535-0023-00L Praktikum Computer-Assisted Drug Design
|Dozierende||G. Schneider, J. A. Hiss|
|Periodizität||jährlich wiederkehrende Veranstaltung|
|Kommentar||Limited number of participants.|
|Kurzbeschreibung||The practical course is open for master and graduate students to get an introduction into hands-on computer-assisted drug design. The class includes an introduction to computer-based screening of a virtual compound library, subsequent synthesis of candidate ligands, and biochemically testing for activity on pharmacologically important drug targets.|
|Lernziel||Participants become familiar with state-of-the-art methodologies in a real-life computer-aided medicinal chemistry project. Participants work as small teams, perform literature research and discuss recent research findings. A seminar talk is to be given presenting the molecular design strategy chosen and the results obtained during the course.|
|Inhalt||The course offers the possibility for people with and without computational and or laboratory background to get an introduction into computer-assisted drug design, as well as practical training in a modern chemical laboratory. Using various software suites, the participants will computationally create and screen a virtual compound library for potential active small molecules. The process will involve an introduction to screening a virtual compound library, synthesizing candidate inhibitors, and biophysical testing against a pharmacologically important drug target.|
|Skript||Detailed information will be handed out during the course.|
Schneider, G. and Baringhaus, K.-H. (2008) Molecular Design - Concepts and Applications. Wiley-VCH, Weinheim, New York.
|Voraussetzungen / Besonderes||The class is organized as a two-week block course.|
The number of participants is limited.
Kick-off meeting and confirmation of registration (Vorbesprechung und Platzvergabe): During the last lecture of the class "Computer-Assisted Drug Design" (535-0022-00)
Ideally, students interested in the course participated and successfully passed the lecture "Computer-Assisted Drug Design" (535-0022-00).