511-1001-00L Biopharmacy (Crash Course)
|Semester||Autumn Semester 2017|
|Periodicity||yearly recurring course|
|Language of instruction||English|
|Comment||Obligatory course if assigned by the Admission committee.|
|Abstract||This course provides the basic concepts of biopharmacy (ADMET, absorption, distribution, metabolism, excretion, toxicity of drugs) and pharmacokinetics. After an introduction to the fundamental parameters and concepts, the participants will study independently and apply and consolidate their knowledge in tutorials.|
|Objective||- Knowledge of the ADMET processes and the respective pharmacokinetic parameters.|
- Interpretation of pharmacokinetic parameters.
- Analysis of drug plasma concentration-time curves.
- Prediction of pharmacokinetic parameters based on in vitro assays and physicochemical drug properties.
- Knowledge of the effects of physiological factors on the pharmacokinetic parameters and on drug plasma and tissue concentrations.
- Design of dosage regimens, based on pharmacokinetic parameters.
- Prediction of drug-drug interaction potentials based on in vitro assays and pharmacokinetic parameters.
|Content||- Introduction to biopharmacy (ADMET) and pharmacokinetics.|
- Definition of the most important pharmacokinetic parameters and their calculation from plasma concentration-time curves.
- Introduction to compartment models, statistical models, physiological models.
- Pharmacokinetic profiling of drugs for therapy optimization and for the analysis of the interaction potential.
- Design of dosage regimens. In vitro assays to predict pharmacokinetic parameters.
|Lecture notes||Slides, see documents repository.|
|Literature||Dennis A. Smith, Charlotte Allerton, Amit S. Kalgutkar, Han van de Waterbeemd, Don K. Walker (Eds.) Pharmacokinetics and Metabolism in Drug Design. 3rd edition, 2012. Wiley online library.|
|Prerequisites / Notice||***|