529-0241-10L Advanced Methods and Strategies in Synthesis
Semester | Autumn Semester 2018 |
Lecturers | J. W. Bode |
Periodicity | yearly recurring course |
Language of instruction | English |
Abstract | Advanced Modern Methods and Strategies in Synthesis |
Objective | Knowledge of modern methods in asymmetric stereocontrol, enantioselective catalysis, and organic reaction mechanisms. |
Content | Current trends in methods for and approaches to synthesis of complex natural products, pharmaceuticals, and biological molecules; fragment coupling and protecting group strategies; chemical ligation and biomolecules synthesis; enantioselective catalysis including ligand design and optimization; cross coupling reactions from preactivated precursors; C-H activation and oxidation chemistry; building block synthesis with chiral auxiliaries and reagents; new concepts in asymmetric catalysis. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized. |
Lecture notes | will be provided in class and online |
Literature | Suggesting Textbooks 1. Walsh and Kozlowski, Fundamentals of Asymmetric Catalysis, 1st Ed., University Science Books, 2009. 2. Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006. |