551-0364-00L  Functional Genomics

SemesterSpring Semester 2014
LecturersK. Bärenfaller, C. von Mering, C. Beyer, L. Pelkmans, H. Rehrauer, M. Robinson, R. Schlapbach, K. Shimizu, N. Zamboni
Periodicityyearly recurring course
Language of instructionEnglish


AbstractFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data.
ObjectiveFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data. Such data provide the basis for systems biology efforts to elucidate the structure, dynamics and regulation of cellular networks.
ContentThe Functional Genomics course builds on the training and information students have received in the Bioinformatics I and II courses (prerequisites). The curriculum of the Functional Genomics course emphasizes an in depth understanding of new technology platforms for modern genomics and advanced genetics, including the application of functional genomics approaches such as advanced microarrays, proteomics, metabolomics, clustering and classification. Students will learn quality controls and standards (benchmarking) that apply to the generation of quantitative data and will be able to analyze and interpret these data. The training obtained in the Functional Genomics course will be immediately applicable to experimental research and design of systems biology projects.
Prerequisites / NoticeThe Functional Genomics course will be taught in English. For the exericse, the presentation and discussion of original research articles will also be in English.

Grading
The final grade for this course will be based on a written exam, also a grade for the exercise based on the presentation and discussion of an original research paper.