Autumn Semester 2020 takes place in a mixed form of online and classroom teaching.
Please read the published information on the individual courses carefully.

227-0393-10L  Bioelectronics and Biosensors

SemesterAutumn Semester 2016
LecturersJ. Vörös, M. F. Yanik, T. Zambelli
Periodicityyearly recurring course
Language of instructionEnglish
CommentNew course. Not to be confounded with 227-0393-00L last offered in the Spring Semester 2015.



Catalogue data

AbstractThe course introduces the concepts of bioelectricity and biosensing. The sources and use of electrical fields and currents in the context of biological systems and problems are discussed. The fundamental challenges of measuring biological signals are introduced. The most important biosensing techniques and their physical concepts are introduced in a quantitative fashion.
ObjectiveDuring this course the students will:
- learn the basic concepts in biosensing and bioelectronics
- be able to solve typical problems in biosensing and bioelectronics
- learn about the remaining challenges in this field
ContentL1. Bioelectronics history, its applications and overview of the field
- Volta and Galvani dispute
- BMI, pacemaker, cochlear implant, retinal implant, limb replacement devices
- Fundamentals of biosensing
- Glucometer and ELISA

L2. Fundamentals of quantum and classical noise in measuring biological signals

L3. Biomeasurement techniques with photons

L4. Acoustics sensors
- Differential equation for quartz crystal resonance
- Acoustic sensors and their applications

L5. Engineering principles of optical probes for measuring and manipulating molecular and cellular processes

L6. Optical biosensors
- Differential equation for optical waveguides
- Optical sensors and their applications
- Plasmonic sensing

L7. Basic notions of molecular adsorption and electron transfer
- Quantum mechanics: Schrödinger equation energy levels from H atom to crystals, energy bands
- Electron transfer: Marcus theory, Gerischer theory

L8. Potentiometric sensors
- Fundamentals of the electrochemical cell at equilibrium (Nernst equation)
- Principles of operation of ion-selective electrodes

L9. Amperometric sensors and bioelectric potentials
- Fundamentals of the electrochemical cell with an applied overpotential to generate a faraday current
- Principles of operation of amperometric sensors
- Ion flow through a membrane (Fick equation, Nernst equation, Donnan equilibrium, Goldman equation)

L10. Channels, amplification, signal gating, and patch clamp Y4

L11. Action potentials and impulse propagation

L12. Functional electric stimulation and recording
- MEA and CMOS based recording
- Applying potential in liquid - simulation of fields and relevance to electric stimulation

L13. Neural networks memory and learning
LiteraturePlonsey and Barr, Bioelectricity: A Quantitative Approach (Third edition)
Prerequisites / NoticeSupervised exercises solving real-world problems. Some Matlab based exercises in groups.

Performance assessment

Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course
ECTS credits6 credits
ExaminersJ. Vörös, M. F. Yanik, T. Zambelli
Typesession examination
Language of examinationEnglish
RepetitionThe performance assessment is only offered in the session after the course unit. Repetition only possible after re-enrolling.
Mode of examinationwritten 180 minutes
Additional information on mode of examinationThe final grade can be improved by submitting solutions to a set of extra problems.
Written aidsAll help materials are permitted except outside help of course.
This information can be updated until the beginning of the semester; information on the examination timetable is binding.

Learning materials

No public learning materials available.
Only public learning materials are listed.

Courses

NumberTitleHoursLecturers
227-0393-10 VBioelectronics and Biosensors2 hrs
Wed14-16ETF C 1 »
J. Vörös, M. F. Yanik, T. Zambelli
227-0393-10 UBioelectronics and Biosensors2 hrs
Wed13-14ETF C 1 »
16-17ETF C 1 »
M. F. Yanik, J. Vörös, T. Zambelli

Groups

No information on groups available.

Restrictions

There are no additional restrictions for the registration.

Offered in

ProgrammeSectionType
Biomedical Engineering MasterTrack Core CoursesWInformation
Biomedical Engineering MasterRecommended Elective CoursesWInformation
Electrical Engineering and Information Technology BachelorThird Year Core CoursesWInformation
Health Sciences and Technology MasterElective Courses IIWInformation
Mechanical Engineering BachelorBiomedical EngineeringWInformation
Mechanical Engineering MasterBioengineeringWInformation