Autumn Semester 2020 takes place in a mixed form of online and classroom teaching.
Please read the published information on the individual courses carefully.

529-0745-00L  General and Environmental Toxicology

SemesterAutumn Semester 2016
LecturersM. Arand, K. Hungerbühler, H. Nägeli, B. B. Stieger, I. Werner
Periodicityyearly recurring course
Language of instructionEnglish


AbstractToxicokinetic and toxicodynamic aspects of xenobiotic interactions with cellular structures and mechanisms. Toxic responses at the level of organs (immune-, neuro-, reproductive and genotoxicity) and organisms. Introduction into developmental toxicology and ecotoxicology.
ObjectiveUnderstanding of the impact of chemicals on biological systems; evaluation of the effects from different biomedical perspectives.
ContentExplanation of important interactions between xeniobiotic chemicals and cellular structures such as membranes, enzymes, and nucleic acids. Relevance of intake, distribution, excretion, and biochemical transformation processes. Relevance of mixtures. Explanation of important modes of toxic action such as immuno toxicity, neurotoxicity, reproduction toxicity, genotoxicity based on examples of certain xenobiotics and their effects on important organs.
Lecture notesCourse material will be handed out as the lectures progress
LiteratureTextbooks of pharmacology and toxicology (cf. list in course material)
Prerequisites / NoticeEducational basis: basic chemistry, biology and biochemistry