Search result: Catalogue data in Spring Semester 2019

Pharmaceutical Sciences Bachelor Information
First Year
First Year Examinations
NumberTitleTypeECTSHoursLecturers
535-0002-00LIntroduction to Pharmaceutical Sciences IIO3 credits2VC. Halin Winter, K.‑H. Altmann, S. M. Ametamey, J. Hall, S.‑D. Krämer, J.‑C. Leroux, D. Neri, U. Quitterer, R. Schibli, C. Steuer
AbstractFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ObjectiveFirst identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities.
ContentIntroduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences, which is focused on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields.
Lecture notesHandouts for individual lectures.
Prerequisites / NoticeInteractive teaching
401-0292-00LMathematics II Information O5 credits3V + 2UE. W. Farkas
AbstractMathematics I/II is an introduction to one- and multidimensional calculus
and linear algebra emphasizing on applications.
ObjectiveStudents understand mathematics as a language for modelling and as a tool for
solving practical problems in natural sciences.
Students can analyze models, describe solutions qualitatively or calculate
them explicitly if need be. They can solve examples as well as their practical
applications manually and using computer algebra systems.
Content## Komplexe Zahlen ##
- Kartesische und Polar-Darstellung
- Rechnen mit komplexen Zahlen
- Lösungen algebraischer Gleichungen

## Lineare Algebra - Fortsetzung ##
- Komplexe Vektoren und Matrizen
- Weitere Arithmetische Aspekte
- LGS und Gauss-Verfahren

## Lineare DGL 2. Ordnung und Systeme 1. Ordnung ##
- Lösen mit Eigenwerten/-vektoren.
- Qualitative Lösungsverhalten
- Ebene und Räumliche (Lösungs-)Kurven

## Integral- und Differentialrechnung (II) ##
- Hauptsatz der Differential/Integralrechnung
- Uneigentliche Integrale
- Anwendungen
- Gebiets- und Volumenintegral
- - - - - - - - - - - - - - - - - - - - -
- Partielle Funktionen und Ableitungen
- Extrema
- Tangentialebene
- Verallgemeinerte Kettenregel

## Vektoranalysis ##
- Potentialtheorie
- Formel von Green
- Rotation und Divergenz
- Oberflächenintegral, Fluss
- Integralsätze von Gauss und Stokes.

## Potenzreihen ##
- Reihen
- Taylor-Reihe
- Potenzreihen und Anwendungen
Lecture notesIn Ergänzung zu den Vorlesungskapiteln der Lehrveranstaltungen fassen wir
wichtige Sachverhalte, Formeln und weitere Ausführungen jeweils in einem
Vademecum zusammen.

Dabei gilt:

* Die Skripte ersetzen nicht die Vorlesung und/oder die Übungen!
* Ohne den Besuch der Lehrveranstaltungen verlieren die Ausführungen
ihren Mehrwert.
* Details entwickeln wir in den Vorlesungen und den Übungen, um die hier
bestehenden Lücken zu schliessen.
* Prüfungsrelevant ist, was wir in der Vorlesung und in den Übungen behandeln.
LiteratureSiehe auch Lernmaterial > Literatur

**Th. Wihler**
Mathematik für Naturwissenschaften, 2 Bände:
Einführung in die Analysis, Einführung in die Lineare Algebra;
Haupt-Verlag Bern, UTB.

**H. H. Storrer**
Einführung in die mathematische Behandlung der Naturwissenschaften I; Birkhäuser.
Via ETHZ-Bibliothek:
<Link>

**Ch. Blatter**
Lineare Algebra; VDF
auch als [pdf]<Link>
Prerequisites / Notice## Voraussetzungen ##
Mathematik I <Link>

## Übungen und Prüfungen ##
+ Die Übungsaufgaben (inkl. Multiple-Choice) sind ein wichtiger Bestandteil
der Lehrveranstaltung.
+ Es wird erwartet, dass Sie mindestens 75 % der wöchentlichen Serien bearbeiten
und zur Korrektur einreichen.
+ Der Prüfungsstoff ist eine Auswahl von Themen aus Vorlesung und Übungen. Für
eine erfolgreiche Prüfung ist die konzentrierte Bearbeitung der Aufgaben
unerlässlich.

## Einschreibung in die Übungen ##
Die Einschreibung in die Übungsgruppen erfolgt online.

## Zugang Übungsserien ##
Erfolgt auch online.
529-1012-00LOrganic Chemistry II (for Students of Biology, Pharmaceutical Sci., and Health Sci. & Tech.)O5 credits5GC. Thilgen
AbstractThe relationship between structure and reactivity of organic molecules is elaborated by studying the mechanisms of the fundamental types of organic reactions. A basic synthesis repertoire is acquired.
ObjectiveUnderstanding the mechanisms of the fundamental types of organic reactions. Particular emphasis is placed on the relationship between structure and reactivity. A basic repertoire for the synthesis of small organic molecules is acquired. Weekly problem solving lessons provide a deeper understanding of the concepts presented during the lecture.
ContentThe basic reactions of organic chemistry and their mechanisms. Chemistry of the most important functional groups, the carbonyl group in particular.

For details, see German version.
Lecture notesPrinted or electronic lecture notes are available. Problem sets, answer keys, and other course materials can be downloaded from the Moodle course "Organic Chemistry II" of the current semester (Link).
LiteratureNo set textbooks. Optional texts will be proposed at the beginning of the class and in the lecture notes (cf. course 529-1011-00L Organic Chemistry I).
Prerequisites / NoticeAttendance of the course 529-1011-00, "Organic Chemistry I for Biology/Pharmaceutical Sciences/HST".
551-0106-00LFundamentals of Biology IBO5 credits5GA. Wutz, S. P. Hart, O. Y. Martin, E. B. Truernit, S. Wielgoss, S. C. Zeeman
AbstractThis course is an introduction into the basic principles of evolution, diversity, animal/plant form and function, and ecology.
ObjectiveIntroduction into aspects of modern biology and fundamental biological concepts.
ContentThe course is divided into distinct chapters
1. Mechanisms of evolution.
2. The evolutionary history of biological diversity (bacteria and archea, protists, plants and animals).
3. Plant form and function (growth and development, nutrient and resource acquisition, reproduction and environmental responses).
4. Animal form and function (nutrition, immune system, hormones, reproduction, nervous system and behaviour).
5. Ecology (population ecology, community ecology, ecosystems and conservation ecology).
Lecture notesNo script
LiteratureThis course is based on the textbook 'Biology' (Campbell, Reece, 9th edition). The structure of the course follows that of the book. It is recommended to purchase the English version.
Prerequisites / NoticePart of the contents of the book need to be learned through independent study.
402-0072-00LPhysicsO5 credits5V + 2UT. M. Ihn
AbstractIntroduction to the concepts and tools in physics with the help of demonstration experiments: mechanics, statistical mechanics, electromagnetism and optics.
ObjectiveThe concepts and tools in physics, as well as the methods of an experimental science are taught. The student should learn to identify, communicate and solve physical problems in his/her own field of science.
Content1. Fundamental concepts of natural sciences

I. MECHANICS
2. Motion in one dimension
3. Motion in two and three dimensions
4. Newton's laws
5. Applications of Newton's laws
6. Forces
7. Work and energy, power, energy conservation
8. Momentum conservation, collisions
9. Angular momentum conservation

II. STATISTICAL MECHANICS
10. Concentration and density
11. Pressure and work
12. Entropy, Second Law of Thermodynamics
13. Temperature and heat
14. First Law of Thermodynamics
15. The Boltzmann-Factor

III. ELECTROMAGNETISM
16. Geometrical optics
17. Light as an electromagnetic wave
18. Quantum aspects of light
Lecture notesT. Ihn: Physics for Students in Biology and Pharmazeutical Sciences (unpublished lecture notes)
LiteratureThe lecture contains elements of:

Paul A. Tipler and Gene P. Mosca, "Physik für Wissenschaftler und Ingenieure", Springer Spektrum.

Feynman, Leighton, Sands, "The Feynman Lectures on Physics", Volume I (Link)

Ruth Chabay and Bruce Sherwood, "Matter and Interactions" (Wiley)
Prerequisites / NoticePrerequisites: Mathematics I
401-0643-00LStatistics I Information O3 credits2V + 1UM. Kalisch
AbstractIntroduction to basic methods and fundamental concepts of statistics and probability theory for non-mathematicians. The concepts are presented on the basis of some descriptive examples.
ObjectiveGrundverständnis für die Gesetze des Zufalls und des Denkens in Wahrscheinlichkeiten. Kenntnis von Methoden zur Darstellung von Daten und zu ihrer quantitativen Interpretation unter Berücksichtigung der statistischen Unsicherheit.
ContentModelle und Statistik für Zähldaten: Diskrete Wahrscheinlichkeitsmodelle, Binomial-Verteilung, Tests und Vertrauensintervalle für eine Wahrscheinlichkeit, Poisson-Verteilung und deren Statistik, weitere Verteilungen.
Modelle und Statistik für Messdaten: Beschreibende Statistik, Zufallsvariablen mit Dichten, t-Test und Wilcoxon-Test und zugehörige Vertrauensintervalle.
Regression: Das Modell der linearen Regression, Tests und Vertrauensintervalle, Residuenanalyse.
Lecture notesEs steht ein kurzes Skript zur Verfügung.
Literature- W. A. Stahel, Statistische Datenanalyse: Eine Einführung für Naturwissenschaftler, 5. Aufl., Vieweg, Braunschweig/Wiesbaden, 2007
Prerequisites / NoticeVoraussetzungen: Grundlegende Mathematik-Kenntnisse wie sie im ersten Semester erworben werden.
Additional First Year Courses
NumberTitleTypeECTSHoursLecturers
551-0102-01LFundamentals of Biology I Information Restricted registration - show details
Registrations via myStudies until 30.1.2019 at the latest. Subsequent registrations will not be considered.
O6 credits8PM. Gstaiger, T. A. Beyer, M. Kopf, R. Kroschewski, M. Künzler, D. Ramseier, M. Stoffel, E. B. Truernit, A. Wutz
AbstractThis 1st year Laboratory course introduces the student to the entire range of classical and modern molecular biosciences. During this course (Praktikum GL BioI) the students will do three praktikum days in:
- Biochemistry
- Cell Biology I
- Microbiology
- Plant Anantomy & Ecology
(total of 12 experiments)

Each experiment takes one full day.
ObjectiveIntroduction to theoretical and experimental biology

General Praktikum-information and course material can be obtained from Moodle

The general Praktikum information (Assignment list, Instructions and Schedule & Performance Sheet) will also be sent to the students directly (E-mail).
ContentThe class is divided into four blocks: Biochemistry, Microbiology, Plant biology & Ecology and Cell Biology I.

BIOCHEMISTRY:
- TAQ Analysis (part 1): Protein purification
- TAQ Analysis (part 2): SDS-Gelelektrophoresis
- TAQ Analysis (part 3): Activity test of the purified protein

MICROBIOLOGY:
Day 1: Basics for the work with microorganisms & Isolation of microorganisms from the environment
Day 2: Morphology and diagnostics of bacteria & Antimicrobial agents
Day 3: Morphology of fungi & Microbial physiology and interactions

PLANT BIOLOGY & ECOLOGY
- Microscopy and plant cell anatomy
- Plant organ anatomy and gene expression
- Ecology

CELL BIOLOGY I:
- Anatomy of mouse & Blood cell determination
- Histology
- Chromosome preparation and analysis
Lecture notesLaboratory manuals

BIOCHEMISTRY:
- The protocols can be downloaded from: Moodle

MICROBIOLOGY:
- The protocols can be found from: Moodle
- You HAVE TO print the pdf-file, which is also used as the lab manual during the experiments. Therefore, you have to have the Script always with you, when doing the experiments in Microbiology.

PLANT BIOLOGY & ECOLOGY:
- The protocols can be found from: Moodle

CELL BIOLOGY I:
- The handouts of the experiments entitled "Histology" will be provided
- The protocols of "Anatomy of mouse & Blood cell determination" and "Chromosome preparation and analysis" can be found from: Moodle
LiteratureNone
Prerequisites / NoticePLEASE NOTE THE FOLLOWING RULES

Your attendance is obligatory and you have to attend all 12 Praktikum days of GL BioI. Absences are only acceptable if you are able to provide a Doctor’s certificate. The original Dr's certificate has to be given to Dr. M. Gstaiger (HPM F43) within five days of the absence of the Praktikum day.

If there will be any exceptional or important situations then you should directly contact the Director of Studies of D-Biol, who will decide if you are allowed to miss a Praktikum day or not.

HIGHLY IMPORTANT!!

1. Due to the increased number of students, the official Praktikum registration has to be done, using myStudies, preferably at the end of HS18 but not later than Wednesday January 30, 2019.

2. Later registration is NOT possible and can NOT be accepted!

3. The course registration for FS2019 is usually possible at the end of Autumn semester 2018 and you will obtain an E-mail from the Rectorate when the course registration using myStudies is possible.

Students can register for a practice group via myStudies. As soon as the course unit is registered in myStudies, a text box appears indicating that a group can be selected. Accordingly, students can select a group in the next step. If more than 240 students register, the surplus students will be placed on a waiting list and then allocated by the course responsible.

Extra Praktikum days have to be organized if more than 220 - 240 students will attend the Praktikum. The group division is random and the reserved Extra Praktikum days are:

3.6 / 4.6 / 6.6

The Praktikum GL BioI will take place during the following days and therefore, you have to make sure already now that you will not have any other activities / commitments during these days:

PRAKTIKUM DAYS FS18 (Thursdays):

21.2 / 28.2 / 7.3 / 14.3 / 21.3 / 28.3 / 4.4 / 11.4 / 2.5 / 9.5 / 16.5 / 23.5

No Praktikum during the Easter vacation: 19.4.-26.4. 2019

EXTRA PRAKTIKUM DAYS (if necessary)

3.6 / 4.6 / 6.6
Second Year
Second Year Core Subjects
NumberTitleTypeECTSHoursLecturers
529-1024-00LPhysical Chemistry II (for Biology and Pharmacy) Information O4 credits2V + 1UR. Riek
AbstractKinetics of chemical and biochemical reactions, in particular catalyzed reactions. Surface- and transport-phenomena, characterization of open systems.
ObjectiveKnowledge on the basics of time dependent process in chemical and biological systems.
ContentGrundbegriffe: Stofftransport, Transport in kontinuierlichen Systemen, Wärmeleitung, Viskosität von Gasen, Laminare Strömung durch Rohre, Ionenleitfähigkeit, Elektrisch geladene Grenzflächen, Elektrophorese, Sedimentation im Zentrifugalfeld, Eigenschaften der Plasmamembran, Transport durch Membranen, Membranpotentiale Reaktionsgeschwindigkeitsgesetze, Elementarreaktionen und zusammengesetzte Reaktionen, Molekularität, Reaktionsordnung, Experimentelle Methoden der Reaktionskinetik. Einfache Theorie chemischer Reaktionen: Temperaturabhängigkeit der Gleichgewichtskonstante und Arrheniusgleichung, Stosstheorie, Reaktionsquerschnitte, Theorie des Übergangszustandes. Zusammengesetzte Reaktionen: Reaktionsmechanismen und komplexe kinetische Systeme, Näherungsverfahren. Enzymkinetik. Kinetik geladener Teilchen. Diffusion und diffusionskontrollierte Reaktionen.
Lecture notesHandouts werden in der Vorlesung verteilt
LiteratureAdam, G., Läuger, P., Stark, G., 2003: Physikalische Chemie und Biophysik, 4. Aufl., Springer Verlag, Berlin.
Prerequisites / NoticeVoraussetzungen: Physikalische Chemie I
551-0108-00LFundamentals of Biology II: Plant BiologyO2 credits2VO. Voinnet, W. Gruissem, S. C. Zeeman
AbstractWater balance, assimilation, transport in plants; developmental biology, stress physiology.
ObjectiveWater balance, assimilation, transport in plants; developmental biology, stress physiology.
Lecture notesPlant Biology: Handouts of the powerpoint presentation will be distributed. It can also be viewed in a password-protected web link.
LiteratureSmith, A.M., et al.: Plant Biology, Garland Science, New York, Oxford, 2010
551-0110-00LFundamentals of Biology II: MicrobiologyO2 credits2VJ. Vorholt-Zambelli, W.‑D. Hardt, J. Piel
AbstractBacterial cell biology, molecular genetics, gene regulation, growth physiology, metabolism (Bacteria and Archaea), natural products, microbial interactions
ObjectiveBasic principles of cell structure, growth physiology, energy metabolism, gene expression and regulation. Biodiversity of Bacteria and Archaea. Phylogeny and evolution.
ContentBacterial cell biology, molecular genetics, gene regulation, growth physiology, metabolism (Bacteria and Archaea), natural products, microbial interactions
LiteratureBrock, Biology of Microorganisms (Madigan, M.T. and Martinko, J.M., eds.), 14th ed., Pearson Prentice Hall, 2015
701-0360-00LSystematic Biology: Plants Restricted registration - show details O5 credits2V + 3PA. Leuchtmann
AbstractThe lecture provides an overview of the diversity of ferns and seed-plants. The fundamentals of systematics are given considering morphological, phylogenetic and ecological aspects. Regarding plant species, emphasis is laid on the flora of Switzerland, but also examples of pharmaceutical relevance and crop plants will be included.
ObjectiveStudents know:
- the fundamentals of plant systematics
- the higher-level plant groups based on morphological and biological characteristics
- selected families of flowering plants
- selected species and their ecology, with special focus on the flora of Switzerland
- examples of medicinal and crop plants
- ecological factors of sites and the most important vegetation types of the lowlands.
ContentDie Vorlesung gibt einen Überblick über Moose, Farne, Gymnospermen und Angiospermen. Ausgewählte Familien der Angiospermen werden ausführlich behandelt. Weitere Themen sind Grundlagen der Pflanzensystematik, Generationswechsel, phylogenetische Stammbäume, morphologische Begriffe, sowie Lebensweise und Ökologie der Pflanzen. Anhand ausgewählter Beispiele wird auf die Bedeutung der Pflanzen als Arznei-, Zeiger- und Nutzpflanzen eingegangen. Zudem wird eine Übersicht über Standorteigenschaften und Vegetation des Tieflandes in der Schweiz gegeben.

Im praktischen Teil lernen die Studierenden Merkmale von Blütenpflanzen zu analysieren und üben das Bestimmen von Pflanzenarten. Auf Exkursionen werden Artkenntnisse vermittelt und ein Einblick gegeben in Flora und Vegetation ausgewählter Standorte im Schweizer Mittelland, wobei auch einheimische Arzneipflanzen berücksichtigt werden.
LiteratureBaltisberger et al., Systematische Botanik. Einheimische Farn- und Samenpflanzen. vdf Hochschulverlag AG an der ETH Zürich (4. Aufl. 2013)
Hess et al., Bestimmunsschlüssel zur Flora der Schweiz. Springer, Basel (7. Aufl. 2015)

Baltisberger, Conradin, Frey & Rudow, 2016: eBot6. Internetapplikation.
Für Studierende frei zugänglich unter Link.
Prerequisites / NoticeFür Studierende der Pharmazeutischen Wissenschaften Bsc obligatorisch, für Studierende Biologie Bsc und Umweltnaturwissenschaften Bsc mit Vertiefungen in Ökologie und Evolution (Biologie), Wald und Landschaft oder Umweltbiologie besonders empfohlen.
535-0224-00LPharmaceutical Analytics IIO3 credits3GC. Steuer
AbstractThis course provides the basic concepts of pharmaceutical analytics in the context of pharmacopeial regulation by Ph. Eur and Ph. helv.
ObjectiveSummarize the structure of the Ph. Eur.
Summarize the most important pharmacopeias and their commonalities and differences (USP, JP, Ph.Eur., Ph. Helv.)
Discuss the structure of a monograph
Explain qualification of instruments and validation of methods
Explain and compare most important analytical techniques for pharmacies and pharmaceutical industry
ContentKnowledge in pharmaceutical analytics to fulfill regulatory equirements in pharmaceutical industry based on the pharmacopeia in force. Focus is set on method validation, equipment qualification, identification, purity testing and content determination of active pharmaceutical ingredients and excipients.
Lecture notesThe slides of the lectures will be provided
LiteratureInstrumentelle Analytik, G. Rücker, M. Neugebauer, G.G. Willems; Deutscher Apotheker Verlag, Stuttgart
Arzneistoffanalyse; H. J. Roth, K. Eger, R. Troschütz; Deutscher Apotheker Verlag, Stuttgart
Introduction to Pharmaceutical Chemical Analysis; S.H. Hansen, S. Pedersen-Bjergaard, K. Rasmussen; Wiley & Sons
Prerequisites / NoticeRequirements for the practical course Pharmaceutical Analytics:
SR 2004: 2 credits Analytical Chemistry (529-1041-00), lecture Pharmaceutical Analytics
SR 2013: 6 credits Analytics/Pharmaceutical Analytics or 36 credits of compulsory lectures 2nd year
376-0152-00LAnatomy and Physiology II Information O5 credits4VM. Ristow, K. De Bock, M. Kopf, L. Slomianka, C. Spengler
AbstractBasic knowledge of the anatomy and physiology of the gastrointestinal tract, endocrine organs, urinary system and the reproductive system. Knowlewdge of the basic mechanisms of pathobiology. Study of all human tissues and selected organs by examining slides under the light microscope.
ObjectiveFoundations of human anatomy and physiology and basics of clinical pathophysiology
ContentShort overview of human anatomy, physiology and general pathology.
3rd semester:
Principles of histology and embryology. Anatomy and physiology: nervous system, muscle, sensory organs, circulatory system, respiratory system.
4rd semester:
Anatomy and physiology: gastrointestinal tract, endocrine system, metabolism and thermoregulation, integumentary system, blood and immune system, urinary system, circadian rhythm, reproductive system, pregnancy and birth.
LiteratureAnatomie: Martini, Timmons, Tallitsch, "Anatomie", Pearson; oder Schiebler, Korf, "Anatomie", Steinkopff / Springer; oder Spornitz, "Anatomie und Physiologie, Lehrbuch und Atlas für Pflege-und Gesundheitsfachberufe", Springer

Physiologie: Thews/Mutschler/Vaupel: Anatomie, Physiologie, Pathophysiologie des Menschen,
Wissenschaftliche Verlagsgesellschaft, Stuttgart

oder

Schmidt/Lang/Thews: Physiologie des Menschen, Springer-Verlag, Heidelberg
Prerequisites / NoticeDer Besuch der Anatomie und Physiologie I - Vorlesung ist Voraussetzung, da die Anatomie und Physiologie II - Vorlesung auf dem Wissen der im vorangegangenen Semester gelesenen Anatomie und Physiologie I - Vorlesung aufbaut.
376-0153-00LHistology Information O2 credits2GD. P. Wolfer, I. Amrein, L. Slomianka
AbstractPractical at the light microscope based on the lectures "Anatomie" 1+2 with an introduction in histological techniques. In the first part participants study examples of epithelia, connective and supporting tissues, muscle and nervous tissue. The second part is devoted to the microscopic anatomy of selected organs.
ObjectiveBy working with the microscope, participants gain a deeper understating of the lecture topics, in particular in microscopic anatomy. They acquire the ability to examine tissue sections with the microscope, to recognize organ-typical structures and to identify the organ of origin.
LiteratureSuggested reading
Lüllmann-Rauch R, Asan E: Taschenlehrbuch Histologie
Kühnel W: Taschenatlas Histologie
Prerequisites / NoticeBased on:
376-0151-00 "Anatomie und Physiologie" I
376-0150-00 "Anatomie und Physiologie" II
Laboratory Courses 2nd Year
NumberTitleTypeECTSHoursLecturers
551-0104-00LFundamentals of Biology II Information Restricted registration - show details
Registrations via myStudies until 30.1.2019 at the latest. Subsequent registrations will not be considered.
O8 credits8PM. Gstaiger, E. Dultz, C. H. Giese, W. Kovacs, D. Santelia, H. Stocker, U. Suter, S. Werner
AbstractThis introductory Laboratory course introduces the student to the entire range of classical and modern molecular biosciences. In the second year (Praktikum GL Bio II) the students will perform three praktikum days in:
- Molecular Biology
- Plant Physiology
- Genetics and
- Cell Biology II.

(total of 12 experiments)

Each experiment takes one full day.
ObjectiveIntroduction to theoretical and experimental biology
Moodle www-link for general Praktikum-information and course material: Moodle

The general Praktikum information (Assignment list, Instructions and Schedule & Performance Sheet) will also be sent to the students directly (E-mail).
ContentThe class is divided into four blocks: Cell Biology II, Genetics, Molecular Biology and Plant Physiology. One block lasts three weeks.

CELL BIOLOGY II:
- Cells: Cell types & staining methods, cell fusion & cell motility,
- Tissue and development: histology of mice embryos & embryogenesis
- Repair mechanisms: DNA repair & wound healing,

GENETICS:
- Yeast genetics
- Drosophila genetics
- Human genetics

MOLECULAR BIOLOGY
- Molecular biology & protein crystallization
- Enzyme kinetics
- Redox potential & stability of a protein

PLANT PHYSIOLOGY:
- Plants and light
- Phytohormones and other growth factors
- Molecular biology of systemic gene silencing
- Literature and presentations

The students will also prepare short presentations (approx. 10 min) of the various topics within this course.
Lecture notesLaboratory manuals

CELL BIOLOGY II
- The protocols can be downloaded from: Moodle

MOLECULAR BIOLOGY:
- The protocols can be found from: Moodle

PLANT PHYSIOLOGY
- The protocols can be found from: Moodle

GENETICS
- The protocols can be found from: Moodle
Prerequisites / NoticeTHE PRAKTIKUM RULES:

Your attendance is obligatory and you have to attend all 12 Praktikum days. Absences are only acceptable if you are able to provide a Doctor’s certificate. The original Dr's certificate has to be given to Dr. M. Gstaiger (HPM F43) within five days of the absence of the Praktikum day.

If there will be any exceptional or important situations then you should directly contact the Director of Studies of D-Biol, who will decide if you are allowed to miss a Praktikum day or not.

HIGHLY IMPORTANT!!

1. Due to the increased number of students, the official Praktikum registration has to be done, using myStudies, preferably at the end of HS18 but not later than Wednesday January 30, 2019.

2. Later registration is NOT possible and can NOT be accepted!

3. The course registration for FS19 is usually possible at the end of HS18 and you will obtain an E-mail from the Rectorate when the course registration using myStudies is possible.

Students can register for a practice group via myStudies. As soon as the course unit is registered in myStudies, a text box appears indicating that a group can be selected. Accordingly, students can select a group in the next step. If more than 180 students register, the surplus students will be placed on a waiting list and then allocated by the course responsible.


The Praktikum GL BioII FS19 will take place during the following days and therefore, you have to make sure already now that you do not have any other activities & commitments during these days:

PRAKTIKUM DAYS DURING FS19 (Fridays):

22.2 / 1.3 / 8.3 / 15.3 / 22.3 / 29.3 / 5.4 / 12.4 / 3.5 / 10.5 / 17.5 / 24.5

No Praktikum during the Easter break: 19.4.-26.4. 2019
529-0430-00LPractical Course Physical Chemistry (for Biol./Pharm.Sci.)O3 credits4PE. C. Meister
AbstractPractical introduction to important basic experimental methods in physical chemistry. Investigation of qualitative and quantitative relations between physico-chemical quantities of the systems under study.
ObjectiveThe students have to carry out selected experiments in physical chemistry using important measurement methods and devices.
The measured data have to be processed, mostly with the aid of computers, and considering error propagation and statistics.
Detailed laboratory reports have to be written to each experiment.
ContentBasic physical chemistry experiments covering chemical thermodynamics and kinetics, electrochemistry, viscosity and optical spectroscopy.
Computer simulation of physical-chemical phenomena.
Lecture notesErich Meister, Grundpraktikum Physikalische Chemie: Theorie und Experimente, 2. Auflage, vdf Hochschul-Verlag an der ETH, Zürich, 2012.
Supplementary material to experiments is available.
376-1156-00LPhysiologyO1 credit1PC. Spengler
AbstractExperiments to evaluate nerve, muscle, heart, circulation, respiration, and sensory organ function in humans.
ObjectivePractical experience of physiology. Learning of fundamental assessments of physiological functions in humans and of correct interpretations of measurement data.
ContentDetermination of nerve conduction time, recording of electromyogram (EMG; single stimuli and summatin) and mechanogram; measurement of lung function and oxygen consumption; assessment of cardiovascular adjustments in response to orthostatic challenges and exercise; computer simulation of the cardiovascular system under different conditions; determination of hearing threshold level, visual acuity, accommodation and field of vision.
Lecture notesScriptum of the Laboratory Experiments in Physiology on Moodle
LiteratureSchmidt/Lang/Heckmann: Physiologie des Menschen, Springer-Verlag, Heidelberg
Prerequisites / NoticeAnatomy + Physiology I / Physiology I
Third Year
Third Year Core Subjects
NumberTitleTypeECTSHoursLecturers
535-0135-00LClinical Chemistry IO1 credit1VM. Hersberger
AbstractIntroduction into the fundamentals of laboratory diagnostics and an overview on the laboratory parameters used in the context of inflammation, lipid metabolism, myocardial infarction, diabetes, kidney function, urinary analysis, liver function, blood coagulation, blood counts, therapeutic drug monitoring and drugs of abuse screening.
ObjectiveOverview on the possibilities and limitations in clinical laboratory diagnostics offered in pharmacies. Indications and methods of often used analyses are known.
ContentIntroduction into medical laboratory diagnostics: immunochemical methods, diagnostics of inflammation, acute myocardial infarction, lipid metabolism, diabetes, kidney function and urinary diagnostics, blood coagulation, blood count, therapeutic drug monitoring, drugs of abuse screening, common diagnostics of liver diseases, point-of-care diagnostics.
Lecture notesDocumentation will be available before the lectures electronically.
Literature- Jürgen Hallbach, Klinische Chemie und Hämatologie für den Einstieg, Thieme Verlag
- Harald Renz, Praktische Labordiagnostik, de Gruyter Verlag
- Walter Guder, Das Laborbuch für Klinik und Praxis, Elsevier Verlag
535-0231-00LMedicinal Chemistry IIO2 credits2VJ. Hall
AbstractThe lectures give an overview of selected drugs and the molecular mechanisms underlying their therapeutic effects in disease. The historical and modern-day methods by which these drugs were discovered and developed are described. Structure-function relationships and the biophysical rules underlying ligand-target interactions will be discussed and illustrated with examples.
ObjectiveBasic understanding of therapeutic agents with respect to molecular, pharmacological and pharmaceutical properties.
ContentMolecular mechanisms of action of drugs. Structure function and biophysical basis of ligand-target interactions.
Lecture notesWill be provided electronically in parts before each individual lecture.
Literature- G.L. Patrick, "An Introduction to Medicinal Chemistry", 5th edition, Oxford University Press (2013)
- D. Steinhilber, M. Schubert-Zsilavecz, H.J. Roth, "Medizinische Chemie", Deutscher Apotheker Verlag Stuttgart (2005)
- J.H. Block, J.M. Beale, "Organic Medicinal and Pharmaceutical Chemistry", 11th edition, Lippincott, Williams, Wilkins (2002)
- A. Gringauz, "How Drugs Act and Why", Wiley (1997)
- R. Silverman and M. Holladay, "The Organic Chemistry of Drug Design and Drug Action" 3rd Edition, Academic Press, (2014)
Prerequisites / NoticeRequirements: Knowledge of physical and organic chemistry, biochemistry and biology; Medicinal Chemistry I.
535-0241-03LBiopharmacyO3 credits3VS.‑D. Krämer
AbstractIntroduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential.
ObjectiveIntroduction to the Basics in Biopharmacy. Pharmacokinetic processes (absorption, distribution, metabolism and excretion, ADME), which determine the fate of a drug in the body. Knowledge of the most important pharmacokinetic parameters. Interpretation of concentration-time-profiles of drugs. Pharmacokinetic profiling of drugs in view of therapy optimization and analysis of interaction potential.
ContentIntroduction to pharmacokinetics; definition of the most important pharmacokinetic parameters and their calculation from clinical data (compartment model, statistical model); kinetics of absorption (absorption profiles); distribution of drugs and role of protein binding; kinetics of elimination: excretion and biotransformation (physiological model); pharmacokinetic profiling of drugs for therapy optimization and for the analysis of the interaction potential; dosage regimen design.
LiteratureP. Langguth, G. Fricker, H. Wunderli-Allenspach "Biopharmazie", Wiley-VCH Verlag, Weinheim, 2004.
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