Ab 2. November 2020 findet das Herbstsemester 2020 online statt. Ausnahmen: Veranstaltungen, die nur mit Präsenz vor Ort durchführbar sind.
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Suchergebnis: Katalogdaten im Herbstsemester 2014

Biomedical Engineering Master Information
Master-Studium gemäss Studienreglement 2013
Vertiefungsfächer
Biomechanics
Wahlfächer der Vertiefung
Diese Fächer sind für die Vertiefung in Biomechanics besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser.
NummerTitelTypECTSUmfangDozierende
376-1720-00LApplication of MATLAB in the Human Movement Sciences Information W2 KP2GR.  van de Langenberg
KurzbeschreibungBasierend auf bewegungstypischen Messungen (Kinematik, Kinetik, Muskelaktivität, etc.) werden die Grundzüge der Datenverarbeitung und Datendarstellung mittels MATLAB vermittelt.
LernzielSelbstständiges Einlesen, Darstellen und Weiterverarbeiten von für die Bewegungs-wissenschaften typischen Messdaten in MATLAB.
InhaltGrenzen von Excel; Möglichkeiten von MATLAB; Einlesen diverses Datentypen, Darstellen eines und mehrerer Signale; Beseitigen eines Offsets und Filtern der Daten anhand von selbstgeschriebenen Funktionen; Normieren und Parametrisieren von Daten; Reliabilität; Interpolieren, Differenzieren und Integrieren in MATLAB.
LiteraturIn der Vorlesung wird auf diverse elektronische Einführungen in MATLAB aufmerksam gemacht. Jede Vorlesung wird den Studenten in Skript-Form zur Verfügung gestellt.
Voraussetzungen / BesonderesLaptop samt installiertem WLAN und MATLAB (Version 2009 oder höher) sind mitzubringen. Gegebenenfalls kann zu zweit an einem Laptop gearbeitet werden. Eine MATLAB-Studentenversion kann gratis über Stud-IDES bezogen werden.
376-1974-00LColloquium in Biomechanics Information W2 KP2KB. Helgason, S. J. Ferguson, R. Müller, J. G. Snedeker, B. Taylor, M. Zenobi-Wong
KurzbeschreibungCurrent topics in biomechanics presented by speakers from academia and industry.
LernzielGetting insight into actual areas and problems of biomechanics.
376-2017-00LBiomechanik von Sportverletzungen und RehabilitationW3 KP2VK.‑U. Schmitt, J. Goldhahn
KurzbeschreibungDie Veranstaltung vermittelt die Grundlagen der Verletzungsbiomechanik. Sportverletzungen und deren Rehabilitation bilden dabei den Schwerpunkt der Vorlesung.
LernzielIn dieser Veranstaltung sollen Sie Grundlagen der Traumabiomechanik erlernen. Anhand von Beispielen aus dem Sport lernen Sie verschiedene Mechanismen, die zu Verletzungen des menschlichen Körpers führen können, kennen. Sie sollen ein Verständnis für das Entstehen von Verletzungen entwickeln, das Sie in die Lage versetzt Verletzungspotentiale abzuschätzen und präventive Massnahmen zu entwickeln.
InhaltDie Veranstaltung beschäftigt sich mit den Grundlagen der Verletzungsmechanik und der Rehabilitation. Es wird untersucht, wie Verletzungen entstehen und wie sie verhindert werden können. Die Vorlesung konzentriert sich dabei auf Verletzungen, die im Sport erlitten werden.
SkriptSteht zum Download zur Verfügung.
LiteraturSchmitt K-U, Niederer P, M. Muser, Walz F: "Trauma Biomechanics - An Introduction to Injury Biomechanics" bzw. "Trauma-Biomechanik - Einführung in die Biomechanik von Verletzungen", beide Springer Verlag
Voraussetzungen / BesonderesDie Mitarbeit an einer Gruppenarbeit ist fester Bestandteil der Veranstaltung. Die Gruppenarbeit wird benotet und zählt somit zur Gesamtnote der Vorlesung hinzu. Nähere Informationen werden in der ersten Vorlesung gegeben.
402-0341-00LMedical Physics IW6 KP2V + 1UP. Manser
KurzbeschreibungIntroduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations.
LernzielUnderstanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society.
InhaltThe lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications.
SkriptA script will be provided.
402-0674-00LPhysics in Medical Research: From Atoms to Cells Information W6 KP2V + 1UB. K. R. Müller
KurzbeschreibungScanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells.
LernzielThe lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour.

As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced.

The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes.

High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering.

Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body.

Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function.

3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented.

Visiting clinical research in a leading university hospital will show the usefulness of the lecture series.
465-0953-00LBiostatistikW2 KP2V + 1UB. Sick
KurzbeschreibungDer Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Varianzanalyse, logistische Regression, Survivalanalyse (Kaplan-Meier Kurven und Cox-Regression).
Lernziel
551-1295-00LIntroduction to Bioinformatics: Concepts and Applications Information W6 KP4GW. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner
KurzbeschreibungSpeicherung, Verarbeitung und Analyse grosser Datenmengen sind in vielen Forschungsbereichen der modernen Biologie essentiell geworden. Die Vorlesung gibt eine grundlegende Einführung in Anwendungsbereiche von Bioinformatik in der Biologie und stellt einige leicht zugängliche Programme und Datenbanken für den Anwender in Theorie und Praxis vor.
LernzielIntroduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks.

In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science.

Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester.
InhaltBioinformatics I will cover the following topics:

From genes to databases and information
BLAST searches
Prediction of gene function and regulation
RNA structure prediction
Gene expression analysis using microarrays
Protein sequence and structure databases
WWW for bioinformatics
Protein sequence comparisons
Proteomics and de novo protein sequencing
Protein structure prediction
Cellular and protein interaction networks
Molecular dynamics simulation
Biologiefächer
NummerTitelTypECTSUmfangDozierende
227-0945-00LCell and Molecular Biology for EngineersW6 KP4GC. Frei
KurzbeschreibungThe course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology.
LernzielAfter completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested.
InhaltLectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells.

In addition, three journal clubs will be held, where one/two publictions will be discussed. For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded, and count as 25% for the final grade.
SkriptScripts of all lectures will be available.
Literatur"Molecular Biology of the Cell" (5th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter.
Medical Physics
Kernfächer der Vertiefung
Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden.
NummerTitelTypECTSUmfangDozierende
227-0385-00LBiomedical Imaging Information W4 KP3GS. Kozerke, U. Moser, M. Rudin
KurzbeschreibungIntroduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques.
LernzielUnderstand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods.
InhaltX-ray imaging
Computed tomography
Single photon emission tomography
Positron emission tomography
Magnetic resonance imaging
Ultrasound/Doppler imaging
SkriptLecture notes and handouts: Biomedical Imaging
LiteraturIntroduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith,
Cambridge University Press
402-0341-00LMedical Physics IW6 KP2V + 1UP. Manser
KurzbeschreibungIntroduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations.
LernzielUnderstanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society.
InhaltThe lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications.
SkriptA script will be provided.
402-0345-00LIntroduction to Medical Physics
Findet dieses Semester nicht statt.
W4 KP2VA. J. Lomax
KurzbeschreibungMedical physics is a fascinating and worthwhile scientific discipline, providing many professional opportunities to apply physics to the care of patients, either in the clinic or in industry. It is also an area allowing for exciting, interesting and fulfilling areas of research.
LernzielIt is the aim of this course to give bachelor and master level students an insight into the wide spectrum of medical applications of physics, and to provide some insight into the work of the medical physicist in clinics, industry and research.
InhaltThe lecture series will begin with a short historical overview of medical physics and an overview of the lecture series (lecture 1). This will be followed by two lectures on the physics of medical imaging. Medical imaging is one of the most important areas of preventative medicine and diagnostics, and in these two lectures, we will summarise the physics aspects of all the most important medical imaging modalities (X-ray, nuclear medicine, CT, MRI, Ultrasound imaging etc.). With lectures 4 and 5, we will move onto one of the other major areas of physics applied to medicine, radiotherapy. As the name implies, this is a physics 'heavy' discipline, being dependent as it is on both accelerator and particle physics. However, what is less well known is that this is also the second most successfu
l treatment of cancer after surgery and a great success story for the application of physics to medicine. In lectures 6 and 7 will then move on to a very different area, that of bio-photonics and bio-physics. Here we will look into the applications of lasers in medicine, from therapy to their use in particle acceleration for medical applications, as well as a variety of optical techniques for studying biological tissues, cells and structures.
In the second half of the lecture series (lectures 8-13) the style changes somewhat, and we will concentrate on professional aspects of medical physics and the role of the medical physicist in various professional scenarios. As such, lectures 8-11 will cover the role of the clinical medical physicist in diagnostic radiology, MRI, nuclear medicine and radiotherapy, whilst the last two lectures will concentrate on their role in industry and research. For many of this second set of lectures, external experts in the various areas will be invited in order to give the student the best possible insight into the life of a professional medical physicist.
227-0943-00LRadiobiologyW2 KP2VM. Pruschy
KurzbeschreibungThe purpose of this course is to impart basic knowledge in radiobiology in order to handle ionizing rays and to provide a basis for predicting the radiation risk.
Lernziel
InhaltEinführung in die Strahlenbiologie ionisierender Strahlen: Allgemeine Grundlagen und Begriffsbestimmungen; Mechanismen der biologischen Strahlenwirkung; Strahlenwirkung auf Zellen, Gewebe und Organe; Modifikation der biologischen Strahlenwirkung; Strahlenzytogenetik: Chromosomenveränderungen, DNA-Defekte, Reparaturprozesse; Molekulare Strahlenbiologie: Bedeutung inter- und intrazellulärer Signalübermittlungsprozesse, Apoptose, Zellzyklus-Checkpoints; Strahlenrisiko: Strahlensyndrome, Krebsinduktion, Mutationsauslösung, pränatale Strahlenwirkung; Strahlenbiologische Grundlagen des Strahlenschutzes; Nutzen-Risiko-Abwägungen bei der medizinischen Strahlenanwendung; Prädiktive strahlenbiologische Methoden zur Optimierung der therapeutischen Strahlenanwendung.
SkriptBeilagen mit zusammenfassenden Texten, Tabellen, Bild- und Grafikdarstellungen werden abgegeben
LiteraturLiteraturliste wird abgegeben.
Für NDS-Absolventen empfohlen: Hall EJ: Radiobiology for the Radiologist, 5th Edition, Lippincott Williams&Wilkins, ISBN 0-7817-2649-2, 2000
Voraussetzungen / BesonderesThe former number of this course unit is 465-0951-00L.
Wahlfächer der Vertiefung
Diese Fächer sind für die Vertiefung in Biomechanics besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser.
NummerTitelTypECTSUmfangDozierende
402-0674-00LPhysics in Medical Research: From Atoms to Cells Information W6 KP2V + 1UB. K. R. Müller
KurzbeschreibungScanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells.
LernzielThe lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour.

As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced.

The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes.

High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering.

Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body.

Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function.

3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented.

Visiting clinical research in a leading university hospital will show the usefulness of the lecture series.
Weitere Wahlfächer
Diese Fächer können für die Vertiefung in Medical Physics geeignet sein. Bitte konsultieren Sie Ihren Track Adviser.
NummerTitelTypECTSUmfangDozierende
227-0447-00LImage Analysis and Computer Vision Information W6 KP3V + 1UG. Székely, O. Göksel, L. Van Gool
KurzbeschreibungLight and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition.
LernzielOverview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises.
InhaltThe first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed.
SkriptCourse material Script, computer demonstrations, exercises and problem solutions
Voraussetzungen / BesonderesPrerequisites:
Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C.
The course language is English.
Biologiefächer
NummerTitelTypECTSUmfangDozierende
227-0945-00LCell and Molecular Biology for EngineersW6 KP4GC. Frei
KurzbeschreibungThe course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology.
LernzielAfter completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested.
InhaltLectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells.

In addition, three journal clubs will be held, where one/two publictions will be discussed. For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded, and count as 25% for the final grade.
SkriptScripts of all lectures will be available.
Literatur"Molecular Biology of the Cell" (5th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter.
Molecular Bioengineering
Kernfächer der Vertiefung
Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden.
NummerTitelTypECTSUmfangDozierende
376-1714-00LBiocompatible MaterialsW4 KP3GK. Maniura, P. M. Kollmannsberger, J. Möller, M. Zenobi-Wong
KurzbeschreibungIntroduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced.
LernzielThe class consists of three parts:
1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials.
2. The concept of biocompatibility.
3. Introduction into methodology used in biomaterials research and application.
InhaltIntroduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed.
In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers.
SkriptHandouts can be accessed online.
LiteraturLiteratur
Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013
Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011

(available online via ETH library)

Handouts provided during the classes and references therin.
402-0674-00LPhysics in Medical Research: From Atoms to Cells Information W6 KP2V + 1UB. K. R. Müller
KurzbeschreibungScanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells.
LernzielThe lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour.

As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced.

The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes.

High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering.

Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body.

Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function.

3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented.

Visiting clinical research in a leading university hospital will show the usefulness of the lecture series.
465-0953-00LBiostatistikW2 KP2V + 1UB. Sick
KurzbeschreibungDer Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Varianzanalyse, logistische Regression, Survivalanalyse (Kaplan-Meier Kurven und Cox-Regression).
Lernziel
551-0103-00LGrundlagen der Biologie II: Zellbiologie Information W5 KP5VU. Kutay, Y. Barral, E. Hafen, G. Schertler, U. Suter, S. Werner
KurzbeschreibungZiel dieses Kurses ist ein breites Grundverständnis für die Zellbiologie zu vermitteln. Dieses Basiswissen wird den Studenten ermöglichen, sich in die Zellbiologie sowie in verwandte Gebiete wie Biochemie, Mikrobiologie, Pharmazie, Molekularbiologie und andere zu vertiefen.
LernzielZiel dieses Kurses ist ein breites Grundverständnis für die Zellbiologie zu vermitteln. Dieses Basiswissen wird den Studenten ermöglichen, sich in die Zellbiologie sowie in verwandte Gebiete wie Biochemie, Mikrobiologie, Pharmazie, Molekularbiologie und andere zu vertiefen.
InhaltDas Hauptaugenmerk liegt auf der Biologie von Säugerzellen und der Entwicklung multizellulärer Organismen mit Schwerpunkt auf molekularen Mechanismen, die zellulären Strukturen und Phänomenen zugrunde liegen. Die behandelten Themen umfassen biologische Membranen, das Zytoskelett, Protein Sorting, Energiemetabolismus, Zellzyklus und Zellteilung, Viren, die extrazelluläre Matrix, Signaltransduktion, Entwicklungsbiologie und Krebsforschung.
SkriptDie Vorlesungsinhalte werden mithilfe von Powerpoint präsentiert. Die Präsentationen können von ETH Studenten heruntergeladen werden (https://sharepoint.biol.ethz.ch/sites/e-learn/551-0103-00L-H13/default.aspx). Ausgewählte Vorlesungen können auf dem ETH Netz im live Format (Livestream) angehört werden.
LiteraturDie Vorlesung folgt Alberts et al. ‘Molecular Biology of the Cell’ Fünfte Auflage, 2008 ISBN 978-0-8153-4105-5 (gebunden) und ISBN 978-0-8153-4106-2 (Taschenbuchausgabe).
Voraussetzungen / BesonderesEinige Vorlesungseinheiten werden in englischer Sprache gehalten.
551-1295-00LIntroduction to Bioinformatics: Concepts and Applications Information W6 KP4GW. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner
KurzbeschreibungSpeicherung, Verarbeitung und Analyse grosser Datenmengen sind in vielen Forschungsbereichen der modernen Biologie essentiell geworden. Die Vorlesung gibt eine grundlegende Einführung in Anwendungsbereiche von Bioinformatik in der Biologie und stellt einige leicht zugängliche Programme und Datenbanken für den Anwender in Theorie und Praxis vor.
LernzielIntroduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks.

In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science.

Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester.
InhaltBioinformatics I will cover the following topics:

From genes to databases and information
BLAST searches
Prediction of gene function and regulation
RNA structure prediction
Gene expression analysis using microarrays
Protein sequence and structure databases
WWW for bioinformatics
Protein sequence comparisons
Proteomics and de novo protein sequencing
Protein structure prediction
Cellular and protein interaction networks
Molecular dynamics simulation
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