Search result: Catalogue data in Autumn Semester 2016
Biomedical Engineering Master | ||||||
Track Courses | ||||||
Molecular Bioengineering | ||||||
Recommended Elective Courses These courses are particularly recommended for the Molecular Bioengineering track. Please consult your track advisor if you wish to select other subjects. | ||||||
Number | Title | Type | ECTS | Hours | Lecturers | |
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151-0604-00L | Microrobotics Does not take place this semester. | W | 4 credits | 3G | B. Nelson | |
Abstract | Microrobotics is an interdisciplinary field that combines aspects of robotics, micro and nanotechnology, biomedical engineering, and materials science. The aim of this course is to expose students to the fundamentals of this emerging field. Throughout the course students are expected to submit assignments. The course concludes with an end-of-semester examination. | |||||
Objective | The objective of this course is to expose students to the fundamental aspects of the emerging field of microrobotics. This includes a focus on physical laws that predominate at the microscale, technologies for fabricating small devices, bio-inspired design, and applications of the field. | |||||
Content | Main topics of the course include: - Scaling laws at micro/nano scales - Electrostatics - Electromagnetism - Low Reynolds number flows - Observation tools - Materials and fabrication methods - Applications of biomedical microrobots | |||||
Lecture notes | The powerpoint slides presented in the lectures will be made available in hardcopy and as pdf files. Several readings will also be made available electronically. | |||||
Prerequisites / Notice | The lecture will be taught in English. | |||||
227-0385-10L | Biomedical Imaging | W | 6 credits | 5G | S. Kozerke, K. P. Prüssmann, M. Rudin | |
Abstract | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Objective | To understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. The mathematical framework is developed to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. Matlab exercises are used to implement and study basic concepts. | |||||
Content | - X-ray imaging - Computed tomography - Single photon emission tomography - Positron emission tomography - Magnetic resonance imaging - Ultrasound/Doppler imaging | |||||
Lecture notes | Lecture notes and handouts | |||||
Literature | Webb A, Smith N.B. Introduction to Medical Imaging: Physics, Engineering and Clinical Applications; Cambridge University Press 2011 | |||||
Prerequisites / Notice | Analysis, Linear Algebra, Physics, Basics of Signal Theory, Basic skills in Matlab programming | |||||
227-0386-00L | Biomedical Engineering | W | 4 credits | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Abstract | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Objective | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Content | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Lecture notes | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0393-10L | Bioelectronics and Biosensors New course. Not to be confounded with 227-0393-00L last offered in the Spring Semester 2015. | W | 6 credits | 2V + 2U | J. Vörös, M. F. Yanik, T. Zambelli | |
Abstract | The course introduces the concepts of bioelectricity and biosensing. The sources and use of electrical fields and currents in the context of biological systems and problems are discussed. The fundamental challenges of measuring biological signals are introduced. The most important biosensing techniques and their physical concepts are introduced in a quantitative fashion. | |||||
Objective | During this course the students will: - learn the basic concepts in biosensing and bioelectronics - be able to solve typical problems in biosensing and bioelectronics - learn about the remaining challenges in this field | |||||
Content | L1. Bioelectronics history, its applications and overview of the field - Volta and Galvani dispute - BMI, pacemaker, cochlear implant, retinal implant, limb replacement devices - Fundamentals of biosensing - Glucometer and ELISA L2. Fundamentals of quantum and classical noise in measuring biological signals L3. Biomeasurement techniques with photons L4. Acoustics sensors - Differential equation for quartz crystal resonance - Acoustic sensors and their applications L5. Engineering principles of optical probes for measuring and manipulating molecular and cellular processes L6. Optical biosensors - Differential equation for optical waveguides - Optical sensors and their applications - Plasmonic sensing L7. Basic notions of molecular adsorption and electron transfer - Quantum mechanics: Schrödinger equation energy levels from H atom to crystals, energy bands - Electron transfer: Marcus theory, Gerischer theory L8. Potentiometric sensors - Fundamentals of the electrochemical cell at equilibrium (Nernst equation) - Principles of operation of ion-selective electrodes L9. Amperometric sensors and bioelectric potentials - Fundamentals of the electrochemical cell with an applied overpotential to generate a faraday current - Principles of operation of amperometric sensors - Ion flow through a membrane (Fick equation, Nernst equation, Donnan equilibrium, Goldman equation) L10. Channels, amplification, signal gating, and patch clamp Y4 L11. Action potentials and impulse propagation L12. Functional electric stimulation and recording - MEA and CMOS based recording - Applying potential in liquid - simulation of fields and relevance to electric stimulation L13. Neural networks memory and learning | |||||
Literature | Plonsey and Barr, Bioelectricity: A Quantitative Approach (Third edition) | |||||
Prerequisites / Notice | Supervised exercises solving real-world problems. Some Matlab based exercises in groups. | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 credits | 3G | M. Stampanoni, P. A. Kaestner | |
Abstract | The lecture introduces the physical and technical know-how of X-ray tomographic microscopy. Several X-ray imaging techniques (absorption-, phase- and darkfield contrast) will be discussed and their use in daily research, in particular biology, is presented. The course discusses the aspects of quantitative evaluation of tomographic data sets like segmentation, morphometry and statistics. | |||||
Objective | Introduction to the basic concepts of X-ray tomographic imaging, image analysis and data quantification at the micro and nano scale with particular emphasis on biological applications | |||||
Content | Synchrotron-based X-ray micro- and nano-tomography is today a powerful technique for non-destructive, high-resolution investigations of a broad range of materials. The high-brilliance and high-coherence of third generation synchrotron radiation facilities allow quantitative, three-dimensional imaging at the micro and nanometer scale and extend the traditional absorption imaging technique to edge-enhanced and phase-sensitive measurements, which are particularly suited for investigating biological samples. The lecture includes a general introduction to the principles of tomographic imaging from image formation to image reconstruction. It provides the physical and engineering basics to understand how imaging beamlines at synchrotron facilities work, looks into the recently developed phase contrast methods, and explores the first applications of X-ray nano-tomographic experiments. The course finally provides the necessary background to understand the quantitative evaluation of tomographic data, from basic image analysis to complex morphometrical computations and 3D visualization, keeping the focus on biomedical applications. | |||||
Lecture notes | Available online | |||||
Literature | Will be indicated during the lecture. | |||||
227-0981-00L | Cross-Disciplinary Research and Development in Medicine and Engineering A maximum of 12 medical degree students and 12 (biomedical) engineering degree students can be admitted, their number should be equal. | W | 4 credits | 2V + 2A | V. Kurtcuoglu, D. de Julien de Zelicourt, M. Meboldt, M. Schmid Daners, O. Ullrich | |
Abstract | Cross-disciplinary collaboration between engineers and medical doctors is indispensable for innovation in health care. This course will bring together engineering students from ETH Zurich and medical students from the University of Zurich to experience the rewards and challenges of such interdisciplinary work in a project based learning environment. | |||||
Objective | The main goal of this course is to demonstrate the differences in communication between the fields of medicine and engineering. Since such differences become the most evident during actual collaborative work, the course is based on a current project in physiology research that combines medicine and engineering. For the engineering students, the specific aims of the course are to: - Acquire a working understanding of the anatomy and physiology of the investigated system; - Identify the engineering challenges in the project and communicate them to the medical students; - Develop and implement, together with the medical students, solution strategies for the identified challenges; - Present the found solutions to a cross-disciplinary audience. | |||||
Content | After a general introduction to interdisciplinary communication and detailed background on the collaborative project, the engineering students will receive tailored lectures on the anatomy and physiology of the relevant system. They will then team up with medical students who have received a basic introduction to engineering methodology to collaborate on said project. In the process, they will be coached both by lecturers from ETH Zurich and the University of Zurich, receiving lectures customized to the project. The course will end with each team presenting their solution to a cross-disciplinary audience. | |||||
Lecture notes | Handouts and relevant literature will be provided. | |||||
327-0505-00L | Surfaces, Interfaces and their Applications I | W | 3 credits | 2V + 1U | N. Spencer, M. P. Heuberger, L. Isa | |
Abstract | After being introduced to the physical/chemical principles and importance of surfaces and interfaces, the student is introduced to the most important techniques that can be used to characterize surfaces. Later, liquid interfaces are treated, followed by an introduction to the fields of tribology (friction, lubrication, and wear) and corrosion. | |||||
Objective | To gain an understanding of the physical and chemical principles, as well as the tools and applications of surface science, and to be able to choose appropriate surface-analytical approaches for solving problems. | |||||
Content | Introduction to Surface Science Physical Structure of Surfaces Surface Forces (static and dynamic) Adsorbates on Surfaces Surface Thermodynamics and Kinetics The Solid-Liquid Interface Electron Spectroscopy Vibrational Spectroscopy on Surfaces Scanning Probe Microscopy Introduction to Tribology Introduction to Corrosion Science | |||||
Lecture notes | Script Download: Link | |||||
Literature | Script (20 CHF) Book: "Surface Analysis--The Principal Techniques", Ed. J.C. Vickerman, Wiley, ISBN 0-471-97292 | |||||
Prerequisites / Notice | Chemistry: General undergraduate chemistry including basic chemical kinetics and thermodynamics Physics: General undergraduate physics including basic theory of diffraction and basic knowledge of crystal structures | |||||
327-1101-00L | Biomineralization | W | 2 credits | 2G | K.‑H. Ernst | |
Abstract | The course addresses undergraduate and graduate students interested in getting introduced into the basic concepts of biomineralization. | |||||
Objective | The course aims to introduce the basic concepts of biomineralization and the underlying principles, such as supersaturation, nucleation and growth of minerals, the interaction of biomolecules with mineral surfaces, and cell biology of inorganic materials creation. An important part of this class is the independent study and the presentation of original literature from the field. | |||||
Content | Biomineralization is a multidisciplinary field. Topics dealing with biology, molecular and cell biology, solid state physics, mineralogy, crystallography, organic and physical chemistry, biochemistry, dentistry, oceanography, geology, etc. are addressed. The course covers definition and general concepts of biomineralization (BM)/ types of biominerals and their function / crystal nucleation and growth / biological induction of BM / control of crystal morphology, habit, shape and orientation by organisms / strategies of compartmentalization / the interface between biomolecules (peptides, polysaccharides) and the mineral phase / modern experimental methods for studying BM phenomena / inter-, intra, extra- and epicellular BM / organic templates and matrices for BM / structure of bone, teeth (vertebrates and invertebrates) and mollusk shells / calcification / silification in diatoms, radiolaria and plants / calcium and iron storage / impact of BM on lithosphere and atmosphere/ evolution / taxonomy of organisms. 1. Introduction and overview 2. Biominerals and their functions 3. Chemical control of biomineralization 4. Control of morphology: Organic templates and additives 5. Modern methods of investigation of BM 6. BM in matrices: bone and nacre 7. Vertebrate teeth 8. Invertebrate teeth 9. BM within vesicles: calcite of coccoliths 10. Silica 11. Iron storage and mineralization | |||||
Lecture notes | Script with more than 600 pages with many illustrations will be distributed free of charge. | |||||
Literature | 1) S. Mann, Biomineralization, Oxford University Press, 2001, Oxford, New York 2) H. Lowenstam, S. Weiner, On Biomineralization, Oxford University Press, 1989, Oxford 3) P. M. Dove, J. J. DeYoreo, S. Weiner (Eds.) Biomineralization, Reviews in Mineralogoy & Geochemistry Vol. 54, 2003 | |||||
Prerequisites / Notice | Each attendee is required to present a publication from the field. The selection of key papers is provided by the lecturer. No special requirements are needed for attending. Basic knowledge in chemistry and cell biology is expected. | |||||
376-1622-00L | Practical Methods in Tissue Engineering Number of participants limited to 12. | W | 5 credits | 4P | K. Würtz-Kozak, M. Zenobi-Wong | |
Abstract | The goal of this course is to teach MSc students the necessary skills for doing research in the fields of tissue engineering and regenerative medicine. | |||||
Objective | Practical exercises and demonstrations on topics including sterile cell culture, light microscopy and histology, protein and gene expression analysis, and viability assays are covered. The advantages of 3D cell cultures will be discussed and practical work on manufacturing and evaluating hydrogels and scaffolds for tissue engineering will be performed in small groups. In addition to practical lab work, the course will teach skills in data acquisition/analysis. | |||||
402-0341-00L | Medical Physics I | W | 6 credits | 2V + 1U | P. Manser | |
Abstract | Introduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations. | |||||
Objective | Understanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society. | |||||
Content | The lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications. | |||||
Lecture notes | A script will be provided. | |||||
535-0423-00L | Drug Delivery and Drug Targeting | W | 2 credits | 2V | J.‑C. Leroux, D. Brambilla | |
Abstract | The students gain an overview on current principles, methodologies and systems for controlled delivery and targeting of drugs. This enables the students to understand and evaluate the field in terms of scientific criteria. | |||||
Objective | The students dispose of an overview on current principles and systems for the controlled delivery and targeting of drugs. The focus of the course lies on developing a capacity to understand the involved technologies and methods, as well as an appreciation of the chances and constraints of their therapeutic usage, with prime attention on anticancer drugs, therapeutic peptides, proteins, nucleic acids and vaccines. | |||||
Content | The course covers the following topics: drug targeting and delivery principles, radiopharmaceuticals, macromolecular drug carriers, liposomes, micelles, micro/nanoparticles, gels and implants, administration of vaccines, delivery of active agents in tissue engineeering, targeting at the gastrointestinal level, synthetic carriers for nucleic acid drugs, ophthalmic devices and novel trends in transdermal and nasal drug delivery. | |||||
Lecture notes | Selected lecture notes, documents and supporting material will be directly provided or may be downloaded using Link The website also displays additional information on peroral delivery systems, transdermal systems and systems for alternative routes (nasal, pulmonary) of delivery. These fields are covered in detail in the course Galenische Pharmazie II (Galenical Pharmacy II). | |||||
Literature | Y. Perrie, T. Rhades. Pharmaceutics - Drug Delivery and Targeting, second edition, Pharmaceutical Press, London and Chicago, 2012. Further references will be provided in the course. | |||||
636-0507-00L | Synthetic Biology II | W | 4 credits | 4A | S. Panke, Y. Benenson, J. Stelling | |
Abstract | 7 months biological design project, during which the students are required to give presentations on advanced topics in synthetic biology (specifically genetic circuit design) and then select their own biological system to design. The system is subsequently modeled, analyzed, and experimentally implemented. Results are presented at an international student competition at the MIT (Cambridge). | |||||
Objective | The students are supposed to acquire a deep understanding of the process of biological design including model representation of a biological system, its thorough analysis, and the subsequent experimental implementation of the system and the related problems. | |||||
Content | Presentations on advanced synthetic biology topics (eg genetic circuit design, adaptation of systems dynamics, analytical concepts, large scale de novo DNA synthesis), project selection, modeling of selected biological system, design space exploration, sensitivity analysis, conversion into DNA sequence, (DNA synthesis external,) implementation and analysis of design, summary of results in form of scientific presentation and poster, presentation of results at the iGEM international student competition (Link). | |||||
Lecture notes | Handouts during course | |||||
Prerequisites / Notice | The final presentation of the project is typically at the MIT (Cambridge, US). Other competing schools include regularly Imperial College, Cambridge University, Harvard University, UC Berkeley, Princeton Universtiy, CalTech, etc. This project takes place between end of Spring Semester and beginning of Autumn Semester. Registration in April. Please note that the number of ECTS credits and the actual work load are disconnected. |
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