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535-0360-00L  Evidence Based Phytotherapy

SemesterAutumn Semester 2018
LecturersJ. Drewe, K. Berger Büter
Periodicityyearly recurring course
Language of instructionGerman


AbstractBased on epidemiology, economic importance and evidence-based medicine, basic principles of rational phytotherapy will be discussed: a) Identification of drug candidates, b) registration requirements, c) criteria to assess efficacy, d) biomarkers and pharmacokinetics, e) safety and f) principles of extract generation. Important prototypes will be discussed
ObjectiveStudents should learn the importance of rational (= evidence based) pharmacotherapy with herbal extracts:

They should get to know the development process of herbal drugs:
o How are interesting development candidates are being identified? What are the strategies?
o What are the regulatory requirements (traditional use, well-established use, new herbal entities)?
o What are the selection criteria?
o Assessment of efficacy (animal-/human studies, biomarker)
o Pharmacokinetics
o Safety (Toxicity, unwanted adverse effects, drug-drug interactions)
o Pharmaceutical quality
o Securing of herbal identity (collections, agriculture)
o Quality management
o selection of appropriate extraction procedures?

Important prototy
pes will be presented and critically discussed:

Hypericum perforatum
Rhodiola rosea
Lavendelöl
Pelargonium
Echinacea
Petasites
Cimicifuga
Silybum marianum
Iberogast®
ContentEffektive Zeiten 14.45 - 15.30; 15.45-16.30)

19.09.2018
Qualität Arzneipflanzen-Fertigprodukte, Monographien (Kommission E, ESCOP, HMPC), Unterschiede hinsichtlich des Registrierungsstatus und -anforderungen: traditional use, well established use und new herbal entities, Methoden Produktentwicklung (Pflanzenauswahl, Anbau, Extraktentwicklung, präklinische und klinische Entwicklung)

26.09.2019
Grundlegende Begriffe der evidenzbasierten Medizin
Hypericum perforatum (inklusive Pyrrolizidinalkaloid Problematik

03.10.2018
Rhodiola rosea
Lavendelöl

10.10.2018
Pelargonium
Echinacea

17.10.2018
Petasites (inklusive Pyrrolizidinalkaloid-Problematik)

24.10.2017
Cimicifuga
Silybum marianum

31.10.2018
Iberogast®
Prüfung (MC)
Lecture notesDie Skripten werden vor den jeweiligen Vorlesungen per Email an die Teilnehmer versandt