529-0241-10L  Advanced Methods and Strategies in Synthesis

SemesterAutumn Semester 2018
LecturersJ. W. Bode
Periodicityyearly recurring course
Language of instructionEnglish


AbstractAdvanced Modern Methods and Strategies in Synthesis
ObjectiveKnowledge of modern methods in asymmetric stereocontrol, enantioselective catalysis, and organic reaction mechanisms.
ContentCurrent trends in methods for and approaches to synthesis of complex natural products, pharmaceuticals, and biological molecules; fragment coupling and protecting group strategies; chemical ligation and biomolecules synthesis; enantioselective catalysis including ligand design and optimization; cross coupling reactions from preactivated precursors; C-H activation and oxidation chemistry; building block synthesis with chiral auxiliaries and reagents; new concepts in asymmetric catalysis. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized.
Lecture noteswill be provided in class and online
LiteratureSuggesting Textbooks
1. Walsh and Kozlowski, Fundamentals of Asymmetric Catalysis, 1st Ed., University Science Books, 2009.
2. Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006.