advances and developments in systems biology, including topics from biology, bioengineering, and computational biology.
LernzielTo provide an overview of current systems biology research.
InhaltThe final list of topics will be available at http://www.bsse.ethz.ch/education/.
636-1004-AALBio IV: Genetics
Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben.

Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen.
5 KP7RR. Platt
Kurzbeschreibung
Lernziel
LiteraturLewin, Genes XI, chapters: 3,15, 16, 19-23, 26-30
636-1008-AALBio Lab III: Molecular Biology I
Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben.

Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen.
1 KP3RR. Platt
Kurzbeschreibung
Lernziel
InhaltPCR, restriction digest, ligation, transformation, gel analysis, Sanger sequencing, Gibson assembly