535-0423-00L Drug Delivery and Drug Targeting
|Semester||Autumn Semester 2018|
|Lecturers||J.‑C. Leroux, B. A. Gander, A. Spyrogianni Roveri|
|Periodicity||yearly recurring course|
|Language of instruction||English|
|Abstract||The students gain an overview on current principles, methodologies and systems for controlled delivery and targeting of drugs. This enables the students to understand and evaluate the field in terms of scientific criteria.|
|Objective||The students dispose of an overview on current principles and systems for the controlled delivery and targeting of drugs. The focus of the course lies on developing a capacity to understand the involved technologies and methods, as well as an appreciation of the chances and constraints of their therapeutic usage, with prime attention on anticancer drugs, therapeutic peptides, proteins, nucleic acids and vaccines.|
|Content||The course covers the following topics: drug targeting and delivery principles, macromolecular drug carriers, liposomes, micelles, micro/nanoparticles, gels and implants, administration of vaccines, targeting at the gastrointestinal level, synthetic carriers for nucleic acid drugs, ophthalmic devices and novel trends in transdermal and nasal drug delivery.|
|Lecture notes||Selected lecture notes, documents and supporting material will be directly provided or may be downloaded using|
The website also displays additional information on peroral delivery systems, transdermal systems and systems for alternative routes (nasal, pulmonary) of delivery. These fields are covered in detail in the course Galenische Pharmazie II (Galenical Pharmacy II).
|Literature||A.M. Hillery, K. Park. Drug Delivery: Fundamentals & Applications, second edition, CRC Press, Boca Raton, FL, 2017.|
B. Wang B, L. Hu, T.J. Siahaan. Drug Delivery - Principles and Applications, second edition, John Wiley & Sons, Hoboken NJ, 2016.
Y. Perrie, T. Rhades. Pharmaceutics - Drug Delivery and Targeting, second edition, Pharmaceutical Press, London and Chicago, 2012.
Further references will be provided in the course.