227-0973-00L Translational Neuromodeling
Semester | Frühjahrssemester 2019 |
Dozierende | K. Stephan |
Periodizität | jährlich wiederkehrende Veranstaltung |
Lehrsprache | Englisch |
Lehrveranstaltungen
Nummer | Titel | Umfang | Dozierende | |||||||
---|---|---|---|---|---|---|---|---|---|---|
227-0973-00 V | Translational Neuromodeling | 3 Std. |
| K. Stephan | ||||||
227-0973-00 U | Translational Neuromodeling | 2 Std. |
| K. Stephan | ||||||
227-0973-00 A | Translational Neuromodeling No presence required. Creative task outside the regular weekly exercises. | 1 Std. | K. Stephan |
Katalogdaten
Kurzbeschreibung | This course provides a systematic introduction to Translational Neuromodeling (the development of mathematical models for diagnostics of brain diseases) and their application to concrete clinical questions (Computational Psychiatry/Psychosomatics). It focuses on a generative modeling strategy and teaches (hierarchical) Bayesian models of neuroimaging data and behaviour, incl. exercises. |
Lernziel | To obtain an understanding of the goals, concepts and methods of Translational Neuromodeling and Computational Psychiatry/Psychosomatics, particularly with regard to Bayesian models of neuroimaging (fMRI, EEG) and behavioural data. |
Inhalt | This course provides a systematic introduction to Translational Neuromodeling (the development of mathematical models for diagnostics of brain diseases) and their application to concrete clinical questions (Computational Psychiatry/Psychosomatics). The first part of the course will introduce disease concepts from psychiatry and psychosomatics, their history, and clinical priority problems. The second part of the course concerns computational modeling of neuronal and cognitive processes for clinical applications. A particular focus is on Bayesian methods and generative models, for example, dynamic causal models for inferring neuronal mechanisms from neuroimaging data, and hierarchical Bayesian models for inference on cognitive mechanisms from behavioural data. The course discusses the mathematical and statistical principles behind these models, illustrates their application to various psychiatric diseases, and outlines a general research strategy based on generative models. Lecture topics include: 1. Introduction to Translational Neuromodeling and Computational Psychiatry/Psychosomatics 2. Psychiatric nosology 3. Pathophysiology of psychiatric disease mechanisms 4. Principles of Bayesian inference and generative modeling 5. Variational Bayes (VB) 6. Bayesian model selection 7. Markov Chain Monte Carlo techniques (MCMC) 8. Bayesian frameworks for understanding psychiatric and psychosomatic diseases 9. Generative models of fMRI data 10. Generative models of electrophysiological data 11. Generative models of behavioural data 12. Computational concepts of schizophrenia, depression and autism 13. Model-based predictions about individual patients Practical exercises include mathematical derivations and the implementation of specific models or inference methods. In additional project work, students are required to use one of the examples discussed in the course as a basis for developing their own generative model and use it for simulations and/or inference in application to a clinical question. Group work (up to 3 students) is permitted. |
Literatur | See TNU website: Link |
Voraussetzungen / Besonderes | Knowledge of principles of statistics, programming skills (MATLAB or Python) |
Leistungskontrolle
Information zur Leistungskontrolle (gültig bis die Lerneinheit neu gelesen wird) | |
Leistungskontrolle als Semesterkurs | |
ECTS Kreditpunkte | 8 KP |
Prüfende | K. Stephan |
Form | benotete Semesterleistung |
Prüfungssprache | Englisch |
Repetition | Repetition nur nach erneuter Belegung der Lerneinheit möglich. |
Zusatzinformation zum Prüfungsmodus | Students are required to use one of the examples discussed in the course as a basis for developing their own generative model and use it for simulations and/or inference in application to a clinical question (a real or fictitious one). This model is to be submitted as open source code (in MATLAB or Python), and the motivation and results are presented in a 10 min oral presentation followed by critical discussion. Group work (up to 3 students) is permitted. The submitted code must be executable without any dependencies on specific operating systems or local setups (e.g., no absolute pathnames). Grading will depend on (i) originality of the question that is addressed, (ii) clarity, technical correctness and practicability of the code, (iii) the quality of the oral presentation and discussion in the report. The code is to be submitted by 30 May 2019; the oral presentations take place on 31 May (12-18h). |
Lernmaterialien
Hauptlink | Translational Neuromodeling |
Es werden nur die öffentlichen Lernmaterialien aufgeführt. |
Gruppen
Keine Informationen zu Gruppen vorhanden. |
Einschränkungen
Keine zusätzlichen Belegungseinschränkungen vorhanden. |