Search result: Catalogue data in Spring Semester 2019

Biology Master Information
Elective Major Subject Areas
Elective Major: Cell Biology
Elective Compulsory Concept Courses
See D-BIOL Master Studies Guide
NumberTitleTypeECTSHoursLecturers
551-0324-00LSystems Biology Information W6 credits4VR. Aebersold, B. Christen, M. Claassen, U. Sauer
AbstractIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Objective- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
ContentOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Lecture notesno script
LiteratureThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
551-0320-00LCellular Biochemistry (Part II)W3 credits2VY. Barral, R. Kroschewski, A. E. Smith
AbstractThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
ObjectiveThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
ContentSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteratureRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Prerequisites / NoticeTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-0318-00LImmunology IIW3 credits2VA. Oxenius, M. Kopf, S. R. Leibundgut, E. Wetter Slack, further lecturers
AbstractIntroduction into the cellular and molecular basis of the immune system and immune responses against diverse pathogens, tumors, transplants, and self (autoimmunity)
ObjectiveThe lectures will provide a detailed understanding:
- how innate and adaptive immune responses interact at the cellular and molecular level.
- how the immune system recognizes and fights against pathogenic microorganisms including viruses, bacteria, and parasites.
- why lymphocytes tolerate self molecules.
- about function and dysfunction the intestinal immune system.
- immunopathology and inflammatory diseases.
ContentThe aim of lecture is to understand:
> How pathogens are recognized by the innate immune system
> Immune defense against various pathogens
> Immunology of the skin, lung and intestines
> Tumor immunology
> Migration and homing of immune cells
> tolerance and autoimmunity
> T cell memory
Lecture notesPresentations of the lecturers are available at the Moodle link
LiteratureRecommended: Kuby Immunology (Freeman)
376-0209-00LMolecular Disease MechanismsW6 credits4VC. Wolfrum, H. Gahlon, M. Kopf
AbstractIn this course the mechanisms of disease development will be studied. Main topics will be:

1. Influence of environmental factors with an emphasis on inflammation and the immune response.
2. Mechanisms underlying disease progression in metabolic disorders, integrating genetic and environmental factors.
3. Mechanisms underlying disease progression in cancer, integrating genetic and environment
ObjectiveTo understand the mechanisms governing disease development with a special emphasis on genetic and environmental associated components
Lecture notesAll information can be found at:

https://moodle-app2.let.ethz.ch/course/view.php?id=690

The enrollment key will be provided by email
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