Suchergebnis: Katalogdaten im Herbstsemester 2014
Biomedical Engineering Master | ||||||
Master-Studium gemäss Studienreglement 2013 | ||||||
Vertiefungsfächer | ||||||
Bioelectronics | ||||||
Kernfächer der Vertiefung Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
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151-0604-00L | Microrobotics | W | 4 KP | 3G | B. Nelson | |
Kurzbeschreibung | Microrobotics is an interdisciplinary field that combines aspects of robotics, micro and nanotechnology, biomedical engineering, and materials science. The aim of this course is to expose students to the fundamentals of this emerging field. Throughout the course students are expected to submit assignments. The course concludes with an end-of-semester examination. | |||||
Lernziel | The objective of this course is to expose students to the fundamental aspects of the emerging field of microrobotics. This includes a focus on physical laws that predominate at the microscale, technologies for fabricating small devices, bio-inspired design, and applications of the field. | |||||
Inhalt | Main topics of the course include: - Scaling laws at micro/nano scales - Electrostatics - Electromagnetism - Low Reynolds number flows - Observation tools - Materials and fabrication methods - Applications of biomedical microrobots | |||||
Skript | The powerpoint slides presented in the lectures will be made available in hardcopy and as pdf files. Several readings will also be made available electronically. | |||||
Voraussetzungen / Besonderes | The lecture will be taught in English. | |||||
151-0605-00L | Nanosystems | W | 4 KP | 4G | A. Stemmer | |
Kurzbeschreibung | From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. Special emphasis on the emerging field of molecular electronic devices. | |||||
Lernziel | Familiarize students with basic science and engineering principles governing the nano domain. | |||||
Inhalt | The course addresses basic science and engineering principles ruling the nano domain. We particularly work out the links between topics that are traditionally taught separately. Special emphasis is placed on the emerging field of molecular electronic devices, their working principles, applications, and how they may be assembled. Topics are treated in 2 blocks: (I) From Quantum to Continuum From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. (II) Interaction Forces on the Micro and Nano Scale Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. | |||||
Literatur | - Kuhn, Hans; Försterling, H.D.: Principles of Physical Chemistry. Understanding Molecules, Molecular Assemblies, Supramolecular Machines. 1999, Wiley, ISBN: 0-471-95902-2 - Chen, Gang: Nanoscale Energy Transport and Conversion. 2005, Oxford University Press, ISBN: 978-0-19-515942-4 - Ouisse, Thierry: Electron Transport in Nanostructures and Mesoscopic Devices. 2008, Wiley, ISBN: 978-1-84821-050-9 - Wolf, Edward L.: Nanophysics and Nanotechnology. 2004, Wiley-VCH, ISBN: 3-527-40407-4 - Israelachvili, Jacob N.: Intermolecular and Surface Forces. 2nd ed., 1992, Academic Press,ISBN: 0-12-375181-0 - Evans, D.F.; Wennerstrom, H.: The Colloidal Domain. Where Physics, Chemistry, Biology, and Technology Meet. Advances in Interfacial Engineering Series. 2nd ed., 1999, Wiley, ISBN: 0-471-24247-0 - Hunter, Robert J.: Foundations of Colloid Science. 2nd ed., 2001, Oxford, ISBN: 0-19-850502-7 | |||||
Voraussetzungen / Besonderes | Course format: Lectures: Thursday 10-12, ML F 36 Homework: Mini-Reviews Students select a paper (list distributed in class) and expand the topic into a Mini-Review that illuminates the particular field beyond the immediate results reported in the paper. | |||||
151-0621-00L | Microsystems Technology | W | 6 KP | 4G | C. Hierold, M. Haluska | |
Kurzbeschreibung | Die Stundenten werden in die Grundlagen der Mikrosystemtechnik und der Halbleiterprozesstechnologie eingeführt und erfahren, wie die Herstellung von Mikrosystemen in einer Serie von genau definierten Prozessschritten erfolgt (Gesamtprozess und Prozessablauf). | |||||
Lernziel | Die Stundenten sind mit den Grundlagen der Mikrosystemtechnik und der Prozesstechnologie für Halbleiter vertraut und verstehen die Herstellung von Mikrosystemen durch die Kombination von Einzelprozesschritten ( = Gesamtprozess oder Prozessablauf). | |||||
Inhalt | - Einführung in die Mikrosystemtechnik (MST) und in mikroelektromechanische Systeme (MEMS) - Grundlegende Siliziumtechnologie: thermische Oxidation, Fotolithografie und Ätztechnik, Diffusion und Ionenimplantation, Dünnschichttechnik. - Besondere Mikrosystemtechnologien: Volumen- und Oberflächenmikromechanik, Trocken- und Nassätzen, isotropisches und anisotropisches Ätzen, Herstellung von Balken und Membranen, Waferbonden, mechanische und thermische Eigenschaften von Dünnschichten, piezoelektrische und piezoresitive Materialien. - Ausgewählte Mikrosysteme: Mechanische Sensoren und Aktoren, Mikroresonatoren, thermische Sensoren und Aktoren, Systemintegration und Aufbautechnik. | |||||
Skript | Handouts (online erhältlich) | |||||
Literatur | - S.M. Sze: Semiconductor Devices, Physics and Technology - W. Menz, J. Mohr, O.Paul: Microsystem Technology - G. Kovacs: Micromachined Transducer Sourcebook | |||||
Voraussetzungen / Besonderes | Voraussetzung: Physik I und II | |||||
227-0385-00L | Biomedical Imaging | W | 4 KP | 3G | S. Kozerke, U. Moser, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | Understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. | |||||
Inhalt | X-ray imaging Computed tomography Single photon emission tomography Positron emission tomography Magnetic resonance imaging Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts: Biomedical Imaging | |||||
Literatur | Introduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith, Cambridge University Press | |||||
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0427-00L | Signal and Information Processing: Modeling, Filtering, Learning | W | 6 KP | 4G | H.‑A. Loeliger | |
Kurzbeschreibung | Fundamentals in signal processing, detection/estimation, and machine learning. I. Linear signal representation and approximation: Hilbert spaces, LMMSE estimation, regularization and sparseness. II. Learning linear and nonlinear functions and filters: kernel methods, neural networks. III. Structured statistical models: hidden Markov models, factor graphs, Kalman filter, parameter estimation. | |||||
Lernziel | The course is an introduction to some basic topics in signal processing, detection/estimation theory, and machine learning. | |||||
Inhalt | Part I - Linear Signal Representation and Approximation: Hilbert spaces, least squares and LMMSE estimation, projection and estimation by linear filtering, learning linear functions and filters, regularization and sparseness, singular-value decomposition and pseudo-inverse, principal-components analysis. Part II - Learning Nonlinear Functions: fundamentals of learning, neural networks, kernel methods. Part III - Structured Statistical Models and Message Passing Algorithms: hidden Markov models, factor graphs, Gaussian message passing, Kalman filter and recursive least squares, Monte Carlo methods, parameter estimation, expectation maximization. | |||||
Skript | Lecture notes. | |||||
Voraussetzungen / Besonderes | Prerequisites: - local bachelors: course "Discrete-Time and Statistical Signal Processing" (5. Sem.) - others: solid basics in linear algebra and probability theory | |||||
376-1714-00L | Biocompatible Materials | W | 4 KP | 3G | K. Maniura, P. M. Kollmannsberger, J. Möller, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced. | |||||
Lernziel | The class consists of three parts: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. | |||||
Inhalt | Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers. | |||||
Skript | Handouts can be accessed online. | |||||
Literatur | Literatur Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts provided during the classes and references therin. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
227-1037-00L | Introduction to Neuroinformatics | W | 6 KP | 2V + 1U | K. A. Martin, M. Cook, V. Mante, M. Pfeiffer | |
Kurzbeschreibung | The course provides an introduction to the functional properties of neurons. Particularly the description of membrane electrical properties (action potentials, channels), neuronal anatomy, synaptic structures, and neuronal networks. Simple models of computation, learning, and behavior will be explained. Some artificial systems (robot, chip) are presented. | |||||
Lernziel | ||||||
Inhalt | This course considers the structure and function of biological neural networks at different levels. The function of neural networks lies fundamentally in their wiring and in the electro-chemical properties of nerve cell membranes. Thus, the biological structure of the nerve cell needs to be understood if biologically-realistic models are to be constructed. These simpler models are used to estimate the electrical current flow through dendritic cables and explore how a more complex geometry of neurons influences this current flow. The active properties of nerves are studied to understand both sensory transduction and the generation and transmission of nerve impulses along axons. The concept of local neuronal circuits arises in the context of the rules governing the formation of nerve connections and topographic projections within the nervous system. Communication between neurons in the network can be thought of as information flow across synapses, which can be modified by experience. We need an understanding of the action of inhibitory and excitatory neurotransmitters and neuromodulators, so that the dynamics and logic of synapses can be interpreted. Finally, the neural architectures of feedforward and recurrent networks will be discussed in the context of co-ordination, control, and integration of sensory and motor information in neural networks. | |||||
Wahlfächer der Vertiefung Diese Fächer sind für die Vertiefung in Bioelectronics besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0166-00L | Analog Integrated Circuits | W | 6 KP | 2V + 2U | Q. Huang | |
Kurzbeschreibung | This course provides a foundation in analog integrated circuit design based on bipolar and CMOS technologies. | |||||
Lernziel | Integrated circuits are responsible for much of the progress in electronics in the last 50 years, particularly the revolutions in the Information and Communications Technologies we witnessed in recent years. Analog integrated circuits play a crucial part in the highly integrated systems that power the popular electronic devices we use daily. Understanding their design is beneficial to both future designers and users of such systems. The basic elements, design issues and techniques for analog integrated circuits will be taught in this course. | |||||
Inhalt | Review of bipolar and MOS devices and their small-signal equivalent circuit models; Building blocks in analog circuits such as current sources, active load, current mirrors, supply independent biasing etc; Amplifiers: differential amplifiers, cascode amplifier, high gain structures, output stages, gain bandwidth product of op-amps; Stability; Comparators; Second-order effects in analog circuits such as mismatch, noise and offset; A/D and D/A converters; Introduction to switched capacitor circuits. The exercise sessions aim to reinforce the lecture material by well guided step-by-step design tasks. The circuit simulator SPECTRE is used to facilitate the tasks. There is also an experimental session on op-amp measurments. | |||||
Skript | Handouts of presented slides. No script but an accompanying textbook is recommended. | |||||
Literatur | Gray, Hurst, Lewis, Meyer, "Analysis and Design of Analog Integrated Circuits", 5th Ed. Wiley, 2010. | |||||
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | G. Székely, O. Göksel, L. Van Gool | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
227-0963-00L | Statistical Parametric Mapping (SPM) | W | 2 KP | 1V | K. Stephan | |
Kurzbeschreibung | This course provides a comprehensive coverage of state-of-the-art statistical methods for fMRI data analysis, focusing on tools provided by the open source software package SPM | |||||
Lernziel | Knowledge of modern statistical methods for fMRI data analysis | |||||
Inhalt | Spatial preprocessing & physiological noise correction Voxel-based morphometry Mass-univariate & multivariate analyses of fMRI 'Resting state' fMRI Bayesian analysis methods Effective connectivity analyses (Dynamic Causal Modeling) | |||||
227-0981-00L | Cross-Disciplinary Research and Development in Medicine and Engineering A maximum of 8 medical degree students and 8 (biomedical) engineering degree students can be admitted, their number should be equal. | W | 4 KP | 2V + 2A | V. Kurtcuoglu, D. de Julien de Zelicourt, M. Meboldt, M. Schmid Daners, O. Ullrich | |
Kurzbeschreibung | Cross-disciplinary collaboration between engineers and medical doctors is indispensable for innovation in health care. This course will bring together engineering students from ETH Zurich and medical students from the University of Zurich to experience the rewards and challenges of such interdisciplinary work in a project based learning environment. | |||||
Lernziel | The main goal of this course is to demonstrate the differences in communication between the fields of medicine and engineering. Since such differences become the most evident during actual collaborative work, the course is based on a current project in physiology research that combines medicine and engineering. For the engineering students, the specific aims of the course are to: - Acquire a working understanding of the anatomy and physiology of the investigated system; - Identify the engineering challenges in the project and communicate them to the medical students; - Develop and implement, together with the medical students, solution strategies for the identified challenges; - Present the found solutions to a cross-disciplinary audience. | |||||
Inhalt | After a general introduction to interdisciplinary communication and detailed background on the collaborative project, the engineering students will receive tailored lectures on the anatomy and physiology of the relevant system. They will then team up with medical students who have received a basic introduction to engineering methodology to collaborate on said project. In the process, they will be coached both by lecturers from ETH Zurich and the University of Zurich, receiving lectures customized to the project. The course will end with each team presenting their solution to a cross-disciplinary audience. | |||||
Skript | Handouts and relevant literature will be provided. | |||||
227-1033-00L | Neuromorphic Engineering I | W | 6 KP | 2V + 3U | T. Delbrück, G. Indiveri, S.‑C. Liu | |
Kurzbeschreibung | This course covers analog circuits with emphasis on neuromorphic engineering: MOS transistors in CMOS technology, static circuits, dynamic circuits, systems (silicon neuron, silicon retina, motion circuits) and an introduction to multi-chip systems. The lectures are accompanied by weekly laboratory sessions. | |||||
Lernziel | Understanding of the characteristics of neuromorphic circuit elements and their interaction in parallel networks. | |||||
Inhalt | Neuromorphic circuits are inspired by the structure, function and plasticity of biological neurons and neural networks. Their computational primitives are based on physics of semiconductor devices. Neuromorphic architectures often rely on collective computation in parallel networks. Adaptation, learning and memory are implemented locally within the individual computational elements. Transistors are often operated in weak inversion (below threshold), where they exhibit exponential I-V characteristics and low currents. These properties lead to the feasibility of high-density, low-power implementations of functions that are computationally intensive in other paradigms. The high parallelism and connectivity of neuromorphic circuits permit structures with massive feedback without iterative methods and convergence problems and real-time processing networks for high-dimensional signals (e.g. vision). Application domains of neuromorphic circuits include silcon retinas and cochleas, real-time emulations of networks of biological neurons, and the development of autonomous robotic systems. This course covers devices in CMOS technology (MOS transistor below and above threshold, floating-gate MOS transistor, phototransducers), static circuits (differential pair, current mirror, transconductance amplifiers, multipliers, power-law circuits, resistive networks, etc.), dynamic circuits (linear and nonlinear filters, adaptive circuits), systems (silicon neuron, silicon retina, motion circuits) and an introduction to multi-chip systems. The lectures are accompanied by weekly laboratory sessions on the characterization of neuromorphic circuits, from elementary devices to systems. | |||||
Literatur | S.-C. Liu et al.: Analog VLSI Circuits and Principles; various publications. | |||||
Voraussetzungen / Besonderes | Particular: The course is highly recommended for those who intend to take the spring semester course 'Neuromorphic Engineering II', that teaches the conception and layout of such circuits with a set of inexpensive software tools, ending with an optional submission of a mini-project for CMOS fabrication. Prerequisites: Background in basics of semiconductor physics helpful, but not required. | |||||
227-2037-00L | Physical Modelling and Simulation | W | 5 KP | 4G | C. Hafner, J. Smajic | |
Kurzbeschreibung | Physical modelling plays an important role in the analysis and design of new structures, especially for micro and nano devices where fabrication and measurement are difficult. After the fundamentals of electromagnetics, mechanics, and thermodynamics, an introduction to the main concepts and most widely used codes for physical modelling is given and commercial codes are applied. | |||||
Lernziel | Basic knowledge of the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics. Knowledge of the main concepts of numerical methods for physical modelling and simulation. Ability 1) to select appropriate software, 2) to apply it for solving given problems, 3) to validate the results, 4) to interactively improve the models until sufficiently accurate results are obtained. | |||||
Inhalt | Since the fabrication and characterization of micro- and nanostructures is difficult, expensive, and time-consuming, numerical modelling drastically reduced the design process. Although many commercial software packages are available, it is important to know the drawbacks and difficulties of the numerical methods behind them and to be able to validate the results obtained with such packages. First, an introduction to the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics is given. This is important for understanding the problems to be analyzed and for validating results obtained from software packages. After this, the main concepts of numerical methods and of the most widely used codes for physical modelling are outlined and compared, which is essential for the adequate selection of software for solving given problems. After this, prominent commercial software packages are applied to various types of problems, ranging from electrodynamics to multiphysics. For becoming able to select appropriate software and to validate the results obtained, different commercial software packages will be used and compared during the exercises in form of small projects. | |||||
151-0255-00L | Energy Conversion and Transport in Biosystems Findet dieses Semester nicht statt. | W | 4 KP | 2V + 1U | D. Poulikakos, A. Ferrari | |
Kurzbeschreibung | Grundlagen und Anwendungen von Thermodynamik, Energieumwandlung und Fluiddynamik in Biosystemen und Biomedizin auf Makro- und Zellebene. | |||||
Lernziel | Grundlagen und Anwendungen von Thermodynamik (Wärmeübertragung) Energieumwandlung und Fluiddynamik in Biosystemen und Biomedizin. Diese Grundlagen werden auf der Makro- als auch der Mikroebene (Zellebene) untersucht. Die Vorlesung vermittelt das für die Analysierung solcher Probleme nötige Wissen. | |||||
Inhalt | Modellierung von Wärmeübergang und Stofftransport (thermische Energie, chemisch gebundene Energie) im menschlichen Körper. Physiologie, Pathologie und biomedizinische Eingriffe mittels extremer Temperaturen (medizinische Radiofrequenztherapie, Einfrieren von Gewebe und Tieftemperaturbehandlungen) . Einführung in die wichtigsten Flüssigkeitssysteme des menschlichen Körpers (Herz-Kreislauf, Hirn-Rückenmarksflüssigkeit usw.). Beschreibung der Funktionalität dieser Systeme mittels analytischer, experimenteller und numerischer Methoden, um ihre Eigenheiten zu erfassen. Einführung in biomedizinische Methoden zur Behandlung von Erkrankungen dieser Flüssigkeitssysteme. Einführung in den Zellstoffwechsel, Energietransport in Zellen und Zell-Thermodynamik. | |||||
Skript | Skript und weitere Literatur wird verteilt. | |||||
Literatur | Im Skript gegeben. | |||||
252-0523-00L | Computational Biology | W | 6 KP | 3V + 2U | G. H. Gonnet | |
Kurzbeschreibung | Study of computational techniques, algorithms and data structures used to solve problems in computational biology. Topics: basic biology, string alignment, phylogeny (distance, character, parsimony), molecular evolution, multiple sequence alignment, probabilistic and statistical models, Markov models, microarrays, dynamic programming, maximum likelihood and specialized DNA and protein analysis. | |||||
Lernziel | Familiarize the students with the basic concepts of molecular biology and the models and algorithms used to understand, classify and predict behaviour of living organism. This course is at the most basic level, where the main issues, mostly of molecular sequences, are studied. | |||||
Inhalt | This course lies in the intersection between Computer Science and Molecular Biology. The main purpose is to study computational techniques, algorithms and data structures which are usually applied to solve problems in Molecular Biology and Biochemistry. The following topics are likely to be covered: Introduction, mathematical models of evolution, protein and DNA sequence alignment and its meaning, phylogenetic tree construction, multiple sequence alignments, secondary structure prediction, molecular dynamics, threading, role of bioinformatics in drug design, etc. From the computer science point of view we concentrate our attention in practical solutions for the above problems. Biological knowledge is an asset but not a prerequisite. | |||||
376-1219-00L | Rehabilitation Engineering II: Rehabilitation of Sensory and Vegetative Functions | W | 3 KP | 2V | R. Riener, R. Gassert | |
Kurzbeschreibung | Rehab. Engineering is the application of science and technology to ameliorate the handicaps of individuals with disabilities to reintegrate them into society.The goal is to present classical and new rehabilitation engineering principles applied to compensate or enhance motor, sensory, and cognitive deficits. Focus is on the restoration and treatment of the human sensory and vegetative system. | |||||
Lernziel | Provide knowledge on the anatomy and physiology of the human sensory system, related dysfunctions and pathologies, and how rehabilitation engineering can provide sensory restoration and substitution. | |||||
Inhalt | Introduction, problem definition, overview Rehabilitation of visual function - Anatomy and physiology of the visual sense - Technical aids (glasses, sensor substitution) - Retina and cortex implants Rehabilitation of hearing function - Anatomy and physiology of the auditory sense - Hearing aids - Cochlea Implants Rehabilitation and use of kinesthetic and tactile function - Anatomy and physiology of the kinesthetic and tactile sense - Tactile/haptic displays for motion therapy (incl. electrical stimulation) - Role of displays in motor learning Rehabilitation of vestibular function - Anatomy and physiology of the vestibular sense - Rehabilitation strategies and devices (e.g. BrainPort) Rehabilitation of vegetative Functions - Cardiac Pacemaker - Phrenic stimulation, artificial breathing aids - Bladder stimulation, artificial sphincter Brain stimulation and recording - Deep brain stimulation for patients with Parkinson, epilepsy, depression - Brain-Computer Interfaces | |||||
Literatur | Introductory Books: An Introduction to Rehabilitation Engineering. R. A. Cooper, H. Ohnabe, D. A. Hobson (Eds.). Taylor & Francis, 2007. Principles of Neural Science. E. R. Kandel, J. H. Schwartz, T. M Jessell (Eds.). Mc Graw Hill, New York, 2000. Force and Touch Feedback for Virtual Reality. G. C. Burdea (Ed.). Wiley, New York, 1996 (available on NEBIS). Human Haptic Perception, Basics and Applications. M. Grunwald (Ed.). Birkhäuser, Basel, 2008. The Sense of Touch and Its Rendering, Springer Tracts in Advanced Robotics 45, A. Bicchi et al.(Eds). Springer-Verlag Berlin, 2008. Interaktive und autonome Systeme der Medizintechnik - Funktionswiederherstellung und Organersatz. Herausgeber: J. Werner, Oldenbourg Wissenschaftsverlag 2005. Neural prostheses - replacing motor function after desease or disability. Eds.: R. Stein, H. Peckham, D. Popovic. New York and Oxford: Oxford University Press. Advances in Rehabilitation Robotics - Human-Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Eds: Z.Z. Bien, D. Stefanov (Lecture Notes in Control and Information Science, No. 306). Springer Verlag Berlin 2004. Intelligent Systems and Technologies in Rehabilitation Engineering. Eds: H.N.L. Teodorescu, L.C. Jain (International Series on Computational Intelligence). CRC Press Boca Raton, 2001. Selected Journal Articles and Web Links: Abbas, J., Riener, R. (2001) Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function. Neuromodulation 4, pp. 187-195. Bach-y-Rita P., Tyler M., and Kaczmarek K (2003). Seeing with the brain. International journal of human-computer-interaction, 15(2):285-295. Burdea, G., Popescu, V., Hentz, V., and Colbert, K. (2000): Virtual reality-based orthopedic telerehabilitation, IEEE Trans. Rehab. Eng., 8, pp. 430-432 Colombo, G., Jörg, M., Schreier, R., Dietz, V. (2000) Treadmill training of paraplegic patients using a robotic orthosis. Journal of Rehabilitation Research and Development, vol. 37, pp. 693-700. Hayward, V. (2008): A Brief Taxonomy of Tactile Illusions and Demonstrations That Can Be Done In a Hardware Store. Brain Research Bulletin, Vol 75, No 6, pp 742-752 Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T. (1998): Robot-aided neurorehabilitation, IEEE Trans. Rehab. Eng., 6, pp. 75-87 Levesque. V. (2005). Blindness, technology and haptics. Technical report, McGill University. Available at: Link Quintern, J. (1998) Application of functional electrical stimulation in paraplegic patients. NeuroRehabilitation 10, pp. 205-250. Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10. Riener, R. (1999) Model-based development of neuroprostheses for paraplegic patients. Royal Philosophical Transactions: Biological Sciences 354, pp. 877-894. The vOICe. Link. VideoTact, ForeThought Development, LLC. Link | |||||
Voraussetzungen / Besonderes | Target Group: Students of higher semesters and PhD students of - D-MAVT, D-ITET, D-INFK, D-HEST - Biomedical Engineering, Robotics, Systems and Control - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome | |||||
376-1351-00L | Micro/Nanotechnology and Microfluidics for Biomedical Applications | W | 2 KP | 2V | E. Delamarche | |
Kurzbeschreibung | This course is an introduction to techniques in micro/nanotechnology and to microfluidics. It reviews how many familiar devices are built and can be used for research and biomedical applications. Transistors for DNA sequencing, beamers for patterning proteins, hard-disk technology for biosensing and scanning microfluidics for analyzing tissue sections are just a few examples of the covered topics. | |||||
Lernziel | The main objective of the course is to introduce micro/nanotechnology and microfluidics to students having a background in the life sciences. The course should familiarize the students with the techniques used in micro/nanotechnology and show them how micro/nanotechnology pervades throughout life sciences. Microfluidics will be emphasized due to their increasing importance in research and medical applications. The second objective is to have life students less intimidated by micro/nanotechnology and make them able to link instruments and techniques to specific problems that they might have in their projects/studies. This will also help students getting access to the ETHZ/IBM Nanotech Center infrastructure if needed. | |||||
Inhalt | Mostly formal lectures (2 × 45 min), with a 2 hour visit and introduction to cleanroom and micro/nanotechnology instruments, last 3 sessions would be dedicated to the presentation and evaluation of projects by students (3 students per team). | |||||
Voraussetzungen / Besonderes | Nanotech center and lab visit at IBM would be mandatory, as well as attending the student project presentations. | |||||
529-0837-00L | Biomicrofluidic Engineering | W | 7 KP | 3G | A. de Mello | |
Kurzbeschreibung | Microfluidics describes the behaviour, control and manipulation of fluids that are geometrically constrained within sub-microliter environments. The use of microfluidic devices offers an opportunity to control physical and chemical processes with unrivalled precision, and in turn provides a route to performing chemistry and biology in an ultra-fast and high-efficiency manner. | |||||
Lernziel | In the course students will investigate the theoretical concepts behind microfluidic device operation, the methods of microfluidic device manufacture and the application of microfluidic architectures to important problems faced in modern day chemical and biological analysis. A design workshop will allow students to develop new microscale flow processes by appreciating the dominant physics at the microscale. The application of these basic ideas will primarily focus on biological problems and will include a treatment of diagnostic devices for use at the point-of-care, advanced functional material synthesis, DNA analysis, proteomics and cell-based assays. Lectures, assignments and the design workshop will acquaint students with the state-of-the-art in applied microfluidics. | |||||
Inhalt | Specific topics in the course include, but not limited to: 1. Theoretical Concepts Features of mass and thermal transport on the microscale Key scaling laws 2. Microfluidic Device Manufacture Conventional lithographic processing of rigid materials Soft lithographic processing of plastics and polymers Mass fabrication of polymeric devices 3. Unit operations and functional components Analytical separations (electrophoresis and chromatography) Chemical and biological synthesis Sample pre-treatment (filtration, SPE, pre-concentration) Molecular detection 4. Design Workshop Design of microfluidic architectures for PCR, distillation & mixing 5. Contemporary Applications in Biological Analysis Microarrays Cellular analyses (single cells, enzymatic assays, cell sorting) Proteomics 6. System integration Applications in radiochemistry, diagnostics and high-throughput experimentation | |||||
Skript | Lecture handouts will be provided | |||||
Voraussetzungen / Besonderes | Die Vorlesung wird für Studierende aus Basel (BSSE) aufgezeichnet, genaue Angaben wann und wo wird später bekannt gegeben. | |||||
636-0003-00L | Biological Engineering and Biotechnology | W | 6 KP | 3G | M. Fussenegger | |
Kurzbeschreibung | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||
Lernziel | 1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development. | |||||
Skript | Handsout during the course. | |||||
Biologiefächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0945-00L | Cell and Molecular Biology for Engineers | W | 6 KP | 4G | C. Frei | |
Kurzbeschreibung | The course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology. | |||||
Lernziel | After completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested. | |||||
Inhalt | Lectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells. In addition, three journal clubs will be held, where one/two publictions will be discussed. For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded, and count as 25% for the final grade. | |||||
Skript | Scripts of all lectures will be available. | |||||
Literatur | "Molecular Biology of the Cell" (5th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter. | |||||
Bioimaging | ||||||
Kernfächer der Vertiefung Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0385-00L | Biomedical Imaging | W | 4 KP | 3G | S. Kozerke, U. Moser, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | Understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. | |||||
Inhalt | X-ray imaging Computed tomography Single photon emission tomography Positron emission tomography Magnetic resonance imaging Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts: Biomedical Imaging | |||||
Literatur | Introduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith, Cambridge University Press | |||||
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | G. Székely, O. Göksel, L. Van Gool | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, K. S. Mader | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
Wahlfächer der Vertiefung Diese Fächer sind für die Vertiefung in Bioimaging besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0389-00L | Advanced Topics in Magnetic Resonance Imaging | Z | 0 KP | 1V | K. P. Prüssmann | |
Kurzbeschreibung | Diese Vorlesung richtet sich an Masterstudierende und Doktorierende mit vertieftem Interesse an biomedizinischer Bildgebung. Sie behandelt fortgeschrittene Aspekte der Magnetresonanzbildgebung in zweijährigem Turnus, darunter die Elektrodynamik der Signaldetektion und des Signalrauschens, Bildrekonsntruktion, Radiofrequenzpulse, Pulsschemata, sowie fortgeschrittene Kontrastmechanismen. | |||||
Lernziel | siehe oben | |||||
227-0391-00L | Medical Image Analysis | W | 3 KP | 2G | P. C. Cattin, M. A. Reyes Aguirre | |
Kurzbeschreibung | It is the objective of this lecture to introduce the basic concepts used in Medical Image Analysis. In particular the lecture focuses on shape representation schemes, segmentation techniques, and the various image registration methods commonly used in Medical Image Analysis applications. | |||||
Lernziel | This lecture aims to give an overview of the basic concepts of Medical Image Analysis and its application areas. | |||||
Voraussetzungen / Besonderes | Basic knowledge of computer vision would be helpful. | |||||
227-0963-00L | Statistical Parametric Mapping (SPM) | W | 2 KP | 1V | K. Stephan | |
Kurzbeschreibung | This course provides a comprehensive coverage of state-of-the-art statistical methods for fMRI data analysis, focusing on tools provided by the open source software package SPM | |||||
Lernziel | Knowledge of modern statistical methods for fMRI data analysis | |||||
Inhalt | Spatial preprocessing & physiological noise correction Voxel-based morphometry Mass-univariate & multivariate analyses of fMRI 'Resting state' fMRI Bayesian analysis methods Effective connectivity analyses (Dynamic Causal Modeling) | |||||
227-0967-00L | Computational Neuroimaging Clinic | W | 3 KP | 2V | K. Stephan | |
Kurzbeschreibung | This seminar teaches problem solving skills for the design and analysis of neuroimaging data (fMRI, EEG). It deals with a wide variety of real-life problems that are brought to this meeting from the neuroimaging community at Zurich. Examples may include mass-univariate and multivariate analyses of fMRI data, dynamic causal modeling of fMRI and EEG data. | |||||
Lernziel | 1. Consolidation of theoretical knowledge (obtained in the 'Methods & models for fMRI data analysis' lecture) in a practical setting. 2. Acquisition of practical problem solving strategies for computational modeling of neuroimaging data. | |||||
Inhalt | This seminar teaches problem solving skills for the design and analysis of neuroimaging data (fMRI, EEG). It deals with a wide variety of real-life problems that are brought to this meeting from the euroimaging community at Zurich. Examples may include mass-univariate and multivariate analyses of fMRI data, dynamic causal modeling of fMRI and EEG data, or analyses of neuroimaging data on the basis of Bayesian models of behaviour. | |||||
227-0969-00L | Methods & Models for fMRI Data Analysis | W | 3 KP | 2V | K. Stephan | |
Kurzbeschreibung | This course teaches methods and models for fMRI data analysis, covering all aspects of statistical parametric mapping (SPM), incl. preprocessing, the general linear model, statistical inference, multiple comparison corrections, event-related designs, and Dynamic Causal Modelling (DCM), a Bayesian framework for identification of nonlinear neuronal systems from neurophysiological data. | |||||
Lernziel | To obtain in-depth knowledge of the theoretical foundations of SPM and DCM and of their application to empirical fMRI data. | |||||
Inhalt | This course teaches state-of-the-art methods and models for fMRI data analysis. It covers all aspects of statistical parametric mapping (SPM), incl. preprocessing, the general linear model, frequentist and Bayesian inference, multiple comparison corrections, and event-related designs, and Dynamic Causal Modelling (DCM), a Bayesian framework for identification of nonlinear neuronal systems from neurophysiological data. A particular emphasis of the course will be on methodological questions arising in the context of neuroeconomic and clinical studies. | |||||
227-0971-00L | Computational Psychiatry | W | 3 KP | 2S | K. Stephan | |
Kurzbeschreibung | Current methods and concepts for deciphering mechanisms of maladaptive behaviour, such as aberrant learning and decision-making in healthy individuals and psychiatric patients.The key goal is to connect methodological training with biological and clinical knowledge about the phenomenology and pathophysiology of psychiatric and neurological diseases. | |||||
Lernziel | To understand current concepts about computational and physiological mechanisms of maladaptive behaviour and psychiatric diseases. | |||||
Inhalt | In this seminar, we discuss current methods and concepts for deciphering mechanisms of maladaptive behaviour, such as aberrant learning and decision-making in healthy individuals and psychiatric patients. The key goal is to connect methodological training (in computational and statistical techniques for analyzing behavioural, fMRI and EEG data) with biological and clinical knowledge about the phenomenology and pathophysiology of psychiatric and neurological diseases. This seminar aims at bridging the gap between mathematical modelers and clinical neuroscientists, enabling more effective communication and joint translational research. To this end, each semester a novel topic is chosen which is examined both from clinical/biological and modeling perspectives. | |||||
227-2037-00L | Physical Modelling and Simulation | W | 5 KP | 4G | C. Hafner, J. Smajic | |
Kurzbeschreibung | Physical modelling plays an important role in the analysis and design of new structures, especially for micro and nano devices where fabrication and measurement are difficult. After the fundamentals of electromagnetics, mechanics, and thermodynamics, an introduction to the main concepts and most widely used codes for physical modelling is given and commercial codes are applied. | |||||
Lernziel | Basic knowledge of the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics. Knowledge of the main concepts of numerical methods for physical modelling and simulation. Ability 1) to select appropriate software, 2) to apply it for solving given problems, 3) to validate the results, 4) to interactively improve the models until sufficiently accurate results are obtained. | |||||
Inhalt | Since the fabrication and characterization of micro- and nanostructures is difficult, expensive, and time-consuming, numerical modelling drastically reduced the design process. Although many commercial software packages are available, it is important to know the drawbacks and difficulties of the numerical methods behind them and to be able to validate the results obtained with such packages. First, an introduction to the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics is given. This is important for understanding the problems to be analyzed and for validating results obtained from software packages. After this, the main concepts of numerical methods and of the most widely used codes for physical modelling are outlined and compared, which is essential for the adequate selection of software for solving given problems. After this, prominent commercial software packages are applied to various types of problems, ranging from electrodynamics to multiphysics. For becoming able to select appropriate software and to validate the results obtained, different commercial software packages will be used and compared during the exercises in form of small projects. | |||||
151-0105-00L | Quantitative Flow Visualization | W | 4 KP | 2V + 1U | T. Rösgen | |
Kurzbeschreibung | The course provides an introduction to digital image analysis in modern flow diagnostics. Different techniques which are discussed include image velocimetry, laser induced fluorescence, liquid crystal thermography and interferometry. The physical foundations and measurement configurations are explained. Image analysis algorithms are presented in detail and programmed during the exercises. | |||||
Lernziel | Introduction to modern imaging techniques and post processing algorithms with special emphasis on flow analysis and visualization. Understanding of hardware and software requirements and solutions. Development of basic programming skills for (generic) imaging applications. | |||||
Inhalt | Fundamentals of optics, flow visualization and electronic image acquisition. Frequently used mage processing techniques (filtering, correlation processing, FFTs, color space transforms). Image Velocimetry (tracking, pattern matching, Doppler imaging). Surface pressure and temperature measurements (fluorescent paints, liquid crystal imaging, infrared thermography). Laser induced fluorescence. (Digital) Schlieren techniques, phase contrast imaging, interferometry, phase unwrapping. Wall shear and heat transfer measurements. Pattern recognition and feature extraction, proper orthogonal decomposition. | |||||
Skript | available | |||||
Voraussetzungen / Besonderes | Prerequisites: Fluiddynamics I, Numerical Mathematics, programming skills. Language: German on request. | |||||
376-1279-00L | Virtual Reality in Medicine Findet dieses Semester nicht statt. | W | 3 KP | 2V | R. Riener | |
Kurzbeschreibung | Virtual Reality has the potential to support medical training and therapy. This lecture will derive the technical principles of multi-modal (audiovisual, haptic, tactile etc.) input devices, displays and rendering techniques. Examples are presented in the fields of surgical training, intra-operative augmentation, and rehabilitation. The lecture is accompanied by practical courses and excursions. | |||||
Lernziel | Provide theoretical and practical knowledge of new principles and applications of multi-modal simulation and interface technologies in medical education, therapy, and rehabilitation. | |||||
Inhalt | Virtual Reality has the potential to provide descriptive and practical information for medical training and therapy while relieving the patient and/or the physician. Multi-modal interactions between the user and the virtual environment facilitate the generation of high-fidelity sensory impressions, by using not only visual and auditory modalities, but also kinesthetic, tactile, and even olfactory feedback. On the basis of the existing physiological constraints, this lecture will derive the technical requirements and principles of multi-modal input devices, displays, and rendering techniques. Several examples are presented that are currently being developed or already applied for surgical training, intra-operative augmentation, and rehabilitation. The lecture will be accompanied by several practical courses on graphical and haptic display devices as well as excursions to facilities equipped with large-scale VR equipment. Target Group: Students of higher semesters and PhD students of - D-HEST, D-MAVT, D-ITET, D-INFK, D-PHYS - Robotics, Systems and Control Master - Biomedical Engineering/Movement Science and Sport - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome! | |||||
Literatur | Book: Virtual Reality in Medicine. Riener, Robert; Harders, Matthias; 2012 Springer. | |||||
Voraussetzungen / Besonderes | The course language is English. Basic experience in Information Technology and Computer Science will be of advantage More details will be announced in the lecture. | |||||
151-0605-00L | Nanosystems | W | 4 KP | 4G | A. Stemmer | |
Kurzbeschreibung | From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. Special emphasis on the emerging field of molecular electronic devices. | |||||
Lernziel | Familiarize students with basic science and engineering principles governing the nano domain. | |||||
Inhalt | The course addresses basic science and engineering principles ruling the nano domain. We particularly work out the links between topics that are traditionally taught separately. Special emphasis is placed on the emerging field of molecular electronic devices, their working principles, applications, and how they may be assembled. Topics are treated in 2 blocks: (I) From Quantum to Continuum From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. (II) Interaction Forces on the Micro and Nano Scale Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. | |||||
Literatur | - Kuhn, Hans; Försterling, H.D.: Principles of Physical Chemistry. Understanding Molecules, Molecular Assemblies, Supramolecular Machines. 1999, Wiley, ISBN: 0-471-95902-2 - Chen, Gang: Nanoscale Energy Transport and Conversion. 2005, Oxford University Press, ISBN: 978-0-19-515942-4 - Ouisse, Thierry: Electron Transport in Nanostructures and Mesoscopic Devices. 2008, Wiley, ISBN: 978-1-84821-050-9 - Wolf, Edward L.: Nanophysics and Nanotechnology. 2004, Wiley-VCH, ISBN: 3-527-40407-4 - Israelachvili, Jacob N.: Intermolecular and Surface Forces. 2nd ed., 1992, Academic Press,ISBN: 0-12-375181-0 - Evans, D.F.; Wennerstrom, H.: The Colloidal Domain. Where Physics, Chemistry, Biology, and Technology Meet. Advances in Interfacial Engineering Series. 2nd ed., 1999, Wiley, ISBN: 0-471-24247-0 - Hunter, Robert J.: Foundations of Colloid Science. 2nd ed., 2001, Oxford, ISBN: 0-19-850502-7 | |||||
Voraussetzungen / Besonderes | Course format: Lectures: Thursday 10-12, ML F 36 Homework: Mini-Reviews Students select a paper (list distributed in class) and expand the topic into a Mini-Review that illuminates the particular field beyond the immediate results reported in the paper. | |||||
252-0543-01L | Computer Graphics | W | 6 KP | 3V + 2U | M. Gross, O. Sorkine Hornung | |
Kurzbeschreibung | This course covers some of the fundamental concepts of computer graphics. The two main parts of the class are image synthesis and geometric modeling. | |||||
Lernziel | At the end of the course students will be able to design and implement a rendering system based on raytracing. You will study the basic principles of modeling with splines and integrate spline-based representations into a rendering system. In addition we want to stimulate your curiosity to explore the field of computer graphics on your own or in future courses. | |||||
Inhalt | This course covers some of the fundamental concepts of computer graphics. The two main parts of the class are rendering and modeling. In the first part, we will discuss the basics of photorealistic image synthesis, i.e. how to generate a realistic image from a digital representation of a 3D scene. After introducing raytracing, we will briefly look at the physics of light transport, discuss the rendering equation, and investigate some advanced techniques to enhance the realism of rendered images. The second part will introduce the basics of modeling with curves and surfaces. We will discuss Bezier curves and surfaces, B-Splines and NURBS, and show how they can be used to design complex 3D geometry. | |||||
Skript | no | |||||
Voraussetzungen / Besonderes | Prerequisites: Fundamentals of calculus and linear algebra, basic concepts of algorithms and data structures, basic programming skills in C-like languages (we use JavaScript for exercises), Visual Computing core course recommended. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
227-1033-00L | Neuromorphic Engineering I | W | 6 KP | 2V + 3U | T. Delbrück, G. Indiveri, S.‑C. Liu | |
Kurzbeschreibung | This course covers analog circuits with emphasis on neuromorphic engineering: MOS transistors in CMOS technology, static circuits, dynamic circuits, systems (silicon neuron, silicon retina, motion circuits) and an introduction to multi-chip systems. The lectures are accompanied by weekly laboratory sessions. | |||||
Lernziel | Understanding of the characteristics of neuromorphic circuit elements and their interaction in parallel networks. | |||||
Inhalt | Neuromorphic circuits are inspired by the structure, function and plasticity of biological neurons and neural networks. Their computational primitives are based on physics of semiconductor devices. Neuromorphic architectures often rely on collective computation in parallel networks. Adaptation, learning and memory are implemented locally within the individual computational elements. Transistors are often operated in weak inversion (below threshold), where they exhibit exponential I-V characteristics and low currents. These properties lead to the feasibility of high-density, low-power implementations of functions that are computationally intensive in other paradigms. The high parallelism and connectivity of neuromorphic circuits permit structures with massive feedback without iterative methods and convergence problems and real-time processing networks for high-dimensional signals (e.g. vision). Application domains of neuromorphic circuits include silcon retinas and cochleas, real-time emulations of networks of biological neurons, and the development of autonomous robotic systems. This course covers devices in CMOS technology (MOS transistor below and above threshold, floating-gate MOS transistor, phototransducers), static circuits (differential pair, current mirror, transconductance amplifiers, multipliers, power-law circuits, resistive networks, etc.), dynamic circuits (linear and nonlinear filters, adaptive circuits), systems (silicon neuron, silicon retina, motion circuits) and an introduction to multi-chip systems. The lectures are accompanied by weekly laboratory sessions on the characterization of neuromorphic circuits, from elementary devices to systems. | |||||
Literatur | S.-C. Liu et al.: Analog VLSI Circuits and Principles; various publications. | |||||
Voraussetzungen / Besonderes | Particular: The course is highly recommended for those who intend to take the spring semester course 'Neuromorphic Engineering II', that teaches the conception and layout of such circuits with a set of inexpensive software tools, ending with an optional submission of a mini-project for CMOS fabrication. Prerequisites: Background in basics of semiconductor physics helpful, but not required. | |||||
227-1037-00L | Introduction to Neuroinformatics | W | 6 KP | 2V + 1U | K. A. Martin, M. Cook, V. Mante, M. Pfeiffer | |
Kurzbeschreibung | The course provides an introduction to the functional properties of neurons. Particularly the description of membrane electrical properties (action potentials, channels), neuronal anatomy, synaptic structures, and neuronal networks. Simple models of computation, learning, and behavior will be explained. Some artificial systems (robot, chip) are presented. | |||||
Lernziel | ||||||
Inhalt | This course considers the structure and function of biological neural networks at different levels. The function of neural networks lies fundamentally in their wiring and in the electro-chemical properties of nerve cell membranes. Thus, the biological structure of the nerve cell needs to be understood if biologically-realistic models are to be constructed. These simpler models are used to estimate the electrical current flow through dendritic cables and explore how a more complex geometry of neurons influences this current flow. The active properties of nerves are studied to understand both sensory transduction and the generation and transmission of nerve impulses along axons. The concept of local neuronal circuits arises in the context of the rules governing the formation of nerve connections and topographic projections within the nervous system. Communication between neurons in the network can be thought of as information flow across synapses, which can be modified by experience. We need an understanding of the action of inhibitory and excitatory neurotransmitters and neuromodulators, so that the dynamics and logic of synapses can be interpreted. Finally, the neural architectures of feedforward and recurrent networks will be discussed in the context of co-ordination, control, and integration of sensory and motor information in neural networks. | |||||
465-0953-00L | Biostatistik | W | 2 KP | 2V + 1U | B. Sick | |
Kurzbeschreibung | Der Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Varianzanalyse, logistische Regression, Survivalanalyse (Kaplan-Meier Kurven und Cox-Regression). | |||||
Lernziel | ||||||
551-1295-00L | Introduction to Bioinformatics: Concepts and Applications | W | 6 KP | 4G | W. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner | |
Kurzbeschreibung | Speicherung, Verarbeitung und Analyse grosser Datenmengen sind in vielen Forschungsbereichen der modernen Biologie essentiell geworden. Die Vorlesung gibt eine grundlegende Einführung in Anwendungsbereiche von Bioinformatik in der Biologie und stellt einige leicht zugängliche Programme und Datenbanken für den Anwender in Theorie und Praxis vor. | |||||
Lernziel | Introduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks. In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science. Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester. | |||||
Inhalt | Bioinformatics I will cover the following topics: From genes to databases and information BLAST searches Prediction of gene function and regulation RNA structure prediction Gene expression analysis using microarrays Protein sequence and structure databases WWW for bioinformatics Protein sequence comparisons Proteomics and de novo protein sequencing Protein structure prediction Cellular and protein interaction networks Molecular dynamics simulation | |||||
Biologiefächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0945-00L | Cell and Molecular Biology for Engineers | O | 6 KP | 4G | C. Frei | |
Kurzbeschreibung | The course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology. | |||||
Lernziel | After completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested. | |||||
Inhalt | Lectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells. In addition, three journal clubs will be held, where one/two publictions will be discussed. For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded, and count as 25% for the final grade. | |||||
Skript | Scripts of all lectures will be available. | |||||
Literatur | "Molecular Biology of the Cell" (5th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter. | |||||
Biomechanics | ||||||
Kernfächer der Vertiefung Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0385-00L | Biomedical Imaging | W | 4 KP | 3G | S. Kozerke, U. Moser, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | Understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. | |||||
Inhalt | X-ray imaging Computed tomography Single photon emission tomography Positron emission tomography Magnetic resonance imaging Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts: Biomedical Imaging | |||||
Literatur | Introduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith, Cambridge University Press | |||||
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | G. Székely, O. Göksel, L. Van Gool | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, K. S. Mader | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
376-1651-00L | Clinical and Movement Biomechanics | W | 4 KP | 3G | S. Lorenzetti, R. List, N. Singh | |
Kurzbeschreibung | Measurement and modeling of the human movement during daily activities and in a clinical environment. | |||||
Lernziel | The students are able to analyse the human movement from a technical point of view, to process the data and perform modeling with a focus towards clinical application. | |||||
Inhalt | This course includes ethical considerations, measurement techniques, clinical testing, accessing movement data and anysis as well as modeling with regards to human movement. | |||||
376-1985-00L | Trauma-Biomechanik | W | 4 KP | 2V + 1U | K.‑U. Schmitt, M. H. Muser | |
Kurzbeschreibung | Trauma-Biomechanik ist ein interdiszipliäres Fach, das sich mit der Biomechanik von Verletzungen sowie Möglichkeiten zur Prävention von Verletzungen beschäftigt. Die Vorlesung stellt die Grundlagen der Trauma-Biomechanik dar. | |||||
Lernziel | Vermittlung von Grundlagen der Trauma-Biomechanik. | |||||
Inhalt | Die Vorlesung beschäftigt sich mit Verletzungen des menschlichen Körpers und den zugrunde liegenden Verletzungsmechanismen. Hierbei bilden Verletzungen, die im Strassenverkehr erlitten werden, den Schwerpunkt. Weitere Vorlesungsthemen sind: Crash-Tests und die dazugehörige Messtechnik (z. B. Dummys), sowie aktuelle Themen der Trauma-Biomechanik wie z.B. Fussgänger-Kollisionen, Kinderrückhaltesysteme und Fahrzeugsitze. | |||||
Skript | Unterlagen können via Homepage bezogen werden. | |||||
Literatur | Schmitt K-U, Niederer P, M. Muser, Walz F: "Trauma Biomechanics - An Introduction to Injury Biomechanics" bzw. "Trauma-Biomechanik - Einführung in die Biomechanik von Verletzungen", beide Springer Verlag. | |||||
Wahlfächer der Vertiefung Diese Fächer sind für die Vertiefung in Biomechanics besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
151-0255-00L | Energy Conversion and Transport in Biosystems Findet dieses Semester nicht statt. | W | 4 KP | 2V + 1U | D. Poulikakos, A. Ferrari | |
Kurzbeschreibung | Grundlagen und Anwendungen von Thermodynamik, Energieumwandlung und Fluiddynamik in Biosystemen und Biomedizin auf Makro- und Zellebene. | |||||
Lernziel | Grundlagen und Anwendungen von Thermodynamik (Wärmeübertragung) Energieumwandlung und Fluiddynamik in Biosystemen und Biomedizin. Diese Grundlagen werden auf der Makro- als auch der Mikroebene (Zellebene) untersucht. Die Vorlesung vermittelt das für die Analysierung solcher Probleme nötige Wissen. | |||||
Inhalt | Modellierung von Wärmeübergang und Stofftransport (thermische Energie, chemisch gebundene Energie) im menschlichen Körper. Physiologie, Pathologie und biomedizinische Eingriffe mittels extremer Temperaturen (medizinische Radiofrequenztherapie, Einfrieren von Gewebe und Tieftemperaturbehandlungen) . Einführung in die wichtigsten Flüssigkeitssysteme des menschlichen Körpers (Herz-Kreislauf, Hirn-Rückenmarksflüssigkeit usw.). Beschreibung der Funktionalität dieser Systeme mittels analytischer, experimenteller und numerischer Methoden, um ihre Eigenheiten zu erfassen. Einführung in biomedizinische Methoden zur Behandlung von Erkrankungen dieser Flüssigkeitssysteme. Einführung in den Zellstoffwechsel, Energietransport in Zellen und Zell-Thermodynamik. | |||||
Skript | Skript und weitere Literatur wird verteilt. | |||||
Literatur | Im Skript gegeben. | |||||
151-0511-00L | Mechanics of Nano- and Micro-Materials | W | 4 KP | 2V + 1U | C. Daraio | |
Kurzbeschreibung | The course provides an introduction to the mechanics of nano- and micro-materials and devices, in the quasistatic and dynamic domains. It reviews scale effects in materials, surveys available characterization techniques and describes the effects of surfaces and microscale contacts. Recent applications of nano- and micro-materials in engineering systems will be discussed. | |||||
Lernziel | Learn the fundamental mechanical properties of nano- and micro-system. Understand the effects of scales on the response of materials. Explore applications and devices exploiting the response of materials at small scales. | |||||
Inhalt | follows soon | |||||
Skript | Slides and notes from the course will be provided. | |||||
Literatur | Relevant articles and reading materials will be provided. Various books will be recommended pertaining to the topics covered. | |||||
Voraussetzungen / Besonderes | Mechanics I, II, III | |||||
151-0524-00L | Continuum Mechanics for Engineers | W | 4 KP | 2V + 1U | E. Mazza | |
Kurzbeschreibung | Konstitutive Gleichungen für strukturmechanische Berechnungen werden behandelt. Dies beinhaltet anisotrope lineare Elastizität, lineare Viskoelastizität, Plastizität und Viscoplastizität. Es werden die Grundlagen der Mikro-Makro Modellierung und der Laminattheorie eingeführt. Die theoretischen Ausführungen werden durch Beispiele aus Ingenieuranwendungen und Experimente ergänzt. | |||||
Lernziel | Behandlung von Grundlagen zur Lösung kontinuumsmechanischer Probleme der Anwendung, mit besonderem Fokus auf konstitutive Gesetze. | |||||
Inhalt | Anisotrope Elastizität, Linearelastisches und linearviskoses Stoffverhalten, Viskoelastizität, mikro-makro Modellierung, Laminattheorie, Plastizität, Viscoplastizität, Beispiele aus der Ingenieuranwendung, Vergleich mit Experimenten. | |||||
Skript | ja | |||||
151-0604-00L | Microrobotics | W | 4 KP | 3G | B. Nelson | |
Kurzbeschreibung | Microrobotics is an interdisciplinary field that combines aspects of robotics, micro and nanotechnology, biomedical engineering, and materials science. The aim of this course is to expose students to the fundamentals of this emerging field. Throughout the course students are expected to submit assignments. The course concludes with an end-of-semester examination. | |||||
Lernziel | The objective of this course is to expose students to the fundamental aspects of the emerging field of microrobotics. This includes a focus on physical laws that predominate at the microscale, technologies for fabricating small devices, bio-inspired design, and applications of the field. | |||||
Inhalt | Main topics of the course include: - Scaling laws at micro/nano scales - Electrostatics - Electromagnetism - Low Reynolds number flows - Observation tools - Materials and fabrication methods - Applications of biomedical microrobots | |||||
Skript | The powerpoint slides presented in the lectures will be made available in hardcopy and as pdf files. Several readings will also be made available electronically. | |||||
Voraussetzungen / Besonderes | The lecture will be taught in English. | |||||
151-0605-00L | Nanosystems | W | 4 KP | 4G | A. Stemmer | |
Kurzbeschreibung | From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. Special emphasis on the emerging field of molecular electronic devices. | |||||
Lernziel | Familiarize students with basic science and engineering principles governing the nano domain. | |||||
Inhalt | The course addresses basic science and engineering principles ruling the nano domain. We particularly work out the links between topics that are traditionally taught separately. Special emphasis is placed on the emerging field of molecular electronic devices, their working principles, applications, and how they may be assembled. Topics are treated in 2 blocks: (I) From Quantum to Continuum From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. (II) Interaction Forces on the Micro and Nano Scale Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. | |||||
Literatur | - Kuhn, Hans; Försterling, H.D.: Principles of Physical Chemistry. Understanding Molecules, Molecular Assemblies, Supramolecular Machines. 1999, Wiley, ISBN: 0-471-95902-2 - Chen, Gang: Nanoscale Energy Transport and Conversion. 2005, Oxford University Press, ISBN: 978-0-19-515942-4 - Ouisse, Thierry: Electron Transport in Nanostructures and Mesoscopic Devices. 2008, Wiley, ISBN: 978-1-84821-050-9 - Wolf, Edward L.: Nanophysics and Nanotechnology. 2004, Wiley-VCH, ISBN: 3-527-40407-4 - Israelachvili, Jacob N.: Intermolecular and Surface Forces. 2nd ed., 1992, Academic Press,ISBN: 0-12-375181-0 - Evans, D.F.; Wennerstrom, H.: The Colloidal Domain. Where Physics, Chemistry, Biology, and Technology Meet. Advances in Interfacial Engineering Series. 2nd ed., 1999, Wiley, ISBN: 0-471-24247-0 - Hunter, Robert J.: Foundations of Colloid Science. 2nd ed., 2001, Oxford, ISBN: 0-19-850502-7 | |||||
Voraussetzungen / Besonderes | Course format: Lectures: Thursday 10-12, ML F 36 Homework: Mini-Reviews Students select a paper (list distributed in class) and expand the topic into a Mini-Review that illuminates the particular field beyond the immediate results reported in the paper. | |||||
227-2037-00L | Physical Modelling and Simulation | W | 5 KP | 4G | C. Hafner, J. Smajic | |
Kurzbeschreibung | Physical modelling plays an important role in the analysis and design of new structures, especially for micro and nano devices where fabrication and measurement are difficult. After the fundamentals of electromagnetics, mechanics, and thermodynamics, an introduction to the main concepts and most widely used codes for physical modelling is given and commercial codes are applied. | |||||
Lernziel | Basic knowledge of the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics. Knowledge of the main concepts of numerical methods for physical modelling and simulation. Ability 1) to select appropriate software, 2) to apply it for solving given problems, 3) to validate the results, 4) to interactively improve the models until sufficiently accurate results are obtained. | |||||
Inhalt | Since the fabrication and characterization of micro- and nanostructures is difficult, expensive, and time-consuming, numerical modelling drastically reduced the design process. Although many commercial software packages are available, it is important to know the drawbacks and difficulties of the numerical methods behind them and to be able to validate the results obtained with such packages. First, an introduction to the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics is given. This is important for understanding the problems to be analyzed and for validating results obtained from software packages. After this, the main concepts of numerical methods and of the most widely used codes for physical modelling are outlined and compared, which is essential for the adequate selection of software for solving given problems. After this, prominent commercial software packages are applied to various types of problems, ranging from electrodynamics to multiphysics. For becoming able to select appropriate software and to validate the results obtained, different commercial software packages will be used and compared during the exercises in form of small projects. | |||||
263-5001-00L | Introduction to Finite Elements and Sparse Linear System Solving | W | 4 KP | 2V + 1U | P. Arbenz, T. Kaman | |
Kurzbeschreibung | The finite element (FE) method is the method of choice for (approximately) solving partial differential equations on complicated domains. In the first third of the lecture, we give an introduction to the method. The rest of the lecture will be devoted to methods for solving the large sparse linear systems of equation that a typical for the FE method. We will consider direct and iterative methods. | |||||
Lernziel | Students will know the most important direct and iterative solvers for sparse linear systems. They will be able to determine which solver to choose in particular situations. | |||||
Inhalt | I. THE FINITE ELEMENT METHOD (1) Introduction, model problems. (2) 1D problems. Piecewise polynomials in 1D. (3) 2D problems. Triangulations. Piecewise polynomials in 2D. (4) Variational formulations. Galerkin finite element method. (5) Implementation aspects. II. DIRECT SOLUTION METHODS (6) LU and Cholesky decomposition. (7) Sparse matrices. (8) Fill-reducing orderings. III. ITERATIVE SOLUTION METHODS (9) Stationary iterative methods, preconditioning. (10) Preconditioned conjugate gradient method (PCG). (11) Incomplete factorization preconditioning. (12) Multigrid preconditioning. (13) Nonsymmetric problems (GMRES, BiCGstab). (14) Indefinite problems (SYMMLQ, MINRES). | |||||
Literatur | [1] M. G. Larson, F. Bengzon: The Finite Element Method: Theory, Implementation, and Applications. Springer, Heidelberg, 2013. [2] H. Elman, D. Sylvester, A. Wathen: Finite elements and fast iterative solvers. OUP, Oxford, 2005. [3] Y. Saad: Iterative methods for sparse linear systems (2nd ed.). SIAM, Philadelphia, 2003. [4] T. Davis: Direct Methods for Sparse Linear Systems. SIAM, Philadelphia, 2006. [5] H.R. Schwarz: Die Methode der finiten Elemente (3rd ed.). Teubner, Stuttgart, 1991. | |||||
Voraussetzungen / Besonderes | Prerequisites: Linear Algebra, Analysis, Computational Science. The exercises are made with Matlab. | |||||
376-1219-00L | Rehabilitation Engineering II: Rehabilitation of Sensory and Vegetative Functions | W | 3 KP | 2V | R. Riener, R. Gassert | |
Kurzbeschreibung | Rehab. Engineering is the application of science and technology to ameliorate the handicaps of individuals with disabilities to reintegrate them into society.The goal is to present classical and new rehabilitation engineering principles applied to compensate or enhance motor, sensory, and cognitive deficits. Focus is on the restoration and treatment of the human sensory and vegetative system. | |||||
Lernziel | Provide knowledge on the anatomy and physiology of the human sensory system, related dysfunctions and pathologies, and how rehabilitation engineering can provide sensory restoration and substitution. | |||||
Inhalt | Introduction, problem definition, overview Rehabilitation of visual function - Anatomy and physiology of the visual sense - Technical aids (glasses, sensor substitution) - Retina and cortex implants Rehabilitation of hearing function - Anatomy and physiology of the auditory sense - Hearing aids - Cochlea Implants Rehabilitation and use of kinesthetic and tactile function - Anatomy and physiology of the kinesthetic and tactile sense - Tactile/haptic displays for motion therapy (incl. electrical stimulation) - Role of displays in motor learning Rehabilitation of vestibular function - Anatomy and physiology of the vestibular sense - Rehabilitation strategies and devices (e.g. BrainPort) Rehabilitation of vegetative Functions - Cardiac Pacemaker - Phrenic stimulation, artificial breathing aids - Bladder stimulation, artificial sphincter Brain stimulation and recording - Deep brain stimulation for patients with Parkinson, epilepsy, depression - Brain-Computer Interfaces | |||||
Literatur | Introductory Books: An Introduction to Rehabilitation Engineering. R. A. Cooper, H. Ohnabe, D. A. Hobson (Eds.). Taylor & Francis, 2007. Principles of Neural Science. E. R. Kandel, J. H. Schwartz, T. M Jessell (Eds.). Mc Graw Hill, New York, 2000. Force and Touch Feedback for Virtual Reality. G. C. Burdea (Ed.). Wiley, New York, 1996 (available on NEBIS). Human Haptic Perception, Basics and Applications. M. Grunwald (Ed.). Birkhäuser, Basel, 2008. The Sense of Touch and Its Rendering, Springer Tracts in Advanced Robotics 45, A. Bicchi et al.(Eds). Springer-Verlag Berlin, 2008. Interaktive und autonome Systeme der Medizintechnik - Funktionswiederherstellung und Organersatz. Herausgeber: J. Werner, Oldenbourg Wissenschaftsverlag 2005. Neural prostheses - replacing motor function after desease or disability. Eds.: R. Stein, H. Peckham, D. Popovic. New York and Oxford: Oxford University Press. Advances in Rehabilitation Robotics - Human-Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Eds: Z.Z. Bien, D. Stefanov (Lecture Notes in Control and Information Science, No. 306). Springer Verlag Berlin 2004. Intelligent Systems and Technologies in Rehabilitation Engineering. Eds: H.N.L. Teodorescu, L.C. Jain (International Series on Computational Intelligence). CRC Press Boca Raton, 2001. Selected Journal Articles and Web Links: Abbas, J., Riener, R. (2001) Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function. Neuromodulation 4, pp. 187-195. Bach-y-Rita P., Tyler M., and Kaczmarek K (2003). Seeing with the brain. International journal of human-computer-interaction, 15(2):285-295. Burdea, G., Popescu, V., Hentz, V., and Colbert, K. (2000): Virtual reality-based orthopedic telerehabilitation, IEEE Trans. Rehab. Eng., 8, pp. 430-432 Colombo, G., Jörg, M., Schreier, R., Dietz, V. (2000) Treadmill training of paraplegic patients using a robotic orthosis. Journal of Rehabilitation Research and Development, vol. 37, pp. 693-700. Hayward, V. (2008): A Brief Taxonomy of Tactile Illusions and Demonstrations That Can Be Done In a Hardware Store. Brain Research Bulletin, Vol 75, No 6, pp 742-752 Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T. (1998): Robot-aided neurorehabilitation, IEEE Trans. Rehab. Eng., 6, pp. 75-87 Levesque. V. (2005). Blindness, technology and haptics. Technical report, McGill University. Available at: Link Quintern, J. (1998) Application of functional electrical stimulation in paraplegic patients. NeuroRehabilitation 10, pp. 205-250. Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10. Riener, R. (1999) Model-based development of neuroprostheses for paraplegic patients. Royal Philosophical Transactions: Biological Sciences 354, pp. 877-894. The vOICe. Link. VideoTact, ForeThought Development, LLC. Link | |||||
Voraussetzungen / Besonderes | Target Group: Students of higher semesters and PhD students of - D-MAVT, D-ITET, D-INFK, D-HEST - Biomedical Engineering, Robotics, Systems and Control - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome | |||||
376-1279-00L | Virtual Reality in Medicine Findet dieses Semester nicht statt. | W | 3 KP | 2V | R. Riener | |
Kurzbeschreibung | Virtual Reality has the potential to support medical training and therapy. This lecture will derive the technical principles of multi-modal (audiovisual, haptic, tactile etc.) input devices, displays and rendering techniques. Examples are presented in the fields of surgical training, intra-operative augmentation, and rehabilitation. The lecture is accompanied by practical courses and excursions. | |||||
Lernziel | Provide theoretical and practical knowledge of new principles and applications of multi-modal simulation and interface technologies in medical education, therapy, and rehabilitation. | |||||
Inhalt | Virtual Reality has the potential to provide descriptive and practical information for medical training and therapy while relieving the patient and/or the physician. Multi-modal interactions between the user and the virtual environment facilitate the generation of high-fidelity sensory impressions, by using not only visual and auditory modalities, but also kinesthetic, tactile, and even olfactory feedback. On the basis of the existing physiological constraints, this lecture will derive the technical requirements and principles of multi-modal input devices, displays, and rendering techniques. Several examples are presented that are currently being developed or already applied for surgical training, intra-operative augmentation, and rehabilitation. The lecture will be accompanied by several practical courses on graphical and haptic display devices as well as excursions to facilities equipped with large-scale VR equipment. Target Group: Students of higher semesters and PhD students of - D-HEST, D-MAVT, D-ITET, D-INFK, D-PHYS - Robotics, Systems and Control Master - Biomedical Engineering/Movement Science and Sport - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome! | |||||
Literatur | Book: Virtual Reality in Medicine. Riener, Robert; Harders, Matthias; 2012 Springer. | |||||
Voraussetzungen / Besonderes | The course language is English. Basic experience in Information Technology and Computer Science will be of advantage More details will be announced in the lecture. | |||||
376-1714-00L | Biocompatible Materials | W | 4 KP | 3G | K. Maniura, P. M. Kollmannsberger, J. Möller, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced. | |||||
Lernziel | The class consists of three parts: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. | |||||
Inhalt | Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers. | |||||
Skript | Handouts can be accessed online. | |||||
Literatur | Literatur Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts provided during the classes and references therin. | |||||
376-1351-00L | Micro/Nanotechnology and Microfluidics for Biomedical Applications | W | 2 KP | 2V | E. Delamarche | |
Kurzbeschreibung | This course is an introduction to techniques in micro/nanotechnology and to microfluidics. It reviews how many familiar devices are built and can be used for research and biomedical applications. Transistors for DNA sequencing, beamers for patterning proteins, hard-disk technology for biosensing and scanning microfluidics for analyzing tissue sections are just a few examples of the covered topics. | |||||
Lernziel | The main objective of the course is to introduce micro/nanotechnology and microfluidics to students having a background in the life sciences. The course should familiarize the students with the techniques used in micro/nanotechnology and show them how micro/nanotechnology pervades throughout life sciences. Microfluidics will be emphasized due to their increasing importance in research and medical applications. The second objective is to have life students less intimidated by micro/nanotechnology and make them able to link instruments and techniques to specific problems that they might have in their projects/studies. This will also help students getting access to the ETHZ/IBM Nanotech Center infrastructure if needed. | |||||
Inhalt | Mostly formal lectures (2 × 45 min), with a 2 hour visit and introduction to cleanroom and micro/nanotechnology instruments, last 3 sessions would be dedicated to the presentation and evaluation of projects by students (3 students per team). | |||||
Voraussetzungen / Besonderes | Nanotech center and lab visit at IBM would be mandatory, as well as attending the student project presentations. | |||||
376-1720-00L | Application of MATLAB in the Human Movement Sciences | W | 2 KP | 2G | R. van de Langenberg | |
Kurzbeschreibung | Basierend auf bewegungstypischen Messungen (Kinematik, Kinetik, Muskelaktivität, etc.) werden die Grundzüge der Datenverarbeitung und Datendarstellung mittels MATLAB vermittelt. | |||||
Lernziel | Selbstständiges Einlesen, Darstellen und Weiterverarbeiten von für die Bewegungs-wissenschaften typischen Messdaten in MATLAB. | |||||
Inhalt | Grenzen von Excel; Möglichkeiten von MATLAB; Einlesen diverses Datentypen, Darstellen eines und mehrerer Signale; Beseitigen eines Offsets und Filtern der Daten anhand von selbstgeschriebenen Funktionen; Normieren und Parametrisieren von Daten; Reliabilität; Interpolieren, Differenzieren und Integrieren in MATLAB. | |||||
Literatur | In der Vorlesung wird auf diverse elektronische Einführungen in MATLAB aufmerksam gemacht. Jede Vorlesung wird den Studenten in Skript-Form zur Verfügung gestellt. | |||||
Voraussetzungen / Besonderes | Laptop samt installiertem WLAN und MATLAB (Version 2009 oder höher) sind mitzubringen. Gegebenenfalls kann zu zweit an einem Laptop gearbeitet werden. Eine MATLAB-Studentenversion kann gratis über Stud-IDES bezogen werden. | |||||
376-1974-00L | Colloquium in Biomechanics | W | 2 KP | 2K | B. Helgason, S. J. Ferguson, R. Müller, J. G. Snedeker, W. R. Taylor, M. Zenobi-Wong | |
Kurzbeschreibung | Current topics in biomechanics presented by speakers from academia and industry. | |||||
Lernziel | Getting insight into actual areas and problems of biomechanics. | |||||
376-2017-00L | Biomechanik von Sportverletzungen und Rehabilitation | W | 3 KP | 2V | K.‑U. Schmitt, J. Goldhahn | |
Kurzbeschreibung | Die Veranstaltung vermittelt die Grundlagen der Verletzungsbiomechanik. Sportverletzungen und deren Rehabilitation bilden dabei den Schwerpunkt der Vorlesung. | |||||
Lernziel | In dieser Veranstaltung sollen Sie Grundlagen der Traumabiomechanik erlernen. Anhand von Beispielen aus dem Sport lernen Sie verschiedene Mechanismen, die zu Verletzungen des menschlichen Körpers führen können, kennen. Sie sollen ein Verständnis für das Entstehen von Verletzungen entwickeln, das Sie in die Lage versetzt Verletzungspotentiale abzuschätzen und präventive Massnahmen zu entwickeln. | |||||
Inhalt | Die Veranstaltung beschäftigt sich mit den Grundlagen der Verletzungsmechanik und der Rehabilitation. Es wird untersucht, wie Verletzungen entstehen und wie sie verhindert werden können. Die Vorlesung konzentriert sich dabei auf Verletzungen, die im Sport erlitten werden. | |||||
Skript | Steht zum Download zur Verfügung. | |||||
Literatur | Schmitt K-U, Niederer P, M. Muser, Walz F: "Trauma Biomechanics - An Introduction to Injury Biomechanics" bzw. "Trauma-Biomechanik - Einführung in die Biomechanik von Verletzungen", beide Springer Verlag | |||||
Voraussetzungen / Besonderes | Die Mitarbeit an einer Gruppenarbeit ist fester Bestandteil der Veranstaltung. Die Gruppenarbeit wird benotet und zählt somit zur Gesamtnote der Vorlesung hinzu. Nähere Informationen werden in der ersten Vorlesung gegeben. | |||||
402-0341-00L | Medical Physics I | W | 6 KP | 2V + 1U | P. Manser | |
Kurzbeschreibung | Introduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations. | |||||
Lernziel | Understanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society. | |||||
Inhalt | The lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications. | |||||
Skript | A script will be provided. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
465-0953-00L | Biostatistik | W | 2 KP | 2V + 1U | B. Sick | |
Kurzbeschreibung | Der Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Varianzanalyse, logistische Regression, Survivalanalyse (Kaplan-Meier Kurven und Cox-Regression). | |||||
Lernziel | ||||||
551-1295-00L | Introduction to Bioinformatics: Concepts and Applications | W | 6 KP | 4G | W. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner | |
Kurzbeschreibung | Speicherung, Verarbeitung und Analyse grosser Datenmengen sind in vielen Forschungsbereichen der modernen Biologie essentiell geworden. Die Vorlesung gibt eine grundlegende Einführung in Anwendungsbereiche von Bioinformatik in der Biologie und stellt einige leicht zugängliche Programme und Datenbanken für den Anwender in Theorie und Praxis vor. | |||||
Lernziel | Introduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks. In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science. Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester. | |||||
Inhalt | Bioinformatics I will cover the following topics: From genes to databases and information BLAST searches Prediction of gene function and regulation RNA structure prediction Gene expression analysis using microarrays Protein sequence and structure databases WWW for bioinformatics Protein sequence comparisons Proteomics and de novo protein sequencing Protein structure prediction Cellular and protein interaction networks Molecular dynamics simulation | |||||
Biologiefächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0945-00L | Cell and Molecular Biology for Engineers | W | 6 KP | 4G | C. Frei | |
Kurzbeschreibung | The course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology. | |||||
Lernziel | After completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested. | |||||
Inhalt | Lectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells. In addition, three journal clubs will be held, where one/two publictions will be discussed. For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded, and count as 25% for the final grade. | |||||
Skript | Scripts of all lectures will be available. | |||||
Literatur | "Molecular Biology of the Cell" (5th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter. | |||||
Medical Physics | ||||||
Kernfächer der Vertiefung Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0385-00L | Biomedical Imaging | W | 4 KP | 3G | S. Kozerke, U. Moser, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | Understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. | |||||
Inhalt | X-ray imaging Computed tomography Single photon emission tomography Positron emission tomography Magnetic resonance imaging Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts: Biomedical Imaging | |||||
Literatur | Introduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith, Cambridge University Press | |||||
402-0341-00L | Medical Physics I | W | 6 KP | 2V + 1U | P. Manser | |
Kurzbeschreibung | Introduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations. | |||||
Lernziel | Understanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society. | |||||
Inhalt | The lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications. | |||||
Skript | A script will be provided. | |||||
402-0345-00L | Introduction to Medical Physics Findet dieses Semester nicht statt. | W | 4 KP | 2V | A. J. Lomax | |
Kurzbeschreibung | Medical physics is a fascinating and worthwhile scientific discipline, providing many professional opportunities to apply physics to the care of patients, either in the clinic or in industry. It is also an area allowing for exciting, interesting and fulfilling areas of research. | |||||
Lernziel | It is the aim of this course to give bachelor and master level students an insight into the wide spectrum of medical applications of physics, and to provide some insight into the work of the medical physicist in clinics, industry and research. | |||||
Inhalt | The lecture series will begin with a short historical overview of medical physics and an overview of the lecture series (lecture 1). This will be followed by two lectures on the physics of medical imaging. Medical imaging is one of the most important areas of preventative medicine and diagnostics, and in these two lectures, we will summarise the physics aspects of all the most important medical imaging modalities (X-ray, nuclear medicine, CT, MRI, Ultrasound imaging etc.). With lectures 4 and 5, we will move onto one of the other major areas of physics applied to medicine, radiotherapy. As the name implies, this is a physics 'heavy' discipline, being dependent as it is on both accelerator and particle physics. However, what is less well known is that this is also the second most successfu l treatment of cancer after surgery and a great success story for the application of physics to medicine. In lectures 6 and 7 will then move on to a very different area, that of bio-photonics and bio-physics. Here we will look into the applications of lasers in medicine, from therapy to their use in particle acceleration for medical applications, as well as a variety of optical techniques for studying biological tissues, cells and structures. In the second half of the lecture series (lectures 8-13) the style changes somewhat, and we will concentrate on professional aspects of medical physics and the role of the medical physicist in various professional scenarios. As such, lectures 8-11 will cover the role of the clinical medical physicist in diagnostic radiology, MRI, nuclear medicine and radiotherapy, whilst the last two lectures will concentrate on their role in industry and research. For many of this second set of lectures, external experts in the various areas will be invited in order to give the student the best possible insight into the life of a professional medical physicist. | |||||
227-0943-00L | Radiobiology | W | 2 KP | 2V | M. Pruschy | |
Kurzbeschreibung | The purpose of this course is to impart basic knowledge in radiobiology in order to handle ionizing rays and to provide a basis for predicting the radiation risk. | |||||
Lernziel | ||||||
Inhalt | Einführung in die Strahlenbiologie ionisierender Strahlen: Allgemeine Grundlagen und Begriffsbestimmungen; Mechanismen der biologischen Strahlenwirkung; Strahlenwirkung auf Zellen, Gewebe und Organe; Modifikation der biologischen Strahlenwirkung; Strahlenzytogenetik: Chromosomenveränderungen, DNA-Defekte, Reparaturprozesse; Molekulare Strahlenbiologie: Bedeutung inter- und intrazellulärer Signalübermittlungsprozesse, Apoptose, Zellzyklus-Checkpoints; Strahlenrisiko: Strahlensyndrome, Krebsinduktion, Mutationsauslösung, pränatale Strahlenwirkung; Strahlenbiologische Grundlagen des Strahlenschutzes; Nutzen-Risiko-Abwägungen bei der medizinischen Strahlenanwendung; Prädiktive strahlenbiologische Methoden zur Optimierung der therapeutischen Strahlenanwendung. | |||||
Skript | Beilagen mit zusammenfassenden Texten, Tabellen, Bild- und Grafikdarstellungen werden abgegeben | |||||
Literatur | Literaturliste wird abgegeben. Für NDS-Absolventen empfohlen: Hall EJ: Radiobiology for the Radiologist, 5th Edition, Lippincott Williams&Wilkins, ISBN 0-7817-2649-2, 2000 | |||||
Voraussetzungen / Besonderes | The former number of this course unit is 465-0951-00L. | |||||
Wahlfächer der Vertiefung Diese Fächer sind für die Vertiefung in Biomechanics besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
Weitere Wahlfächer Diese Fächer können für die Vertiefung in Medical Physics geeignet sein. Bitte konsultieren Sie Ihren Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | G. Székely, O. Göksel, L. Van Gool | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
Biologiefächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0945-00L | Cell and Molecular Biology for Engineers | W | 6 KP | 4G | C. Frei | |
Kurzbeschreibung | The course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology. | |||||
Lernziel | After completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested. | |||||
Inhalt | Lectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells. In addition, three journal clubs will be held, where one/two publictions will be discussed. For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded, and count as 25% for the final grade. | |||||
Skript | Scripts of all lectures will be available. | |||||
Literatur | "Molecular Biology of the Cell" (5th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter. | |||||
Molecular Bioengineering | ||||||
Kernfächer der Vertiefung Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-1714-00L | Biocompatible Materials | W | 4 KP | 3G | K. Maniura, P. M. Kollmannsberger, J. Möller, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced. | |||||
Lernziel | The class consists of three parts: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. | |||||
Inhalt | Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers. | |||||
Skript | Handouts can be accessed online. | |||||
Literatur | Literatur Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts provided during the classes and references therin. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
465-0953-00L | Biostatistik | W | 2 KP | 2V + 1U | B. Sick | |
Kurzbeschreibung | Der Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Varianzanalyse, logistische Regression, Survivalanalyse (Kaplan-Meier Kurven und Cox-Regression). | |||||
Lernziel | ||||||
551-0103-00L | Grundlagen der Biologie II: Zellbiologie | W | 5 KP | 5V | U. Kutay, Y. Barral, E. Hafen, G. Schertler, U. Suter, S. Werner | |
Kurzbeschreibung | Ziel dieses Kurses ist ein breites Grundverständnis für die Zellbiologie zu vermitteln. Dieses Basiswissen wird den Studenten ermöglichen, sich in die Zellbiologie sowie in verwandte Gebiete wie Biochemie, Mikrobiologie, Pharmazie, Molekularbiologie und andere zu vertiefen. | |||||
Lernziel | Ziel dieses Kurses ist ein breites Grundverständnis für die Zellbiologie zu vermitteln. Dieses Basiswissen wird den Studenten ermöglichen, sich in die Zellbiologie sowie in verwandte Gebiete wie Biochemie, Mikrobiologie, Pharmazie, Molekularbiologie und andere zu vertiefen. | |||||
Inhalt | Das Hauptaugenmerk liegt auf der Biologie von Säugerzellen und der Entwicklung multizellulärer Organismen mit Schwerpunkt auf molekularen Mechanismen, die zellulären Strukturen und Phänomenen zugrunde liegen. Die behandelten Themen umfassen biologische Membranen, das Zytoskelett, Protein Sorting, Energiemetabolismus, Zellzyklus und Zellteilung, Viren, die extrazelluläre Matrix, Signaltransduktion, Entwicklungsbiologie und Krebsforschung. | |||||
Skript | Die Vorlesungsinhalte werden mithilfe von Powerpoint präsentiert. Die Präsentationen können von ETH Studenten heruntergeladen werden (Link). Ausgewählte Vorlesungen können auf dem ETH Netz im live Format (Livestream) angehört werden. | |||||
Literatur | Die Vorlesung folgt Alberts et al. ‘Molecular Biology of the Cell’ Fünfte Auflage, 2008 ISBN 978-0-8153-4105-5 (gebunden) und ISBN 978-0-8153-4106-2 (Taschenbuchausgabe). | |||||
Voraussetzungen / Besonderes | Einige Vorlesungseinheiten werden in englischer Sprache gehalten. | |||||
551-1295-00L | Introduction to Bioinformatics: Concepts and Applications | W | 6 KP | 4G | W. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner | |
Kurzbeschreibung | Speicherung, Verarbeitung und Analyse grosser Datenmengen sind in vielen Forschungsbereichen der modernen Biologie essentiell geworden. Die Vorlesung gibt eine grundlegende Einführung in Anwendungsbereiche von Bioinformatik in der Biologie und stellt einige leicht zugängliche Programme und Datenbanken für den Anwender in Theorie und Praxis vor. | |||||
Lernziel | Introduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks. In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science. Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester. | |||||
Inhalt | Bioinformatics I will cover the following topics: From genes to databases and information BLAST searches Prediction of gene function and regulation RNA structure prediction Gene expression analysis using microarrays Protein sequence and structure databases WWW for bioinformatics Protein sequence comparisons Proteomics and de novo protein sequencing Protein structure prediction Cellular and protein interaction networks Molecular dynamics simulation | |||||
636-0003-00L | Biological Engineering and Biotechnology | W | 6 KP | 3G | M. Fussenegger | |
Kurzbeschreibung | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||
Lernziel | 1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development. | |||||
Skript | Handsout during the course. | |||||
Wahlfächer der Vertiefung Diese Fächer sind für die Vertiefung in Molecular Bioengineering besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
151-0604-00L | Microrobotics | W | 4 KP | 3G | B. Nelson | |
Kurzbeschreibung | Microrobotics is an interdisciplinary field that combines aspects of robotics, micro and nanotechnology, biomedical engineering, and materials science. The aim of this course is to expose students to the fundamentals of this emerging field. Throughout the course students are expected to submit assignments. The course concludes with an end-of-semester examination. | |||||
Lernziel | The objective of this course is to expose students to the fundamental aspects of the emerging field of microrobotics. This includes a focus on physical laws that predominate at the microscale, technologies for fabricating small devices, bio-inspired design, and applications of the field. | |||||
Inhalt | Main topics of the course include: - Scaling laws at micro/nano scales - Electrostatics - Electromagnetism - Low Reynolds number flows - Observation tools - Materials and fabrication methods - Applications of biomedical microrobots | |||||
Skript | The powerpoint slides presented in the lectures will be made available in hardcopy and as pdf files. Several readings will also be made available electronically. | |||||
Voraussetzungen / Besonderes | The lecture will be taught in English. | |||||
227-0385-00L | Biomedical Imaging | W | 4 KP | 3G | S. Kozerke, U. Moser, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | Understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. | |||||
Inhalt | X-ray imaging Computed tomography Single photon emission tomography Positron emission tomography Magnetic resonance imaging Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts: Biomedical Imaging | |||||
Literatur | Introduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith, Cambridge University Press | |||||
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, K. S. Mader | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
327-0505-00L | Surfaces, Interfaces & their Applications I | W | 3 KP | 2V + 1U | N. Spencer, M. P. Heuberger, L. Isa | |
Kurzbeschreibung | After being introduced to the physical/chemical principles and importance of surfaces and interfaces, the student is introduced to the most important techniques that can be used to characterize surfaces. Later, liquid interfaces are treated, followed by an introduction to the fields of tribology (friction, lubrication, and wear) and corrosion. | |||||
Lernziel | To gain an understanding of the physical and chemical principles, as well as the tools and applications of surface science, and to be able to choose appropriate surface-analytical approaches for solving problems. | |||||
Inhalt | Introduction to Surface Science Physical Structure of Surfaces Surface Forces (static and dynamic) Adsorbates on Surfaces Surface Thermodynamics and Kinetics The Solid-Liquid Interface Electron Spectroscopy Vibrational Spectroscopy on Surfaces Scanning Probe Microscopy Introduction to Tribology Introduction to Corrosion Science | |||||
Skript | Script Download: Link | |||||
Literatur | Script (20 CHF) Book: "Surface Analysis--The Principal Techniques", Ed. J.C. Vickerman, Wiley, ISBN 0-471-97292 | |||||
Voraussetzungen / Besonderes | Chemistry: General undergraduate chemistry including basic chemical kinetics and thermodynamics Physics: General undergraduate physics including basic theory of diffraction and basic knowledge of crystal structures | |||||
327-1101-00L | Biomineralization | W | 2 KP | 2V | K.‑H. Ernst | |
Kurzbeschreibung | The course addresses undergraduate and graduate students interested in getting introduced into the basic concepts of biomineralization. | |||||
Lernziel | The course aims to introduce the basic concepts of biomineralization and the underlying principles, such as supersaturation, nucleation and growth of minerals, the interaction of biomolecules with mineral surfaces, and cell biology of inorganic materials creation. An important part of this class is the independent study and the presentation of original literature from the field. | |||||
Inhalt | Biomineralization is a multidisciplinary field. Topics dealing with biology, molecular and cell biology, solid state physics, mineralogy, crystallography, organic and physical chemistry, biochemistry, dentistry, oceanography, geology, etc. are addressed. The course covers definition and general concepts of biomineralization (BM)/ types of biominerals and their function / crystal nucleation and growth / biological induction of BM / control of crystal morphology, habit, shape and orientation by organisms / strategies of compartmentalization / the interface between biomolecules (peptides, polysaccharides) and the mineral phase / modern experimental methods for studying BM phenomena / inter-, intra, extra- and epicellular BM / organic templates and matrices for BM / structure of bone, teeth (vertebrates and invertebrates) and mollusk shells / calcification / silification in diatoms, radiolaria and plants / calcium and iron storage / impact of BM on lithosphere and atmosphere/ evolution / taxonomy of organisms. 1. Introduction and overview 2. Biominerals and their functions 3. Chemical control of biomineralization 4. Control of morphology: Organic templates and additives 5. Modern methods of investigation of BM 6. BM in matrices: bone and nacre 7. Vertebrate teeth 8. Invertebrate teeth 9. BM within vesicles: calcite of coccoliths 10. Silica 11. Iron storage and mineralization | |||||
Skript | Script with more than 600 pages with many illustrations will be distributed free of charge. | |||||
Literatur | 1) S. Mann, Biomineralization, Oxford University Press, 2001, Oxford, New York 2) H. Lowenstam, S. Weiner, On Biomineralization, Oxford University Press, 1989, Oxford 3) P. M. Dove, J. J. DeYoreo, S. Weiner (Eds.) Biomineralization, Reviews in Mineralogoy & Geochemistry Vol. 54, 2003 | |||||
Voraussetzungen / Besonderes | Each attendee is required to present a publication from the field. The selection of key papers is provided by the lecturer. No special requirements are needed for attending. Basic knowledge in chemistry and cell biology is expected. | |||||
402-0341-00L | Medical Physics I | W | 6 KP | 2V + 1U | P. Manser | |
Kurzbeschreibung | Introduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations. | |||||
Lernziel | Understanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society. | |||||
Inhalt | The lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications. | |||||
Skript | A script will be provided. | |||||
535-0423-00L | Drug Delivery and Drug Targeting | W | 2 KP | 2V | J.‑C. Leroux, P. Luciani | |
Kurzbeschreibung | Die Studierenden erwerben einen Überblick über derzeit aktuelle Prinzipien, Methoden und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Damit sind die Studierenden in der Lage, das Gebiet gemäss wissenschaftlichen Kriterien zu verstehen und zu beurteilen. | |||||
Lernziel | Die Studierenden verfügen über einen Überblick über derzeit aktuelle Prinzipien und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Im Vordergrund der Lehrveranstaltung steht die Entwicklung von Fähigkeiten zum Verständnis der betreffenden Technologien und Methoden, ebenso wie der Möglichkeiten und Grenzen ihres therapeutischen Einsatzes. Im Zentrum stehen therapeutische Peptide, Proteine, Nukleinsäuren und Impfstoffe. | |||||
Inhalt | Der Kurs behandelt folgende Themen: Arzneistoff-targeting und Freigabeprinzipien, Radiopharmaka, makromolekulare Arzneistofftransporter, Liposomen, Mizellen, Mikro/Nanopartikel, Gele und Implantate, Anwendung von Impfstoffen, Abgabe von Wirkstoffen im Rahmen von Tissue engineering, Abgabe im Gastrointestinaltrakt, synthetische Transporter für Arzneistoffe auf Nukleinsäurebasis, ophthalmische Vehikel und neue Trends in transdermaler und nasaler Arzneistofffreigabe. | |||||
Skript | Ausgewählte Skripten, Vorlesungsunterlagen und unterstützendes Material werden entweder direkt an der Vorlesung ausgegeben oder sind über das Web zugänglich: Link Diese Website enthält auch zusätzliche Unterlagen zu peroralen Abgabesystemen, zur gastrointestinalen Passage von Arzneiformen, transdermalen Systemen und über Abgabesysteme für alternative Absorptionswege. Diese Stoffgebiete werden speziell in der Vorlesung Galenische Pharmazie II behandelt. | |||||
Literatur | A.M. Hillery, A.W. Lloyd, J. Swarbrick (Hrsg). Drug Delivery and Targeting, Taylor & Francis, London and New York 2001. Y. Perrie, T. Rhades. Pharmaceutics - Drug Delivery and Targeting, Pharmaceutical Press, London and Chicago, 2010. Weitere Literatur in der Vorlesung. | |||||
636-0507-00L | Synthetic Biology II | W | 4 KP | 4A | S. Panke, Y. Benenson, J. Stelling | |
Kurzbeschreibung | 7 months biological design project, during which the students are required to give presentations on advanced topics in synthetic biology (specifically genetic circuit design) and then select their own biological system to design. The system is subsequently modeled, analyzed, and experimentally implemented. Results are presented at an international student competition at the MIT (Cambridge). | |||||
Lernziel | The students are supposed to acquire a deep understanding of the process of biological design including model representation of a biological system, its thorough analysis, and the subsequent experimental implementation of the system and the related problems. | |||||
Inhalt | Presentations on advanced synthetic biology topics (eg genetic circuit design, adaptation of systems dynamics, analytical concepts, large scale de novo DNA synthesis), project selection, modeling of selected biological system, design space exploration, sensitivity analysis, conversion into DNA sequence, (DNA synthesis external,) implementation and analysis of design, summary of results in form of scientific presentation and poster, presentation of results at the iGEM international student competition (Link). | |||||
Skript | Handouts during course | |||||
Voraussetzungen / Besonderes | The final presentation of the project is typically at the MIT (Cambridge, US). Other competing schools include regularly Imperial College, Cambridge University, Harvard University, UC Berkeley, Princeton Universtiy, CalTech, etc. This project takes place between end of Spring Semester and beginning of Autumn Semester. Registration in April. Please note that the number of ECTS credits and the actual work load are disconnected. | |||||
Weitere Wahlfächer Diese Fächer können für die Vertiefung in Molecular Bioengineering geeignet sein. Bitte konsultieren Sie Ihren Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
551-0313-00L | Microbiology (Part I) | W | 3 KP | 2V | W.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel | |
Kurzbeschreibung | Advanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Lernziel | This concept class will be based on common concepts (Grundlagen der Biologie IIB, Teil Mikrobiologie) and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Inhalt | Advanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Skript | Updated handouts will be provided during the class. | |||||
Literatur | Current literature references will be provided during the lectures. | |||||
Voraussetzungen / Besonderes | English The lecture "Grundlagen der Biologie IIB", Mikrobiologie is the basis for this advanced lecture. | |||||
551-1103-00L | Microbial Biochemistry | W | 4 KP | 2V | J. Vorholt-Zambelli, T. J. Erb, J. Piel | |
Kurzbeschreibung | The lecture course aims at providing an advanced understanding of the physiology and metabolism of microorganisms. Emphasis is on processes that are specific to bacteria and archaea and that contribute to the widespread occurrence of prokaryotes. Applied aspects of microbial biochemistry will be pointed out as well as research fields of current scientific interest. | |||||
Lernziel | The lecture course aims at providing an advanced understanding of the physiology and metabolism of microorganisms. | |||||
Inhalt | Important biochemical processes specific to bacteria and archaea will be presented that contribute to the widespread occurrence of prokaryotes. Applied aspects of microbial biochemistry will be pointed out as well as research fields of current scientific interest. Emphasis is on concepts of energy generation and assimilation. List of topics: Eating sugars and letting them in Challenging: Aromatics, xenobiotics, and oil Complex: (Ligno-)Cellulose and in demand for bioenergy Living on a diet and the anaplerotic provocation Of climate relevance: The microbial C1 cycle What are AMO and Anammox? 20 amino acids: the making of Extending the genetic code The 21st and 22nd amino acid Some exotic biochemistry: nucleotides, cofactors Ancient biochemistry? Iron-sulfur clusters, polymers Secondary metabolites: playground of evolution | |||||
Skript | A script will be provided during the course. | |||||
Biologiefächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0945-00L | Cell and Molecular Biology for Engineers | W | 6 KP | 4G | C. Frei | |
Kurzbeschreibung | The course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology. | |||||
Lernziel | After completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested. | |||||
Inhalt | Lectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells. In addition, three journal clubs will be held, where one/two publictions will be discussed. For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded, and count as 25% for the final grade. | |||||
Skript | Scripts of all lectures will be available. | |||||
Literatur | "Molecular Biology of the Cell" (5th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter. | |||||
Semesterarbeit | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-1101-00L | How to Write Scientific Texts in Engineering Sciences Strongly recommended prerequisite for Semester Projects and Master Theses at D-ITET (MSc BME, MSc EEIT, MSc EST). | E- | 0 KP | J. Leuthold | ||
Kurzbeschreibung | The 2 to 3 hour lecture will cover the basics of writing a scientific text. The focus will be on the structure and elements of scientific text and not on the language. | |||||
Lernziel | Knowledge on structure and content of a scientific text. | |||||
Inhalt | Topic 1: Structure of a Scientific Text Topic 2: The Title, the author list, the abstract, State-of-the Art, the "in this paper" paragraph, the scientific part, the summary Topic 3: Equations, Figures Topic 4: Citation rules | |||||
Literatur | ETH "Citation Etiquette", see Link. ETH Guidlines on "Guidelines for Research Integrity", see Link > Education > > Contacts, links & documents > Forms and documents > Brochures / guides. | |||||
Voraussetzungen / Besonderes | Students should already have a Bachelor degree and plan to do either a semester project or a master thesis in the immediate future. | |||||
227-1772-10L | Semester Project Only for Biomedical Engineering MSc Programme Regulations 2013 (i.e. students having started the MSc BME in or after autumn 2013). Please fill in the following form before registering: Link. | O | 8 KP | 20A | Professor/innen | |
Kurzbeschreibung | Die Semesterarbeit leitet die Studierenden zu selbstständigem wissenschaftlichen Arbeiten an. Mit der Studienarbeit können die technischen und auch die sozialen Fähigkeiten gefördert werden. Die Studienarbeit wird von einem Professor geleitet. | |||||
Lernziel | siehe oben | |||||
Master-Studium gemäss Studienreglement 2009 | ||||||
Vertiefungsfächer | ||||||
Bioelectronics | ||||||
Kernfächer der Vertiefung Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
151-0604-00L | Microrobotics | W | 4 KP | 3G | B. Nelson | |
Kurzbeschreibung | Microrobotics is an interdisciplinary field that combines aspects of robotics, micro and nanotechnology, biomedical engineering, and materials science. The aim of this course is to expose students to the fundamentals of this emerging field. Throughout the course students are expected to submit assignments. The course concludes with an end-of-semester examination. | |||||
Lernziel | The objective of this course is to expose students to the fundamental aspects of the emerging field of microrobotics. This includes a focus on physical laws that predominate at the microscale, technologies for fabricating small devices, bio-inspired design, and applications of the field. | |||||
Inhalt | Main topics of the course include: - Scaling laws at micro/nano scales - Electrostatics - Electromagnetism - Low Reynolds number flows - Observation tools - Materials and fabrication methods - Applications of biomedical microrobots | |||||
Skript | The powerpoint slides presented in the lectures will be made available in hardcopy and as pdf files. Several readings will also be made available electronically. | |||||
Voraussetzungen / Besonderes | The lecture will be taught in English. | |||||
151-0605-00L | Nanosystems | W | 4 KP | 4G | A. Stemmer | |
Kurzbeschreibung | From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. Special emphasis on the emerging field of molecular electronic devices. | |||||
Lernziel | Familiarize students with basic science and engineering principles governing the nano domain. | |||||
Inhalt | The course addresses basic science and engineering principles ruling the nano domain. We particularly work out the links between topics that are traditionally taught separately. Special emphasis is placed on the emerging field of molecular electronic devices, their working principles, applications, and how they may be assembled. Topics are treated in 2 blocks: (I) From Quantum to Continuum From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. (II) Interaction Forces on the Micro and Nano Scale Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. | |||||
Literatur | - Kuhn, Hans; Försterling, H.D.: Principles of Physical Chemistry. Understanding Molecules, Molecular Assemblies, Supramolecular Machines. 1999, Wiley, ISBN: 0-471-95902-2 - Chen, Gang: Nanoscale Energy Transport and Conversion. 2005, Oxford University Press, ISBN: 978-0-19-515942-4 - Ouisse, Thierry: Electron Transport in Nanostructures and Mesoscopic Devices. 2008, Wiley, ISBN: 978-1-84821-050-9 - Wolf, Edward L.: Nanophysics and Nanotechnology. 2004, Wiley-VCH, ISBN: 3-527-40407-4 - Israelachvili, Jacob N.: Intermolecular and Surface Forces. 2nd ed., 1992, Academic Press,ISBN: 0-12-375181-0 - Evans, D.F.; Wennerstrom, H.: The Colloidal Domain. Where Physics, Chemistry, Biology, and Technology Meet. Advances in Interfacial Engineering Series. 2nd ed., 1999, Wiley, ISBN: 0-471-24247-0 - Hunter, Robert J.: Foundations of Colloid Science. 2nd ed., 2001, Oxford, ISBN: 0-19-850502-7 | |||||
Voraussetzungen / Besonderes | Course format: Lectures: Thursday 10-12, ML F 36 Homework: Mini-Reviews Students select a paper (list distributed in class) and expand the topic into a Mini-Review that illuminates the particular field beyond the immediate results reported in the paper. | |||||
151-0621-00L | Microsystems Technology | W | 6 KP | 4G | C. Hierold, M. Haluska | |
Kurzbeschreibung | Die Stundenten werden in die Grundlagen der Mikrosystemtechnik und der Halbleiterprozesstechnologie eingeführt und erfahren, wie die Herstellung von Mikrosystemen in einer Serie von genau definierten Prozessschritten erfolgt (Gesamtprozess und Prozessablauf). | |||||
Lernziel | Die Stundenten sind mit den Grundlagen der Mikrosystemtechnik und der Prozesstechnologie für Halbleiter vertraut und verstehen die Herstellung von Mikrosystemen durch die Kombination von Einzelprozesschritten ( = Gesamtprozess oder Prozessablauf). | |||||
Inhalt | - Einführung in die Mikrosystemtechnik (MST) und in mikroelektromechanische Systeme (MEMS) - Grundlegende Siliziumtechnologie: thermische Oxidation, Fotolithografie und Ätztechnik, Diffusion und Ionenimplantation, Dünnschichttechnik. - Besondere Mikrosystemtechnologien: Volumen- und Oberflächenmikromechanik, Trocken- und Nassätzen, isotropisches und anisotropisches Ätzen, Herstellung von Balken und Membranen, Waferbonden, mechanische und thermische Eigenschaften von Dünnschichten, piezoelektrische und piezoresitive Materialien. - Ausgewählte Mikrosysteme: Mechanische Sensoren und Aktoren, Mikroresonatoren, thermische Sensoren und Aktoren, Systemintegration und Aufbautechnik. | |||||
Skript | Handouts (online erhältlich) | |||||
Literatur | - S.M. Sze: Semiconductor Devices, Physics and Technology - W. Menz, J. Mohr, O.Paul: Microsystem Technology - G. Kovacs: Micromachined Transducer Sourcebook | |||||
Voraussetzungen / Besonderes | Voraussetzung: Physik I und II | |||||
227-0385-00L | Biomedical Imaging | W | 4 KP | 3G | S. Kozerke, U. Moser, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | Understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. | |||||
Inhalt | X-ray imaging Computed tomography Single photon emission tomography Positron emission tomography Magnetic resonance imaging Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts: Biomedical Imaging | |||||
Literatur | Introduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith, Cambridge University Press | |||||
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0427-00L | Signal and Information Processing: Modeling, Filtering, Learning | W | 6 KP | 4G | H.‑A. Loeliger | |
Kurzbeschreibung | Fundamentals in signal processing, detection/estimation, and machine learning. I. Linear signal representation and approximation: Hilbert spaces, LMMSE estimation, regularization and sparseness. II. Learning linear and nonlinear functions and filters: kernel methods, neural networks. III. Structured statistical models: hidden Markov models, factor graphs, Kalman filter, parameter estimation. | |||||
Lernziel | The course is an introduction to some basic topics in signal processing, detection/estimation theory, and machine learning. | |||||
Inhalt | Part I - Linear Signal Representation and Approximation: Hilbert spaces, least squares and LMMSE estimation, projection and estimation by linear filtering, learning linear functions and filters, regularization and sparseness, singular-value decomposition and pseudo-inverse, principal-components analysis. Part II - Learning Nonlinear Functions: fundamentals of learning, neural networks, kernel methods. Part III - Structured Statistical Models and Message Passing Algorithms: hidden Markov models, factor graphs, Gaussian message passing, Kalman filter and recursive least squares, Monte Carlo methods, parameter estimation, expectation maximization. | |||||
Skript | Lecture notes. | |||||
Voraussetzungen / Besonderes | Prerequisites: - local bachelors: course "Discrete-Time and Statistical Signal Processing" (5. Sem.) - others: solid basics in linear algebra and probability theory | |||||
376-1714-00L | Biocompatible Materials | W | 4 KP | 3G | K. Maniura, P. M. Kollmannsberger, J. Möller, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced. | |||||
Lernziel | The class consists of three parts: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. | |||||
Inhalt | Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers. | |||||
Skript | Handouts can be accessed online. | |||||
Literatur | Literatur Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts provided during the classes and references therin. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
227-1037-00L | Introduction to Neuroinformatics | W | 6 KP | 2V + 1U | K. A. Martin, M. Cook, V. Mante, M. Pfeiffer | |
Kurzbeschreibung | The course provides an introduction to the functional properties of neurons. Particularly the description of membrane electrical properties (action potentials, channels), neuronal anatomy, synaptic structures, and neuronal networks. Simple models of computation, learning, and behavior will be explained. Some artificial systems (robot, chip) are presented. | |||||
Lernziel | ||||||
Inhalt | This course considers the structure and function of biological neural networks at different levels. The function of neural networks lies fundamentally in their wiring and in the electro-chemical properties of nerve cell membranes. Thus, the biological structure of the nerve cell needs to be understood if biologically-realistic models are to be constructed. These simpler models are used to estimate the electrical current flow through dendritic cables and explore how a more complex geometry of neurons influences this current flow. The active properties of nerves are studied to understand both sensory transduction and the generation and transmission of nerve impulses along axons. The concept of local neuronal circuits arises in the context of the rules governing the formation of nerve connections and topographic projections within the nervous system. Communication between neurons in the network can be thought of as information flow across synapses, which can be modified by experience. We need an understanding of the action of inhibitory and excitatory neurotransmitters and neuromodulators, so that the dynamics and logic of synapses can be interpreted. Finally, the neural architectures of feedforward and recurrent networks will be discussed in the context of co-ordination, control, and integration of sensory and motor information in neural networks. | |||||
Empfohlene Wahlfächer Diese Fächer sind für die Vertiefung in Bioelectronics besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0166-00L | Analog Integrated Circuits | W | 6 KP | 2V + 2U | Q. Huang | |
Kurzbeschreibung | This course provides a foundation in analog integrated circuit design based on bipolar and CMOS technologies. | |||||
Lernziel | Integrated circuits are responsible for much of the progress in electronics in the last 50 years, particularly the revolutions in the Information and Communications Technologies we witnessed in recent years. Analog integrated circuits play a crucial part in the highly integrated systems that power the popular electronic devices we use daily. Understanding their design is beneficial to both future designers and users of such systems. The basic elements, design issues and techniques for analog integrated circuits will be taught in this course. | |||||
Inhalt | Review of bipolar and MOS devices and their small-signal equivalent circuit models; Building blocks in analog circuits such as current sources, active load, current mirrors, supply independent biasing etc; Amplifiers: differential amplifiers, cascode amplifier, high gain structures, output stages, gain bandwidth product of op-amps; Stability; Comparators; Second-order effects in analog circuits such as mismatch, noise and offset; A/D and D/A converters; Introduction to switched capacitor circuits. The exercise sessions aim to reinforce the lecture material by well guided step-by-step design tasks. The circuit simulator SPECTRE is used to facilitate the tasks. There is also an experimental session on op-amp measurments. | |||||
Skript | Handouts of presented slides. No script but an accompanying textbook is recommended. | |||||
Literatur | Gray, Hurst, Lewis, Meyer, "Analysis and Design of Analog Integrated Circuits", 5th Ed. Wiley, 2010. | |||||
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | G. Székely, O. Göksel, L. Van Gool | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
227-2037-00L | Physical Modelling and Simulation | W | 5 KP | 4G | C. Hafner, J. Smajic | |
Kurzbeschreibung | Physical modelling plays an important role in the analysis and design of new structures, especially for micro and nano devices where fabrication and measurement are difficult. After the fundamentals of electromagnetics, mechanics, and thermodynamics, an introduction to the main concepts and most widely used codes for physical modelling is given and commercial codes are applied. | |||||
Lernziel | Basic knowledge of the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics. Knowledge of the main concepts of numerical methods for physical modelling and simulation. Ability 1) to select appropriate software, 2) to apply it for solving given problems, 3) to validate the results, 4) to interactively improve the models until sufficiently accurate results are obtained. | |||||
Inhalt | Since the fabrication and characterization of micro- and nanostructures is difficult, expensive, and time-consuming, numerical modelling drastically reduced the design process. Although many commercial software packages are available, it is important to know the drawbacks and difficulties of the numerical methods behind them and to be able to validate the results obtained with such packages. First, an introduction to the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics is given. This is important for understanding the problems to be analyzed and for validating results obtained from software packages. After this, the main concepts of numerical methods and of the most widely used codes for physical modelling are outlined and compared, which is essential for the adequate selection of software for solving given problems. After this, prominent commercial software packages are applied to various types of problems, ranging from electrodynamics to multiphysics. For becoming able to select appropriate software and to validate the results obtained, different commercial software packages will be used and compared during the exercises in form of small projects. | |||||
376-1219-00L | Rehabilitation Engineering II: Rehabilitation of Sensory and Vegetative Functions | W | 3 KP | 2V | R. Riener, R. Gassert | |
Kurzbeschreibung | Rehab. Engineering is the application of science and technology to ameliorate the handicaps of individuals with disabilities to reintegrate them into society.The goal is to present classical and new rehabilitation engineering principles applied to compensate or enhance motor, sensory, and cognitive deficits. Focus is on the restoration and treatment of the human sensory and vegetative system. | |||||
Lernziel | Provide knowledge on the anatomy and physiology of the human sensory system, related dysfunctions and pathologies, and how rehabilitation engineering can provide sensory restoration and substitution. | |||||
Inhalt | Introduction, problem definition, overview Rehabilitation of visual function - Anatomy and physiology of the visual sense - Technical aids (glasses, sensor substitution) - Retina and cortex implants Rehabilitation of hearing function - Anatomy and physiology of the auditory sense - Hearing aids - Cochlea Implants Rehabilitation and use of kinesthetic and tactile function - Anatomy and physiology of the kinesthetic and tactile sense - Tactile/haptic displays for motion therapy (incl. electrical stimulation) - Role of displays in motor learning Rehabilitation of vestibular function - Anatomy and physiology of the vestibular sense - Rehabilitation strategies and devices (e.g. BrainPort) Rehabilitation of vegetative Functions - Cardiac Pacemaker - Phrenic stimulation, artificial breathing aids - Bladder stimulation, artificial sphincter Brain stimulation and recording - Deep brain stimulation for patients with Parkinson, epilepsy, depression - Brain-Computer Interfaces | |||||
Literatur | Introductory Books: An Introduction to Rehabilitation Engineering. R. A. Cooper, H. Ohnabe, D. A. Hobson (Eds.). Taylor & Francis, 2007. Principles of Neural Science. E. R. Kandel, J. H. Schwartz, T. M Jessell (Eds.). Mc Graw Hill, New York, 2000. Force and Touch Feedback for Virtual Reality. G. C. Burdea (Ed.). Wiley, New York, 1996 (available on NEBIS). Human Haptic Perception, Basics and Applications. M. Grunwald (Ed.). Birkhäuser, Basel, 2008. The Sense of Touch and Its Rendering, Springer Tracts in Advanced Robotics 45, A. Bicchi et al.(Eds). Springer-Verlag Berlin, 2008. Interaktive und autonome Systeme der Medizintechnik - Funktionswiederherstellung und Organersatz. Herausgeber: J. Werner, Oldenbourg Wissenschaftsverlag 2005. Neural prostheses - replacing motor function after desease or disability. Eds.: R. Stein, H. Peckham, D. Popovic. New York and Oxford: Oxford University Press. Advances in Rehabilitation Robotics - Human-Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Eds: Z.Z. Bien, D. Stefanov (Lecture Notes in Control and Information Science, No. 306). Springer Verlag Berlin 2004. Intelligent Systems and Technologies in Rehabilitation Engineering. Eds: H.N.L. Teodorescu, L.C. Jain (International Series on Computational Intelligence). CRC Press Boca Raton, 2001. Selected Journal Articles and Web Links: Abbas, J., Riener, R. (2001) Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function. Neuromodulation 4, pp. 187-195. Bach-y-Rita P., Tyler M., and Kaczmarek K (2003). Seeing with the brain. International journal of human-computer-interaction, 15(2):285-295. Burdea, G., Popescu, V., Hentz, V., and Colbert, K. (2000): Virtual reality-based orthopedic telerehabilitation, IEEE Trans. Rehab. Eng., 8, pp. 430-432 Colombo, G., Jörg, M., Schreier, R., Dietz, V. (2000) Treadmill training of paraplegic patients using a robotic orthosis. Journal of Rehabilitation Research and Development, vol. 37, pp. 693-700. Hayward, V. (2008): A Brief Taxonomy of Tactile Illusions and Demonstrations That Can Be Done In a Hardware Store. Brain Research Bulletin, Vol 75, No 6, pp 742-752 Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T. (1998): Robot-aided neurorehabilitation, IEEE Trans. Rehab. Eng., 6, pp. 75-87 Levesque. V. (2005). Blindness, technology and haptics. Technical report, McGill University. Available at: Link Quintern, J. (1998) Application of functional electrical stimulation in paraplegic patients. NeuroRehabilitation 10, pp. 205-250. Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10. Riener, R. (1999) Model-based development of neuroprostheses for paraplegic patients. Royal Philosophical Transactions: Biological Sciences 354, pp. 877-894. The vOICe. Link. VideoTact, ForeThought Development, LLC. Link | |||||
Voraussetzungen / Besonderes | Target Group: Students of higher semesters and PhD students of - D-MAVT, D-ITET, D-INFK, D-HEST - Biomedical Engineering, Robotics, Systems and Control - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome | |||||
151-0255-00L | Energy Conversion and Transport in Biosystems Findet dieses Semester nicht statt. | W | 4 KP | 2V + 1U | D. Poulikakos, A. Ferrari | |
Kurzbeschreibung | Grundlagen und Anwendungen von Thermodynamik, Energieumwandlung und Fluiddynamik in Biosystemen und Biomedizin auf Makro- und Zellebene. | |||||
Lernziel | Grundlagen und Anwendungen von Thermodynamik (Wärmeübertragung) Energieumwandlung und Fluiddynamik in Biosystemen und Biomedizin. Diese Grundlagen werden auf der Makro- als auch der Mikroebene (Zellebene) untersucht. Die Vorlesung vermittelt das für die Analysierung solcher Probleme nötige Wissen. | |||||
Inhalt | Modellierung von Wärmeübergang und Stofftransport (thermische Energie, chemisch gebundene Energie) im menschlichen Körper. Physiologie, Pathologie und biomedizinische Eingriffe mittels extremer Temperaturen (medizinische Radiofrequenztherapie, Einfrieren von Gewebe und Tieftemperaturbehandlungen) . Einführung in die wichtigsten Flüssigkeitssysteme des menschlichen Körpers (Herz-Kreislauf, Hirn-Rückenmarksflüssigkeit usw.). Beschreibung der Funktionalität dieser Systeme mittels analytischer, experimenteller und numerischer Methoden, um ihre Eigenheiten zu erfassen. Einführung in biomedizinische Methoden zur Behandlung von Erkrankungen dieser Flüssigkeitssysteme. Einführung in den Zellstoffwechsel, Energietransport in Zellen und Zell-Thermodynamik. | |||||
Skript | Skript und weitere Literatur wird verteilt. | |||||
Literatur | Im Skript gegeben. | |||||
252-0523-00L | Computational Biology | W | 6 KP | 3V + 2U | G. H. Gonnet | |
Kurzbeschreibung | Study of computational techniques, algorithms and data structures used to solve problems in computational biology. Topics: basic biology, string alignment, phylogeny (distance, character, parsimony), molecular evolution, multiple sequence alignment, probabilistic and statistical models, Markov models, microarrays, dynamic programming, maximum likelihood and specialized DNA and protein analysis. | |||||
Lernziel | Familiarize the students with the basic concepts of molecular biology and the models and algorithms used to understand, classify and predict behaviour of living organism. This course is at the most basic level, where the main issues, mostly of molecular sequences, are studied. | |||||
Inhalt | This course lies in the intersection between Computer Science and Molecular Biology. The main purpose is to study computational techniques, algorithms and data structures which are usually applied to solve problems in Molecular Biology and Biochemistry. The following topics are likely to be covered: Introduction, mathematical models of evolution, protein and DNA sequence alignment and its meaning, phylogenetic tree construction, multiple sequence alignments, secondary structure prediction, molecular dynamics, threading, role of bioinformatics in drug design, etc. From the computer science point of view we concentrate our attention in practical solutions for the above problems. Biological knowledge is an asset but not a prerequisite. | |||||
376-1351-00L | Micro/Nanotechnology and Microfluidics for Biomedical Applications | W | 2 KP | 2V | E. Delamarche | |
Kurzbeschreibung | This course is an introduction to techniques in micro/nanotechnology and to microfluidics. It reviews how many familiar devices are built and can be used for research and biomedical applications. Transistors for DNA sequencing, beamers for patterning proteins, hard-disk technology for biosensing and scanning microfluidics for analyzing tissue sections are just a few examples of the covered topics. | |||||
Lernziel | The main objective of the course is to introduce micro/nanotechnology and microfluidics to students having a background in the life sciences. The course should familiarize the students with the techniques used in micro/nanotechnology and show them how micro/nanotechnology pervades throughout life sciences. Microfluidics will be emphasized due to their increasing importance in research and medical applications. The second objective is to have life students less intimidated by micro/nanotechnology and make them able to link instruments and techniques to specific problems that they might have in their projects/studies. This will also help students getting access to the ETHZ/IBM Nanotech Center infrastructure if needed. | |||||
Inhalt | Mostly formal lectures (2 × 45 min), with a 2 hour visit and introduction to cleanroom and micro/nanotechnology instruments, last 3 sessions would be dedicated to the presentation and evaluation of projects by students (3 students per team). | |||||
Voraussetzungen / Besonderes | Nanotech center and lab visit at IBM would be mandatory, as well as attending the student project presentations. | |||||
529-0837-00L | Biomicrofluidic Engineering | W | 7 KP | 3G | A. de Mello | |
Kurzbeschreibung | Microfluidics describes the behaviour, control and manipulation of fluids that are geometrically constrained within sub-microliter environments. The use of microfluidic devices offers an opportunity to control physical and chemical processes with unrivalled precision, and in turn provides a route to performing chemistry and biology in an ultra-fast and high-efficiency manner. | |||||
Lernziel | In the course students will investigate the theoretical concepts behind microfluidic device operation, the methods of microfluidic device manufacture and the application of microfluidic architectures to important problems faced in modern day chemical and biological analysis. A design workshop will allow students to develop new microscale flow processes by appreciating the dominant physics at the microscale. The application of these basic ideas will primarily focus on biological problems and will include a treatment of diagnostic devices for use at the point-of-care, advanced functional material synthesis, DNA analysis, proteomics and cell-based assays. Lectures, assignments and the design workshop will acquaint students with the state-of-the-art in applied microfluidics. | |||||
Inhalt | Specific topics in the course include, but not limited to: 1. Theoretical Concepts Features of mass and thermal transport on the microscale Key scaling laws 2. Microfluidic Device Manufacture Conventional lithographic processing of rigid materials Soft lithographic processing of plastics and polymers Mass fabrication of polymeric devices 3. Unit operations and functional components Analytical separations (electrophoresis and chromatography) Chemical and biological synthesis Sample pre-treatment (filtration, SPE, pre-concentration) Molecular detection 4. Design Workshop Design of microfluidic architectures for PCR, distillation & mixing 5. Contemporary Applications in Biological Analysis Microarrays Cellular analyses (single cells, enzymatic assays, cell sorting) Proteomics 6. System integration Applications in radiochemistry, diagnostics and high-throughput experimentation | |||||
Skript | Lecture handouts will be provided | |||||
Voraussetzungen / Besonderes | Die Vorlesung wird für Studierende aus Basel (BSSE) aufgezeichnet, genaue Angaben wann und wo wird später bekannt gegeben. | |||||
636-0003-00L | Biological Engineering and Biotechnology | W | 6 KP | 3G | M. Fussenegger | |
Kurzbeschreibung | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||
Lernziel | 1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development. | |||||
Skript | Handsout during the course. | |||||
Bioimaging | ||||||
Kernfächer der Vertiefung Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0385-00L | Biomedical Imaging | W | 4 KP | 3G | S. Kozerke, U. Moser, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | Understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. | |||||
Inhalt | X-ray imaging Computed tomography Single photon emission tomography Positron emission tomography Magnetic resonance imaging Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts: Biomedical Imaging | |||||
Literatur | Introduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith, Cambridge University Press | |||||
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | G. Székely, O. Göksel, L. Van Gool | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, K. S. Mader | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
Empfohlene Wahlfächer Diese Fächer sind für die Vertiefung in Bioimaging besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0389-00L | Advanced Topics in Magnetic Resonance Imaging | Z | 0 KP | 1V | K. P. Prüssmann | |
Kurzbeschreibung | Diese Vorlesung richtet sich an Masterstudierende und Doktorierende mit vertieftem Interesse an biomedizinischer Bildgebung. Sie behandelt fortgeschrittene Aspekte der Magnetresonanzbildgebung in zweijährigem Turnus, darunter die Elektrodynamik der Signaldetektion und des Signalrauschens, Bildrekonsntruktion, Radiofrequenzpulse, Pulsschemata, sowie fortgeschrittene Kontrastmechanismen. | |||||
Lernziel | siehe oben | |||||
227-0391-00L | Medical Image Analysis | W | 3 KP | 2G | P. C. Cattin, M. A. Reyes Aguirre | |
Kurzbeschreibung | It is the objective of this lecture to introduce the basic concepts used in Medical Image Analysis. In particular the lecture focuses on shape representation schemes, segmentation techniques, and the various image registration methods commonly used in Medical Image Analysis applications. | |||||
Lernziel | This lecture aims to give an overview of the basic concepts of Medical Image Analysis and its application areas. | |||||
Voraussetzungen / Besonderes | Basic knowledge of computer vision would be helpful. | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, K. S. Mader | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
227-0967-00L | Computational Neuroimaging Clinic | W | 3 KP | 2V | K. Stephan | |
Kurzbeschreibung | This seminar teaches problem solving skills for the design and analysis of neuroimaging data (fMRI, EEG). It deals with a wide variety of real-life problems that are brought to this meeting from the neuroimaging community at Zurich. Examples may include mass-univariate and multivariate analyses of fMRI data, dynamic causal modeling of fMRI and EEG data. | |||||
Lernziel | 1. Consolidation of theoretical knowledge (obtained in the 'Methods & models for fMRI data analysis' lecture) in a practical setting. 2. Acquisition of practical problem solving strategies for computational modeling of neuroimaging data. | |||||
Inhalt | This seminar teaches problem solving skills for the design and analysis of neuroimaging data (fMRI, EEG). It deals with a wide variety of real-life problems that are brought to this meeting from the euroimaging community at Zurich. Examples may include mass-univariate and multivariate analyses of fMRI data, dynamic causal modeling of fMRI and EEG data, or analyses of neuroimaging data on the basis of Bayesian models of behaviour. | |||||
227-0969-00L | Methods & Models for fMRI Data Analysis | W | 3 KP | 2V | K. Stephan | |
Kurzbeschreibung | This course teaches methods and models for fMRI data analysis, covering all aspects of statistical parametric mapping (SPM), incl. preprocessing, the general linear model, statistical inference, multiple comparison corrections, event-related designs, and Dynamic Causal Modelling (DCM), a Bayesian framework for identification of nonlinear neuronal systems from neurophysiological data. | |||||
Lernziel | To obtain in-depth knowledge of the theoretical foundations of SPM and DCM and of their application to empirical fMRI data. | |||||
Inhalt | This course teaches state-of-the-art methods and models for fMRI data analysis. It covers all aspects of statistical parametric mapping (SPM), incl. preprocessing, the general linear model, frequentist and Bayesian inference, multiple comparison corrections, and event-related designs, and Dynamic Causal Modelling (DCM), a Bayesian framework for identification of nonlinear neuronal systems from neurophysiological data. A particular emphasis of the course will be on methodological questions arising in the context of neuroeconomic and clinical studies. | |||||
227-0971-00L | Computational Psychiatry | W | 3 KP | 2S | K. Stephan | |
Kurzbeschreibung | Current methods and concepts for deciphering mechanisms of maladaptive behaviour, such as aberrant learning and decision-making in healthy individuals and psychiatric patients.The key goal is to connect methodological training with biological and clinical knowledge about the phenomenology and pathophysiology of psychiatric and neurological diseases. | |||||
Lernziel | To understand current concepts about computational and physiological mechanisms of maladaptive behaviour and psychiatric diseases. | |||||
Inhalt | In this seminar, we discuss current methods and concepts for deciphering mechanisms of maladaptive behaviour, such as aberrant learning and decision-making in healthy individuals and psychiatric patients. The key goal is to connect methodological training (in computational and statistical techniques for analyzing behavioural, fMRI and EEG data) with biological and clinical knowledge about the phenomenology and pathophysiology of psychiatric and neurological diseases. This seminar aims at bridging the gap between mathematical modelers and clinical neuroscientists, enabling more effective communication and joint translational research. To this end, each semester a novel topic is chosen which is examined both from clinical/biological and modeling perspectives. | |||||
227-2037-00L | Physical Modelling and Simulation | W | 5 KP | 4G | C. Hafner, J. Smajic | |
Kurzbeschreibung | Physical modelling plays an important role in the analysis and design of new structures, especially for micro and nano devices where fabrication and measurement are difficult. After the fundamentals of electromagnetics, mechanics, and thermodynamics, an introduction to the main concepts and most widely used codes for physical modelling is given and commercial codes are applied. | |||||
Lernziel | Basic knowledge of the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics. Knowledge of the main concepts of numerical methods for physical modelling and simulation. Ability 1) to select appropriate software, 2) to apply it for solving given problems, 3) to validate the results, 4) to interactively improve the models until sufficiently accurate results are obtained. | |||||
Inhalt | Since the fabrication and characterization of micro- and nanostructures is difficult, expensive, and time-consuming, numerical modelling drastically reduced the design process. Although many commercial software packages are available, it is important to know the drawbacks and difficulties of the numerical methods behind them and to be able to validate the results obtained with such packages. First, an introduction to the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics is given. This is important for understanding the problems to be analyzed and for validating results obtained from software packages. After this, the main concepts of numerical methods and of the most widely used codes for physical modelling are outlined and compared, which is essential for the adequate selection of software for solving given problems. After this, prominent commercial software packages are applied to various types of problems, ranging from electrodynamics to multiphysics. For becoming able to select appropriate software and to validate the results obtained, different commercial software packages will be used and compared during the exercises in form of small projects. | |||||
151-0105-00L | Quantitative Flow Visualization | W | 4 KP | 2V + 1U | T. Rösgen | |
Kurzbeschreibung | The course provides an introduction to digital image analysis in modern flow diagnostics. Different techniques which are discussed include image velocimetry, laser induced fluorescence, liquid crystal thermography and interferometry. The physical foundations and measurement configurations are explained. Image analysis algorithms are presented in detail and programmed during the exercises. | |||||
Lernziel | Introduction to modern imaging techniques and post processing algorithms with special emphasis on flow analysis and visualization. Understanding of hardware and software requirements and solutions. Development of basic programming skills for (generic) imaging applications. | |||||
Inhalt | Fundamentals of optics, flow visualization and electronic image acquisition. Frequently used mage processing techniques (filtering, correlation processing, FFTs, color space transforms). Image Velocimetry (tracking, pattern matching, Doppler imaging). Surface pressure and temperature measurements (fluorescent paints, liquid crystal imaging, infrared thermography). Laser induced fluorescence. (Digital) Schlieren techniques, phase contrast imaging, interferometry, phase unwrapping. Wall shear and heat transfer measurements. Pattern recognition and feature extraction, proper orthogonal decomposition. | |||||
Skript | available | |||||
Voraussetzungen / Besonderes | Prerequisites: Fluiddynamics I, Numerical Mathematics, programming skills. Language: German on request. | |||||
376-1279-00L | Virtual Reality in Medicine Findet dieses Semester nicht statt. | W | 3 KP | 2V | R. Riener | |
Kurzbeschreibung | Virtual Reality has the potential to support medical training and therapy. This lecture will derive the technical principles of multi-modal (audiovisual, haptic, tactile etc.) input devices, displays and rendering techniques. Examples are presented in the fields of surgical training, intra-operative augmentation, and rehabilitation. The lecture is accompanied by practical courses and excursions. | |||||
Lernziel | Provide theoretical and practical knowledge of new principles and applications of multi-modal simulation and interface technologies in medical education, therapy, and rehabilitation. | |||||
Inhalt | Virtual Reality has the potential to provide descriptive and practical information for medical training and therapy while relieving the patient and/or the physician. Multi-modal interactions between the user and the virtual environment facilitate the generation of high-fidelity sensory impressions, by using not only visual and auditory modalities, but also kinesthetic, tactile, and even olfactory feedback. On the basis of the existing physiological constraints, this lecture will derive the technical requirements and principles of multi-modal input devices, displays, and rendering techniques. Several examples are presented that are currently being developed or already applied for surgical training, intra-operative augmentation, and rehabilitation. The lecture will be accompanied by several practical courses on graphical and haptic display devices as well as excursions to facilities equipped with large-scale VR equipment. Target Group: Students of higher semesters and PhD students of - D-HEST, D-MAVT, D-ITET, D-INFK, D-PHYS - Robotics, Systems and Control Master - Biomedical Engineering/Movement Science and Sport - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome! | |||||
Literatur | Book: Virtual Reality in Medicine. Riener, Robert; Harders, Matthias; 2012 Springer. | |||||
Voraussetzungen / Besonderes | The course language is English. Basic experience in Information Technology and Computer Science will be of advantage More details will be announced in the lecture. | |||||
151-0605-00L | Nanosystems | W | 4 KP | 4G | A. Stemmer | |
Kurzbeschreibung | From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. Special emphasis on the emerging field of molecular electronic devices. | |||||
Lernziel | Familiarize students with basic science and engineering principles governing the nano domain. | |||||
Inhalt | The course addresses basic science and engineering principles ruling the nano domain. We particularly work out the links between topics that are traditionally taught separately. Special emphasis is placed on the emerging field of molecular electronic devices, their working principles, applications, and how they may be assembled. Topics are treated in 2 blocks: (I) From Quantum to Continuum From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. (II) Interaction Forces on the Micro and Nano Scale Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. | |||||
Literatur | - Kuhn, Hans; Försterling, H.D.: Principles of Physical Chemistry. Understanding Molecules, Molecular Assemblies, Supramolecular Machines. 1999, Wiley, ISBN: 0-471-95902-2 - Chen, Gang: Nanoscale Energy Transport and Conversion. 2005, Oxford University Press, ISBN: 978-0-19-515942-4 - Ouisse, Thierry: Electron Transport in Nanostructures and Mesoscopic Devices. 2008, Wiley, ISBN: 978-1-84821-050-9 - Wolf, Edward L.: Nanophysics and Nanotechnology. 2004, Wiley-VCH, ISBN: 3-527-40407-4 - Israelachvili, Jacob N.: Intermolecular and Surface Forces. 2nd ed., 1992, Academic Press,ISBN: 0-12-375181-0 - Evans, D.F.; Wennerstrom, H.: The Colloidal Domain. Where Physics, Chemistry, Biology, and Technology Meet. Advances in Interfacial Engineering Series. 2nd ed., 1999, Wiley, ISBN: 0-471-24247-0 - Hunter, Robert J.: Foundations of Colloid Science. 2nd ed., 2001, Oxford, ISBN: 0-19-850502-7 | |||||
Voraussetzungen / Besonderes | Course format: Lectures: Thursday 10-12, ML F 36 Homework: Mini-Reviews Students select a paper (list distributed in class) and expand the topic into a Mini-Review that illuminates the particular field beyond the immediate results reported in the paper. | |||||
252-0543-01L | Computer Graphics | W | 6 KP | 3V + 2U | M. Gross, O. Sorkine Hornung | |
Kurzbeschreibung | This course covers some of the fundamental concepts of computer graphics. The two main parts of the class are image synthesis and geometric modeling. | |||||
Lernziel | At the end of the course students will be able to design and implement a rendering system based on raytracing. You will study the basic principles of modeling with splines and integrate spline-based representations into a rendering system. In addition we want to stimulate your curiosity to explore the field of computer graphics on your own or in future courses. | |||||
Inhalt | This course covers some of the fundamental concepts of computer graphics. The two main parts of the class are rendering and modeling. In the first part, we will discuss the basics of photorealistic image synthesis, i.e. how to generate a realistic image from a digital representation of a 3D scene. After introducing raytracing, we will briefly look at the physics of light transport, discuss the rendering equation, and investigate some advanced techniques to enhance the realism of rendered images. The second part will introduce the basics of modeling with curves and surfaces. We will discuss Bezier curves and surfaces, B-Splines and NURBS, and show how they can be used to design complex 3D geometry. | |||||
Skript | no | |||||
Voraussetzungen / Besonderes | Prerequisites: Fundamentals of calculus and linear algebra, basic concepts of algorithms and data structures, basic programming skills in C-like languages (we use JavaScript for exercises), Visual Computing core course recommended. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
227-1033-00L | Neuromorphic Engineering I | W | 6 KP | 2V + 3U | T. Delbrück, G. Indiveri, S.‑C. Liu | |
Kurzbeschreibung | This course covers analog circuits with emphasis on neuromorphic engineering: MOS transistors in CMOS technology, static circuits, dynamic circuits, systems (silicon neuron, silicon retina, motion circuits) and an introduction to multi-chip systems. The lectures are accompanied by weekly laboratory sessions. | |||||
Lernziel | Understanding of the characteristics of neuromorphic circuit elements and their interaction in parallel networks. | |||||
Inhalt | Neuromorphic circuits are inspired by the structure, function and plasticity of biological neurons and neural networks. Their computational primitives are based on physics of semiconductor devices. Neuromorphic architectures often rely on collective computation in parallel networks. Adaptation, learning and memory are implemented locally within the individual computational elements. Transistors are often operated in weak inversion (below threshold), where they exhibit exponential I-V characteristics and low currents. These properties lead to the feasibility of high-density, low-power implementations of functions that are computationally intensive in other paradigms. The high parallelism and connectivity of neuromorphic circuits permit structures with massive feedback without iterative methods and convergence problems and real-time processing networks for high-dimensional signals (e.g. vision). Application domains of neuromorphic circuits include silcon retinas and cochleas, real-time emulations of networks of biological neurons, and the development of autonomous robotic systems. This course covers devices in CMOS technology (MOS transistor below and above threshold, floating-gate MOS transistor, phototransducers), static circuits (differential pair, current mirror, transconductance amplifiers, multipliers, power-law circuits, resistive networks, etc.), dynamic circuits (linear and nonlinear filters, adaptive circuits), systems (silicon neuron, silicon retina, motion circuits) and an introduction to multi-chip systems. The lectures are accompanied by weekly laboratory sessions on the characterization of neuromorphic circuits, from elementary devices to systems. | |||||
Literatur | S.-C. Liu et al.: Analog VLSI Circuits and Principles; various publications. | |||||
Voraussetzungen / Besonderes | Particular: The course is highly recommended for those who intend to take the spring semester course 'Neuromorphic Engineering II', that teaches the conception and layout of such circuits with a set of inexpensive software tools, ending with an optional submission of a mini-project for CMOS fabrication. Prerequisites: Background in basics of semiconductor physics helpful, but not required. | |||||
227-1037-00L | Introduction to Neuroinformatics | W | 6 KP | 2V + 1U | K. A. Martin, M. Cook, V. Mante, M. Pfeiffer | |
Kurzbeschreibung | The course provides an introduction to the functional properties of neurons. Particularly the description of membrane electrical properties (action potentials, channels), neuronal anatomy, synaptic structures, and neuronal networks. Simple models of computation, learning, and behavior will be explained. Some artificial systems (robot, chip) are presented. | |||||
Lernziel | ||||||
Inhalt | This course considers the structure and function of biological neural networks at different levels. The function of neural networks lies fundamentally in their wiring and in the electro-chemical properties of nerve cell membranes. Thus, the biological structure of the nerve cell needs to be understood if biologically-realistic models are to be constructed. These simpler models are used to estimate the electrical current flow through dendritic cables and explore how a more complex geometry of neurons influences this current flow. The active properties of nerves are studied to understand both sensory transduction and the generation and transmission of nerve impulses along axons. The concept of local neuronal circuits arises in the context of the rules governing the formation of nerve connections and topographic projections within the nervous system. Communication between neurons in the network can be thought of as information flow across synapses, which can be modified by experience. We need an understanding of the action of inhibitory and excitatory neurotransmitters and neuromodulators, so that the dynamics and logic of synapses can be interpreted. Finally, the neural architectures of feedforward and recurrent networks will be discussed in the context of co-ordination, control, and integration of sensory and motor information in neural networks. | |||||
465-0953-00L | Biostatistik | W | 2 KP | 2V + 1U | B. Sick | |
Kurzbeschreibung | Der Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Varianzanalyse, logistische Regression, Survivalanalyse (Kaplan-Meier Kurven und Cox-Regression). | |||||
Lernziel | ||||||
551-1295-00L | Introduction to Bioinformatics: Concepts and Applications | W | 6 KP | 4G | W. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner | |
Kurzbeschreibung | Speicherung, Verarbeitung und Analyse grosser Datenmengen sind in vielen Forschungsbereichen der modernen Biologie essentiell geworden. Die Vorlesung gibt eine grundlegende Einführung in Anwendungsbereiche von Bioinformatik in der Biologie und stellt einige leicht zugängliche Programme und Datenbanken für den Anwender in Theorie und Praxis vor. | |||||
Lernziel | Introduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks. In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science. Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester. | |||||
Inhalt | Bioinformatics I will cover the following topics: From genes to databases and information BLAST searches Prediction of gene function and regulation RNA structure prediction Gene expression analysis using microarrays Protein sequence and structure databases WWW for bioinformatics Protein sequence comparisons Proteomics and de novo protein sequencing Protein structure prediction Cellular and protein interaction networks Molecular dynamics simulation | |||||
Biomechanics | ||||||
Kernfächer der Vertiefung Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0385-00L | Biomedical Imaging | W | 4 KP | 3G | S. Kozerke, U. Moser, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | Understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. | |||||
Inhalt | X-ray imaging Computed tomography Single photon emission tomography Positron emission tomography Magnetic resonance imaging Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts: Biomedical Imaging | |||||
Literatur | Introduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith, Cambridge University Press | |||||
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | G. Székely, O. Göksel, L. Van Gool | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, K. S. Mader | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
376-1651-00L | Clinical and Movement Biomechanics | W | 4 KP | 3G | S. Lorenzetti, R. List, N. Singh | |
Kurzbeschreibung | Measurement and modeling of the human movement during daily activities and in a clinical environment. | |||||
Lernziel | The students are able to analyse the human movement from a technical point of view, to process the data and perform modeling with a focus towards clinical application. | |||||
Inhalt | This course includes ethical considerations, measurement techniques, clinical testing, accessing movement data and anysis as well as modeling with regards to human movement. | |||||
376-1985-00L | Trauma-Biomechanik | W | 4 KP | 2V + 1U | K.‑U. Schmitt, M. H. Muser | |
Kurzbeschreibung | Trauma-Biomechanik ist ein interdiszipliäres Fach, das sich mit der Biomechanik von Verletzungen sowie Möglichkeiten zur Prävention von Verletzungen beschäftigt. Die Vorlesung stellt die Grundlagen der Trauma-Biomechanik dar. | |||||
Lernziel | Vermittlung von Grundlagen der Trauma-Biomechanik. | |||||
Inhalt | Die Vorlesung beschäftigt sich mit Verletzungen des menschlichen Körpers und den zugrunde liegenden Verletzungsmechanismen. Hierbei bilden Verletzungen, die im Strassenverkehr erlitten werden, den Schwerpunkt. Weitere Vorlesungsthemen sind: Crash-Tests und die dazugehörige Messtechnik (z. B. Dummys), sowie aktuelle Themen der Trauma-Biomechanik wie z.B. Fussgänger-Kollisionen, Kinderrückhaltesysteme und Fahrzeugsitze. | |||||
Skript | Unterlagen können via Homepage bezogen werden. | |||||
Literatur | Schmitt K-U, Niederer P, M. Muser, Walz F: "Trauma Biomechanics - An Introduction to Injury Biomechanics" bzw. "Trauma-Biomechanik - Einführung in die Biomechanik von Verletzungen", beide Springer Verlag. | |||||
Empfohlene Wahlfächer Diese Fächer sind für die Vertiefung in Biomechanics besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
151-0255-00L | Energy Conversion and Transport in Biosystems Findet dieses Semester nicht statt. | W | 4 KP | 2V + 1U | D. Poulikakos, A. Ferrari | |
Kurzbeschreibung | Grundlagen und Anwendungen von Thermodynamik, Energieumwandlung und Fluiddynamik in Biosystemen und Biomedizin auf Makro- und Zellebene. | |||||
Lernziel | Grundlagen und Anwendungen von Thermodynamik (Wärmeübertragung) Energieumwandlung und Fluiddynamik in Biosystemen und Biomedizin. Diese Grundlagen werden auf der Makro- als auch der Mikroebene (Zellebene) untersucht. Die Vorlesung vermittelt das für die Analysierung solcher Probleme nötige Wissen. | |||||
Inhalt | Modellierung von Wärmeübergang und Stofftransport (thermische Energie, chemisch gebundene Energie) im menschlichen Körper. Physiologie, Pathologie und biomedizinische Eingriffe mittels extremer Temperaturen (medizinische Radiofrequenztherapie, Einfrieren von Gewebe und Tieftemperaturbehandlungen) . Einführung in die wichtigsten Flüssigkeitssysteme des menschlichen Körpers (Herz-Kreislauf, Hirn-Rückenmarksflüssigkeit usw.). Beschreibung der Funktionalität dieser Systeme mittels analytischer, experimenteller und numerischer Methoden, um ihre Eigenheiten zu erfassen. Einführung in biomedizinische Methoden zur Behandlung von Erkrankungen dieser Flüssigkeitssysteme. Einführung in den Zellstoffwechsel, Energietransport in Zellen und Zell-Thermodynamik. | |||||
Skript | Skript und weitere Literatur wird verteilt. | |||||
Literatur | Im Skript gegeben. | |||||
151-0511-00L | Mechanics of Nano- and Micro-Materials | W | 4 KP | 2V + 1U | C. Daraio | |
Kurzbeschreibung | The course provides an introduction to the mechanics of nano- and micro-materials and devices, in the quasistatic and dynamic domains. It reviews scale effects in materials, surveys available characterization techniques and describes the effects of surfaces and microscale contacts. Recent applications of nano- and micro-materials in engineering systems will be discussed. | |||||
Lernziel | Learn the fundamental mechanical properties of nano- and micro-system. Understand the effects of scales on the response of materials. Explore applications and devices exploiting the response of materials at small scales. | |||||
Inhalt | follows soon | |||||
Skript | Slides and notes from the course will be provided. | |||||
Literatur | Relevant articles and reading materials will be provided. Various books will be recommended pertaining to the topics covered. | |||||
Voraussetzungen / Besonderes | Mechanics I, II, III | |||||
151-0524-00L | Continuum Mechanics for Engineers | W | 4 KP | 2V + 1U | E. Mazza | |
Kurzbeschreibung | Konstitutive Gleichungen für strukturmechanische Berechnungen werden behandelt. Dies beinhaltet anisotrope lineare Elastizität, lineare Viskoelastizität, Plastizität und Viscoplastizität. Es werden die Grundlagen der Mikro-Makro Modellierung und der Laminattheorie eingeführt. Die theoretischen Ausführungen werden durch Beispiele aus Ingenieuranwendungen und Experimente ergänzt. | |||||
Lernziel | Behandlung von Grundlagen zur Lösung kontinuumsmechanischer Probleme der Anwendung, mit besonderem Fokus auf konstitutive Gesetze. | |||||
Inhalt | Anisotrope Elastizität, Linearelastisches und linearviskoses Stoffverhalten, Viskoelastizität, mikro-makro Modellierung, Laminattheorie, Plastizität, Viscoplastizität, Beispiele aus der Ingenieuranwendung, Vergleich mit Experimenten. | |||||
Skript | ja | |||||
151-0604-00L | Microrobotics | W | 4 KP | 3G | B. Nelson | |
Kurzbeschreibung | Microrobotics is an interdisciplinary field that combines aspects of robotics, micro and nanotechnology, biomedical engineering, and materials science. The aim of this course is to expose students to the fundamentals of this emerging field. Throughout the course students are expected to submit assignments. The course concludes with an end-of-semester examination. | |||||
Lernziel | The objective of this course is to expose students to the fundamental aspects of the emerging field of microrobotics. This includes a focus on physical laws that predominate at the microscale, technologies for fabricating small devices, bio-inspired design, and applications of the field. | |||||
Inhalt | Main topics of the course include: - Scaling laws at micro/nano scales - Electrostatics - Electromagnetism - Low Reynolds number flows - Observation tools - Materials and fabrication methods - Applications of biomedical microrobots | |||||
Skript | The powerpoint slides presented in the lectures will be made available in hardcopy and as pdf files. Several readings will also be made available electronically. | |||||
Voraussetzungen / Besonderes | The lecture will be taught in English. | |||||
151-0605-00L | Nanosystems | W | 4 KP | 4G | A. Stemmer | |
Kurzbeschreibung | From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. Special emphasis on the emerging field of molecular electronic devices. | |||||
Lernziel | Familiarize students with basic science and engineering principles governing the nano domain. | |||||
Inhalt | The course addresses basic science and engineering principles ruling the nano domain. We particularly work out the links between topics that are traditionally taught separately. Special emphasis is placed on the emerging field of molecular electronic devices, their working principles, applications, and how they may be assembled. Topics are treated in 2 blocks: (I) From Quantum to Continuum From atoms to molecules to condensed matter: characteristic properties of simple nanosystems and how they evolve when moving towards complex ensembles. (II) Interaction Forces on the Micro and Nano Scale Intermolecular forces, their macroscopic manifestations, and ways to control such interactions. Self-assembly and directed assembly of 2D and 3D structures. | |||||
Literatur | - Kuhn, Hans; Försterling, H.D.: Principles of Physical Chemistry. Understanding Molecules, Molecular Assemblies, Supramolecular Machines. 1999, Wiley, ISBN: 0-471-95902-2 - Chen, Gang: Nanoscale Energy Transport and Conversion. 2005, Oxford University Press, ISBN: 978-0-19-515942-4 - Ouisse, Thierry: Electron Transport in Nanostructures and Mesoscopic Devices. 2008, Wiley, ISBN: 978-1-84821-050-9 - Wolf, Edward L.: Nanophysics and Nanotechnology. 2004, Wiley-VCH, ISBN: 3-527-40407-4 - Israelachvili, Jacob N.: Intermolecular and Surface Forces. 2nd ed., 1992, Academic Press,ISBN: 0-12-375181-0 - Evans, D.F.; Wennerstrom, H.: The Colloidal Domain. Where Physics, Chemistry, Biology, and Technology Meet. Advances in Interfacial Engineering Series. 2nd ed., 1999, Wiley, ISBN: 0-471-24247-0 - Hunter, Robert J.: Foundations of Colloid Science. 2nd ed., 2001, Oxford, ISBN: 0-19-850502-7 | |||||
Voraussetzungen / Besonderes | Course format: Lectures: Thursday 10-12, ML F 36 Homework: Mini-Reviews Students select a paper (list distributed in class) and expand the topic into a Mini-Review that illuminates the particular field beyond the immediate results reported in the paper. | |||||
227-2037-00L | Physical Modelling and Simulation | W | 5 KP | 4G | C. Hafner, J. Smajic | |
Kurzbeschreibung | Physical modelling plays an important role in the analysis and design of new structures, especially for micro and nano devices where fabrication and measurement are difficult. After the fundamentals of electromagnetics, mechanics, and thermodynamics, an introduction to the main concepts and most widely used codes for physical modelling is given and commercial codes are applied. | |||||
Lernziel | Basic knowledge of the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics. Knowledge of the main concepts of numerical methods for physical modelling and simulation. Ability 1) to select appropriate software, 2) to apply it for solving given problems, 3) to validate the results, 4) to interactively improve the models until sufficiently accurate results are obtained. | |||||
Inhalt | Since the fabrication and characterization of micro- and nanostructures is difficult, expensive, and time-consuming, numerical modelling drastically reduced the design process. Although many commercial software packages are available, it is important to know the drawbacks and difficulties of the numerical methods behind them and to be able to validate the results obtained with such packages. First, an introduction to the fundamental equations and effects of electromagnetics, mechanics, and thermodynamics is given. This is important for understanding the problems to be analyzed and for validating results obtained from software packages. After this, the main concepts of numerical methods and of the most widely used codes for physical modelling are outlined and compared, which is essential for the adequate selection of software for solving given problems. After this, prominent commercial software packages are applied to various types of problems, ranging from electrodynamics to multiphysics. For becoming able to select appropriate software and to validate the results obtained, different commercial software packages will be used and compared during the exercises in form of small projects. | |||||
263-5001-00L | Introduction to Finite Elements and Sparse Linear System Solving | W | 4 KP | 2V + 1U | P. Arbenz, T. Kaman | |
Kurzbeschreibung | The finite element (FE) method is the method of choice for (approximately) solving partial differential equations on complicated domains. In the first third of the lecture, we give an introduction to the method. The rest of the lecture will be devoted to methods for solving the large sparse linear systems of equation that a typical for the FE method. We will consider direct and iterative methods. | |||||
Lernziel | Students will know the most important direct and iterative solvers for sparse linear systems. They will be able to determine which solver to choose in particular situations. | |||||
Inhalt | I. THE FINITE ELEMENT METHOD (1) Introduction, model problems. (2) 1D problems. Piecewise polynomials in 1D. (3) 2D problems. Triangulations. Piecewise polynomials in 2D. (4) Variational formulations. Galerkin finite element method. (5) Implementation aspects. II. DIRECT SOLUTION METHODS (6) LU and Cholesky decomposition. (7) Sparse matrices. (8) Fill-reducing orderings. III. ITERATIVE SOLUTION METHODS (9) Stationary iterative methods, preconditioning. (10) Preconditioned conjugate gradient method (PCG). (11) Incomplete factorization preconditioning. (12) Multigrid preconditioning. (13) Nonsymmetric problems (GMRES, BiCGstab). (14) Indefinite problems (SYMMLQ, MINRES). | |||||
Literatur | [1] M. G. Larson, F. Bengzon: The Finite Element Method: Theory, Implementation, and Applications. Springer, Heidelberg, 2013. [2] H. Elman, D. Sylvester, A. Wathen: Finite elements and fast iterative solvers. OUP, Oxford, 2005. [3] Y. Saad: Iterative methods for sparse linear systems (2nd ed.). SIAM, Philadelphia, 2003. [4] T. Davis: Direct Methods for Sparse Linear Systems. SIAM, Philadelphia, 2006. [5] H.R. Schwarz: Die Methode der finiten Elemente (3rd ed.). Teubner, Stuttgart, 1991. | |||||
Voraussetzungen / Besonderes | Prerequisites: Linear Algebra, Analysis, Computational Science. The exercises are made with Matlab. | |||||
376-1219-00L | Rehabilitation Engineering II: Rehabilitation of Sensory and Vegetative Functions | W | 3 KP | 2V | R. Riener, R. Gassert | |
Kurzbeschreibung | Rehab. Engineering is the application of science and technology to ameliorate the handicaps of individuals with disabilities to reintegrate them into society.The goal is to present classical and new rehabilitation engineering principles applied to compensate or enhance motor, sensory, and cognitive deficits. Focus is on the restoration and treatment of the human sensory and vegetative system. | |||||
Lernziel | Provide knowledge on the anatomy and physiology of the human sensory system, related dysfunctions and pathologies, and how rehabilitation engineering can provide sensory restoration and substitution. | |||||
Inhalt | Introduction, problem definition, overview Rehabilitation of visual function - Anatomy and physiology of the visual sense - Technical aids (glasses, sensor substitution) - Retina and cortex implants Rehabilitation of hearing function - Anatomy and physiology of the auditory sense - Hearing aids - Cochlea Implants Rehabilitation and use of kinesthetic and tactile function - Anatomy and physiology of the kinesthetic and tactile sense - Tactile/haptic displays for motion therapy (incl. electrical stimulation) - Role of displays in motor learning Rehabilitation of vestibular function - Anatomy and physiology of the vestibular sense - Rehabilitation strategies and devices (e.g. BrainPort) Rehabilitation of vegetative Functions - Cardiac Pacemaker - Phrenic stimulation, artificial breathing aids - Bladder stimulation, artificial sphincter Brain stimulation and recording - Deep brain stimulation for patients with Parkinson, epilepsy, depression - Brain-Computer Interfaces | |||||
Literatur | Introductory Books: An Introduction to Rehabilitation Engineering. R. A. Cooper, H. Ohnabe, D. A. Hobson (Eds.). Taylor & Francis, 2007. Principles of Neural Science. E. R. Kandel, J. H. Schwartz, T. M Jessell (Eds.). Mc Graw Hill, New York, 2000. Force and Touch Feedback for Virtual Reality. G. C. Burdea (Ed.). Wiley, New York, 1996 (available on NEBIS). Human Haptic Perception, Basics and Applications. M. Grunwald (Ed.). Birkhäuser, Basel, 2008. The Sense of Touch and Its Rendering, Springer Tracts in Advanced Robotics 45, A. Bicchi et al.(Eds). Springer-Verlag Berlin, 2008. Interaktive und autonome Systeme der Medizintechnik - Funktionswiederherstellung und Organersatz. Herausgeber: J. Werner, Oldenbourg Wissenschaftsverlag 2005. Neural prostheses - replacing motor function after desease or disability. Eds.: R. Stein, H. Peckham, D. Popovic. New York and Oxford: Oxford University Press. Advances in Rehabilitation Robotics - Human-Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Eds: Z.Z. Bien, D. Stefanov (Lecture Notes in Control and Information Science, No. 306). Springer Verlag Berlin 2004. Intelligent Systems and Technologies in Rehabilitation Engineering. Eds: H.N.L. Teodorescu, L.C. Jain (International Series on Computational Intelligence). CRC Press Boca Raton, 2001. Selected Journal Articles and Web Links: Abbas, J., Riener, R. (2001) Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function. Neuromodulation 4, pp. 187-195. Bach-y-Rita P., Tyler M., and Kaczmarek K (2003). Seeing with the brain. International journal of human-computer-interaction, 15(2):285-295. Burdea, G., Popescu, V., Hentz, V., and Colbert, K. (2000): Virtual reality-based orthopedic telerehabilitation, IEEE Trans. Rehab. Eng., 8, pp. 430-432 Colombo, G., Jörg, M., Schreier, R., Dietz, V. (2000) Treadmill training of paraplegic patients using a robotic orthosis. Journal of Rehabilitation Research and Development, vol. 37, pp. 693-700. Hayward, V. (2008): A Brief Taxonomy of Tactile Illusions and Demonstrations That Can Be Done In a Hardware Store. Brain Research Bulletin, Vol 75, No 6, pp 742-752 Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T. (1998): Robot-aided neurorehabilitation, IEEE Trans. Rehab. Eng., 6, pp. 75-87 Levesque. V. (2005). Blindness, technology and haptics. Technical report, McGill University. Available at: Link Quintern, J. (1998) Application of functional electrical stimulation in paraplegic patients. NeuroRehabilitation 10, pp. 205-250. Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10. Riener, R. (1999) Model-based development of neuroprostheses for paraplegic patients. Royal Philosophical Transactions: Biological Sciences 354, pp. 877-894. The vOICe. Link. VideoTact, ForeThought Development, LLC. Link | |||||
Voraussetzungen / Besonderes | Target Group: Students of higher semesters and PhD students of - D-MAVT, D-ITET, D-INFK, D-HEST - Biomedical Engineering, Robotics, Systems and Control - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome | |||||
376-1279-00L | Virtual Reality in Medicine Findet dieses Semester nicht statt. | W | 3 KP | 2V | R. Riener | |
Kurzbeschreibung | Virtual Reality has the potential to support medical training and therapy. This lecture will derive the technical principles of multi-modal (audiovisual, haptic, tactile etc.) input devices, displays and rendering techniques. Examples are presented in the fields of surgical training, intra-operative augmentation, and rehabilitation. The lecture is accompanied by practical courses and excursions. | |||||
Lernziel | Provide theoretical and practical knowledge of new principles and applications of multi-modal simulation and interface technologies in medical education, therapy, and rehabilitation. | |||||
Inhalt | Virtual Reality has the potential to provide descriptive and practical information for medical training and therapy while relieving the patient and/or the physician. Multi-modal interactions between the user and the virtual environment facilitate the generation of high-fidelity sensory impressions, by using not only visual and auditory modalities, but also kinesthetic, tactile, and even olfactory feedback. On the basis of the existing physiological constraints, this lecture will derive the technical requirements and principles of multi-modal input devices, displays, and rendering techniques. Several examples are presented that are currently being developed or already applied for surgical training, intra-operative augmentation, and rehabilitation. The lecture will be accompanied by several practical courses on graphical and haptic display devices as well as excursions to facilities equipped with large-scale VR equipment. Target Group: Students of higher semesters and PhD students of - D-HEST, D-MAVT, D-ITET, D-INFK, D-PHYS - Robotics, Systems and Control Master - Biomedical Engineering/Movement Science and Sport - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome! | |||||
Literatur | Book: Virtual Reality in Medicine. Riener, Robert; Harders, Matthias; 2012 Springer. | |||||
Voraussetzungen / Besonderes | The course language is English. Basic experience in Information Technology and Computer Science will be of advantage More details will be announced in the lecture. | |||||
376-1351-00L | Micro/Nanotechnology and Microfluidics for Biomedical Applications | W | 2 KP | 2V | E. Delamarche | |
Kurzbeschreibung | This course is an introduction to techniques in micro/nanotechnology and to microfluidics. It reviews how many familiar devices are built and can be used for research and biomedical applications. Transistors for DNA sequencing, beamers for patterning proteins, hard-disk technology for biosensing and scanning microfluidics for analyzing tissue sections are just a few examples of the covered topics. | |||||
Lernziel | The main objective of the course is to introduce micro/nanotechnology and microfluidics to students having a background in the life sciences. The course should familiarize the students with the techniques used in micro/nanotechnology and show them how micro/nanotechnology pervades throughout life sciences. Microfluidics will be emphasized due to their increasing importance in research and medical applications. The second objective is to have life students less intimidated by micro/nanotechnology and make them able to link instruments and techniques to specific problems that they might have in their projects/studies. This will also help students getting access to the ETHZ/IBM Nanotech Center infrastructure if needed. | |||||
Inhalt | Mostly formal lectures (2 × 45 min), with a 2 hour visit and introduction to cleanroom and micro/nanotechnology instruments, last 3 sessions would be dedicated to the presentation and evaluation of projects by students (3 students per team). | |||||
Voraussetzungen / Besonderes | Nanotech center and lab visit at IBM would be mandatory, as well as attending the student project presentations. | |||||
376-1714-00L | Biocompatible Materials | W | 4 KP | 3G | K. Maniura, P. M. Kollmannsberger, J. Möller, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced. | |||||
Lernziel | The class consists of three parts: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. | |||||
Inhalt | Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers. | |||||
Skript | Handouts can be accessed online. | |||||
Literatur | Literatur Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts provided during the classes and references therin. | |||||
376-1720-00L | Application of MATLAB in the Human Movement Sciences | W | 2 KP | 2G | R. van de Langenberg | |
Kurzbeschreibung | Basierend auf bewegungstypischen Messungen (Kinematik, Kinetik, Muskelaktivität, etc.) werden die Grundzüge der Datenverarbeitung und Datendarstellung mittels MATLAB vermittelt. | |||||
Lernziel | Selbstständiges Einlesen, Darstellen und Weiterverarbeiten von für die Bewegungs-wissenschaften typischen Messdaten in MATLAB. | |||||
Inhalt | Grenzen von Excel; Möglichkeiten von MATLAB; Einlesen diverses Datentypen, Darstellen eines und mehrerer Signale; Beseitigen eines Offsets und Filtern der Daten anhand von selbstgeschriebenen Funktionen; Normieren und Parametrisieren von Daten; Reliabilität; Interpolieren, Differenzieren und Integrieren in MATLAB. | |||||
Literatur | In der Vorlesung wird auf diverse elektronische Einführungen in MATLAB aufmerksam gemacht. Jede Vorlesung wird den Studenten in Skript-Form zur Verfügung gestellt. | |||||
Voraussetzungen / Besonderes | Laptop samt installiertem WLAN und MATLAB (Version 2009 oder höher) sind mitzubringen. Gegebenenfalls kann zu zweit an einem Laptop gearbeitet werden. Eine MATLAB-Studentenversion kann gratis über Stud-IDES bezogen werden. | |||||
376-1974-00L | Colloquium in Biomechanics | W | 2 KP | 2K | B. Helgason, S. J. Ferguson, R. Müller, J. G. Snedeker, W. R. Taylor, M. Zenobi-Wong | |
Kurzbeschreibung | Current topics in biomechanics presented by speakers from academia and industry. | |||||
Lernziel | Getting insight into actual areas and problems of biomechanics. | |||||
376-2017-00L | Biomechanik von Sportverletzungen und Rehabilitation | W | 3 KP | 2V | K.‑U. Schmitt, J. Goldhahn | |
Kurzbeschreibung | Die Veranstaltung vermittelt die Grundlagen der Verletzungsbiomechanik. Sportverletzungen und deren Rehabilitation bilden dabei den Schwerpunkt der Vorlesung. | |||||
Lernziel | In dieser Veranstaltung sollen Sie Grundlagen der Traumabiomechanik erlernen. Anhand von Beispielen aus dem Sport lernen Sie verschiedene Mechanismen, die zu Verletzungen des menschlichen Körpers führen können, kennen. Sie sollen ein Verständnis für das Entstehen von Verletzungen entwickeln, das Sie in die Lage versetzt Verletzungspotentiale abzuschätzen und präventive Massnahmen zu entwickeln. | |||||
Inhalt | Die Veranstaltung beschäftigt sich mit den Grundlagen der Verletzungsmechanik und der Rehabilitation. Es wird untersucht, wie Verletzungen entstehen und wie sie verhindert werden können. Die Vorlesung konzentriert sich dabei auf Verletzungen, die im Sport erlitten werden. | |||||
Skript | Steht zum Download zur Verfügung. | |||||
Literatur | Schmitt K-U, Niederer P, M. Muser, Walz F: "Trauma Biomechanics - An Introduction to Injury Biomechanics" bzw. "Trauma-Biomechanik - Einführung in die Biomechanik von Verletzungen", beide Springer Verlag | |||||
Voraussetzungen / Besonderes | Die Mitarbeit an einer Gruppenarbeit ist fester Bestandteil der Veranstaltung. Die Gruppenarbeit wird benotet und zählt somit zur Gesamtnote der Vorlesung hinzu. Nähere Informationen werden in der ersten Vorlesung gegeben. | |||||
402-0341-00L | Medical Physics I | W | 6 KP | 2V + 1U | P. Manser | |
Kurzbeschreibung | Introduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations. | |||||
Lernziel | Understanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society. | |||||
Inhalt | The lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications. | |||||
Skript | A script will be provided. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
465-0953-00L | Biostatistik | W | 2 KP | 2V + 1U | B. Sick | |
Kurzbeschreibung | Der Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Varianzanalyse, logistische Regression, Survivalanalyse (Kaplan-Meier Kurven und Cox-Regression). | |||||
Lernziel | ||||||
551-1295-00L | Introduction to Bioinformatics: Concepts and Applications | W | 6 KP | 4G | W. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner | |
Kurzbeschreibung | Speicherung, Verarbeitung und Analyse grosser Datenmengen sind in vielen Forschungsbereichen der modernen Biologie essentiell geworden. Die Vorlesung gibt eine grundlegende Einführung in Anwendungsbereiche von Bioinformatik in der Biologie und stellt einige leicht zugängliche Programme und Datenbanken für den Anwender in Theorie und Praxis vor. | |||||
Lernziel | Introduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks. In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science. Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester. | |||||
Inhalt | Bioinformatics I will cover the following topics: From genes to databases and information BLAST searches Prediction of gene function and regulation RNA structure prediction Gene expression analysis using microarrays Protein sequence and structure databases WWW for bioinformatics Protein sequence comparisons Proteomics and de novo protein sequencing Protein structure prediction Cellular and protein interaction networks Molecular dynamics simulation | |||||
Molecular Bioengineering | ||||||
Kernfächer der Vertiefung Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-1714-00L | Biocompatible Materials | W | 4 KP | 3G | K. Maniura, P. M. Kollmannsberger, J. Möller, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced. | |||||
Lernziel | The class consists of three parts: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. | |||||
Inhalt | Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers. | |||||
Skript | Handouts can be accessed online. | |||||
Literatur | Literatur Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts provided during the classes and references therin. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
465-0953-00L | Biostatistik | W | 2 KP | 2V + 1U | B. Sick | |
Kurzbeschreibung | Der Kurs behandelt einfache quantitative und graphische als auch komplexere Methoden der Biostatistik. Inhalt: Deskriptive Statistik, Wahrscheinlichkeitsrechnung und Versuchsplanung, Prüfung von Hypothesen, Konfidenzintervalle, Korrelation, einfache und multiple lineare Regression, Varianzanalyse, logistische Regression, Survivalanalyse (Kaplan-Meier Kurven und Cox-Regression). | |||||
Lernziel | ||||||
551-0103-00L | Grundlagen der Biologie II: Zellbiologie | W | 5 KP | 5V | U. Kutay, Y. Barral, E. Hafen, G. Schertler, U. Suter, S. Werner | |
Kurzbeschreibung | Ziel dieses Kurses ist ein breites Grundverständnis für die Zellbiologie zu vermitteln. Dieses Basiswissen wird den Studenten ermöglichen, sich in die Zellbiologie sowie in verwandte Gebiete wie Biochemie, Mikrobiologie, Pharmazie, Molekularbiologie und andere zu vertiefen. | |||||
Lernziel | Ziel dieses Kurses ist ein breites Grundverständnis für die Zellbiologie zu vermitteln. Dieses Basiswissen wird den Studenten ermöglichen, sich in die Zellbiologie sowie in verwandte Gebiete wie Biochemie, Mikrobiologie, Pharmazie, Molekularbiologie und andere zu vertiefen. | |||||
Inhalt | Das Hauptaugenmerk liegt auf der Biologie von Säugerzellen und der Entwicklung multizellulärer Organismen mit Schwerpunkt auf molekularen Mechanismen, die zellulären Strukturen und Phänomenen zugrunde liegen. Die behandelten Themen umfassen biologische Membranen, das Zytoskelett, Protein Sorting, Energiemetabolismus, Zellzyklus und Zellteilung, Viren, die extrazelluläre Matrix, Signaltransduktion, Entwicklungsbiologie und Krebsforschung. | |||||
Skript | Die Vorlesungsinhalte werden mithilfe von Powerpoint präsentiert. Die Präsentationen können von ETH Studenten heruntergeladen werden (Link). Ausgewählte Vorlesungen können auf dem ETH Netz im live Format (Livestream) angehört werden. | |||||
Literatur | Die Vorlesung folgt Alberts et al. ‘Molecular Biology of the Cell’ Fünfte Auflage, 2008 ISBN 978-0-8153-4105-5 (gebunden) und ISBN 978-0-8153-4106-2 (Taschenbuchausgabe). | |||||
Voraussetzungen / Besonderes | Einige Vorlesungseinheiten werden in englischer Sprache gehalten. | |||||
551-1295-00L | Introduction to Bioinformatics: Concepts and Applications | W | 6 KP | 4G | W. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner | |
Kurzbeschreibung | Speicherung, Verarbeitung und Analyse grosser Datenmengen sind in vielen Forschungsbereichen der modernen Biologie essentiell geworden. Die Vorlesung gibt eine grundlegende Einführung in Anwendungsbereiche von Bioinformatik in der Biologie und stellt einige leicht zugängliche Programme und Datenbanken für den Anwender in Theorie und Praxis vor. | |||||
Lernziel | Introduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks. In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science. Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester. | |||||
Inhalt | Bioinformatics I will cover the following topics: From genes to databases and information BLAST searches Prediction of gene function and regulation RNA structure prediction Gene expression analysis using microarrays Protein sequence and structure databases WWW for bioinformatics Protein sequence comparisons Proteomics and de novo protein sequencing Protein structure prediction Cellular and protein interaction networks Molecular dynamics simulation | |||||
636-0003-00L | Biological Engineering and Biotechnology | W | 6 KP | 3G | M. Fussenegger | |
Kurzbeschreibung | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||
Lernziel | 1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development. | |||||
Skript | Handsout during the course. | |||||
Empfohlene Wahlfächer Diese Fächer sind für die Vertiefung in Molecular Bioengineering besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
151-0604-00L | Microrobotics | W | 4 KP | 3G | B. Nelson | |
Kurzbeschreibung | Microrobotics is an interdisciplinary field that combines aspects of robotics, micro and nanotechnology, biomedical engineering, and materials science. The aim of this course is to expose students to the fundamentals of this emerging field. Throughout the course students are expected to submit assignments. The course concludes with an end-of-semester examination. | |||||
Lernziel | The objective of this course is to expose students to the fundamental aspects of the emerging field of microrobotics. This includes a focus on physical laws that predominate at the microscale, technologies for fabricating small devices, bio-inspired design, and applications of the field. | |||||
Inhalt | Main topics of the course include: - Scaling laws at micro/nano scales - Electrostatics - Electromagnetism - Low Reynolds number flows - Observation tools - Materials and fabrication methods - Applications of biomedical microrobots | |||||
Skript | The powerpoint slides presented in the lectures will be made available in hardcopy and as pdf files. Several readings will also be made available electronically. | |||||
Voraussetzungen / Besonderes | The lecture will be taught in English. | |||||
227-0385-00L | Biomedical Imaging | W | 4 KP | 3G | S. Kozerke, U. Moser, M. Rudin | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | Understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. Develop the mathematical framework to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. | |||||
Inhalt | X-ray imaging Computed tomography Single photon emission tomography Positron emission tomography Magnetic resonance imaging Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts: Biomedical Imaging | |||||
Literatur | Introduction to Medical Imaging: Physics, Engineering and Clinical Applications by Andrew Webb, Nadine Barrie Smith, Cambridge University Press | |||||
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, K. S. Mader | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
327-0505-00L | Surfaces, Interfaces & their Applications I | W | 3 KP | 2V + 1U | N. Spencer, M. P. Heuberger, L. Isa | |
Kurzbeschreibung | After being introduced to the physical/chemical principles and importance of surfaces and interfaces, the student is introduced to the most important techniques that can be used to characterize surfaces. Later, liquid interfaces are treated, followed by an introduction to the fields of tribology (friction, lubrication, and wear) and corrosion. | |||||
Lernziel | To gain an understanding of the physical and chemical principles, as well as the tools and applications of surface science, and to be able to choose appropriate surface-analytical approaches for solving problems. | |||||
Inhalt | Introduction to Surface Science Physical Structure of Surfaces Surface Forces (static and dynamic) Adsorbates on Surfaces Surface Thermodynamics and Kinetics The Solid-Liquid Interface Electron Spectroscopy Vibrational Spectroscopy on Surfaces Scanning Probe Microscopy Introduction to Tribology Introduction to Corrosion Science | |||||
Skript | Script Download: Link | |||||
Literatur | Script (20 CHF) Book: "Surface Analysis--The Principal Techniques", Ed. J.C. Vickerman, Wiley, ISBN 0-471-97292 | |||||
Voraussetzungen / Besonderes | Chemistry: General undergraduate chemistry including basic chemical kinetics and thermodynamics Physics: General undergraduate physics including basic theory of diffraction and basic knowledge of crystal structures | |||||
327-1101-00L | Biomineralization | W | 2 KP | 2V | K.‑H. Ernst | |
Kurzbeschreibung | The course addresses undergraduate and graduate students interested in getting introduced into the basic concepts of biomineralization. | |||||
Lernziel | The course aims to introduce the basic concepts of biomineralization and the underlying principles, such as supersaturation, nucleation and growth of minerals, the interaction of biomolecules with mineral surfaces, and cell biology of inorganic materials creation. An important part of this class is the independent study and the presentation of original literature from the field. | |||||
Inhalt | Biomineralization is a multidisciplinary field. Topics dealing with biology, molecular and cell biology, solid state physics, mineralogy, crystallography, organic and physical chemistry, biochemistry, dentistry, oceanography, geology, etc. are addressed. The course covers definition and general concepts of biomineralization (BM)/ types of biominerals and their function / crystal nucleation and growth / biological induction of BM / control of crystal morphology, habit, shape and orientation by organisms / strategies of compartmentalization / the interface between biomolecules (peptides, polysaccharides) and the mineral phase / modern experimental methods for studying BM phenomena / inter-, intra, extra- and epicellular BM / organic templates and matrices for BM / structure of bone, teeth (vertebrates and invertebrates) and mollusk shells / calcification / silification in diatoms, radiolaria and plants / calcium and iron storage / impact of BM on lithosphere and atmosphere/ evolution / taxonomy of organisms. 1. Introduction and overview 2. Biominerals and their functions 3. Chemical control of biomineralization 4. Control of morphology: Organic templates and additives 5. Modern methods of investigation of BM 6. BM in matrices: bone and nacre 7. Vertebrate teeth 8. Invertebrate teeth 9. BM within vesicles: calcite of coccoliths 10. Silica 11. Iron storage and mineralization | |||||
Skript | Script with more than 600 pages with many illustrations will be distributed free of charge. | |||||
Literatur | 1) S. Mann, Biomineralization, Oxford University Press, 2001, Oxford, New York 2) H. Lowenstam, S. Weiner, On Biomineralization, Oxford University Press, 1989, Oxford 3) P. M. Dove, J. J. DeYoreo, S. Weiner (Eds.) Biomineralization, Reviews in Mineralogoy & Geochemistry Vol. 54, 2003 | |||||
Voraussetzungen / Besonderes | Each attendee is required to present a publication from the field. The selection of key papers is provided by the lecturer. No special requirements are needed for attending. Basic knowledge in chemistry and cell biology is expected. | |||||
402-0341-00L | Medical Physics I | W | 6 KP | 2V + 1U | P. Manser | |
Kurzbeschreibung | Introduction to the fundamentals of medical radiation physics. Functional chain due to radiation exposure from the primary physical effect to the radiobiological and medically manifest secondary effects. Dosimetric concepts of radiation protection in medicine. Mode of action of radiation sources used in medicine and its illustration by means of Monte Carlo simulations. | |||||
Lernziel | Understanding the functional chain from primary physical effects of ionizing radiation to clinical radiation effects. Dealing with dose as a quantitative measure of medical exposure. Getting familiar with methods to generate ionizing radiation in medicine and learn how they are applied for medical purposes. Eventually, the lecture aims to show the students that medical physics is a fascinating and evolving discipline where physics can directly be used for the benefits of patients and the society. | |||||
Inhalt | The lecture is covering the basic principles of ionzing radiation and its physical and biological effects. The physical interactions of photons as well as of charged particles will be reviewed and their consequences for medical applications will be discussed. The concept of Monte Carlo simulation will be introduced in the excercises and will help the student to understand the characteristics of ionizing radiation in simple and complex situations. Fundamentals in dosimetry will be provided in order to understand the physical and biological effects of ionizing radiation. Deterministic as well as stochastic effects will be discussed and fundamental knowledge about radiation protection will be provided. In the second part of the lecture series, we will cover the generation of ionizing radiation. By this means, the x-ray tube, the clinical linear accelarator, and different radioactive sources in radiology, radiotherapy and nuclear medicine will be addressed. Applications in radiolgoy, nuclear medicine and radiotherapy will be described with a special focus on the physics underlying these applications. | |||||
Skript | A script will be provided. | |||||
535-0423-00L | Drug Delivery and Drug Targeting | W | 2 KP | 2V | J.‑C. Leroux, P. Luciani | |
Kurzbeschreibung | Die Studierenden erwerben einen Überblick über derzeit aktuelle Prinzipien, Methoden und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Damit sind die Studierenden in der Lage, das Gebiet gemäss wissenschaftlichen Kriterien zu verstehen und zu beurteilen. | |||||
Lernziel | Die Studierenden verfügen über einen Überblick über derzeit aktuelle Prinzipien und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Im Vordergrund der Lehrveranstaltung steht die Entwicklung von Fähigkeiten zum Verständnis der betreffenden Technologien und Methoden, ebenso wie der Möglichkeiten und Grenzen ihres therapeutischen Einsatzes. Im Zentrum stehen therapeutische Peptide, Proteine, Nukleinsäuren und Impfstoffe. | |||||
Inhalt | Der Kurs behandelt folgende Themen: Arzneistoff-targeting und Freigabeprinzipien, Radiopharmaka, makromolekulare Arzneistofftransporter, Liposomen, Mizellen, Mikro/Nanopartikel, Gele und Implantate, Anwendung von Impfstoffen, Abgabe von Wirkstoffen im Rahmen von Tissue engineering, Abgabe im Gastrointestinaltrakt, synthetische Transporter für Arzneistoffe auf Nukleinsäurebasis, ophthalmische Vehikel und neue Trends in transdermaler und nasaler Arzneistofffreigabe. | |||||
Skript | Ausgewählte Skripten, Vorlesungsunterlagen und unterstützendes Material werden entweder direkt an der Vorlesung ausgegeben oder sind über das Web zugänglich: Link Diese Website enthält auch zusätzliche Unterlagen zu peroralen Abgabesystemen, zur gastrointestinalen Passage von Arzneiformen, transdermalen Systemen und über Abgabesysteme für alternative Absorptionswege. Diese Stoffgebiete werden speziell in der Vorlesung Galenische Pharmazie II behandelt. | |||||
Literatur | A.M. Hillery, A.W. Lloyd, J. Swarbrick (Hrsg). Drug Delivery and Targeting, Taylor & Francis, London and New York 2001. Y. Perrie, T. Rhades. Pharmaceutics - Drug Delivery and Targeting, Pharmaceutical Press, London and Chicago, 2010. Weitere Literatur in der Vorlesung. | |||||
636-0507-00L | Synthetic Biology II | W | 4 KP | 4A | S. Panke, Y. Benenson, J. Stelling | |
Kurzbeschreibung | 7 months biological design project, during which the students are required to give presentations on advanced topics in synthetic biology (specifically genetic circuit design) and then select their own biological system to design. The system is subsequently modeled, analyzed, and experimentally implemented. Results are presented at an international student competition at the MIT (Cambridge). | |||||
Lernziel | The students are supposed to acquire a deep understanding of the process of biological design including model representation of a biological system, its thorough analysis, and the subsequent experimental implementation of the system and the related problems. | |||||
Inhalt | Presentations on advanced synthetic biology topics (eg genetic circuit design, adaptation of systems dynamics, analytical concepts, large scale de novo DNA synthesis), project selection, modeling of selected biological system, design space exploration, sensitivity analysis, conversion into DNA sequence, (DNA synthesis external,) implementation and analysis of design, summary of results in form of scientific presentation and poster, presentation of results at the iGEM international student competition (Link). | |||||
Skript | Handouts during course | |||||
Voraussetzungen / Besonderes | The final presentation of the project is typically at the MIT (Cambridge, US). Other competing schools include regularly Imperial College, Cambridge University, Harvard University, UC Berkeley, Princeton Universtiy, CalTech, etc. This project takes place between end of Spring Semester and beginning of Autumn Semester. Registration in April. Please note that the number of ECTS credits and the actual work load are disconnected. | |||||
Weitere Wahlfächer Diese Fächer können für die Vertiefung in Molecular Bioengineering geeignet sein. Bitte konsultieren Sie Ihren Track Adviser. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
551-0313-00L | Microbiology (Part I) | W | 3 KP | 2V | W.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel | |
Kurzbeschreibung | Advanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Lernziel | This concept class will be based on common concepts (Grundlagen der Biologie IIB, Teil Mikrobiologie) and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Inhalt | Advanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Skript | Updated handouts will be provided during the class. | |||||
Literatur | Current literature references will be provided during the lectures. | |||||
Voraussetzungen / Besonderes | English The lecture "Grundlagen der Biologie IIB", Mikrobiologie is the basis for this advanced lecture. | |||||
551-1103-00L | Microbial Biochemistry | W | 4 KP | 2V | J. Vorholt-Zambelli, T. J. Erb, J. Piel | |
Kurzbeschreibung | The lecture course aims at providing an advanced understanding of the physiology and metabolism of microorganisms. Emphasis is on processes that are specific to bacteria and archaea and that contribute to the widespread occurrence of prokaryotes. Applied aspects of microbial biochemistry will be pointed out as well as research fields of current scientific interest. | |||||
Lernziel | The lecture course aims at providing an advanced understanding of the physiology and metabolism of microorganisms. | |||||
Inhalt | Important biochemical processes specific to bacteria and archaea will be presented that contribute to the widespread occurrence of prokaryotes. Applied aspects of microbial biochemistry will be pointed out as well as research fields of current scientific interest. Emphasis is on concepts of energy generation and assimilation. List of topics: Eating sugars and letting them in Challenging: Aromatics, xenobiotics, and oil Complex: (Ligno-)Cellulose and in demand for bioenergy Living on a diet and the anaplerotic provocation Of climate relevance: The microbial C1 cycle What are AMO and Anammox? 20 amino acids: the making of Extending the genetic code The 21st and 22nd amino acid Some exotic biochemistry: nucleotides, cofactors Ancient biochemistry? Iron-sulfur clusters, polymers Secondary metabolites: playground of evolution | |||||
Skript | A script will be provided during the course. | |||||
Grundlagenfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0945-00L | Cell and Molecular Biology for Engineers | O | 6 KP | 4G | C. Frei | |
Kurzbeschreibung | The course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology. | |||||
Lernziel | After completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested. | |||||
Inhalt | Lectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells. In addition, three journal clubs will be held, where one/two publictions will be discussed. For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded, and count as 25% for the final grade. | |||||
Skript | Scripts of all lectures will be available. | |||||
Literatur | "Molecular Biology of the Cell" (5th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter. | |||||
Semesterarbeit | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-1101-00L | How to Write Scientific Texts in Engineering Sciences Strongly recommended prerequisite for Semester Projects and Master Theses at D-ITET (MSc BME, MSc EEIT, MSc EST). | E- | 0 KP | J. Leuthold | ||
Kurzbeschreibung | The 2 to 3 hour lecture will cover the basics of writing a scientific text. The focus will be on the structure and elements of scientific text and not on the language. | |||||
Lernziel | Knowledge on structure and content of a scientific text. | |||||
Inhalt | Topic 1: Structure of a Scientific Text Topic 2: The Title, the author list, the abstract, State-of-the Art, the "in this paper" paragraph, the scientific part, the summary Topic 3: Equations, Figures Topic 4: Citation rules | |||||
Literatur | ETH "Citation Etiquette", see Link. ETH Guidlines on "Guidelines for Research Integrity", see Link > Education > > Contacts, links & documents > Forms and documents > Brochures / guides. | |||||
Voraussetzungen / Besonderes | Students should already have a Bachelor degree and plan to do either a semester project or a master thesis in the immediate future. | |||||
227-1772-00L | Semester Project Only for Biomedical Engineering MSc Programme Regulations 2009 (i.e. students having started the MSc BME before autumn 2013). Please fill in the following form before registering: Link. | O | 10 KP | 20A | Professor/innen | |
Kurzbeschreibung | Die Semesterarbeit leitet die Studierenden zu selbstständigem wissenschaftlichen Arbeiten an. Mit der Studienarbeit können die technischen und auch die sozialen Fähigkeiten gefördert werden. Die Studienarbeit wird von einem Professor geleitet. | |||||
Lernziel | siehe oben | |||||
Master-Arbeit | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-1101-00L | How to Write Scientific Texts in Engineering Sciences Strongly recommended prerequisite for Semester Projects and Master Theses at D-ITET (MSc BME, MSc EEIT, MSc EST). | E- | 0 KP | J. Leuthold | ||
Kurzbeschreibung | The 2 to 3 hour lecture will cover the basics of writing a scientific text. The focus will be on the structure and elements of scientific text and not on the language. | |||||
Lernziel | Knowledge on structure and content of a scientific text. | |||||
Inhalt | Topic 1: Structure of a Scientific Text Topic 2: The Title, the author list, the abstract, State-of-the Art, the "in this paper" paragraph, the scientific part, the summary Topic 3: Equations, Figures Topic 4: Citation rules | |||||
Literatur | ETH "Citation Etiquette", see Link. ETH Guidlines on "Guidelines for Research Integrity", see Link > Education > > Contacts, links & documents > Forms and documents > Brochures / guides. | |||||
Voraussetzungen / Besonderes | Students should already have a Bachelor degree and plan to do either a semester project or a master thesis in the immediate future. | |||||
227-1700-00L | Master Thesis Admission only if all of the following apply: a. bachelor program successfully completed; b. successfull completion of the track core courses, the biology laboratory and the semester project; c. acquired (if applicable) all credits from additional requirements for admission to master program. Please fill in the following form before registering: Link. | O | 30 KP | 40D | Professor/innen | |
Kurzbeschreibung | Die Masterarbeit bildet den Abschluss des Master-Studiengangs. Sie umfasst in einem Bericht die Ergebnisse eines sechsmonatigen Forschungsprojekts. Die Studierenden haben damit belegt, dass sie eine wissenschaftliche Arbeit über ein spezifisches Problem selbstständig ausführen können. Die Diplomarbeit wird von einem Professor geleitet. | |||||
Lernziel | siehe oben | |||||
Pflichtwahlfach Geistes-, Sozial- und Staatswissenschaften | ||||||
» siehe Studiengang GESS-Pflichtwahlfächer | ||||||
Allgemein zugängliche Seminarien und Kolloquien | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0970-00L | Research Topics in Biomedical Engineering | Z | 1 KP | 2K | M. Rudin, S. Kozerke, K. P. Prüssmann, M. Stampanoni, K. Stephan, J. Vörös | |
Kurzbeschreibung | Current topics in Biomedical Engineering presented by speakers from academia and industry. | |||||
Lernziel | Getting insight into actual areas and problems of Biomedical Engineering an Health Care. | |||||
227-0980-00L | Seminar on Biomedical Magnetic Resonance | Z | 0 KP | 2K | K. P. Prüssmann, S. Kozerke, M. Rudin | |
Kurzbeschreibung | Actuel developments and problems of magnetic resonance imaging (MRI) | |||||
Lernziel | Getting insight to advanced topics in Magnetic Resonance Imaging |