Suchergebnis: Katalogdaten im Herbstsemester 2016
|Biomedical Engineering Master|
| Kernfächer der Vertiefung|
Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden.
|376-1103-00L||Frontiers in Nanotechnology||W||4 KP||4V||V. Vogel, weitere Dozierende|
|Kurzbeschreibung||Many disciplines are meeting at the nanoscale, from physics, chemistry to engineering, from the life sciences to medicine. The course will prepare students to communicate more effectively across disciplinary boundaries, and will provide them with deep insights into the various frontiers.|
|Lernziel||Building upon advanced technologies to create, visualize, analyze and manipulate nano-structures, as well as to probe their nano-chemistry, nano-mechanics and other properties within manmade and living systems, many exciting discoveries are currently made. They change the way we do science and result in so many new technologies.|
The goal of the course is to give Master and Graduate students from all interested departments an overview of what nanotechnology is all about, from analytical techniques to nanosystems, from physics to biology. Students will start to appreciate the extent to which scientific communities are meeting at the nanoscale. They will learn about the specific challenges and what is currently “sizzling” in the respective fields, and learn the vocabulary that is necessary to communicate effectively across departmental boundaries.
Each lecturer will first give an overview of the state-of-the art in his/her field, and then describe the research highlights in his/her own research group. While preparing their Final Projects and discussing them in front of the class, the students will deepen their understanding of how to apply a range of new technologies to solve specific scientific problems and technical challenges. Exposure to the different frontiers will also improve their ability to conduct effective nanoscale research, recognize the broader significance of their work and to start collaborations.
|Inhalt||Starting with the fabrication and analysis of nanoparticles and nanostructured materials that enable a variety of scientific and technical applications, we will transition to discussing biological nanosystems, how they work and what bioinspired engineering principles can be derived, to finally discussing biomedical applications and potential health risk issues. Scientific aspects as well as the many of the emerging technologies will be covered that start impacting so many aspects of our lives. This includes new phenomena in physics, advanced materials, novel technologies and new methods to address major medical challenges.|
|Skript||All the enrolled students will get access to a password protected website where they can find pdf files of the lecture notes, and typically 1-2 journal articles per lecture that cover selected topics.|
|376-1714-00L||Biocompatible Materials||W||4 KP||3G||K. Maniura, J. Möller, M. Zenobi-Wong|
|Kurzbeschreibung||Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced.|
|Lernziel||The class consists of three parts: |
1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials.
2. The concept of biocompatibility.
3. Introduction into methodology used in biomaterials research and application.
|Inhalt||Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed.|
In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers.
|Skript||Handouts can be accessed online.|
Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013
Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011
(available online via ETH library)
Handouts provided during the classes and references therin.
|402-0674-00L||Physics in Medical Research: From Atoms to Cells||W||6 KP||2V + 1U||B. K. R. Müller|
|Kurzbeschreibung||Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells.|
|Lernziel||The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour.|
As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced.
The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes.
High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering.
Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body.
Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function.
3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented.
Visiting clinical research in a leading university hospital will show the usefulness of the lecture series.
|465-0953-00L||Biostatistics||W||4 KP||2V + 1U||B. Sick|
|Kurzbeschreibung||Der Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Klassifikation und Prognose, Diagnostische Tests, Bestimmung der Zuverlässigkeit von Messungen|
|551-0103-00L||Grundlagen der Biologie II: Zellbiologie||W||5 KP||5V||E. Hafen, J. Fernandes de Matos, U. Kutay, G. Schertler, U. Suter, S. Werner|
|Kurzbeschreibung||Ziel dieses Kurses ist ein breites Grundverständnis für die Zellbiologie zu vermitteln. Dieses Basiswissen wird den Studenten ermöglichen, sich in die Zellbiologie sowie in verwandte Gebiete wie Biochemie, Mikrobiologie, Pharmazie, Molekularbiologie und andere zu vertiefen.|
|Lernziel||Ziel dieses Kurses ist ein breites Grundverständnis für die Zellbiologie zu vermitteln. Dieses Basiswissen wird den Studenten ermöglichen, sich in die Zellbiologie sowie in verwandte Gebiete wie Biochemie, Mikrobiologie, Pharmazie, Molekularbiologie und andere zu vertiefen.|
|Inhalt||Das Hauptaugenmerk liegt auf der Biologie von Säugerzellen und der Entwicklung multizellulärer Organismen mit Schwerpunkt auf molekularen Mechanismen, die zellulären Strukturen und Phänomenen zugrunde liegen. Die behandelten Themen umfassen biologische Membranen, das Zytoskelett, Protein Sorting, Energiemetabolismus, Zellzyklus und Zellteilung, Viren, die extrazelluläre Matrix, Signaltransduktion, Entwicklungsbiologie und Krebsforschung.|
|Skript||Die Vorlesungsinhalte werden mithilfe von Powerpoint präsentiert. Die Präsentationen können von ETH Studenten heruntergeladen werden (Moodle). Ausgewählte Vorlesungen können auf dem ETH Netz im live Format (Livestream) angehört werden.|
|Literatur||Die Vorlesung folgt Alberts et al. `Molecular Biology of the Cell' 6th Auflage, 2014, ISBN 9780815344322 (gebunden) und ISBN 9780815345244|
|Voraussetzungen / Besonderes||Einige Vorlesungseinheiten werden in englischer Sprache gehalten. Einzelne Teile des Inhalts des Lehrbuchs müssen im Selbststudium erarbeitet werden.|
|551-1295-00L||Introduction to Bioinformatics: Concepts and Applications||W||6 KP||4G||W. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner|
|Kurzbeschreibung||Storage, handling and analysis of large datasets have become essential in biological research. The course will introduce students to a number of applications of bioinformatics in biology. Freely accessible software tools and databases will be explained and explored in theory and praxis.|
|Lernziel||Introduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks.|
In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science.
Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester.
|Inhalt||Bioinformatics I will cover the following topics:|
From genes to databases and information
Prediction of gene function and regulation
RNA structure prediction
Gene expression analysis using microarrays
Protein sequence and structure databases
WWW for bioinformatics
Protein sequence comparisons
Proteomics and de novo protein sequencing
Protein structure prediction
Cellular and protein interaction networks
Molecular dynamics simulation
|636-0003-00L||Biological Engineering and Biotechnology||W||6 KP||3V||M. Fussenegger|
|Kurzbeschreibung||Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.|
|Lernziel||1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development.|
|Skript||Handsout during the course.|
| Wahlfächer der Vertiefung|
Diese Fächer sind für die Vertiefung in Molecular Bioengineering besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser.
Findet dieses Semester nicht statt.
|W||4 KP||3G||B. Nelson|
|Kurzbeschreibung||Microrobotics is an interdisciplinary field that combines aspects of robotics, micro and nanotechnology, biomedical engineering, and materials science. The aim of this course is to expose students to the fundamentals of this emerging field. Throughout the course students are expected to submit assignments. The course concludes with an end-of-semester examination.|
|Lernziel||The objective of this course is to expose students to the fundamental aspects of the emerging field of microrobotics. This includes a focus on physical laws that predominate at the microscale, technologies for fabricating small devices, bio-inspired design, and applications of the field.|
|Inhalt||Main topics of the course include:|
- Scaling laws at micro/nano scales
- Low Reynolds number flows
- Observation tools
- Materials and fabrication methods
- Applications of biomedical microrobots
|Skript||The powerpoint slides presented in the lectures will be made available in hardcopy and as pdf files. Several readings will also be made available electronically.|
|Voraussetzungen / Besonderes||The lecture will be taught in English.|
|227-0385-10L||Biomedical Imaging||W||6 KP||5G||S. Kozerke, K. P. Prüssmann, M. Rudin|
|Kurzbeschreibung||Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques.|
|Lernziel||To understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. The mathematical framework is developed to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. Matlab exercises are used to implement and study basic concepts.|
|Inhalt||- X-ray imaging |
- Computed tomography
- Single photon emission tomography
- Positron emission tomography
- Magnetic resonance imaging
- Ultrasound/Doppler imaging
|Skript||Lecture notes and handouts|
|Literatur||Webb A, Smith N.B. Introduction to Medical Imaging: Physics, Engineering and Clinical Applications; Cambridge University Press 2011|
|Voraussetzungen / Besonderes||Analysis, Linear Algebra, Physics, Basics of Signal Theory, Basic skills in Matlab programming|
|227-0386-00L||Biomedical Engineering||W||4 KP||3G||J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong|
|Kurzbeschreibung||Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined.|
|Lernziel||Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations.|
|Inhalt||Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. |
Practical and theoretical exercises in small groups in the laboratory.
|Skript||Introduction to Biomedical Engineering|
by Enderle, Banchard, and Bronzino
|227-0393-10L||Bioelectronics and Biosensors|
New course. Not to be confounded with 227-0393-00L last offered in the Spring Semester 2015.
|W||6 KP||2V + 2U||J. Vörös, M. F. Yanik, T. Zambelli|
|Kurzbeschreibung||The course introduces the concepts of bioelectricity and biosensing. The sources and use of electrical fields and currents in the context of biological systems and problems are discussed. The fundamental challenges of measuring biological signals are introduced. The most important biosensing techniques and their physical concepts are introduced in a quantitative fashion.|
|Lernziel||During this course the students will:|
- learn the basic concepts in biosensing and bioelectronics
- be able to solve typical problems in biosensing and bioelectronics
- learn about the remaining challenges in this field
|Inhalt||L1. Bioelectronics history, its applications and overview of the field|
- Volta and Galvani dispute
- BMI, pacemaker, cochlear implant, retinal implant, limb replacement devices
- Fundamentals of biosensing
- Glucometer and ELISA
L2. Fundamentals of quantum and classical noise in measuring biological signals
L3. Biomeasurement techniques with photons
L4. Acoustics sensors
- Differential equation for quartz crystal resonance
- Acoustic sensors and their applications
L5. Engineering principles of optical probes for measuring and manipulating molecular and cellular processes
L6. Optical biosensors
- Differential equation for optical waveguides
- Optical sensors and their applications
- Plasmonic sensing
L7. Basic notions of molecular adsorption and electron transfer
- Quantum mechanics: Schrödinger equation energy levels from H atom to crystals, energy bands
- Electron transfer: Marcus theory, Gerischer theory
L8. Potentiometric sensors
- Fundamentals of the electrochemical cell at equilibrium (Nernst equation)
- Principles of operation of ion-selective electrodes
L9. Amperometric sensors and bioelectric potentials
- Fundamentals of the electrochemical cell with an applied overpotential to generate a faraday current
- Principles of operation of amperometric sensors
- Ion flow through a membrane (Fick equation, Nernst equation, Donnan equilibrium, Goldman equation)
L10. Channels, amplification, signal gating, and patch clamp Y4
L11. Action potentials and impulse propagation
L12. Functional electric stimulation and recording
- MEA and CMOS based recording
- Applying potential in liquid - simulation of fields and relevance to electric stimulation
L13. Neural networks memory and learning
|Literatur||Plonsey and Barr, Bioelectricity: A Quantitative Approach (Third edition)|
|Voraussetzungen / Besonderes||Supervised exercises solving real-world problems. Some Matlab based exercises in groups.|
|227-0965-00L||Micro and Nano-Tomography of Biological Tissues||W||4 KP||3G||M. Stampanoni, P. A. Kaestner|
|Kurzbeschreibung||Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht.|
|Lernziel||Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen.|
|Inhalt||Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind.|
Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen.
Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen.
|Literatur||Wird in der Vorlesung angegeben.|
|227-0981-00L||Cross-Disciplinary Research and Development in Medicine and Engineering |
A maximum of 12 medical degree students and 12 (biomedical) engineering degree students can be admitted, their number should be equal.
|W||4 KP||2V + 2A||V. Kurtcuoglu, D. de Julien de Zelicourt, M. Meboldt, M. Schmid Daners, O. Ullrich|
|Kurzbeschreibung||Cross-disciplinary collaboration between engineers and medical doctors is indispensable for innovation in health care. This course will bring together engineering students from ETH Zurich and medical students from the University of Zurich to experience the rewards and challenges of such interdisciplinary work in a project based learning environment.|
|Lernziel||The main goal of this course is to demonstrate the differences in communication between the fields of medicine and engineering. Since such differences become the most evident during actual collaborative work, the course is based on a current project in physiology research that combines medicine and engineering. For the engineering students, the specific aims of the course are to:|
- Acquire a working understanding of the anatomy and physiology of the investigated system;
- Identify the engineering challenges in the project and communicate them to the medical students;
- Develop and implement, together with the medical students, solution strategies for the identified challenges;
- Present the found solutions to a cross-disciplinary audience.
|Inhalt||After a general introduction to interdisciplinary communication and detailed background on the collaborative project, the engineering students will receive tailored lectures on the anatomy and physiology of the relevant system. They will then team up with medical students who have received a basic introduction to engineering methodology to collaborate on said project. In the process, they will be coached both by lecturers from ETH Zurich and the University of Zurich, receiving lectures customized to the project. The course will end with each team presenting their solution to a cross-disciplinary audience.|
|Skript||Handouts and relevant literature will be provided.|
|327-0505-00L||Surfaces, Interfaces and their Applications I||W||3 KP||2V + 1U||N. Spencer, M. P. Heuberger, L. Isa|
|Kurzbeschreibung||After being introduced to the physical/chemical principles and importance of surfaces and interfaces, the student is introduced to the most important techniques that can be used to characterize surfaces. Later, liquid interfaces are treated, followed by an introduction to the fields of tribology (friction, lubrication, and wear) and corrosion.|
|Lernziel||To gain an understanding of the physical and chemical principles, as well as the tools and applications of surface science, and to be able to choose appropriate surface-analytical approaches for solving problems.|
|Inhalt||Introduction to Surface Science |
Physical Structure of Surfaces
Surface Forces (static and dynamic)
Adsorbates on Surfaces
Surface Thermodynamics and Kinetics
The Solid-Liquid Interface
Vibrational Spectroscopy on Surfaces
Scanning Probe Microscopy
Introduction to Tribology
Introduction to Corrosion Science
|Literatur||Script (20 CHF)|
Book: "Surface Analysis--The Principal Techniques", Ed. J.C. Vickerman, Wiley, ISBN 0-471-97292
|Voraussetzungen / Besonderes||Chemistry:|
General undergraduate chemistry
including basic chemical kinetics and thermodynamics
General undergraduate physics
including basic theory of diffraction and basic knowledge of crystal structures
|327-1101-00L||Biomineralization||W||2 KP||2G||K.‑H. Ernst|
|Kurzbeschreibung||The course addresses undergraduate and graduate students interested in getting introduced into the basic concepts of biomineralization.|
|Lernziel||The course aims to introduce the basic concepts of biomineralization and the underlying principles, such as supersaturation, nucleation and growth of minerals, the interaction of biomolecules with mineral surfaces, and cell biology of inorganic materials creation. An important part of this class is the independent study and the presentation of original literature from the field.|
|Inhalt||Biomineralization is a multidisciplinary field. Topics dealing with biology, molecular and cell biology, solid state physics, mineralogy, crystallography, organic and physical chemistry, biochemistry, dentistry, oceanography, geology, etc. are addressed. The course covers definition and general concepts of biomineralization (BM)/ types of biominerals and their function / crystal nucleation and growth / biological induction of BM / control of crystal morphology, habit, shape and orientation by organisms / strategies of compartmentalization / the interface between biomolecules (peptides, polysaccharides) and the mineral phase / modern experimental methods for studying BM phenomena / inter-, intra, extra- and epicellular BM / organic templates and matrices for BM / structure of bone, teeth (vertebrates and invertebrates) and mollusk shells / calcification / silification in diatoms, radiolaria and plants / calcium and iron storage / impact of BM on lithosphere and atmosphere/ evolution / taxonomy of organisms.|
1. Introduction and overview
2. Biominerals and their functions
3. Chemical control of biomineralization
4. Control of morphology: Organic templates and additives
5. Modern methods of investigation of BM
6. BM in matrices: bone and nacre
7. Vertebrate teeth
8. Invertebrate teeth
9. BM within vesicles: calcite of coccoliths
11. Iron storage and mineralization
|Skript||Script with more than 600 pages with many illustrations will be distributed free of charge.|
|Literatur||1) S. Mann, Biomineralization, Oxford University Press, 2001, Oxford, New York|
2) H. Lowenstam, S. Weiner, On Biomineralization, Oxford University Press, 1989, Oxford
3) P. M. Dove, J. J. DeYoreo, S. Weiner (Eds.) Biomineralization, Reviews in Mineralogoy & Geochemistry Vol. 54, 2003
|Voraussetzungen / Besonderes||Each attendee is required to present a publication from the field. The selection of key papers is provided by the lecturer.|
No special requirements are needed for attending. Basic knowledge in chemistry and cell biology is expected.
|376-1622-00L||Practical Methods in Tissue Engineering |
Number of participants limited to 12.
|W||5 KP||4P||K. Würtz-Kozak, M. Zenobi-Wong|
|Kurzbeschreibung||The goal of this course is to teach MSc students the necessary skills for doing research in the fields of tissue engineering and regenerative medicine.|
|Lernziel||Practical exercises and demonstrations on topics including sterile cell culture, light microscopy and histology, protein and gene expression analysis, and viability assays are covered. The advantages of 3D cell cultures will be discussed and practical work on manufacturing and evaluating hydrogels and scaffolds for tissue engineering will be performed in small groups. In addition to practical lab work, the course will teach skills in data acquisition/analysis.|
|402-0341-00L||Medical Physics I||W||6 KP||2V + 1U||P. Manser|
|Kurzbeschreibung||Introduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations.|
|Lernziel||Understanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society.|
|Inhalt||The lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications.|
|Skript||A script will be provided.|
|535-0423-00L||Drug Delivery and Drug Targeting||W||2 KP||2V||J.‑C. Leroux, D. Brambilla|
|Kurzbeschreibung||Die Studierenden erwerben einen Überblick über derzeit aktuelle Prinzipien, Methoden und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Damit sind die Studierenden in der Lage, das Gebiet gemäss wissenschaftlichen Kriterien zu verstehen und zu beurteilen.|
|Lernziel||Die Studierenden verfügen über einen Überblick über derzeit aktuelle Prinzipien und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Im Vordergrund der Lehrveranstaltung steht die Entwicklung von Fähigkeiten zum Verständnis der betreffenden Technologien und Methoden, ebenso wie der Möglichkeiten und Grenzen ihres therapeutischen Einsatzes. Im Zentrum stehen therapeutische Peptide, Proteine, Nukleinsäuren und Impfstoffe.|
|Inhalt||Der Kurs behandelt folgende Themen: Arzneistoff-targeting und Freigabeprinzipien, Radiopharmaka, makromolekulare Arzneistofftransporter, Liposomen, Mizellen, Mikro/Nanopartikel, Gele und Implantate, Anwendung von Impfstoffen, Abgabe von Wirkstoffen im Rahmen von Tissue engineering, Abgabe im Gastrointestinaltrakt, synthetische Transporter für Arzneistoffe auf Nukleinsäurebasis, ophthalmische Vehikel und neue Trends in transdermaler und nasaler Arzneistofffreigabe.|
|Skript||Ausgewählte Skripten, Vorlesungsunterlagen und unterstützendes Material werden entweder direkt an der Vorlesung ausgegeben oder sind über das Web zugänglich:|
Diese Website enthält auch zusätzliche Unterlagen zu peroralen Abgabesystemen, zur gastrointestinalen Passage von Arzneiformen, transdermalen Systemen und über Abgabesysteme für alternative Absorptionswege. Diese Stoffgebiete werden speziell in der Vorlesung Galenische Pharmazie II behandelt.
|Literatur||Y. Perrie, T. Rhades. Pharmaceutics - Drug Delivery and Targeting, second edition, Pharmaceutical Press, London and Chicago, 2012.|
Weitere Literatur in der Vorlesung.
|636-0507-00L||Synthetic Biology II||W||4 KP||4A||S. Panke, Y. Benenson, J. Stelling|
|Kurzbeschreibung||7 months biological design project, during which the students are required to give presentations on advanced topics in synthetic biology (specifically genetic circuit design) and then select their own biological system to design. The system is subsequently modeled, analyzed, and experimentally implemented. Results are presented at an international student competition at the MIT (Cambridge).|
|Lernziel||The students are supposed to acquire a deep understanding of the process of biological design including model representation of a biological system, its thorough analysis, and the subsequent experimental implementation of the system and the related problems.|
|Inhalt||Presentations on advanced synthetic biology topics (eg genetic circuit design, adaptation of systems dynamics, analytical concepts, large scale de novo DNA synthesis), project selection, modeling of selected biological system, design space exploration, sensitivity analysis, conversion into DNA sequence, (DNA synthesis external,) implementation and analysis of design, summary of results in form of scientific presentation and poster, presentation of results at the iGEM international student competition (www.igem.org).|
|Skript||Handouts during course|
|Voraussetzungen / Besonderes||The final presentation of the project is typically at the MIT (Cambridge, US). Other competing schools include regularly Imperial College, Cambridge University, Harvard University, UC Berkeley, Princeton Universtiy, CalTech, etc.|
This project takes place between end of Spring Semester and beginning of Autumn Semester. Registration in April.
Please note that the number of ECTS credits and the actual work load are disconnected.
| Weitere Wahlfächer|
Diese Fächer können für die Vertiefung in Molecular Bioengineering geeignet sein. Bitte konsultieren Sie Ihren Track Adviser.
|551-0313-00L||Microbiology (Part I)||W||3 KP||2V||W.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, M. Pilhofer|
|Kurzbeschreibung||Advanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.|
|Lernziel||This concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.|
|Inhalt||Advanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.|
|Skript||Updated handouts will be provided during the class.|
|Literatur||Current literature references will be provided during the lectures.|
|Voraussetzungen / Besonderes||English|
The lecture "Grundlagen der Biologie II: Mikrobiologie" is the basis for this advanced lecture.
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