227-0973-00L  Translational Neuromodeling

SemesterSpring Semester 2018
LecturersK. Stephan
Periodicityyearly recurring course
Language of instructionEnglish


AbstractThis course provides a systematic introduction to Translational Neuromodeling (the development of mathematical models for diagnostics of brain diseases) and their application to concrete clinical questions (Computational Psychiatry/Psychosomatics). It focuses on a generative modeling strategy and discusses (hierarchical) Bayesian models of neuroimaging data and behaviour in detail.
ObjectiveTo obtain an understanding of the goals, concepts and methods of Translational Neuromodeling and Computational Psychiatry/Psychosomatics, particularly with regard to Bayesian models of neuroimaging (fMRI, EEG) and behavioural data.
ContentThis course provides a systematic introduction to Translational Neuromodeling (the development of mathematical models for diagnostics of brain diseases) and their application to concrete clinical questions (Computational Psychiatry/Psychosomatics). The first part of the course will introduce disease concepts from Psychiatry and Psychosomatics, their history, and clinical priority problems. The second part of the course concerns computational modeling of neuronal and cognitive processes for clinical applications. A particular focus is on Bayesian methods and generative models, e.g. dynamic causal models (DCMs) for inferring neuronal mechanisms from neuroimaging data, and hierarchical Bayesian models for inference on cognitive mechanisms from behavioural data. The course discusses the mathematical and statistical principles behind these models, illustrates their application to various psychiatric diseases, and outlines a general research strategy based on generative models.
In the practical exercises, students are asked to program their own generative model (in MATLAB) and use it for simulations and inference from real fMRI or behavioural data.
LiteratureSee TNU website:
https://www.tnu.ethz.ch/en/teaching.html
Prerequisites / NoticeBasic statistical knowledge, MATLAB programming skills