Suchergebnis: Katalogdaten im Frühjahrssemester 2015

Gesundheitswissenschaften und Technologie Master Information
Vertiefung in Bewegungswissenschaften und Sport
Pflichtfächer
NummerTitelTypECTSUmfangDozierende
376-0302-00LPracticing Translational Science Information Belegung eingeschränkt - Details anzeigen
Nur für Gesundheitswissenschaften und Technologie MSc.
O3 KP1G + 6AJ. Goldhahn, G. Senti
KurzbeschreibungTranslational science is a cross disciplinary scientific research that is motivated by the need for practical applications that help patients. The students should apply knowledge they gained in the prior course Translational science for health and medicine mandatory during a team approach focused on one topic provided by the supervisor. Each student has to take a role in the team and label clear
LernzielAfter completing this course, students will be able to apply:
a) Principles of translational science (including project planning, ethics application, basics of resource management and interdisciplinary communication)
b) The use of a translational approach in project planning and management
Voraussetzungen / BesonderesPrerequisite: lecture 376-0300-00 "Translational Science for Health and Medicine" passed.

Two initial lectures to introduce the key elements of the project plan as well as the topics available and two final lectures to present it. The groups can have in total three consultations with the supervisor to initiate, check and finally prepare the project plan.
Di 9.6. (Modul 1) und Di 16.6. (Modul 2)
Wahlfächer
Wahlfächer I
NummerTitelTypECTSUmfangDozierende
376-0224-00LClinical Exercise PhysiologyW3 KP2VC. Spengler
KurzbeschreibungThis lecture series provides a comprehensive overview of the most important aspects of clinical exercise testing for diagnosis and assessment of functional status in different patient populations, e.g. patients with pulmonary, cardiac or neuro-muscular disease, with obesity, young or old age. Also, special aspects in the context of training perscriptions in these populations will be discussed.
LernzielBy the end of this module, students:
- Have the theoretical basis for disease-specific exercise testing and interpretation in clinical settings
- Know important aspects for disease-specific exercise-training prescriptions and assessment of training progress
- Are able to critically review and interpret scientific literature in the context of physical fitness, performance and training in different patient populations
SkriptHandouts will be provided via moodle.
LiteraturHandouts.
Voraussetzungen / BesonderesThe courses "Anatomie & Physiologie I+II", as well as "Sportphysiologie" (or Anatomy, Physiology and Exercise Physiology - equivalents for students without HST-BSc), are required.
376-1306-00LClinical Neuroscience Information W3 KP3GM. E. Schwab, Uni-Dozierende
KurzbeschreibungThe lecture series "Clinical Neuroscience" presents a comprehensive, condensed overview of the most important neurological diseases, their clinical presentation, diagnosis, therapy options and possible causes. Patient demonstrations (Übungen) follow every lecture that is dedicated to a particular disease.
LernzielBy the end of this module students should be able to:
- demonstrate their understanding and deep knowledge concerning the main neurological diseases
-dentify and explain the different clinical presentation of these diseases, the methodology of diagnosis and the current therapies available
- summarise and critically review scientific literature efficiently and effectively
376-1168-00LSports Biomechanics Belegung eingeschränkt - Details anzeigen W3 KP2VS. Lorenzetti, H. Gerber
KurzbeschreibungVarious types of sport are studied from a mechanical point of view. Of particular interest are the key parameters of a sport as well as the performance relevant indicators.
LernzielThe aim of this lecture is to enable the students to study a sport from a biomechanical viewpoint and to develop significant models for which evaluations of the limitations and verifications can be carried out.
InhaltSport biomechanics is concerned with the physical and mechanical basic principles of sports. The lecture requires an in-depth mechanical understanding on the side of the student. In this respect, the pre-attendance of the lectures Biomechanics II and Movement and Sports Biomechanics or an equivalent course is expected. The human body is treated as a mechanical system during sport. The interaction of the active and passive movements and outside influences is analysed. Using sports such as ski-jumping, cycling, or weight training, applicable models are created, analyzed and suitable measuring methods are introduced. In particular, the constraints as well as the limitations of the models are of great relevance. The students develop their own models for different sport types, critically discuss the advantages and disadvantages and evaluate applicable measurement methods.
SkriptHandout will be distributed.
376-1719-00LStatistics for Experimental Research Information W2 KP2VR. van de Langenberg, E. de Bruin
KurzbeschreibungStudents will learn the necessary statistical concepts and skills to independently (1) design experiments (2) analyse experimental data and (3) report analyses and results in a scientifically appropriate manner.
LernzielAfter successful completion of the course, students should be able to:
1. Determine appropriate experimental designs and choose, justify and perform the appropriate statistical analyses using SPSS.
2. Report analyses and results in a scientifically appropriate manner, as laid out by the Publication Manual of the American Psychological Association (APA, sixth edition).
InhaltWe will cover basic statistical concepts (e.g., central tendency, variability, data distribution), the t-test (dependent and independent), ANOVA (univariate, factorial and repeated measures), correlation, multiple regression, nonparametric techniques, validity and reliability tests, effect size, data transformation, power and sample size estimation.
SkriptLecture notes will be delivered in the form of commented presentations in Microsoft Powerpoint (i.e. pptx) format. SPSS practical session assignments will be delivered in pdf-format.
LiteraturBoth in the lectures and in the tutorials and practical sessions, we will refer students to the following publication:

Field A (2013) Discovering Statistics Using SPSS, Fourth Edition. Sage Publications Ltd, London, UK
376-1660-00LWriting, Reporting and Communication Information Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 30

Nur für Gesundheitswissenschaften und Technologie MSc und Bewegungswissenschaften und Sport MSc.
W3 KP2VW. R. Taylor, E. de Bruin
KurzbeschreibungThis course aims to teach many of the unwritten rules on how to communicate effectively, from writing reports or manuscripts (or indeed their Master thesis!) through to improving skills in oral presentations, and presenting themselves at interview.
LernzielThis course will teach students to communicate effectively in official environments, including:
- writing manuscripts, theses, CVs, reports etc
- presenting posters
- oral presentations
- critical reviews of literature
Wahlfächer II
NummerTitelTypECTSUmfangDozierende
151-0104-00LUncertainty Quantification for Engineering & Life Sciences Belegung eingeschränkt - Details anzeigen
Findet dieses Semester nicht statt.
Number of participants limited to 40.
W4 KP3GP. Koumoutsakos
KurzbeschreibungQuantification of uncertainties in computational models pertaining to applications in engineering and life sciences. Exploitation of massively available data to develop computational models with quantifiable predictive capabilities. Applications of Uncertainty Quantification and Propagation to problems in mechanics, control, systems and cell biology.
LernzielThe course will teach fundamental concept of Uncertainty Quantification and Propagation (UQ+P) for computational models of systems in Engineering and Life Sciences. Emphasis will be placed on practical and computational aspects of UQ+P including the implementation of relevant algorithms in multicore architectures.
InhaltTopics that will be covered include: Uncertainty quantification under
parametric and non-parametric modelling uncertainty, Bayesian inference with model class assessment, Markov Chain Monte Carlo simulation, prior and posterior reliability analysis.
SkriptThe class will be largely based on the book: Data Analysis: A Bayesian Tutorial by Devinderjit Sivia as well as on class notes and related literature that will be distributed in class.
Literatur1. Data Analysis: A Bayesian Tutorial by Devinderjit Sivia
2. Probability Theory: The Logic of Science by E. T. Jaynes
3. Class Notes
Voraussetzungen / BesonderesFundamentals of Probability, Fundamentals of Computational Modeling
376-0202-00LNeural Control of Movement and Motor LearningW4 KP3GN. Wenderoth
KurzbeschreibungThis course extends the students' knowledge regarding the neural control of movement and motor learning. Particular emphasis will be put on those methods and experimental findings that have shaped current knowledge of this area.
LernzielKnowledge of the physiological and anatomic basis underlying the neural control of movement and motor learning. One central element is that students have first hands-on experience in the lab where small experiments are independently executed, analysed and interpreted.
376-0204-00LTrainingswissenschaften Information W4 KP3GE. de Bruin, A. Krebs, L. Tomatis Canonaco
KurzbeschreibungInformationen über Struktur und Funktion der Körper-Systeme und wie sich diese durch Training anpassen. Motorisches Lernen (Lernen von Bewegungsfähigkeiten). Überprüfen, bewerten, und üben, um bestimmte Trainingsziele zu erreichen. Programmgestaltung und Trainingsorganisation. Die theoretischen Vorträge werden durch praktische Arbeiten ergänzt.
LernzielVerstehen, sichere und wirksame Kraft und Konditionierungs-Programme zu entwickeln und zu verwalten.
InhaltAnpassung an anaerobe & aerobe Trainingsprogramme, Krafttraining (und Plyometrisches Training), Entwicklung von Geschwindigkeit, Agility und Geschwindigkeitausdauer, Ausdauertraining, Trainings-Planung/Trainingsprinzipien, Leistungstests. Praktische Grundlagen, Motor learning I-IV.
SkriptFolien der Vorlesung.
Literaturempfohlene Literatur:
- Thomas R. Baechle & Roger W. Earle (eds). Essentials of Strength Training and Conditioning (3rd edition). Human Kinetics.

- Jürgen Weineck; Optimales Training (Spita Verlag, 16. Aufllage)
376-0206-00LBiomechanik IIW4 KP3GS. Lorenzetti, R. List, W. R. Taylor
KurzbeschreibungEinführung in die Dynamik, Kinetik und Kinematik von starren und elastischen Mehrkörpersystemen mit Anwendungen in Biologie und Medizin und insbesondere der menschlichen Bewegung.
LernzielDie Studierenden können
- dynamische Systeme analysieren und beschreiben.
- die mechanischen Grundsätze erklären und in der Biologie und Medizin anwenden.
InhaltMenschliche Bewegung aus mechanischer Sicht. Kinetische und kinematische Konzepte und deren mechanische Beschreibung. Energie und Impuls einer Bewegung. Mechanische Beschreibung von Mehrkörpersystemen.
376-0905-00LFunktionelle Anatomie Information W3 KP2VD. P. Wolfer, I. Amrein
KurzbeschreibungEinführung in die allgemeine und spezielle Anatomie des Bewegungsapparates mit dem Ziel, Bewegungen und die Entstehung von Verletzungen besser zu verstehen.
Lernziel- Erlangen einer räumlichen Vorstellung des menschlichen Bewegungsapparates
- Korrekte Anwendung der Nomenklatur bei der Beschreibung anatomischer Sachverhalte
- Verstehen der Zusammenhänge zwischen Morphologie und normaler Funktion des Bewegungsapparates
- Kenntnis der anatomischen Grundlagen ausgewählter Verletzungsmechanismen
Inhalt- Allgemeine Anatomie des Bewegungsapparates (Bindegewebe, Knochen, Gelenke, Muskeln)
- Becken und freie untere Extremität (Skelett, Gelenke, Muskeln)
- Wirbelsäule, Brustkorb, Bauchwand (Skelett, Gelenke, Muskeln)
- Schulter und freie obere Extremität (Skelett, Gelenke, Muskeln)
Literatur- Gehrke T, Sportanatomie, Rowohlt Taschenbuch Verlag
- Weineck J, Sportanatomie, Spitta-Verlag
- Appel H-J, Stang-Voss C, Funktionelle Anatomie, Springer-Verlag
376-1150-00LClinical Challenges in Musculoskeletal Disorders Belegung eingeschränkt - Details anzeigen W2 KP2GM. Leunig, S. J. Ferguson, A. Müller
KurzbeschreibungThis course reviews musculoskeletal disorders focusing on the clinical presentation, current treatment approaches and future challenges and opportunities to overcome failures.
LernzielAppreciation of the surgical and technical challenges, and future perspectives offered through advances in surgical technique, new biomaterials and advanced medical device construction methods.
InhaltFoot deformities, knee injuries, knee OA, hip disorders in the child and adolescent, hip OA, spine deformities, degenerative spine disease, shoulder in-stability, hand, rheumatoid diseases, neuromuscular diseases, sport injuries and prevention
376-1178-00LHuman Factors IIW2 KP2VM. Menozzi Jäckli, R. Boutellier, R. Huang, M. Siegrist
KurzbeschreibungStrategies, individual abilities and needs, as well as properties of products are factors controlling quality and performance in everyday interactions with products. In this second block of lectures, cognitive aspects are in focus therefore complementing the more physical oriented approach in the first block. A basic scientific approach is adopted and relevant links to practice are illustrated.
LernzielThe goal of the lecture is to empower students in designing products enabling an efficient and qualitatively high standing interaction between human and the environment, considering costs, benefits, health, and safety as well. The goal is achieved in addressing a broad variety of topics and embedding the discussion in macroscopic factors such as the behavior of consumers and objectives of economy.
InhaltCognitive factors in perception and information processing, Experimental techniques in assessing human performance and well-being, human factors and ergonomics in product development and innovation, decision taking, consumer behavior
LiteraturSalvendy G. (ed), Handbook of Human Factors, Wiley & Sons, 2012
376-1217-00LRehabilitation Engineering I: Motor Functions Information W3 KP2V + 1UR. Riener
Kurzbeschreibung“Rehabilitation engineering” is the application of science and technology to ameliorate the handicaps of individuals with disabilities in order to reintegrate them into society. The goal of this lecture is to present classical and new rehabilitation engineering principles and examples applied to compensate or enhance especially motor deficits.
LernzielProvide theoretical and practical knowledge of principles and applications used to rehabilitate individuals with motor disabilities.
Inhalt“Rehabilitation” is the (re)integration of an individual with a disability into society. Rehabilitation engineering is “the application of science and technology to ameliorate the handicaps of individuals with disability”. Such handicaps can be classified into motor, sensor, and cognitive (also communicational) disabilities. In general, one can distinguish orthotic and prosthetic methods to overcome these disabilities. Orthoses support existing but affected body functions (e.g., glasses, crutches), while prostheses compensate for lost body functions (e.g., cochlea implant, artificial limbs). In case of sensory disorders, the lost function can also be substituted by other modalities (e.g. tactile Braille display for vision impaired persons).

The goal of this lecture is to present classical and new technical principles as well as specific examples applied to compensate or enhance mainly motor deficits. Modern methods rely more and more on the application of multi-modal and interactive techniques. Multi-modal means that visual, acoustical, tactile, and kinaesthetic sensor channels are exploited by displaying the patient with a maximum amount of information in order to compensate his/her impairment. Interaction means that the exchange of information and energy occurs bi-directionally between the rehabilitation device and the human being. Thus, the device cooperates with the patient rather than imposing an inflexible strategy (e.g., movement) upon the patient. Multi-modality and interactivity have the potential to increase the therapeutical outcome compared to classical rehabilitation strategies.
In the 1 h exercise the students will learn how to solve representative problems with computational methods applied to exoprosthetics, wheelchair dynamics, rehabilitation robotics and neuroprosthetics.
SkriptLecture notes will be distributed at the beginning of the lecture (1st session)
LiteraturIntroductory Books

Neural prostheses - replacing motor function after desease or disability. Eds.: R. Stein, H. Peckham, D. Popovic. New York and Oxford: Oxford University Press.

Advances in Rehabilitation Robotics – Human-Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Eds: Z.Z. Bien, D. Stefanov (Lecture Notes in Control and Information Science, No. 306). Springer Verlag Berlin 2004.

Intelligent Systems and Technologies in Rehabilitation Engineering. Eds: H.N.L. Teodorescu, L.C. Jain (International Series on Computational Intelligence). CRC Press Boca Raton, 2001.

Control of Movement for the Physically Disabled. Eds.: D. Popovic, T. Sinkjaer. Springer Verlag London, 2000.

Interaktive und autonome Systeme der Medizintechnik - Funktionswiederherstellung und Organersatz. Herausgeber: J. Werner, Oldenbourg Wissenschaftsverlag 2005.

Biomechanics and Neural Control of Posture and Movement. Eds.: J.M. Winters, P.E. Crago. Springer New York, 2000.

Selected Journal Articles

Abbas, J., Riener, R. (2001) Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function. Neuromodulation 4, pp. 187-195.

Burdea, G., Popescu, V., Hentz, V., and Colbert, K. (2000): Virtual reality-based orthopedic telerehabilitation, IEEE Trans. Rehab. Eng., 8, pp. 430-432

Colombo, G., Jörg, M., Schreier, R., Dietz, V. (2000) Treadmill training of paraplegic patients using a robotic orthosis. Journal of Rehabilitation Research and Development, vol. 37, pp. 693-700.

Colombo, G., Jörg, M., Jezernik, S. (2002) Automatisiertes Lokomotionstraining auf dem Laufband. Automatisierungstechnik at, vol. 50, pp. 287-295.

Cooper, R. (1993) Stability of a wheelchair controlled by a human. IEEE Transactions on Rehabilitation Engineering 1, pp. 193-206.

Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T. (1998): Robot-aided neurorehabilitation, IEEE Trans. Rehab. Eng., 6, pp. 75-87

Leifer, L. (1981): Rehabilitive robotics, Robot Age, pp. 4-11

Platz, T. (2003): Evidenzbasierte Armrehabilitation: Eine systematische Literaturübersicht, Nervenarzt, 74, pp. 841-849

Quintern, J. (1998) Application of functional electrical stimulation in paraplegic patients. NeuroRehabilitation 10, pp. 205-250.

Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10.

Riener, R., Fuhr, T., Schneider, J. (2002) On the complexity of biomechanical models used for neuroprosthesis development. International Journal of Mechanics in Medicine and Biology 2, pp. 389-404.

Riener, R. (1999) Model-based development of neuroprostheses for paraplegic patients. Royal Philosophical Transactions: Biological Sciences 354, pp. 877-894.
Voraussetzungen / BesonderesTarget Group:
Students of higher semesters and PhD students of
- D-MAVT, D-ITET, D-INFK
- Biomedical Engineering
- Medical Faculty, University of Zurich
Students of other departments, faculties, courses are also welcome
376-1308-00LDevelopment Strategies for Medical Implants Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 25 bis 30.
Die Einschreibungen werden nach chronologischem Eingang berücksichtigt.
W3 KP2V + 1UJ. Mayer-Spetzler, S. Hofmann Boss
KurzbeschreibungIntroduction to development strategies for implantable devices considering the interdependecies of biocompatibility, clinical and economical requirements ; discussion of the state of the art and actual trends in in orthopedics, sports medicine, traumatology and cardio-vascular surgery as well as regenerative medicine (tissue engineering).
LernzielBasic considerations in implant development
Concept of structural and surface biocompatiblity and its relevance for the design of implant and surgical technique
Understanding of conflicting factors, e.g. clinical need, economics and regulatory requirements
Concepts of tissue engineering, its strengths and weaknesses as current and future clinical solution
InhaltBiocompatibility as bionic guide line for the development of medical implants; implant and implantation related tissue reactions, biocompatible materials and material processing technologies; implant testing and regulatory procedures; discussion of the state of the art and actual trends in implant development in orthopedics, sports medicine, traumatology, spinal and cardio-vascular surgery; introduction to tissue engineering. Selected topics will be further illustrated by commented movies from surgeries.

Seminar:
Group seminars on selected controversial topics in implant development. Participation is mandatory

Planned excursions (limited availability, not mandatory, to be confirmed):
1. Participation (as visitor) on a life surgery (travel at own expense)
SkriptScribt (electronically available):
- presented slides
- selected scientific papers for further reading
LiteraturTextbooks on selected topics will be introduced during the lectures
Voraussetzungen / BesonderesStudents need to have a Bachelor degree or an equivalent

The number of participants in the course is limited to 25-30 students in total.

Students will be exposed to surgical movies which may cause emotional reactions. The viewing of the surgical movies is voluntary and is on the student's own responsability.
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 KP2GA. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong
KurzbeschreibungThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
LernzielThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
InhaltTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include all forms of myogenesis (cardiac, skeletal and smooth muscles), osteogenesis (bones), chondrogenesis (cartilage), tendogenesis (tendons) and angiogenesis (blood vessels). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Skriptn/a
LiteraturTopical Scientific Manuscripts
376-1397-00LOrthopaedic BiomechanicsW4 KP3GR. Müller, K. S. Stok, G. H. Van Lenthe
KurzbeschreibungThis course is aimed at studying the mechanical and structural engineering of the musculoskeletal system alongside the analysis and design of orthopaedic solutions to musculoskeletal failure.
LernzielTo apply engineering and design principles to orthopaedic biomechanics, to quantitatively assess the musculoskeletal system and model it, and to review rigid-body dynamics in an interesting context.
InhaltEngineering principles are very important in the development and application of quantitative approaches in biology and medicine. This course includes a general introduction to structure and function of the musculoskeletal system: anatomy and physiology of musculoskeletal tissues and joints; biomechanical methods to assess and quantify tissues and large joint systems. These methods will also be applied to musculoskeletal failure, joint replacement and reconstruction; implants; biomaterials and tissue engineering.
SkriptLecture notes and exercises will be placed online:
Link
LiteraturOrthopaedic Biomechanics:
Mechanics and Design in Musculoskeletal Systems

Authors: Donald L. Bartel, Dwight T. Davy, Tony M. Keaveny
Publisher: Prentice Hall; Copyright: 2007
ISBN-10: 0130089095; ISBN-13: 9780130089090
Voraussetzungen / BesonderesLectures will be given in English.
376-1620-00LSkeletal Repair Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 45

Nur für Gesundheitswissenschaften und Technologie MSc und Biomedical Engineering MSc.
W3 KP3GS. Grad, D. Eglin, F. Moriarty, M. Stoddart
KurzbeschreibungThe course gives an introduction into traumatic and degenerative pathologies of skeletal tissues. Emphasis is put on bone, cartilage and intervertebral disc. Established and new treatments are described, including cell, gene and molecular therapy, biomaterials, tissue engineering and infection prevention. In vitro/in vivo models are explained.
LernzielThe objectives of this course are to acquire a basic understanding of
(1) important pathologies of skeletal tissues and their consequences for the patient and the public health
(2) current surgical approaches for skeletal repair, their advantages and drawbacks
(3) recent advances in biological strategies for skeletal repair, such as (stem) cell therapy, gene therapy, biomaterials and tissue engineering
(4) pathology, prevention and treatment of implant associated infections
(5) in vitro and in vivo models for basic, translational and pre-clinical studies
InhaltDepending on the expected background knowledge, the cellular and extracellular composition
and the structure of the skeletal tissues, including bone, cartilage, intervertebral disc, ligament
and tendon will briefly be recapitulated. The functions of the healthy tissues and the impact of
acute injury (e.g. bone fracture) or progressive degenerative failure (e.g. osteoarthritis) will be
demonstrated. Physiological self-repair mechanisms, their limitations, and current (surgical)
treatment options will be outlined. Particular emphasis will then be put on novel approaches for
biological repair or regeneration of critical bone defects, damaged hyaline cartilage of major
articulating joints, and degenerative intervertebral disc tissues. These new treatment options
include autologous cell therapies, stem cell applications, growth factors, gene therapy,
biomaterials or biopolymers; while tissue engineering is considered as a combination of some of
these factors. In vitro bioreactor systems and in vivo animal models will be described for preclinical
testing of newly developed materials and techniques. Bacterial infection as a major
complication of invasive treatment will be explained, covering also established and new methods
for its effective inhibition. Finally, the translation of new therapies for skeletal repair from the
laboratory to the clinical application will be illustrated by recent developments.
Voraussetzungen / BesonderesBasic knowledge in the cellular and molecular composition, structure and function of healthy skeletal tissues, especially bone, cartilage and intervertebral disc are required; furthermore, basic understanding of biomaterial properties, cell-surface interactions, and bacterial infection are necessary to enter this course. E.g., students should have previously attended the courses "biomedical interfaces", "biocompatible materials" and "tissue engineering".
376-1721-00LBone Biology and Consequences for Human HealthW2 KP2VJ. Goldhahn, G. A. Kuhn, P. Richards
KurzbeschreibungBone is a complex tissue that continuously adapts to mechanical and metabolic demands. Failure of this remodeling results in reduced mechanic stability ot the skeleton. This course will provide the basic knowledge to understand the biology and pathophysiology of bone necessary for engineering of bone tissue and design of implants.
LernzielAfter completing this course, students will be able to understand:
a) the biological and mechanical aspects of normal bone remodeling
b) pathological changes and their consequences for the musculoskeletal system
c) the consequences for implant design, tissue engineering and treatment interventions.
InhaltBone adapts continuously to mechanical and metabolic demands by complex remodeling processes. This course will deal with biological processes in bone tissue from cell to tissue level. This lecture will cover mechanisms of bone building (anabolic side), bone resorption (catabolic side), their coupling, and regulation mechanisms. It will also cover pathological changes and typical diseases like osteoporosis. Consequences for musculoskeletal health and their clinical relevance will be discussed. Requirements for tissue engineering as well as implant modification will be presented. Actual examples from research and development will be utilized for illustration.
376-1974-00LColloquium in Biomechanics Information W2 KP2KB. Helgason, S. J. Ferguson, R. Müller, J. G. Snedeker, W. R. Taylor
KurzbeschreibungCurrent topics in biomechanics presented by speakers from academia and industry.
LernzielGetting insight into actual areas and problems of biomechanics.
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