Suchergebnis: Katalogdaten im Herbstsemester 2017
Gesundheitswissenschaften und Technologie Master | ||||||
Vertiefung in Bewegungswissenschaften und Sport | ||||||
Pflichtfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
---|---|---|---|---|---|---|
376-0300-00L | Translational Science for Health and Medicine | O | 3 KP | 2G | J. Goldhahn, G. von Krogh, C. Wolfrum | |
Kurzbeschreibung | Translational science is a cross disciplinary scientific research that is motivated by the need for practical applications that help people. The course should help to clarify basics of translational science, illustrate successful applications and should enable students to integrate key features into their future projects. | |||||
Lernziel | After completing this course, students will be able to understand: Principles of translational science (including project planning, ethics application, basics of resource management and interdisciplinary communication) | |||||
Inhalt | What is translational science and what is it not? How to identify need? - Disease concepts and consequences for research - Basics about incidence, prevalence etc., and orphan indications How to choose the appropriate research type and methodology - Ethical considerations including ethics application - Pros and cons of different types of research - Coordination of complex approaches incl. timing and resources How to measure success? - Outcome variables - Improving the translational process Challenges of communication? How independent is translational science? - Academic boundary conditions vs. industrial influences Positive and negative examples will be illustrated by distinguished guest speakers. | |||||
376-0302-01L | GCP Basic Course (Modul 1 and 2) Nur für Gesundheitswissenschaften und Technologie MSc. | O | 1 KP | 1G | G. Senti | |
Kurzbeschreibung | The basic course in "Good Clinical Practice" (GCP) contains of two full-time training days (Module 1 and Module 2) and addresses elementary aspects for the appropriate conduct of clinical trials and non-clinical research projects involving human beings. Successful participation will be confirmed by a certificate that is recognized by the Swiss authorities. | |||||
Lernziel | Students will get familiar with: - Key Ethics documents - (Inter)national Guidelines and Laws (e.g. ICH-GCP, DIN EN ISO 14155, TPA, HRA) - Sequence of research projects and project-involved parties - Planning of research projects (statistics, resources, study design, set-up of the study protocol) - Approval of research projects by Authorities (SwissEthics, Swissmedic, FOPH) - Roles and responsibilities of project-involved parties Students will learn how to: - Classify research projects according the risk-based approach of the HRA - Write a study protocol - Inform participating patients/study subjects - Obtain consent by participating patients/study subjects - Classify, document and report Adverse Events - Handle projects with biological material from humans and/or health- related personal data | |||||
Inhalt | Module 1: Research and Research Ethics, Guidelines, (inter)national Legislation, Development of therapeutic products, Methodology (Study Design), Study documents (Study protocol, Investigator's Brochure, Patient Information Leaflet, Informed Consent Form) Module 2: Roles and Responsibilities, Approval procedures, Notification and Reporting, Study documentation, Research with biological material and health-related data, data protection, data retention | |||||
Wahlfächer | ||||||
Wahlfächer I | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-0221-00L | Methods and Concepts in Human Systems Neuroscience and Motor Control Maximale Teilnehmerzahl: 18 | W | 4 KP | 3P | N. Wenderoth | |
Kurzbeschreibung | This course provides hands-on experience with measurement and analysis methods relevant for Humans Systems Neuroscience and Motor control (nerve/brain stimulation, EMG, EEG, psycho-physical paradigms etc). Students read scientific material, set up experiments, perform measurements in the lab, analyse data, apply statistics and write short reports or essays. | |||||
Lernziel | This course will prepare students for experimental work as it is typically done during the master thesis. The goal is to gain hands-on experience with measurement and analysis methods relevant for Humans Systems Neuroscience and Motor control (ifor example peripheral nerve stimulation, electrical and magnetic brain stimulation, EMG, EEG, psycho-physical paradigms etc). Students will learn how to perform small scientific projects in this area. Students will work individually or in small groups and solve scientific problems which require them to perform measurements in human participants, extract relevant readouts from the data, apply appropriate statistics and interpret the results. They will also be required to write small essays and reports and they will get feedback on their writing throughout the course. | |||||
Voraussetzungen / Besonderes | Students are required to have successfully completed the course "Neural control of movement and motor learning" and to have basic knowledge of applied statistics. Self-study material about applied statistics will be available at the beginning of the course and statistical knowledge will be tested (central element) in the second course week. Passing this test is a requirement for continuing the course. Students will have to solve scientific problems, requiring them to independently study scientific material, apply statistics and report their results in the form of written reports and essays. Assessments will be made on the basis of the completed theoretical and practical work that will be performed either in small groups or individually. | |||||
376-0223-00L | Advanced Topics in Exercise Physiology | W | 3 KP | 2S | C. Spengler, F. Gabe Beltrami, J. M. Kroepfl | |
Kurzbeschreibung | In this course, students read, present and discuss seminal publications in the area of exercise physiology. The focus lies on critical analysis of scientific content, conceptual as well as ethical aspects of publications. Students are trained in the most common scientific presentation techniques such as oral and poster presentations. | |||||
Lernziel | Students gain further knowledge and a deeper understanding of concepts in exercise physiology. Emphasis is put on critical analysis and discussion of scientific publications as well as on improving scientific presentation skills. | |||||
Literatur | Material will be provided in moodle. | |||||
Voraussetzungen / Besonderes | Vorlesung Sportphysiologie erfolgreich abgeschlossen. | |||||
376-0225-00L | Physical Activities and Health | W | 3 KP | 2V | E. de Bruin | |
Kurzbeschreibung | This course introduces/explores the complex relationship between physical activity, sedentary behavior and health. It will discuss the evolution of current physical activity recommendations. It will examine the current evidence base that has informed physical activity recommendations and that identified physical activity as a key modifiable lifestyle behavior contributing to disease and mortality. | |||||
Lernziel | On completion of this course students will be able to demonstrate: 1. knowledge of and critical awareness of the role of physical activity and sedentary behavior in the maintenance of health and the aetiology, prevention and treatment of disease. 2. thorough knowledge and critical awareness of current recommendations for physical activity, and current prevalence and trends of physical activity and associated diseases 3. awareness of current national and international physical activity policies and how these impact on global challenges | |||||
Inhalt | Introduction to Physical Activity for Health, including sedentary behavior Physical activity epidemiology; concepts principles and approaches Physical activity and all cause morbidity and mortality Physical activity and chronic disease; Coronary heart disease, diabetes, bone health, cancer and obesity Physical activity and brain health Physical activity and sedentary behavior recommendations Population prevalence of physical activity and sedentary behavior Physical activity policies Physical activity assessment | |||||
Literatur | Core texts for this course are: Hardman, A. and Stensel, D. Physical activity and health : the evidence explained. 2nd edition. (2009) UK, Routledge. Bouchard, C., Blair, S. N., & Haskell, W. L. (Eds.). (2012). Physical activity and health. Champaign, IL: Human Kinetics. Selective journal articles from relevant journals such as Journal of Physical Activity and Health and Journal of Aging and Physical Activity | |||||
Voraussetzungen / Besonderes | From the BSc-course the following book is recommended: 'Essentials of strength training and conditioning' T. Baechle, R. Earle (3rd Edition) | |||||
376-1651-00L | Clinical and Movement Biomechanics | W | 4 KP | 3G | S. Lorenzetti, R. List, N. Singh | |
Kurzbeschreibung | Measurement and modeling of the human movement during daily activities and in a clinical environment. | |||||
Lernziel | The students are able to analyse the human movement from a technical point of view, to process the data and perform modeling with a focus towards clinical application. | |||||
Inhalt | This course includes study design, measurement techniques, clinical testing, accessing movement data and anysis as well as modeling with regards to human movement. | |||||
752-6101-00L | Dietary Etiologies of Chronic Disease | W | 3 KP | 2V | M. B. Zimmermann | |
Kurzbeschreibung | To have the student gain understanding of the links between the diet and the etiology and progression of chronic diseases, including diabetes, gastrointestinal diseases, kidney disease, cardiovascular disease, arthritis and food allergies. | |||||
Lernziel | To examine and understand the protective effect of foods and food ingredients in the maintenance of health and the prevention of chronic disease, as well as the progression of complications of the chronic diseases. | |||||
Inhalt | The course evaluates food and food ingredients in relation to primary and secondary prevention of chronic diseases including diabetes, gastrointestinal diseases, kidney disease, cardiovascular disease, arthritis and food allergies. | |||||
Skript | There is no script. Powerpoint presentations will be made available on-line to students. | |||||
Literatur | To be provided by the individual lecturers, at their discretion. | |||||
Voraussetzungen / Besonderes | No compulsory prerequisites, but prior completion of Introduction to Nutritional Science and Advanced Topics in Nutritional Science is strongly advised. | |||||
Wahlfächer II | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0385-10L | Biomedical Imaging | W | 6 KP | 5G | S. Kozerke, K. P. Prüssmann | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | To understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. The mathematical framework is developed to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. Matlab exercises are used to implement and study basic concepts. | |||||
Inhalt | - X-ray imaging - Computed tomography - Single photon emission tomography - Positron emission tomography - Magnetic resonance imaging - Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts | |||||
Literatur | Webb A, Smith N.B. Introduction to Medical Imaging: Physics, Engineering and Clinical Applications; Cambridge University Press 2011 | |||||
Voraussetzungen / Besonderes | Analysis, Linear Algebra, Physics, Basics of Signal Theory, Basic skills in Matlab programming | |||||
227-0386-00L | Biomedical Engineering | W | 4 KP | 3G | J. Vörös, S. J. Ferguson, S. Kozerke, U. Moser, M. Rudin, M. P. Wolf, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The focus is on learning the concepts that govern common medical instruments and the most important organs from an engineering point of view. In addition, the most recent achievements and trends of the field of biomedical engineering are also outlined. | |||||
Lernziel | Introduction into selected topics of biomedical engineering as well as their relationship with physics and physiology. The course provides an overview of the various topics of the different tracks of the biomedical engineering master course and helps orienting the students in selecting their specialized classes and project locations. | |||||
Inhalt | Introduction into neuro- and electrophysiology. Functional analysis of peripheral nerves, muscles, sensory organs and the central nervous system. Electrograms, evoked potentials. Audiometry, optometry. Functional electrostimulation: Cardiac pacemakers. Function of the heart and the circulatory system, transport and exchange of substances in the human body, pharmacokinetics. Endoscopy, medical television technology. Lithotripsy. Electrical Safety. Orthopaedic biomechanics. Lung function. Bioinformatics and Bioelectronics. Biomaterials. Biosensors. Microcirculation.Metabolism. Practical and theoretical exercises in small groups in the laboratory. | |||||
Skript | Introduction to Biomedical Engineering by Enderle, Banchard, and Bronzino AND Link | |||||
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | L. Van Gool, O. Göksel, E. Konukoglu | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
327-2125-00L | Microscopy Training SEM I - Introduction to SEM Number of participants limited to 9. Master students will have priority over PhD students. PhD students may still enrol, but will be asked for a fee (Link). | W | 2 KP | 3P | S. Rodighiero, A. G. Bittermann, L. Grafulha Morales, K. Kunze, J. Reuteler | |
Kurzbeschreibung | Der Einführungskurs in Rasterelektronenmikroskopie (SEM) betont praktisches Lernen. Die Studierenden haben die Möglichkeit an zwei Elektronenmikroskopen ihre eigenen Proben oder Standard-Testproben zu untersuchen, sowie von ScopeM-Wissenschafler vorbereitete Übungen zu lösen. | |||||
Lernziel | - Set-up, align and operate a SEM successfully and safely. - Accomplish imaging tasks successfully and optimize microscope performances. - Master the operation of a low-vacuum and field-emission SEM and EDX instrument. - Perform sample preparation with corresponding techniques and equipment for imaging and analysis - Acquire techniques in obtaining secondary electron and backscatter electron micrographs - Perform EDX qualitative and semi-quantitative analysis | |||||
Inhalt | During the course, students learn through lectures, demonstrations, and hands-on sessions how to setup and operate SEM instruments, including low-vacuum and low-voltage applications. This course gives basic skills for students new to SEM. At the end of the course, students with no prior experience are able to align a SEM, to obtain secondary electron (SE) and backscatter electron (BSE) micrographs and to perform energy dispersive X-ray spectroscopy (EDX) qualitative and semi-quantitative analysis. The procedures to better utilize SEM to solve practical problems and to optimize SEM analysis for a wide range of materials will be emphasized. - Discussion of students' sample/interest - Introduction and discussion on Electron Microscopy and instrumentation - Lectures on electron sources, electron lenses and probe formation - Lectures on beam/specimen interaction, image formation, image contrast and imaging modes. - Lectures on sample preparation techniques for EM - Brief description and demonstration of the SEM microscope - Practice on beam/specimen interaction, image formation, image contrast (and image processing) - Student participation on sample preparation techniques - Scanning Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities - Lecture and demonstrations on X-ray micro-analysis (theory and detection), qualitative and semi-quantitative EDX and point analysis, linescans and spectral mapping - Practice on real-world samples and report results | |||||
Literatur | - Detailed course manual - Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 - Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007 | |||||
Voraussetzungen / Besonderes | No mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite. | |||||
327-2126-00L | Microscopy Training TEM I - Introduction to TEM Number of participants limited to 6. Master students will have priority over PhD students. PhD students may still enrol, but will be asked for a fee (Link). | W | 2 KP | 3P | S. Rodighiero, E. J. Barthazy Meier, A. G. Bittermann, F. Gramm | |
Kurzbeschreibung | Der Einführungskurs in Transmissionselektronenmikroskopie (TEM) bietet neuen Nutzern die Möglichkeit theoretisches Wissen und praktische Kenntnisse in TEM zu erwerben | |||||
Lernziel | - Overview of TEM theory, instrumentation, operation and applications. - Alignment and operation of a TEM, as well as acquisition and interpretation of images, diffraction patterns, accomplishing basic tasks successfully. - Knowledge of electron imaging modes (including Scanning Transmission Electron Microscopy), magnification calibration, and image acquisition using CCD cameras. - To set up the TEM to acquire diffraction patterns, perform camera length calibration, as well as measure and interpret diffraction patterns. - Overview of techniques for specimen preparation. | |||||
Inhalt | Using two Transmission Electron Microscopes the students learn how to align a TEM, select parameters for acquisition of images in bright field (BF) and dark field (DF), perform scanning transmission electron microscopy (STEM) imaging, phase contrast imaging, and acquire electron diffraction patterns. The participants will also learn basic and advanced use of digital cameras and digital imaging methods. - Introduction and discussion on Electron Microscopy and instrumentation. - Lectures on electron sources, electron lenses and probe formation. - Lectures on beam/specimen interaction, image formation, image contrast and imaging modes. - Lectures on sample preparation techniques for EM. - Brief description and demonstration of the TEM microscope. - Practice on beam/specimen interaction, image formation, Image contrast (and image processing). - Demonstration of Transmission Electron Microscopes and imaging modes (Phase contrast, BF, DF, STEM). - Student participation on sample preparation techniques. - Transmission Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities. - TEM alignment, calibration, correction to improve image contrast and quality. - Electron diffraction. - Practice on real-world samples and report results. | |||||
Literatur | - Detailed course manual - Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 - Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007 | |||||
Voraussetzungen / Besonderes | No mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite. | |||||
363-0301-00L | Work Design and Organizational Change | W | 3 KP | 2G | G. Grote | |
Kurzbeschreibung | Good work design is crucial for individual and company effectiveness and a core element to be considered in organizational change. Meaning of work, organization-technology interaction, and uncertainty management are discussed with respect to work design and sustainable organizational change. As course project, students learn and apply a method for analyzing and designing work in business settings. | |||||
Lernziel | - Know effects of work design on competence, motivation, and well-being - Understand links between design of individual jobs and work processes - Know basic processes involved in systematic organizational change - Understand the interaction between organization and technology and its impact on organizational change - Understand relevance of work design for company performance and strategy - Know and apply methods for analyzing and designing work | |||||
Inhalt | - Work design: From Adam Smith to job crafting - Effects of work design on performance and well-being - Approaches to analyzing and designing work - Modes of organizational change and change methods - Balancing stability and flexibility in organizations as design criterium - The organization-technology interaction and its impact on work design and organizational change - Example Flexible working arrangements - Strategic choices for work design | |||||
Literatur | A list of required readings will be provided at the beginning of the course. | |||||
Voraussetzungen / Besonderes | The course includes the completion of a course project to be conducted in groups of four students. The project entails applying a particular method for analyzing and designing work processes and is carried out by means of interviews and observations in companies chosen by the students. | |||||
376-0121-00L | Multiscale Bone Biomechanics Number of participants limited to 25. | W | 6 KP | 4S | R. Müller | |
Kurzbeschreibung | The seminar provides state-of-the-art insight to the biomechanical function of bone from molecules, to cells, tissue and up to the organ. Multiscale imaging and simulation allows linking different levels of hierarchy, where systems biology helps understanding the mechanobiological response of bone to loading and injury in scenarios relevant for personalized health and translational medicine. | |||||
Lernziel | The learning objectives include 1. advanced knowledge of the state-of-the-are in multiscale bone biomechanics; 2. basic understanding of the biological principles governing bone in health, disease and treatment from molecules, to cells, tissue and up to the organ; 3. good understanding of the prevalent biomechanical testing and imaging techniques on the various levels of bone hierarchy; 4. practical implementation of state-of-the-art multiscale simulation techniques; 5. improved programing skills through the use of 4th generation scripting language; 6. hands on experience in designing solutions for clinical and industrial problems; 7. encouragement of critical thinking and creating an environment for independent and self-directed studying. | |||||
Inhalt | Bone is one of the most investigated biological materials due to its primary function of providing skeletal stability. Bone is susceptible to different local stimuli including mechanical forces and has great capabilities in adapting its mechanical properties to the changes in its environment. Nevertheless, aging or hormonal changes can make bone lose its ability to remodel appropriately, with loss of strength and increased fracture risk as a result, leading to devastating diseases such as osteoporosis. To better understand the biomechanical function of bone, one has to understand the hierarchical organization of this fascinating material down from the molecules, to the cells, tissue and up to the organ. Multiscale imaging and simulation allows to link these different levels of hierarchy. Incorporating systems biology approaches, not only biomechanical strength of the material can be assessed but also the mechanobiological response of the bone triggered by loading and injury in scenarios relevant for personalized health and translational medicine. Watching cells working together to build and repair bone in a coordinated fashion is a spectacle, which will need dynamic image content and deep discussions in the lecture room to probe the imagination of the individual student interested in the topic. For the seminar, concepts of video lectures will be used in a flipped class room setup, where students can study the basic biology, engineering and mathematical concepts in video tutorials online. All videos and animations will be incorporated in an eSkript (eskript.ethz.ch) allowing studying and eventually even interactive course participation online. It is anticipated that the students need to prepare 2x45 minutes for the study of the actual lecture material. The Friday morning time slots will be used for students, who want to complete these assignments in a classroom setting. The student will have to study independently or in groups, but lecturer will be available for questions and answers during that time. In the Friday afternoon time slots, short clips with video/animation content will be used to introduce problems and discuss specific scientific findings using multiscale imaging and simulation technology. The students will have to form small groups to try to solve such problems and to present their solutions for advanced multiscale investigation of bone ranging from basic science to personalized health and onto translational medicine. | |||||
Skript | Material will be provided in Moodle and eScript (eskript.ethz.ch). | |||||
Voraussetzungen / Besonderes | Seminar will be held in English. | |||||
363-0790-00L | Technology Entrepreneurship | W | 2 KP | 2V | U. Claesson, B. Clarysse | |
Kurzbeschreibung | Technology ventures are significantly changing the global economic picture. Technological skills increasingly need to be complemented by entrepreneurial understanding. This course offers the fundamentals in theory and practice of entrepreneurship in new technology ventures. Main topics covered are success factors in the creation of new firms, including founding, financing and growing a venture. | |||||
Lernziel | This course provides theory-grounded knowledge and practice-driven skills for founding, financing, and growing new technology ventures. A critical understanding of dos and don'ts is provided through highlighting and discussing real life examples and cases. | |||||
Inhalt | See course website: Link | |||||
Skript | Lecture slides and case material | |||||
376-0130-00L | Praktikum Sportphysiologie Maximale Teilnehmerzahl: 48 Studiengang HST: ab 5. Semester möglich | W | 3 KP | 4P | C. Spengler | |
Kurzbeschreibung | Durchführung sportphysiologischer Tests und Erhebungen, welche bei Sportlern und/oder bei der Untersuchung verschiedener Krankheitsbilder Anwendung finden, und die das Verständnis für die physiologischen Adaptationsmechanismen an unterschiedliche körperliche Belastungen vertiefen. | |||||
Lernziel | Die Sportphysiologie praktisch erfahren und das Verständnis der körperlichen Anpassungsmechanismen an unterschiedliche Belastungen und klimatische Verhältnisse vertiefen. Erlernen elementarer Untersuchungsmethoden der muskulären, der kardio-respiratorischen und der gesamten körperlichen Leistungsfähigkeit des Menschen, der wissenschaftlich korrekten Datenauswertung und Interpretation der Resultate. Einblick in die aktuelle Sportmedizin. | |||||
Inhalt | Praktikum: Verschiedene sportphysiologische Leistungstests und Untersuchungen der physiologischen Anpassungen an unterschiedliche Arten der Aktivität (Beispiele sind VO2max-Test, Conconi-Test, Bestimmung der anaeroben Schwelle, 1-Repetition Maximum-Test, Wingate-Test, Cooper-Test, Laktatsenke-Test, Atmungsmuskel-Test, Dynamometrie und Mechanographie, Körperzusammensetzung etc.). Kennenlernen aktueller Messmethodiken in der Sportmedizin. | |||||
Skript | Anleitung zum Praktikum Sportphysiologie (Herausgeber: Exercise Physiology Lab) | |||||
Literatur | Schmidt/Lang/Heckmann: Physiologie des Menschen, Springer-Verlag, Heidelberg Kenney/Wilmore/Costill: Physiology of Sport and Exercise, Human Kinetics | |||||
Voraussetzungen / Besonderes | Voraussetzung: Anatomie-Physiologie-Vorlesung und Physiologie-Praktikum erfolgreich besucht (BWS-Studierende kontaktieren bitte C. M. Spengler) Erwünscht: Begleitend oder abgeschlossen: Sportphysiologie-Vorlesung (Selektionskriterium bei mehr Anmeldungen als Praktikumsplätzen) | |||||
376-0203-00L | Bewegungs- und Sportbiomechanik | W | 4 KP | 3G | W. R. Taylor, R. List, S. Lorenzetti | |
Kurzbeschreibung | Vermitteln der Methode den menschlichen Bewegungsapparat als (bio-)mechanisches System zu betrachten. Erstellen des Zusammenhanges von Bewegungen im Alltag und im Sport zu Verletzungen und Beschwerden, Prävention und Rehabilitation. | |||||
Lernziel | - Die Studierenden können den Bewegungsapparat als ein mechanisches System darstellen. - Sie analysieren und beschreiben menschliche Bewegungen entsprechend den Gesetzen der Mechanik. | |||||
Inhalt | Die Bewegungs- und Sportbiomechanik befasst sich mit den Eigenschaften des Bewegungsapparates und deren Verknüpfung zur Mechanik. Die Vorlesung beinhaltet einerseits Themenkreise wie funktionelle Anatomie, Charakteristik von elementaren menschlichen Bewegungen (Gehen, Laufen, etc.), und beachtet Bewegungen im Sport aus mechanischer Sicht. Ferner werden einfache Betrachtungen zur Belastungsanalysen diverser Gelenke in verschiedenen Situationen diskutiert. Im Weiteren werden Fragen der Statik und Dynamik starrer Körper, und die inverse Dynamik, die in der Biomechanik relevant sind, behandelt. | |||||
376-0207-00L | Sportphysiologie | W | 4 KP | 3G | C. Spengler | |
Kurzbeschreibung | Die Vorlesung gibt einen Überblick über die neuromuskulären, kardiovaskulären und respiratorischen Anpassungen an akute und chronische körperliche Aktivität auf molekularer und systemischer Ebene, sowie der Interaktionen dieser Systeme und der beeinflussenden Faktoren (Genetik, Geschlecht, Alter, Höhe/Tiefe, Hitze, Kälte) in Bezug auf die Leistungsfähigkeit und auf gesundheistrelevante Aspekte. | |||||
Lernziel | Ziel ist das Verständnis der neuromuskulären, kardiovaskulären und respiratorischen Anpassungen an akute und chronische körperliche Aktivität auf molekularer und systemischer Ebene, sowie das Verständnis der Interaktion dieser Systeme in Bezug auf gesundheitsrelevante Aspekte wie auch auf die Leistungsfähigkeit beim Gesunden und bei exemplarischen Krankheitsbildern. Weiter werden Kenntnisse der wichtigsten beeinflussenden Faktoren wie Genetik, Geschlecht, Alter, Höhe/Tiefe, Hitze und Kälte erworben. | |||||
Inhalt | Geschichte der Sportphysiologie, Forschungsmethodik und Pitfalls, Muskelfasertypen-Heterogenität und deren funktionelle Bedeutung, neuronale Kontrolle der Muskelkraft, molekulare und zelluläre Mechanismen der Anpassung an Kraft-, Ausdauer- und Dehungs-Übungen, interindividuelle Variabilität in der Trainingsantwort, kardiorespiratorische und metabolische Antworten auf akute und chronische körperliche Aktivität, Effekte des Geschlechts auf die Leistungsfähigkeit, körperliche Aktivität in der Höhe, Tiefe, Hitze und Kälte, spezifische Aspekte der verschiedenen Altersstufen hinsichtlich Sport und Leistungsfähigkeit, gesundheitsrelevante Mechanismen von körperlicher Aktivität beim Gesunden und, exemplarisch, bei Kranken. | |||||
Skript | Online Material wird im Laufe des Kurses zur Verfügung gestellt. | |||||
Literatur | Empfohlene Bücher: William D. McArdle, Frank I. Katch, Victor L. Katch Exercise Physiology: Nutrition, Energy, and Human Performance, Eighth Edition, 2014 ISBN/ISSN: 9781451191554 W.L. Kenney, J.H. Wilmore, D.L. Costill Physiology of Sport and Exercise 5th Edition, 2012 ISBN-13: 978-0-7360-9409-2 / ISBN-10: 0-7360-9409-1 | |||||
Voraussetzungen / Besonderes | Anatomie und Physiologie I + II | |||||
376-1033-00L | Sportgeschichte | W | 2 KP | 2V | M. Gisler | |
Kurzbeschreibung | Verständnis für Entstehung und Veränderung des Sports von der Antike bis zur Gegenwart. Darstellung des Sports im Dienst nationaler Ideen, von Bildung und Erziehung, der Gesundheitsförderung von der Mitte des 18. Jahrhunderts bis heute. | |||||
Lernziel | Verständnis für Entstehung und Veränderung des Sports von der Antike bis zur Gegenwart. | |||||
Inhalt | Kurzüberblick über Antike bis frühe Neuzeit. Darstellung des Sports im Dienst nationaler Ideen, von Bildung und Erziehung, der Gesundheitsförderung von der Mitte des 18. Jahrhunderts bis heute.Überblick über die Geschichte der Olympischen Spiele in der Antike und Gegenwart. | |||||
Skript | Ein Skript für die aktuelle Veranstaltung wird abgegeben. | |||||
Literatur | Literaturangaben für eine Vertiefung der Inhalte werden im Skript gemacht. Die Anschaffung von Spezialliteratur ist allerdings nicht notwendig. | |||||
376-1107-00L | Sportpädagogik | W | 2 KP | 2V | M. Wagner | |
Kurzbeschreibung | Die Lehrer-Schüler Interaktion stellt ein komplexes psychosoziales Geschehen, was die Notwendigkeit einer psychologischen Erweiterung der klassischen sozialwissenschaftlichen/sportpädagogischen Perspektive verdeutlicht. Im Zentrum der Vorlesung stehen daher "Pädagogisch-Psychologische Aspekte der Kompetenzentwicklung im Rahmen eines mehrperspektivischen Sportunterrichts". | |||||
Lernziel | Entwicklung pädagogisch-psychologischer Kompetenzen zur Optimierung der zukünftigen Lehrtätigkeit. | |||||
Inhalt | - Gegenstandsbereich der pädagogischen Psychologie - Schüler im Sportunterricht motivieren - Selbstwirksamkeit aufbauen und das Selbstkonzept stärken - Positive Emotionen und einen positiven Umgang mit Angst fördern - Selbstgesteuertes Lernen anregen - Klassen führen und Kooperation fördern - Effizient mit Schülern kommunizieren - Eigene Erwartungen kritisch reflektieren - Mit Geschlechterfragen sensibel umgehen - Inklusion fördern / Soziale und moralische Entwicklung stärken - Mit schwierigen Schülern umgehen - Leistungen von Schülern bewerten | |||||
Skript | Unterrichtsmaterialien zu den einzelnen Veranstaltungen werden den Studierenden über moodle zur Verfügung gestellt. | |||||
Literatur | Primärliteratur: Gerber, M. (2014). Pädagogische Psychologie im Sportunterricht. Ein Lehrbuch in 14 Lektionen. Aachen: Meyer & Meyer Verlag. | |||||
376-1127-00L | Sportsoziologie | W | 2 KP | 2V | M. Lamprecht | |
Kurzbeschreibung | Die Vorlesung befasst sich mit den aktuellen Veränderungen in Gesellschaft und Sport und gibt einen Überblick über die vielfältigen Problemstellungen und Sichtweisen der Sportsoziologie. | |||||
Lernziel | Die Vorlesung will: - die verschiedenen Dimensionen, Funktionen und Verflechtungen des heutigen Sports darstellen. - in die zentralen Theorien und Modelle der (Sport-) Soziologie einführen. - aufzeigen, inwieweit der Sport ein Abbild der Gesellschaft ist und wie er sich dabei verändert und ausdifferenziert. - anhand von aktuellen Beispielen aus Zeitungen, Zeitschriften und Fernsehen den soziologischen Blick auf den Sport schärfen. | |||||
Inhalt | • Sport und sozialer Wandel: Entwicklungen und Trends • Wirtschaft und Medien: Abhängigkeiten, Wirkungen, Skandale • Unterschiede und Ungleichheiten: Geschlechterdifferenz, Gruppenverhalten, Szenen • Konflikte und Politik: Sportorganisationen, Doping, Gewalt | |||||
Skript | Ausgewählte Materialien zur Vorlesung finden sich unter Link --> Lehre | |||||
Literatur | - Coakley, Jay und Elizabeth Pike (2009): Sport in Society: Issues and Controversies. New York: Mc.Graw-Hill. - Lamprecht, Markus und Hanspeter Stamm (2002): Sport zwischen Kultur, Kult und Kommerz. Zürich: Seismo. - Thiel Ansgar, Klaus Seiberth und Jochen Mayer (2013): Sportsoziologie: Ein Lehrbuch in 13 Lektionen. Aachen: Meyer & Meyer. - Weis, Kurt und Robert Gugutzer (Hg.) (2008): Handbuch Sportsoziologie. Schorndorf: Hofmann. Eine detaillierte Programmübersicht mit weiterführenden Literaturhinweisen wird zu Beginn der Vorlesung abgegeben. | |||||
376-1117-00L | Sportpsychologie | W | 2 KP | 2V | H. Gubelmann | |
Kurzbeschreibung | Die Vorlesung ist als Einführung in die Sportpsychologie konzipiert und vermittelt Wissen zu ausgewählten Themenbereichen. | |||||
Lernziel | Die Studierenden erhalten Einblicke in verschiedene Arbeitsbereiche der Sportpsychologie. Um zu verstehen, was «Sportpsychologie» ist und was sie will, müssen Gegenstand, die Aufgaben und die Bezüge der Sportpsychologie geklärt und Grundlagen zu Hauptthemen wie Kognitionen und Emotionen erarbeitet werden. Mit der Vermittlung und Vertiefung weiterer Themen der Sportpsychologie soll die Sachkenntnis gemehrt werden. Ausgewählte Interventionsformen sollen Einblicke in die angewandte Sportpsychologie ermöglichen und psychische Prozesse und ihre Wirkungen im Sport erkennen lassen. Lehrbeispiele aus der Praxis (Fallbeispiele) und praktische Übungen (z.B. Zielsetzungstraining) sollen die Studierenden dazu animieren, vermehrt sportpsychologische Anwendungsformen in ihrer Sportpraxis zu reflektieren und zu integrieren. | |||||
Inhalt | Thematische Schwerpunkte: - Einführung in die Sportpsychologie - Kognitionen: Visualisierung und Mentales Training - Emotionen und Stress: - Motivation: Zielsetzung - Karriere im Leistungssport - Trainer-Athlet-Interaktion - Mentale Rehabilitation von Sportverletzungen - Gruppe, Mannschaft und Zuschauer: Sozialpsychologische Phänomene Lernformen: Die ausgewählten Themen und Inhalte werden in Form einer Vorlesung vermittelt. Die Kombination von wissenschaftlichen Theorien und Studien mit Anwendungsbeispielen und Trainingsmethoden erleichtert den Studierenden den Theorie-Praxisbezug. Eine abschliessende Feldexkursion (Weltcup-Skispringen in Engelberg) dient der Veranschaulichung sportpsychologischer Interventionen im Spitzensport. | |||||
Skript | Unterrichtsmaterialien zu den einzelnen Veranstaltungen werden den Studierenden zur Verfügung gestellt. | |||||
Literatur | Pflichtlektüre: Alfermann, D. & Stoll, O. (2010). Sportpsychologie: Ein Lehrbuch in 12 Lektionen. (3. Aufl.), Aachen u.a.: Meyer & Meyer. Empfohlen: Gerrig, J.P. (2014). Psychologie. (20. Aufl.), München u.a.: Pearson. | |||||
376-1151-00L | Translation of Basic Research Findings from Genetics and Molecular Mechanisms of Aging Number of participants limited to 30. | W | 3 KP | 2V | C. Ewald | |
Kurzbeschreibung | Recently, several start-up companies are aiming to translate basic molecular findings into new drugs/therapeutic interventions to slow aging or post-pone age-related diseases (e.g., Google founded Calico or Craig Venter's Human Longevity, Inc.). This course will teach students the basic skill sets to formulate their own ideas, design experiments to test them and explains the next steps to translat | |||||
Lernziel | The overall goal of this course is to be able to analyse current therapeutic interventions to identify an unmet need in molecular biology of aging and apply scientific thinking to discover new mechanisms that could be used as a novel therapeutic intervention. Learning objectives include: 1. Evaluate the current problem of our aging population, the impact of age-dependent diseases and current strategies to prevent these age-dependent diseases. 2. Analyse/compare current molecular/genetic strategies that address these aging problems. 3. Analyse case studies about biotech companies in the aging sector. Apply the scientific methods to formulate basic research questions to address these problems. 4. Generate own hypotheses (educated guess/idea), design experiments to test them, and map out the next steps to translate them. | |||||
Inhalt | Overview of aging and age-related diseases. Key discoveries in molecular biology of aging. Case studies of biotech companies addressing age-related complications. Brief introduction from bench to bedside with focus on start-up companies. | |||||
Voraussetzungen / Besonderes | No compulsory prerequisites, but student should have basic knowledge about genetics and molecular biology. | |||||
376-1177-00L | Human Factors I | W | 3 KP | 2V | M. Menozzi Jäckli, R. Huang, M. Siegrist | |
Kurzbeschreibung | Every day humans interact with various systems. Strategies of interaction, individual needs, physical & mental abilities, and system properties are important factors in controlling the quality and performance in interaction processes. In the lecture, factors are investigated by basic scientific approaches. Discussed topics are important for optimizing people's satisfaction & overall performance. | |||||
Lernziel | The goal of the lecture is to empower students in better understanding the applied theories, principles, and methods in various applications. Students are expected to learn about how to enable an efficient and qualitatively high standing interaction between human and the environment, considering costs, benefits, health, and safety as well. Thus, an ergonomic design and evaluation process of products, tasks, and environments may be promoted in different disciplines. The goal is achieved in addressing a broad variety of topics and embedding the discussion in macroscopic factors such as the behavior of consumers and objectives of economy. | |||||
Inhalt | - Physiological, physical, and cognitive factors in sensation and perception - Body spaces and functional anthropometry, Digital Human Models - Experimental techniques in assessing human performance and well-being - Human factors and ergonomics in system designs, product development and innovation - Human information processing and biological cybernetics - Interaction among consumers, environments, behavior, and tasks | |||||
Literatur | - Gavriel Salvendy, Handbook of Human Factors and Ergonomics, 4th edition (2012), is available on NEBIS as electronic version and for free to ETH students - Further textbooks are introduced in the lecture - Brouchures, checklists, key articles etc. are uploaded in ILIAS | |||||
376-1179-00L | Applications of Cybernetics in Ergonomics | W | 1 KP | 1U | M. Menozzi Jäckli, Y.‑Y. Hedinger Huang, R. Huang | |
Kurzbeschreibung | Cybernetics systems have been studied and applied in various research fields, such as applications in the ergonomics domain. Research interests include the man-machine interaction (MMI) topic which involving the performance in multi-model interactions, quantification in gestalt principles in product development; or the information processing matter. | |||||
Lernziel | To learn and practice cybernetics principles in interface designs and product development. | |||||
Inhalt | - Fitt's law applied in manipulation tasks - Hick-Hyman law applied in design of the driver assistance systems - Vigilance applied in quality inspection - Accommodation/vergence crosslink function - Cross-link models in neurobiology- the ocular motor control system - Human performance in optimization of production lines | |||||
Literatur | Gavriel Salvendy, Handbook of Human Factors and Ergonomics, 4th edition (2012) | |||||
376-1219-00L | Rehabilitation Engineering II: Rehabilitation of Sensory and Vegetative Functions | W | 3 KP | 2V | R. Riener, O. Lambercy | |
Kurzbeschreibung | Rehabilitation Engng is the application of science and technology to ameliorate the handicaps of individuals with disabilities to reintegrate them into society.The goal is to present classical and new rehabilitation engineering principles applied to compensate or enhance motor, sensory, and cognitive deficits. Focus is on the restoration and treatment of the human sensory and vegetative system. | |||||
Lernziel | Provide knowledge on the anatomy and physiology of the human sensory system, related dysfunctions and pathologies, and how rehabilitation engineering can provide sensory restoration and substitution. This lecture is independent from Rehabilitation Engineering I. Thus, both lectures can be visited in arbitrary order. | |||||
Inhalt | Introduction, problem definition, overview Rehabilitation of visual function - Anatomy and physiology of the visual sense - Technical aids (glasses, sensor substitution) - Retina and cortex implants Rehabilitation of hearing function - Anatomy and physiology of the auditory sense - Hearing aids - Cochlea Implants Rehabilitation and use of kinesthetic and tactile function - Anatomy and physiology of the kinesthetic and tactile sense - Tactile/haptic displays for motion therapy (incl. electrical stimulation) - Role of displays in motor learning Rehabilitation of vestibular function - Anatomy and physiology of the vestibular sense - Rehabilitation strategies and devices (e.g. BrainPort) Rehabilitation of vegetative Functions - Cardiac Pacemaker - Phrenic stimulation, artificial breathing aids - Bladder stimulation, artificial sphincter Brain stimulation and recording - Deep brain stimulation for patients with Parkinson, epilepsy, depression - Brain-Computer Interfaces | |||||
Literatur | Introductory Books: An Introduction to Rehabilitation Engineering. R. A. Cooper, H. Ohnabe, D. A. Hobson (Eds.). Taylor & Francis, 2007. Principles of Neural Science. E. R. Kandel, J. H. Schwartz, T. M Jessell (Eds.). Mc Graw Hill, New York, 2000. Force and Touch Feedback for Virtual Reality. G. C. Burdea (Ed.). Wiley, New York, 1996 (available on NEBIS). Human Haptic Perception, Basics and Applications. M. Grunwald (Ed.). Birkhäuser, Basel, 2008. The Sense of Touch and Its Rendering, Springer Tracts in Advanced Robotics 45, A. Bicchi et al.(Eds). Springer-Verlag Berlin, 2008. Interaktive und autonome Systeme der Medizintechnik - Funktionswiederherstellung und Organersatz. Herausgeber: J. Werner, Oldenbourg Wissenschaftsverlag 2005. Neural prostheses - replacing motor function after desease or disability. Eds.: R. Stein, H. Peckham, D. Popovic. New York and Oxford: Oxford University Press. Advances in Rehabilitation Robotics - Human-Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Eds: Z.Z. Bien, D. Stefanov (Lecture Notes in Control and Information Science, No. 306). Springer Verlag Berlin 2004. Intelligent Systems and Technologies in Rehabilitation Engineering. Eds: H.N.L. Teodorescu, L.C. Jain (International Series on Computational Intelligence). CRC Press Boca Raton, 2001. Selected Journal Articles and Web Links: Abbas, J., Riener, R. (2001) Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function. Neuromodulation 4, pp. 187-195. Bach-y-Rita P., Tyler M., and Kaczmarek K (2003). Seeing with the brain. International journal of human-computer-interaction, 15(2):285-295. Burdea, G., Popescu, V., Hentz, V., and Colbert, K. (2000): Virtual reality-based orthopedic telerehabilitation, IEEE Trans. Rehab. Eng., 8, pp. 430-432 Colombo, G., Jörg, M., Schreier, R., Dietz, V. (2000) Treadmill training of paraplegic patients using a robotic orthosis. Journal of Rehabilitation Research and Development, vol. 37, pp. 693-700. Hayward, V. (2008): A Brief Taxonomy of Tactile Illusions and Demonstrations That Can Be Done In a Hardware Store. Brain Research Bulletin, Vol 75, No 6, pp 742-752 Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T. (1998): Robot-aided neurorehabilitation, IEEE Trans. Rehab. Eng., 6, pp. 75-87 Levesque. V. (2005). Blindness, technology and haptics. Technical report, McGill University. Available at: Link Quintern, J. (1998) Application of functional electrical stimulation in paraplegic patients. NeuroRehabilitation 10, pp. 205-250. Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10. Riener, R. (1999) Model-based development of neuroprostheses for paraplegic patients. Royal Philosophical Transactions: Biological Sciences 354, pp. 877-894. The vOICe. Link. VideoTact, ForeThought Development, LLC. Link | |||||
Voraussetzungen / Besonderes | Target Group: Students of higher semesters and PhD students of - D-MAVT, D-ITET, D-INFK, D-HEST - Biomedical Engineering, Robotics, Systems and Control - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome This lecture is independent from Rehabilitation Engineering I. Thus, both lectures can be visited in arbitrary order. | |||||
376-1714-00L | Biocompatible Materials | W | 4 KP | 3G | K. Maniura, J. Möller, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced. | |||||
Lernziel | The class consists of three parts: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. | |||||
Inhalt | Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers. | |||||
Skript | Handouts can be accessed online. | |||||
Literatur | Literatur Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts provided during the classes and references therin. | |||||
376-1720-00L | Application of MATLAB in the Human Movement Sciences | W | 2 KP | 2G | R. van de Langenberg | |
Kurzbeschreibung | Basierend auf bewegungstypischen Messungen (Kinematik, Kinetik, Muskelaktivität, etc.) werden die Grundzüge der Datenverarbeitung und Datendarstellung mittels MATLAB vermittelt. | |||||
Lernziel | Selbstständiges Einlesen, Darstellen und Weiterverarbeiten von für die Bewegungs-wissenschaften typischen Messdaten in MATLAB. | |||||
Inhalt | Grenzen von Excel; Möglichkeiten von MATLAB; Einlesen diverses Datentypen, Darstellen eines und mehrerer Signale; Beseitigen eines Offsets und Filtern der Daten anhand von selbstgeschriebenen Funktionen; Normieren und Parametrisieren von Daten; Reliabilität; Interpolieren, Differenzieren und Integrieren in MATLAB. | |||||
Literatur | In der Vorlesung wird auf diverse elektronische Einführungen in MATLAB aufmerksam gemacht. Jede Vorlesung wird den Studenten in Skript-Form zur Verfügung gestellt. | |||||
Voraussetzungen / Besonderes | Laptop samt installiertem WLAN und MATLAB (Version 2009 oder höher) sind mitzubringen. Gegebenenfalls kann zu zweit an einem Laptop gearbeitet werden. Eine MATLAB-Studentenversion kann gratis über Stud-IDES bezogen werden. | |||||
376-1722-00L | Paraplegie und Sport Voraussetzung: Anatomie und Physiologie | W | 2 KP | 2V | C. Perret | |
Kurzbeschreibung | Vertiefte Auseinandersetzung mit den Einschränkungen und Komplikationen infolge einer Querschnittlähmung, sowie deren Auswirkungen auf Trainierbarkeit und Leistungsfähigkeit von Menschen im Rollstuhl. Überblick über die klinische Anwendung leistungsdiagnostischer Testverfahren sowie die Umsetzung sportwissenschaftlicher Erkenntnisse zur Optimierung der Rehabilitation bis hin zum Spitzensport. | |||||
Lernziel | Kenntnis der grundlegenden Pathophysiologie und Komplikationen nach Eintritt einer Querschnittlähmung, deren Auswirkungen auf körperliches Training und Trainierbarkeit in der Rehabilitation, sowie im Breiten- und Spitzensport | |||||
Inhalt | Folgende paraplegiologischen Themen werden behandelt: Epidemiologie und Aetiologie Querschnittsyndrome; Komplikationen und Auswirkungen einer Querschnittlähmung; Trainierbarkeit/Leistungsphysiologie bei Querschnittlähmung; Geschichte und Organisation Rollstuhlsport; Spitzensport und Querschnittlähmung | |||||
Literatur | Allgemeine weiterführende Literatur: G.A. Zäch, H. G. Koch Paraplegie - ganzheitliche Rehabilitation Karger-Verlag, 2006 ISBN 3-8055-7980-2 V. Goosey-Tolfrey Wheelchair sport: A complete guide for athletes, coaches and teachers Human Kinetics, 2010 Y.C. Vanlandewijck, W.R. Thompson The Paralympic Athlete Wiley-Blackwell, 2011 ISBN 978-1-4443-3404-3 Liz Broad Sports Nutrition for Paralympic Athletes CRC Press 2014 ISBN 978-1-4665-0756-2 Y.C. Vanlandewijck, W.R. Thompson Training and Coaching the Paralympic Athlete Wiley-Blackwell, 2016 ISBN 978-1-119-04433-8 | |||||
Voraussetzungen / Besonderes | Voraussetzung:Vorlesung Anatomie/Physiologie besucht! | |||||
376-1974-00L | Colloquium in Biomechanics | W | 2 KP | 2K | B. Helgason, S. J. Ferguson, R. Müller, J. G. Snedeker, W. R. Taylor, K. Würtz-Kozak, M. Zenobi-Wong | |
Kurzbeschreibung | Current topics in biomechanics presented by speakers from academia and industry. | |||||
Lernziel | Getting insight into actual areas and problems of biomechanics. | |||||
376-1985-00L | Trauma Biomechanics | W | 4 KP | 2V + 1U | K.‑U. Schmitt, M. H. Muser | |
Kurzbeschreibung | Trauma-Biomechanik ist ein interdiszipliäres Fach, das sich mit der Biomechanik von Verletzungen sowie Möglichkeiten zur Prävention von Verletzungen beschäftigt. Die Vorlesung stellt die Grundlagen der Trauma-Biomechanik dar. | |||||
Lernziel | Vermittlung von Grundlagen der Trauma-Biomechanik. | |||||
Inhalt | Die Vorlesung beschäftigt sich mit Verletzungen des menschlichen Körpers und den zugrunde liegenden Verletzungsmechanismen. Hierbei bilden Verletzungen, die im Strassenverkehr erlitten werden, den Schwerpunkt. Weitere Vorlesungsthemen sind: Crash-Tests und die dazugehörige Messtechnik (z. B. Dummys), sowie aktuelle Themen der Trauma-Biomechanik. | |||||
Skript | Unterlagen werden zur Verfügung gestellt. | |||||
Literatur | Schmitt K-U, Niederer P, M. Muser, Walz F: "Trauma Biomechanics - An Introduction to Injury Biomechanics" bzw. "Trauma-Biomechanik - Einführung in die Biomechanik von Verletzungen", beide Springer Verlag. | |||||
376-2017-00L | Biomechanik von Sportverletzungen und Rehabilitation | W | 3 KP | 2V | K.‑U. Schmitt, J. Goldhahn | |
Kurzbeschreibung | Die Veranstaltung vermittelt die Grundlagen der Verletzungsbiomechanik. Sportverletzungen und deren Rehabilitation bilden dabei den Schwerpunkt der Vorlesung. | |||||
Lernziel | In dieser Veranstaltung sollen Sie Grundlagen der Traumabiomechanik erlernen. Anhand von Beispielen aus dem Sport lernen Sie verschiedene Mechanismen, die zu Verletzungen des menschlichen Körpers führen können, kennen. Sie sollen ein Verständnis für das Entstehen von Verletzungen entwickeln, das Sie in die Lage versetzt Verletzungspotentiale abzuschätzen und präventive Massnahmen zu entwickeln. | |||||
Inhalt | Die Veranstaltung beschäftigt sich mit den Grundlagen der Verletzungsmechanik und der Rehabilitation. Es wird untersucht, wie Verletzungen entstehen und wie sie verhindert werden können. Die Vorlesung konzentriert sich dabei auf Verletzungen, die im Sport erlitten werden. | |||||
Skript | Unterlagen werden zur Verfügung gestellt. | |||||
Literatur | Schmitt K-U, Niederer P, M. Muser, Walz F: "Trauma Biomechanics - An Introduction to Injury Biomechanics" bzw. "Trauma-Biomechanik - Einführung in die Biomechanik von Verletzungen", beide Springer Verlag | |||||
Voraussetzungen / Besonderes | Die Mitarbeit an einer Gruppenarbeit ist fester Bestandteil der Veranstaltung. Die Gruppenarbeit wird benotet und zählt somit zur Gesamtnote der Vorlesung hinzu. Nähere Informationen werden in der ersten Vorlesung gegeben. | |||||
376-2019-00L | Angewandte Bewegungsanalyse | W | 2 KP | 2G | R. Scharpf, S. Lorenzetti | |
Kurzbeschreibung | Anhand von praktischen Beispielen aus Sport, Alltag und Therapie werden verschiedene Methoden der Bewegungsanalyse angewendet und verglichen. | |||||
Lernziel | Die Studierenden können menschliche Bewegungen mithilfe verschiedener Methoden der Bewegungsanalyse gezielt beurteilen. | |||||
Inhalt | Im Verlauf des Studiums lernen Studierende verschiedene Methoden der Bewegungsanalyse kennen: Funktionale, morphologische, klinische, mechanische, systemdynamische, usw. Diese werden anhand von konkreten Beispielen angewendet und gegenübergestellt. Basis bilden Bewegungen aus Sport, Alltag und Therapie wie Unihockey, Geräteturnen/ Akrobatik, Badminton, Gehen/ Laufen, Krafttraining. In einer ersten Phase der Vorlesung werden die Ansätze im Plenum vorgestellt und praktisch umgesetzt. In einer zweiten werden individuelle Projekte in kleinen Teams ausgearbeitet, vorgestellt und bewertet. | |||||
Skript | Allfällige Unterlagen werden auf moodle zur Verfügung gestellt. | |||||
551-1153-00L | Systems Biology of Metabolism Number of participants limited to 15. | W | 4 KP | 2V | U. Sauer, N. Zamboni, M. Zampieri | |
Kurzbeschreibung | Starting from contemporary biological problems related to metabolism, the course focuses on systems biological approaches to address them. In a problem-oriented, this-is-how-it-is-done manner, we thereby teach modern methods and concepts. | |||||
Lernziel | Develop a deeper understanding of how relevant biological problems can be solved, thereby providing advanced insights to key experimental and computational methods in systems biology. | |||||
Inhalt | The course will be given as a mixture of lectures, studies of original research and guided discussions that focus on current research topics. For each particular problem studied, we will work out how the various methods work and what their capabilities/limits are. The problem areas range from microbial metabolism to cancer cell metabolism and from metabolic networks to regulation networks in populations and single cells. Key methods to be covered are various modeling approaches, metabolic flux analyses, metabolomics and other omics. | |||||
Skript | Script and original publications will be supplied during the course. | |||||
Voraussetzungen / Besonderes | The course extends many of the generally introduced concepts and methods of the Concept Course in Systems Biology. It requires a good knowledge of biochemistry and basics of mathematics and chemistry. | |||||
752-3105-00L | Physiology Guided Food Structure and Process Design | W | 3 KP | 2V | E. J. Windhab, B. Le Révérend, T. Wooster | |
Kurzbeschreibung | A “cook-and look” approach to process design is no longer applicable in the current environmental, nutritional and competitive constraints. The modern R&D chemical/food engineer should have a clear focus on the desired structure that needs to be achieved to design a process line or a processing equipment, coupled with in depth knowledge of the processed materials. | |||||
Lernziel | The objective of this course is to highlight the intimate links between human physiology and product sensory and nutritional functions. To optimize these functions, an understanding of the physiological functions that interact and encode the actions of those product structures must be well understood. Therefore the objective of this course is for students to be equipped with a skill set that will encompass basic digestion and sensory physiology knowledge and food structures. The students will be exposed to this interplay all along the GI tract, including taste, aroma and texture perception, swallowing mechanics and gastro intestinal digestion with an engineering or physical sciences angle. | |||||
752-6105-00L | Epidemiology and Prevention Information für UZH Studierende: Die Lerneinheit kann nur an der ETH belegt werden. Die Belegung des Moduls CS16_101 an der UZH ist nicht möglich. Beachten Sie die Einschreibungstermine an der ETH für UZH Studierende: Link | W | 3 KP | 2V | M. Puhan, R. Heusser | |
Kurzbeschreibung | The module „Epidemiology and prevention“ describes the process of scientific discovery from the detection of a disease and its causes, to the development and evaluation of preventive and treatment interventions and to improved population health. | |||||
Lernziel | The overall goal of the course is to introduce students to epidemiological thinking and methods, which are criticial pillars for medical and public health research. Students will also become aware on how epidemiological facts are used in prevention, practice and politics. | |||||
Inhalt | The module „Epidemiology and prevention“ follows an overall framework that describes the course of scientific discovery from the detection of a disease to the development of prevention and treatment interventions and their evaluation in clinical trials and real world settings. We will discuss study designs in the context of existing knowledge and the type of evidence needed to advance knowledge. Examples form nutrition, chronic and infectious diseases will be used in order to show the underlying concepts and methods. | |||||
752-6151-00L | Public Health Concepts | W | 3 KP | 2V | R. Heusser | |
Kurzbeschreibung | The module "public health concepts" offers an introduction to key principles of public health. Students get acquainted with the concepts and methods of epidemiology. Students also learn to use epidemiological data for prevention and health promotion purposes. Public health concepts and intervention strategies are presented, using examples from infectious and chronic diseases. | |||||
Lernziel | At the end of this module students are able: - to interpret the results of epidemiological studies - to critically assess scientific literature - to know the definition, dimensions and determinants of health - to plan public health interventions and health promotion projects | |||||
Inhalt | Concepts of descriptive and analytical epidemiology, study designs, measures of effect, confounding and bias, screening, surveilllance, definition of health and health promotion, health dimensions and health determinants, prevention strategies, public health interventions, public health action cycle, epidemiology and prevention of infectious and chronic diseases (HIV, Tuberculosis, Obesity, Public health nutrition). | |||||
Skript | Handouts are provided to students in the classroom. | |||||
Voraussetzungen / Besonderes | Language of the course is english | |||||
752-6403-00L | Nutrition and Performance | W | 2 KP | 2V | S. Mettler, M. B. Zimmermann | |
Kurzbeschreibung | The course introduces basic concepts of the interaction between nutrition and exercise and cognitive performance. | |||||
Lernziel | To understand the potential effects of nutrition on exercise performance, with a focus on concepts and principles of nutrition before, during and after exercise. | |||||
Inhalt | The course will cover elementary aspects of sports nutrition physiology, including carbohydrate, glycogen, fat, protein and energy metabolism. A main focus will be to understand nutritional aspects before exercise to be prepared for intensive exercise bouts, how exercise performance can be supported by nutrition during exercise and how recovery can be assisted by nutrition after exercise. Although this is a scientific course, it is a goal of the course to translate basic sports nutrition science into practical sports nutrition examples. | |||||
Skript | Lecture slides and required handouts will be available on the ETH website. | |||||
Literatur | Information on further reading will be announced during the lecture. There will be some mandatory as well as voluntary readings. | |||||
Voraussetzungen / Besonderes | General knowledge about nutrition, human biology, physiology and biochemistry is a prerequisite for this course. The course builds on basic nutrition and biochemistry knowledge to address exercise and performance related aspects of nutrition. The course is designed for 3rd year Bachelor students, Master students and postgraduate students (MAS/CAS). Language: English It is strongly recommended to attend the lectures. The lecture (including the handouts) is not designed for distance education. | |||||
Vertiefung in Gesundheit, Ernährung und Umwelt | ||||||
Pflichtfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
701-1701-00L | Human Health, Nutrition and Environment: Term Paper Only for students of the Major Human Health, Nutrition and Environment. | O | 6 KP | 13A | J. Nuessli Guth, T. Julian, K. McNeill, M. B. Zimmermann | |
Kurzbeschreibung | Writing of a review paper of scientific quality on a topic in the domain of Human Health, Nutrition and Environment based on critical evaluation of scientific literature. | |||||
Lernziel | - Acquisition of knowledge in the field of the review paper - Assessment of original literature as well as synthesis and analysis of the findings - Practising of academic writing in English - Giving an oral presentation with discussion on the topic of the review paper | |||||
Inhalt | Topics are offered in the domains of the major 'Human Health, Nutrition and Environment' covering 'Public Health', 'Infectious Diseases', 'Nutrition and Health' and 'Environment and Health'. | |||||
Skript | Guidelines will be handed out in the beginning. | |||||
Literatur | Literature will be identified based on the topic chosen. | |||||
376-0300-00L | Translational Science for Health and Medicine | O | 3 KP | 2G | J. Goldhahn, G. von Krogh, C. Wolfrum | |
Kurzbeschreibung | Translational science is a cross disciplinary scientific research that is motivated by the need for practical applications that help people. The course should help to clarify basics of translational science, illustrate successful applications and should enable students to integrate key features into their future projects. | |||||
Lernziel | After completing this course, students will be able to understand: Principles of translational science (including project planning, ethics application, basics of resource management and interdisciplinary communication) | |||||
Inhalt | What is translational science and what is it not? How to identify need? - Disease concepts and consequences for research - Basics about incidence, prevalence etc., and orphan indications How to choose the appropriate research type and methodology - Ethical considerations including ethics application - Pros and cons of different types of research - Coordination of complex approaches incl. timing and resources How to measure success? - Outcome variables - Improving the translational process Challenges of communication? How independent is translational science? - Academic boundary conditions vs. industrial influences Positive and negative examples will be illustrated by distinguished guest speakers. | |||||
376-0302-01L | GCP Basic Course (Modul 1 and 2) Nur für Gesundheitswissenschaften und Technologie MSc. | O | 1 KP | 1G | G. Senti | |
Kurzbeschreibung | The basic course in "Good Clinical Practice" (GCP) contains of two full-time training days (Module 1 and Module 2) and addresses elementary aspects for the appropriate conduct of clinical trials and non-clinical research projects involving human beings. Successful participation will be confirmed by a certificate that is recognized by the Swiss authorities. | |||||
Lernziel | Students will get familiar with: - Key Ethics documents - (Inter)national Guidelines and Laws (e.g. ICH-GCP, DIN EN ISO 14155, TPA, HRA) - Sequence of research projects and project-involved parties - Planning of research projects (statistics, resources, study design, set-up of the study protocol) - Approval of research projects by Authorities (SwissEthics, Swissmedic, FOPH) - Roles and responsibilities of project-involved parties Students will learn how to: - Classify research projects according the risk-based approach of the HRA - Write a study protocol - Inform participating patients/study subjects - Obtain consent by participating patients/study subjects - Classify, document and report Adverse Events - Handle projects with biological material from humans and/or health- related personal data | |||||
Inhalt | Module 1: Research and Research Ethics, Guidelines, (inter)national Legislation, Development of therapeutic products, Methodology (Study Design), Study documents (Study protocol, Investigator's Brochure, Patient Information Leaflet, Informed Consent Form) Module 2: Roles and Responsibilities, Approval procedures, Notification and Reporting, Study documentation, Research with biological material and health-related data, data protection, data retention | |||||
Wahlfächer | ||||||
Wahlfächer I | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
401-0629-00L | Applied Biostatistics | W | 4 KP | 3G | M. Müller | |
Kurzbeschreibung | Principles and main methods in biostatistics with emphasis on practical aspects. Experimental and observational studies. Regression and analysis of variance. Introduction into survival analysis. | |||||
Lernziel | Getting an overwiew of the problems and statistical methods used in health sciences. Practise in using the software R to analyze data and interpreting the sults. | |||||
Inhalt | Experimental and observational studies. Relative risks and odds ratios. Diagnostic tests, ROC analysis. Multiple linear and logistic regression, analysis of variance. Introduction into survival analysis. | |||||
Skript | see teaching document repository | |||||
Literatur | Le, Chap T. and Eberly, L.: Introductory Biostatistics. Wiley Interscience, 2014. Norman, G. and Streiner, D.: Biostatistics. The Bare Essentials. pmph USA. 3th edition 2008. Rosner B: Fundamentals of Biostatistics. Duxbury Press, 7th edition, 2010. | |||||
Voraussetzungen / Besonderes | The statistical package R will be used in the exercises. If you are unfamiliar with R, I highly recommend the online R course etutoR. | |||||
752-6105-00L | Epidemiology and Prevention Information für UZH Studierende: Die Lerneinheit kann nur an der ETH belegt werden. Die Belegung des Moduls CS16_101 an der UZH ist nicht möglich. Beachten Sie die Einschreibungstermine an der ETH für UZH Studierende: Link | W | 3 KP | 2V | M. Puhan, R. Heusser | |
Kurzbeschreibung | The module „Epidemiology and prevention“ describes the process of scientific discovery from the detection of a disease and its causes, to the development and evaluation of preventive and treatment interventions and to improved population health. | |||||
Lernziel | The overall goal of the course is to introduce students to epidemiological thinking and methods, which are criticial pillars for medical and public health research. Students will also become aware on how epidemiological facts are used in prevention, practice and politics. | |||||
Inhalt | The module „Epidemiology and prevention“ follows an overall framework that describes the course of scientific discovery from the detection of a disease to the development of prevention and treatment interventions and their evaluation in clinical trials and real world settings. We will discuss study designs in the context of existing knowledge and the type of evidence needed to advance knowledge. Examples form nutrition, chronic and infectious diseases will be used in order to show the underlying concepts and methods. | |||||
752-6151-00L | Public Health Concepts | W | 3 KP | 2V | R. Heusser | |
Kurzbeschreibung | The module "public health concepts" offers an introduction to key principles of public health. Students get acquainted with the concepts and methods of epidemiology. Students also learn to use epidemiological data for prevention and health promotion purposes. Public health concepts and intervention strategies are presented, using examples from infectious and chronic diseases. | |||||
Lernziel | At the end of this module students are able: - to interpret the results of epidemiological studies - to critically assess scientific literature - to know the definition, dimensions and determinants of health - to plan public health interventions and health promotion projects | |||||
Inhalt | Concepts of descriptive and analytical epidemiology, study designs, measures of effect, confounding and bias, screening, surveilllance, definition of health and health promotion, health dimensions and health determinants, prevention strategies, public health interventions, public health action cycle, epidemiology and prevention of infectious and chronic diseases (HIV, Tuberculosis, Obesity, Public health nutrition). | |||||
Skript | Handouts are provided to students in the classroom. | |||||
Voraussetzungen / Besonderes | Language of the course is english | |||||
Wahlfächer II | ||||||
Modul: Infektionskrankheiten | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
551-0223-00L | Immunology III | W | 4 KP | 2V | M. Kopf, M. Bachmann, S. B. Freigang, J. Kisielow, S. R. Leibundgut, A. Oxenius, R. Spörri | |
Kurzbeschreibung | Diese Vorlesung liefert einen detaillierten Einblick in die - Entwicklung von T Zellen und B Zellen - Dynamik einer Immunantwort bei akuten und chronischen Infektionen - Mechanismen von Immunpathologie - neue Impfstoffstrategien | |||||
Lernziel | Sie verstehen - die Entwicklung, Aktivierung, und Differenzierung verschiedener Typen von T Zellen und deren Effektormechanismen während einer Immunantwort - die Erkennung von pathogenen Mikroorganismen und molekulare Ereignisse nach Infektion einer Zelle - Ereignisse und Signale für die Reifung von naiven B Zellen zu antikörperproduzierenden Plasmazellen und Gedächtniszellen, - Optimierung von B Zellantworten durch das intelligente Design neuer Impfstoffe | |||||
Inhalt | o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg) o NK T cells and responses to lipid antigens o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17 o Overview of cytokines and their effector function o Co-stimulation (signals 1-3) o Dendritic cells o Evolution of the "Danger" concept o Cells expressing Pattern Recognition Receptors and their downstream signals o T cell function and dysfunction in acute and chronic viral infections | |||||
Literatur | Unterlagen zur Vorlesung sind erhältlich bei: Link | |||||
Voraussetzungen / Besonderes | Immunology I and II recommended but not compulsory | |||||
701-0263-01L | Seminar in Evolutionary Ecology of Infectious Diseases | W | 3 KP | 2G | A. Mikaberidze, S. Bonhoeffer, R. R. Regös | |
Kurzbeschreibung | Students of this course will discuss current topics from the field of infectious disease biology. From a list of publications, each student chooses some themes that he/she is going to explain and discuss with all other participants and under supervision. The actual topics will change from year to year corresponding to the progress and new results occuring in the field. | |||||
Lernziel | This is an advanced course that will require significant student participation. Students will learn how to evaluate and present scientific literature and trace the development of ideas related to understanding the ecology and evolutionary biology of infectious diseases. | |||||
Inhalt | A core set of ~10 classic publications encompassing unifying themes in infectious disease ecology and evolution, such as virulence, resistance, metapopulations, networks, and competition will be presented and discussed. Pathogens will include bacteria, viruses and fungi. Hosts will include animals, plants and humans. | |||||
Skript | Publications and class notes can be downloaded from a web page announced during the lecture. | |||||
Literatur | Papers will be assigned and downloaded from a web page announced during the lecture. | |||||
701-1471-00L | Ecological Parasitology Number of participants limited to 20. A minimum of 6 students is required that the course will take place. Waiting list will be deleted on September 29th, 2017. | W | 3 KP | 1V + 1P | O. E. Seppälä, H. Hartikainen, J. Jokela | |
Kurzbeschreibung | Course focuses on the ecology and evolution of macroparasites and their hosts. Through lectures and practical work, students learn about diversity and natural history of parasites, adaptations of parasites, ecology of host-parasite interactions, applied parasitology, and human macroparasites in the modern world. | |||||
Lernziel | 1. Identify common macroparasites in aquatic organisms. 2. Understand ecological and evolutionary processes in host-parasite interactions. 3. Conduct parasitological research | |||||
Inhalt | Lectures: 1. Diversity and natural history of parasites (i.e. systematic groups and life-cycles). 2. Adaptations of parasites (e.g. evolution of life-cycles, host manipulation). 3. Ecology of host-parasite interactions (e.g. parasite communities, effects of environmental changes). 4. Applied parasitology (e.g. aquaculture and fisheries). 5. Human macroparasites (schistosomiasis, malaria). Practical exercises: 1. Examination of parasites in fish (identification of species and description of parasite communities). 2. Examination of parasites in molluscs (identification and examination of host exploitation strategies). 3. Examination of parasites in amphipods (identification and examination of effects on hosts). | |||||
Voraussetzungen / Besonderes | The three practicals will take place at the 10.10.2017, the 24.10.2017 and the 7.11.2017 at Eawag Dübendorf from 08:15 - 12:00. | |||||
701-1703-00L | Evolutionary Medicine for Infectious Diseases | W | 3 KP | 2G | A. Hall | |
Kurzbeschreibung | This course explores infectious disease from both the host and pathogen perspective. Through short lectures, reading and active discussion, students will identify areas where evolutionary thinking can improve our understanding of infectious diseases and, ultimately, our ability to treat them effectively. | |||||
Lernziel | Students will learn to (i) identify evolutionary explanations for the origins and characteristics of infectious diseases in a range of organisms and (ii) evaluate ways of integrating evolutionary thinking into improved strategies for treating infections of humans and animals. This will incorporate principles that apply across any host-pathogen interaction, as well as system-specific mechanistic information, with particular emphasis on bacteria and viruses. | |||||
Inhalt | We will cover several topics where evolutionary thinking is relevant to understanding or treating infectious diseases. This includes: (i) determinants of pathogen host range and virulence, (ii) dynamics of host-parasite coevolution, (iii) pathogen adaptation to evade or suppress immune responses, (iv) antimicrobial resistance, (v) evolution-proof medicine. For each topic there will be a short (< 20 minutes) introductory lecture, before students independently research the primary literature and develop discussion points and questions, followed by interactive discussion in class. | |||||
Literatur | The focus is on primary literature, but for some parts the following text books provide good background information: Schmid Hempel 2011 Evolutionary Parasitology Stearns & Medzhitov 2016 Evolutionary Medicine | |||||
Voraussetzungen / Besonderes | A basic understanding of evolutionary biology, microbiology or parasitology will be advantageous but is not essential. | |||||
752-4009-00L | Molecular Biology of Foodborne Pathogens | W | 3 KP | 2V | M. Loessner, M. Schuppler | |
Kurzbeschreibung | The course offers detailed information on selected foodborne pathogens and toxin producing organisms; the focus lies on relevant molecular biological aspects of pathogenicity and virulence, as well as on the occurrence and survival of these organisms in foods. | |||||
Lernziel | Detailed and current status of research and insights into the molecular basis of foodborne diseases, with focus on interactions of the microorganism or the toxins they produce with the human system. Understanding the relationship between specific types of food and the associated pathogens and microbial risks. Another focus lies on the currently available methods and techniques useful for the various purposes, i.e., detection, differentiation (typing), and antimicrobial agents. | |||||
Inhalt | Molecular biology of infectious foodborne pathogens (Listeria, Vibrio, E. coli, Campylobacter, etc) and toxin-producing organisms (Bacillus, Clostridium, Staphylococcus). How and under which conditions will toxins and virulence factors be produced, and how do they work? How is the interaction between the human host and the microbial pathogen? What are the roles of food and the environment ? What can be done to interfere with the potential risks? Which methods are best suited for what approach? Last, but not least, the role of bacteriophages in microbial pathogenicity will be highlighted, in addition to various applications of bacteriophage for both diagnostics and antimicrobial intervention. | |||||
Skript | Electronic copies of the presentation slides (PDF) and additional material will be made available for download to registered students. | |||||
Literatur | Recommendations will be given in the first lecture | |||||
Voraussetzungen / Besonderes | Lectures (2 hours) will be held as a single session of approximately 60+ minutes (10:15 until approx. 11:15 h), without break ! | |||||
Modul: Ernährung und Gesundheit | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
752-2122-00L | Food and Consumer Behaviour | W | 2 KP | 2V | M. Siegrist, C. Hartmann | |
Kurzbeschreibung | This course focuses on food consumer behavior, consumer's decision-making processes and consumer's attitudes towards food products. | |||||
Lernziel | The course provides an overview about the following topics: Factors influencing consumer's food choice, food and health, attitudes towards new foods and food technologies, labeling and food policy issues | |||||
752-5103-00L | Functional Microorganisms in Foods | W | 3 KP | 2G | C. Lacroix, A. Geirnaert, L. Meile, C. Schwab | |
Kurzbeschreibung | This integration course will discuss new applications of microorganisms with functional properties in food and functional food products. Selected topics will be used to illustrate the rapid development but also limits of basic knowledge for applications of functional microorganisms to produce food with high quality, safety and potential health benefits for consumers. | |||||
Lernziel | To understand the principles, roles and mechanisms of microorganisms with metabolic activities of high potential for application in traditional and functional foods utilization with high quality, safety and potential health benefits for the consumers. This course will integrate basic knowledge in food microbiology, microbial physiology, biochemistry, and technology. | |||||
Inhalt | This course will address selected and current topics on new applications of microorganisms with functional properties in food and functional food products and characterization of functionality and safety of food bacteria. Specialists from the Laboratory of Food Biotechnology, as well as invited speakers from the industry will contribute to the selected topics as follows: - Probiotics and Prebiotics: Probiotics, functional foods and health, towards understanding molecular modes of probiotic action; Challenges for the production and addition of probiotics to foods; Prebiotics and other microbial substrates for gut functionality. - Bioprotective Cultures and Antimicrobial Metabolites: Antifungal cultures and applications in foods; Antimicrobial peptide-producing cultures (bacteriocins) for enhancing food quality and safety; Development of new protective cultures, the long path from research to industry. - Legal and Protection Issues Related Functional Foods - Industrial Biotechnology of Flavor and Taste Development - Safety of Food Starter Cultures and Probiotics Students will be required to complete a group project on food products and ingredients with of from functional bacteria. The project will involve information research and analysis followed by an oral presentation and short writen report. | |||||
Skript | Copy of the power point slides from lectures will be provided. | |||||
Literatur | A list of references will be given at the beginning of the course for the different topics presented during this course. | |||||
752-6101-00L | Dietary Etiologies of Chronic Disease | W | 3 KP | 2V | M. B. Zimmermann | |
Kurzbeschreibung | To have the student gain understanding of the links between the diet and the etiology and progression of chronic diseases, including diabetes, gastrointestinal diseases, kidney disease, cardiovascular disease, arthritis and food allergies. | |||||
Lernziel | To examine and understand the protective effect of foods and food ingredients in the maintenance of health and the prevention of chronic disease, as well as the progression of complications of the chronic diseases. | |||||
Inhalt | The course evaluates food and food ingredients in relation to primary and secondary prevention of chronic diseases including diabetes, gastrointestinal diseases, kidney disease, cardiovascular disease, arthritis and food allergies. | |||||
Skript | There is no script. Powerpoint presentations will be made available on-line to students. | |||||
Literatur | To be provided by the individual lecturers, at their discretion. | |||||
Voraussetzungen / Besonderes | No compulsory prerequisites, but prior completion of Introduction to Nutritional Science and Advanced Topics in Nutritional Science is strongly advised. | |||||
752-6402-00L | Nutrigenomics | W | 3 KP | 2V | G. Vergères | |
Kurzbeschreibung | Nutrigenomics - toward personalized nutrition? Breakthroughs in biology recently led nutrition scientists to apply modern tools (genomics, transcriptomics, proteomics, metabolomics, genetics, epigenetics) to the analysis of the interactions of food with humans. The lecture presents these tools and illustrates their application in selected topics relevant to human nutrition and food sciences. | |||||
Lernziel | - Overall understanding of the transdisciplinary research being conducted under the term nutrigenomics. - Overall understating of the omics technologies used in nutrigenomics and their applications to human nutrition and food science. - Ability to critically evaluate the potential and risks associated with the field of nutrigenomics | |||||
Inhalt | - For the content of the script see section "Skript" below - The lecture is completed by short presentations of the students (in group) of material related to the lecture. Contribution of the students to the presentation is a prerequisite for registration to the exam. | |||||
Skript | The script is composed of circa 400 slides (ca 15 slides/lecture) organized in 9 modules Module A From biochemical nutrition research to nutrigenomics Module B Nutritional genomics Module C Nutrigenetics Module D Nutri-epigenomics Module E Transcriptomics in nutrition research Module F Proteomics in nutrition research Module G Metabolomics in nutrition research Module H Nutritional systems biology Module I Personalized nutrition - opportunities and challenges | |||||
Literatur | No extra reading requested. Most slides in the lecture are referenced with web adresses. | |||||
Voraussetzungen / Besonderes | Basic training in biochemistry, molecular biology, physiology, and human nutrition. Interest in interdisciplinary sciences linking molecular biology to human health. Interest in the application of analytical laboratory methods to the understanding of human biology, in particular nutrition. | |||||
Modul: Umwelt und Gesundheit | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
701-1341-00L | Water Resources and Drinking Water Findet dieses Semester nicht statt. | W | 3 KP | 2G | S. Hug, M. Berg, F. Hammes, U. von Gunten | |
Kurzbeschreibung | The course covers qualitative (chemistry and microbiology) and quantitative aspects of drinking water from the resource to the tap. Natural processes, anthropogenic pollution, legislation of groundwater and surface water and of drinking water as well as water treatment will be discussed for industrialized and developing countries. | |||||
Lernziel | The goal of this lecture is to give an overview over the whole path of drinking water from the source to the tap and understand the involved physical, chemical and biological processes which determine the drinking water quality. | |||||
Inhalt | The course covers qualitative (chemistry and microbiology) and quantitative aspects of drinking water from the resource to the tap. The various water resources, particularly groundwater and surface water, are discussed as part of the natural water cycle influenced by anthropogenic activities such as agriculture, industry, urban water systems. Furthermore legislation related to water resources and drinking water will be discussed. The lecture is focused on industrialized countries, but also addresses global water issues and problems in the developing world. Finally unit processes for drinking water treatment (filtration, adsorption, oxidation, disinfection etc.) will be presented and discussed. | |||||
Skript | Handouts will be distributed | |||||
Literatur | Will be mentioned in handouts | |||||
Vertiefung in Medizintechnik | ||||||
Pflichtfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-0300-00L | Translational Science for Health and Medicine | O | 3 KP | 2G | J. Goldhahn, G. von Krogh, C. Wolfrum | |
Kurzbeschreibung | Translational science is a cross disciplinary scientific research that is motivated by the need for practical applications that help people. The course should help to clarify basics of translational science, illustrate successful applications and should enable students to integrate key features into their future projects. | |||||
Lernziel | After completing this course, students will be able to understand: Principles of translational science (including project planning, ethics application, basics of resource management and interdisciplinary communication) | |||||
Inhalt | What is translational science and what is it not? How to identify need? - Disease concepts and consequences for research - Basics about incidence, prevalence etc., and orphan indications How to choose the appropriate research type and methodology - Ethical considerations including ethics application - Pros and cons of different types of research - Coordination of complex approaches incl. timing and resources How to measure success? - Outcome variables - Improving the translational process Challenges of communication? How independent is translational science? - Academic boundary conditions vs. industrial influences Positive and negative examples will be illustrated by distinguished guest speakers. | |||||
376-0302-01L | GCP Basic Course (Modul 1 and 2) Nur für Gesundheitswissenschaften und Technologie MSc. | O | 1 KP | 1G | G. Senti | |
Kurzbeschreibung | The basic course in "Good Clinical Practice" (GCP) contains of two full-time training days (Module 1 and Module 2) and addresses elementary aspects for the appropriate conduct of clinical trials and non-clinical research projects involving human beings. Successful participation will be confirmed by a certificate that is recognized by the Swiss authorities. | |||||
Lernziel | Students will get familiar with: - Key Ethics documents - (Inter)national Guidelines and Laws (e.g. ICH-GCP, DIN EN ISO 14155, TPA, HRA) - Sequence of research projects and project-involved parties - Planning of research projects (statistics, resources, study design, set-up of the study protocol) - Approval of research projects by Authorities (SwissEthics, Swissmedic, FOPH) - Roles and responsibilities of project-involved parties Students will learn how to: - Classify research projects according the risk-based approach of the HRA - Write a study protocol - Inform participating patients/study subjects - Obtain consent by participating patients/study subjects - Classify, document and report Adverse Events - Handle projects with biological material from humans and/or health- related personal data | |||||
Inhalt | Module 1: Research and Research Ethics, Guidelines, (inter)national Legislation, Development of therapeutic products, Methodology (Study Design), Study documents (Study protocol, Investigator's Brochure, Patient Information Leaflet, Informed Consent Form) Module 2: Roles and Responsibilities, Approval procedures, Notification and Reporting, Study documentation, Research with biological material and health-related data, data protection, data retention | |||||
Wahlfächer | ||||||
Wahlfächer I | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-0021-00L | Introduction to Biomedical Engineering I | W | 4 KP | 3G | R. Müller, J. G. Snedeker, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction to biomechanics, biomaterials, tissue engineering, medical imaging as well as the history of biomedical engineering. | |||||
Lernziel | Understanding of physical and technical principles in biomechanics, biomaterials, tissue engineering, medical imaging as well as the history of biomedical engineering. Mathematical description and problem solving. Knowledge of biomedical engineering applications in research and clinical practice. | |||||
Inhalt | Tissue and Cellular Biomechanics, Molecular Biomechanics and Biopolymers, Computational Biomechanics, Biomaterials, Tissue Engineering, Radiation and Radiographic Imaging, Diagnostic Ultrasound Imaging, Magnetic Resonance Imaging, Biomedical Optics and Lasers. | |||||
Skript | Stored on ILIAS. | |||||
Literatur | Introduction to Biomedical Engineering, 3rd Edition 2011, Autor: John Enderle, Joseph Bronzino, ISBN 9780123749796 Academic Press | |||||
376-1714-00L | Biocompatible Materials | W | 4 KP | 3G | K. Maniura, J. Möller, M. Zenobi-Wong | |
Kurzbeschreibung | Introduction to molecules used for biomaterials, molecular interactions between different materials and biological systems (molecules, cells, tissues). The concept of biocompatibility is discussed and important techniques from biomaterials research and development are introduced. | |||||
Lernziel | The class consists of three parts: 1. Introdcution into molecular characteristics of molecules involved in the materials-to-biology interface. Molecular design of biomaterials. 2. The concept of biocompatibility. 3. Introduction into methodology used in biomaterials research and application. | |||||
Inhalt | Introduction into native and polymeric biomaterials used for medical applications. The concepts of biocompatibility, biodegradation and the consequences of degradation products are discussed on the molecular level. Different classes of materials with respect to potential applications in tissue engineering and drug delivery are introduced. Strong focus lies on the molecular interactions between materials having very different bulk and/or surface chemistry with living cells, tissues and organs. In particular the interface between the materials surfaces and the eukaryotic cell surface and possible reactions of the cells with an implant material are elucidated. Techniques to design, produce and characterize materials in vitro as well as in vivo analysis of implanted and explanted materials are discussed. In addition, a link between academic research and industrial entrepreneurship is established by external guest speakers. | |||||
Skript | Handouts can be accessed online. | |||||
Literatur | Literatur Biomaterials Science: An Introduction to Materials in Medicine, Ratner B.D. et al, 3rd Edition, 2013 Comprehensive Biomaterials, Ducheyne P. et al., 1st Edition, 2011 (available online via ETH library) Handouts provided during the classes and references therin. | |||||
Wahlfächer II | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
151-0255-00L | Energy Conversion and Transport in Biosystems | W | 4 KP | 2V + 1U | A. Ferrari | |
Kurzbeschreibung | Theorie und Anwendung von Thermodynamik und Energieerhaltung in biologischen Systemen mit Schwerpunkt auf Zellebene. | |||||
Lernziel | Theorie und Anwendung von Energieerhaltung auf Zellebene. Verständnis für die grundlegenden Stofftransport-Kreisläufe in menschlichen Zellen und die Mechanismen, welche diese Kreisläufe beeinflussen. Parallelen zu anderen Gebieten im Ingenieurswesen erkennen. Wärme- und Massentransport Prozesse in der Zelle, Kraft Entwicklung der Zelle, und die Verbindung zu modernen biomedizinischen Technologien. | |||||
Inhalt | Massentransportmodelle für den Transport von chemischen Spezies in der menschlichen Zelle. Organisation und Funktion der Zellmembran und des Zytoskeletts. Die Rolle molekularer Motoren in der Kraftentwicklung der Zelle und deren Funktion in der Fortbewegung der Zelle. Beschreibung der Funktionsweise dieser Systeme sowie der experimentellen Analyse und Simulationen um sie besser zu verstehen. Einführung in den Zell-Metabolismus, Zell-Energietransport und die Zelluläre Thermodynamik. | |||||
Skript | Kursmaterial wird in Form von Hand-outs verteilt. | |||||
Literatur | Notizen sowie Referenzen aus der Vorlesung. | |||||
151-0604-00L | Microrobotics | W | 4 KP | 3G | B. Nelson | |
Kurzbeschreibung | Microrobotics is an interdisciplinary field that combines aspects of robotics, micro and nanotechnology, biomedical engineering, and materials science. The aim of this course is to expose students to the fundamentals of this emerging field. Throughout the course students are expected to submit assignments. The course concludes with an end-of-semester examination. | |||||
Lernziel | The objective of this course is to expose students to the fundamental aspects of the emerging field of microrobotics. This includes a focus on physical laws that predominate at the microscale, technologies for fabricating small devices, bio-inspired design, and applications of the field. | |||||
Inhalt | Main topics of the course include: - Scaling laws at micro/nano scales - Electrostatics - Electromagnetism - Low Reynolds number flows - Observation tools - Materials and fabrication methods - Applications of biomedical microrobots | |||||
Skript | The powerpoint slides presented in the lectures will be mad available as pdf files. Several readings will also be made available electronically. | |||||
Voraussetzungen / Besonderes | The lecture will be taught in English. | |||||
227-0385-10L | Biomedical Imaging | W | 6 KP | 5G | S. Kozerke, K. P. Prüssmann | |
Kurzbeschreibung | Introduction and analysis of medical imaging technology including X-ray procedures, computed tomography, nuclear imaging techniques using single photon and positron emission tomography, magnetic resonance imaging and ultrasound imaging techniques. | |||||
Lernziel | To understand the physical and technical principles underlying X-ray imaging, computed tomography, single photon and positron emission tomography, magnetic resonance imaging, ultrasound and Doppler imaging techniques. The mathematical framework is developed to describe image encoding/decoding, point-spread function/modular transfer function, signal-to-noise ratio, contrast behavior for each of the methods. Matlab exercises are used to implement and study basic concepts. | |||||
Inhalt | - X-ray imaging - Computed tomography - Single photon emission tomography - Positron emission tomography - Magnetic resonance imaging - Ultrasound/Doppler imaging | |||||
Skript | Lecture notes and handouts | |||||
Literatur | Webb A, Smith N.B. Introduction to Medical Imaging: Physics, Engineering and Clinical Applications; Cambridge University Press 2011 | |||||
Voraussetzungen / Besonderes | Analysis, Linear Algebra, Physics, Basics of Signal Theory, Basic skills in Matlab programming | |||||
227-0391-00L | Medical Image Analysis Findet dieses Semester nicht statt. | W | 3 KP | 2G | E. Konukoglu | |
Kurzbeschreibung | It is the objective of this lecture to introduce the basic concepts used in Medical Image Analysis. In particular the lecture focuses on shape representation schemes, segmentation techniques, and the various image registration methods commonly used in Medical Image Analysis applications. | |||||
Lernziel | This lecture aims to give an overview of the basic concepts of Medical Image Analysis and its application areas. | |||||
Voraussetzungen / Besonderes | Basic knowledge of computer vision would be helpful. | |||||
227-0393-10L | Bioelectronics and Biosensors | W | 6 KP | 2V + 2U | J. Vörös, M. F. Yanik, T. Zambelli | |
Kurzbeschreibung | The course introduces the concepts of bioelectricity and biosensing. The sources and use of electrical fields and currents in the context of biological systems and problems are discussed. The fundamental challenges of measuring biological signals are introduced. The most important biosensing techniques and their physical concepts are introduced in a quantitative fashion. | |||||
Lernziel | During this course the students will: - learn the basic concepts in biosensing and bioelectronics - be able to solve typical problems in biosensing and bioelectronics - learn about the remaining challenges in this field | |||||
Inhalt | L1. Bioelectronics history, its applications and overview of the field - Volta and Galvani dispute - BMI, pacemaker, cochlear implant, retinal implant, limb replacement devices - Fundamentals of biosensing - Glucometer and ELISA L2. Fundamentals of quantum and classical noise in measuring biological signals L3. Biomeasurement techniques with photons L4. Acoustics sensors - Differential equation for quartz crystal resonance - Acoustic sensors and their applications L5. Engineering principles of optical probes for measuring and manipulating molecular and cellular processes L6. Optical biosensors - Differential equation for optical waveguides - Optical sensors and their applications - Plasmonic sensing L7. Basic notions of molecular adsorption and electron transfer - Quantum mechanics: Schrödinger equation energy levels from H atom to crystals, energy bands - Electron transfer: Marcus theory, Gerischer theory L8. Potentiometric sensors - Fundamentals of the electrochemical cell at equilibrium (Nernst equation) - Principles of operation of ion-selective electrodes L9. Amperometric sensors and bioelectric potentials - Fundamentals of the electrochemical cell with an applied overpotential to generate a faraday current - Principles of operation of amperometric sensors - Ion flow through a membrane (Fick equation, Nernst equation, Donnan equilibrium, Goldman equation) L10. Channels, amplification, signal gating, and patch clamp Y4 L11. Action potentials and impulse propagation L12. Functional electric stimulation and recording - MEA and CMOS based recording - Applying potential in liquid - simulation of fields and relevance to electric stimulation L13. Neural networks memory and learning | |||||
Literatur | Plonsey and Barr, Bioelectricity: A Quantitative Approach (Third edition) | |||||
Voraussetzungen / Besonderes | Supervised exercises solving real-world problems. Some Matlab based exercises in groups. | |||||
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | L. Van Gool, O. Göksel, E. Konukoglu | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
227-0965-00L | Micro and Nano-Tomography of Biological Tissues | W | 4 KP | 3G | M. Stampanoni, P. A. Kaestner | |
Kurzbeschreibung | Einführung in die physikalischen und technischen Grundkenntnisse der tomographischen Röntgenmikroskopie. Verschiedene Röntgenbasierten-Abbildungsmechanismen (Absorptions-, Phasen- und Dunkelfeld-Kontrast) werden erklärt und deren Einsatz in der aktuellen Forschung vorgestellt, insbesondere in der Biologie. Die quantitative Auswertung tomographische Datensätzen wird ausführlich beigebracht. | |||||
Lernziel | Einführung in die Grundlagen der Röntgentomographie auf der Mikrometer- und Nanometerskala, sowie in die entsprechenden Bildbearbeitungs- und Quantifizierungsmethoden, unter besonderer Berücksichtigung von biologischen Anwendungen. | |||||
Inhalt | Synchrotron basierte Röntgenmikro- und Nanotomographie ist heutzutage eine leistungsfähige Technik für die hochaufgelösten zerstörungsfreien Untersuchungen einer Vielfalt von Materialien. Die aussergewöhnlichen Stärke und Kohärenz der Strahlung einer Synchrotronquelle der dritten Generation erlauben quantitative drei-dimensionale Aufnahmen auf der Mikro- und Nanometerskala und erweitern die klassischen Absorption-basierten Verfahrensweisen auf die kontrastreicheren kantenverstärkten und phasenempfindlichen Methoden, die für die Analyse von biologischen Proben besonders geeignet sind. Die Vorlesung umfasst eine allgemeine Einführung in die Grundsätze der Röntgentomographie, von der Bildentstehung bis zur 3D Bildrekonstruktion. Sie liefert die physikalischen und technischen Grundkentnisse über die bildgebenden Synchrotronstrahllinien, vertieft die neusten Phasenkontrastmethoden und beschreibt die ersten Anwendungen nanotomographischer Röntgenuntersuchungen. Schliesslich liefert der Kurs den notwendigen Hintergrund, um die quantitative Auswertung tomographischer Daten zu verstehen, von der grundlegenden Bildanalyse bis zur komplexen morphometrischen Berechnung und zur 3D-Visualisierung, unter besonderer Berücksichtigung von biomedizinischen Anwendungen. | |||||
Skript | Online verfügbar | |||||
Literatur | Wird in der Vorlesung angegeben. | |||||
227-0969-00L | Methods & Models for fMRI Data Analysis | W | 6 KP | 4V | K. Stephan | |
Kurzbeschreibung | This course teaches methods and models for fMRI data analysis, covering all aspects of statistical parametric mapping (SPM), incl. preprocessing, the general linear model, statistical inference, multiple comparison corrections, event-related designs, and Dynamic Causal Modelling (DCM), a Bayesian framework for identification of nonlinear neuronal systems from neurophysiological data. | |||||
Lernziel | To obtain in-depth knowledge of the theoretical foundations of SPM and DCM and of their application to empirical fMRI data. | |||||
Inhalt | This course teaches state-of-the-art methods and models for fMRI data analysis. It covers all aspects of statistical parametric mapping (SPM), incl. preprocessing, the general linear model, frequentist and Bayesian inference, multiple comparison corrections, and event-related designs, and Dynamic Causal Modelling (DCM), a Bayesian framework for identification of nonlinear neuronal systems from neurophysiological data. A particular emphasis of the course will be on methodological questions arising in the context of studies in psychiatry, neurology and neuroeconomics. | |||||
327-0505-00L | Surfaces, Interfaces and their Applications I | W | 3 KP | 2V + 1U | N. Spencer, M. P. Heuberger, L. Isa | |
Kurzbeschreibung | After being introduced to the physical/chemical principles and importance of surfaces and interfaces, the student is introduced to the most important techniques that can be used to characterize surfaces. Later, liquid interfaces are treated, followed by an introduction to the fields of tribology (friction, lubrication, and wear) and corrosion. | |||||
Lernziel | To gain an understanding of the physical and chemical principles, as well as the tools and applications of surface science, and to be able to choose appropriate surface-analytical approaches for solving problems. | |||||
Inhalt | Introduction to Surface Science Physical Structure of Surfaces Surface Forces (static and dynamic) Adsorbates on Surfaces Surface Thermodynamics and Kinetics The Solid-Liquid Interface Electron Spectroscopy Vibrational Spectroscopy on Surfaces Scanning Probe Microscopy Introduction to Tribology Introduction to Corrosion Science | |||||
Skript | Script Download: Link | |||||
Literatur | Script (20 CHF) Book: "Surface Analysis--The Principal Techniques", Ed. J.C. Vickerman, Wiley, ISBN 0-471-97292 | |||||
Voraussetzungen / Besonderes | Chemistry: General undergraduate chemistry including basic chemical kinetics and thermodynamics Physics: General undergraduate physics including basic theory of diffraction and basic knowledge of crystal structures | |||||
327-2125-00L | Microscopy Training SEM I - Introduction to SEM Number of participants limited to 9. Master students will have priority over PhD students. PhD students may still enrol, but will be asked for a fee (Link). | W | 2 KP | 3P | S. Rodighiero, A. G. Bittermann, L. Grafulha Morales, K. Kunze, J. Reuteler | |
Kurzbeschreibung | Der Einführungskurs in Rasterelektronenmikroskopie (SEM) betont praktisches Lernen. Die Studierenden haben die Möglichkeit an zwei Elektronenmikroskopen ihre eigenen Proben oder Standard-Testproben zu untersuchen, sowie von ScopeM-Wissenschafler vorbereitete Übungen zu lösen. | |||||
Lernziel | - Set-up, align and operate a SEM successfully and safely. - Accomplish imaging tasks successfully and optimize microscope performances. - Master the operation of a low-vacuum and field-emission SEM and EDX instrument. - Perform sample preparation with corresponding techniques and equipment for imaging and analysis - Acquire techniques in obtaining secondary electron and backscatter electron micrographs - Perform EDX qualitative and semi-quantitative analysis | |||||
Inhalt | During the course, students learn through lectures, demonstrations, and hands-on sessions how to setup and operate SEM instruments, including low-vacuum and low-voltage applications. This course gives basic skills for students new to SEM. At the end of the course, students with no prior experience are able to align a SEM, to obtain secondary electron (SE) and backscatter electron (BSE) micrographs and to perform energy dispersive X-ray spectroscopy (EDX) qualitative and semi-quantitative analysis. The procedures to better utilize SEM to solve practical problems and to optimize SEM analysis for a wide range of materials will be emphasized. - Discussion of students' sample/interest - Introduction and discussion on Electron Microscopy and instrumentation - Lectures on electron sources, electron lenses and probe formation - Lectures on beam/specimen interaction, image formation, image contrast and imaging modes. - Lectures on sample preparation techniques for EM - Brief description and demonstration of the SEM microscope - Practice on beam/specimen interaction, image formation, image contrast (and image processing) - Student participation on sample preparation techniques - Scanning Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities - Lecture and demonstrations on X-ray micro-analysis (theory and detection), qualitative and semi-quantitative EDX and point analysis, linescans and spectral mapping - Practice on real-world samples and report results | |||||
Literatur | - Detailed course manual - Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 - Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007 | |||||
Voraussetzungen / Besonderes | No mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite. | |||||
327-2126-00L | Microscopy Training TEM I - Introduction to TEM Number of participants limited to 6. Master students will have priority over PhD students. PhD students may still enrol, but will be asked for a fee (Link). | W | 2 KP | 3P | S. Rodighiero, E. J. Barthazy Meier, A. G. Bittermann, F. Gramm | |
Kurzbeschreibung | Der Einführungskurs in Transmissionselektronenmikroskopie (TEM) bietet neuen Nutzern die Möglichkeit theoretisches Wissen und praktische Kenntnisse in TEM zu erwerben | |||||
Lernziel | - Overview of TEM theory, instrumentation, operation and applications. - Alignment and operation of a TEM, as well as acquisition and interpretation of images, diffraction patterns, accomplishing basic tasks successfully. - Knowledge of electron imaging modes (including Scanning Transmission Electron Microscopy), magnification calibration, and image acquisition using CCD cameras. - To set up the TEM to acquire diffraction patterns, perform camera length calibration, as well as measure and interpret diffraction patterns. - Overview of techniques for specimen preparation. | |||||
Inhalt | Using two Transmission Electron Microscopes the students learn how to align a TEM, select parameters for acquisition of images in bright field (BF) and dark field (DF), perform scanning transmission electron microscopy (STEM) imaging, phase contrast imaging, and acquire electron diffraction patterns. The participants will also learn basic and advanced use of digital cameras and digital imaging methods. - Introduction and discussion on Electron Microscopy and instrumentation. - Lectures on electron sources, electron lenses and probe formation. - Lectures on beam/specimen interaction, image formation, image contrast and imaging modes. - Lectures on sample preparation techniques for EM. - Brief description and demonstration of the TEM microscope. - Practice on beam/specimen interaction, image formation, Image contrast (and image processing). - Demonstration of Transmission Electron Microscopes and imaging modes (Phase contrast, BF, DF, STEM). - Student participation on sample preparation techniques. - Transmission Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities. - TEM alignment, calibration, correction to improve image contrast and quality. - Electron diffraction. - Practice on real-world samples and report results. | |||||
Literatur | - Detailed course manual - Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 - Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007 | |||||
Voraussetzungen / Besonderes | No mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite. | |||||
363-0790-00L | Technology Entrepreneurship | W | 2 KP | 2V | U. Claesson, B. Clarysse | |
Kurzbeschreibung | Technology ventures are significantly changing the global economic picture. Technological skills increasingly need to be complemented by entrepreneurial understanding. This course offers the fundamentals in theory and practice of entrepreneurship in new technology ventures. Main topics covered are success factors in the creation of new firms, including founding, financing and growing a venture. | |||||
Lernziel | This course provides theory-grounded knowledge and practice-driven skills for founding, financing, and growing new technology ventures. A critical understanding of dos and don'ts is provided through highlighting and discussing real life examples and cases. | |||||
Inhalt | See course website: Link | |||||
Skript | Lecture slides and case material | |||||
363-1065-00L | Design Thinking: Human-Centred Solutions to Real World Challenges Due to didactic reasons, the number of participants is limited to 30. All interested students are invited to apply for this course by sending a by sending a short motivation letter until the 18 of September 2017 to Florian Rittiner (Link). Additionally please enroll via mystudies. Please note that all students are put on the waiting list and that your current position on the waiting list is irrelevant, as places will be assigned after the first lecture on the basis of your motivation letter and commitment for the class. | W | 5 KP | 5G | A. Cabello Llamas, F. Rittiner, S. Brusoni, C. Hölscher, M. Meboldt | |
Kurzbeschreibung | The goal of this course is to engage students in a multidisciplinary collaboration to tackle real world problems. Following a design thinking approach, students will work in teams to solve a set of design challenges that are organized as a one-week, a three-week, and a final six-week project in collaboration with an external project partner. Information and application: Link | |||||
Lernziel | During the course, students will learn about different design thinking methods and tools. This will enable them to: - Generate deep insights through the systematic observation and interaction of key stakeholders (empathy). - Engage in collaborative ideation with a multidisciplinary team. - Rapidly prototype and iteratively test ideas and concepts by using various materials and techniques. | |||||
Inhalt | The purpose of this course is to equip the students with methods and tools to tackle a broad range of problems. Following a Design Thinking approach, the students will learn how to observe and interact with key stakeholders in order to develop an in-depth understanding of what is truly important and emotionally meaningful to the people at the center of a problem. Based on these insights, the students ideate on possible solutions and immediately validated them through quick iterations of prototyping and testing using different tools and materials. The students will work in multidisciplinary teams on a set of challenges that are organized as a one-week, a three-week, and a final six-week project with an external project partner. In this course, the students will learn about the different Design Thinking methods and tools that are needed to generate deep insights, to engage in collaborative ideation, rapid prototyping and iterative testing. Design Thinking is a deeply human process that taps into the creative abilities we all have, but that get often overlooked by more conventional problem solving practices. It relies on our ability to be intuitive, to recognize patterns, to construct ideas that are emotionally meaningful as well as functional, and to express ourselves through means beyond words or symbols. Design Thinking provides an integrated way by incorporating tools, processes and techniques from design, engineering, the humanities and social sciences to identify, define and address diverse challenges. This integration leads to a highly productive collaboration between different disciplines. For more information and the application visit: Link | |||||
Voraussetzungen / Besonderes | Open mind, ability to manage uncertainty and to work with students from various background. Class attendance and active participation is crucial as much of the learning occurs through the work in teams during class. Therefore, attendance is obligatory for every session. Please also note that the group work outside class is an essential element of this course, so that students must expect an above-average workload. Please note that the class is designed for full-time MSc students. Interested MAS students need to send an email to Florian Rittiner (Link) to learn about the requirements of the class. | |||||
376-0121-00L | Multiscale Bone Biomechanics Number of participants limited to 25. | W | 6 KP | 4S | R. Müller | |
Kurzbeschreibung | The seminar provides state-of-the-art insight to the biomechanical function of bone from molecules, to cells, tissue and up to the organ. Multiscale imaging and simulation allows linking different levels of hierarchy, where systems biology helps understanding the mechanobiological response of bone to loading and injury in scenarios relevant for personalized health and translational medicine. | |||||
Lernziel | The learning objectives include 1. advanced knowledge of the state-of-the-are in multiscale bone biomechanics; 2. basic understanding of the biological principles governing bone in health, disease and treatment from molecules, to cells, tissue and up to the organ; 3. good understanding of the prevalent biomechanical testing and imaging techniques on the various levels of bone hierarchy; 4. practical implementation of state-of-the-art multiscale simulation techniques; 5. improved programing skills through the use of 4th generation scripting language; 6. hands on experience in designing solutions for clinical and industrial problems; 7. encouragement of critical thinking and creating an environment for independent and self-directed studying. | |||||
Inhalt | Bone is one of the most investigated biological materials due to its primary function of providing skeletal stability. Bone is susceptible to different local stimuli including mechanical forces and has great capabilities in adapting its mechanical properties to the changes in its environment. Nevertheless, aging or hormonal changes can make bone lose its ability to remodel appropriately, with loss of strength and increased fracture risk as a result, leading to devastating diseases such as osteoporosis. To better understand the biomechanical function of bone, one has to understand the hierarchical organization of this fascinating material down from the molecules, to the cells, tissue and up to the organ. Multiscale imaging and simulation allows to link these different levels of hierarchy. Incorporating systems biology approaches, not only biomechanical strength of the material can be assessed but also the mechanobiological response of the bone triggered by loading and injury in scenarios relevant for personalized health and translational medicine. Watching cells working together to build and repair bone in a coordinated fashion is a spectacle, which will need dynamic image content and deep discussions in the lecture room to probe the imagination of the individual student interested in the topic. For the seminar, concepts of video lectures will be used in a flipped class room setup, where students can study the basic biology, engineering and mathematical concepts in video tutorials online. All videos and animations will be incorporated in an eSkript (eskript.ethz.ch) allowing studying and eventually even interactive course participation online. It is anticipated that the students need to prepare 2x45 minutes for the study of the actual lecture material. The Friday morning time slots will be used for students, who want to complete these assignments in a classroom setting. The student will have to study independently or in groups, but lecturer will be available for questions and answers during that time. In the Friday afternoon time slots, short clips with video/animation content will be used to introduce problems and discuss specific scientific findings using multiscale imaging and simulation technology. The students will have to form small groups to try to solve such problems and to present their solutions for advanced multiscale investigation of bone ranging from basic science to personalized health and onto translational medicine. | |||||
Skript | Material will be provided in Moodle and eScript (eskript.ethz.ch). | |||||
Voraussetzungen / Besonderes | Seminar will be held in English. | |||||
376-1151-00L | Translation of Basic Research Findings from Genetics and Molecular Mechanisms of Aging Number of participants limited to 30. | W | 3 KP | 2V | C. Ewald | |
Kurzbeschreibung | Recently, several start-up companies are aiming to translate basic molecular findings into new drugs/therapeutic interventions to slow aging or post-pone age-related diseases (e.g., Google founded Calico or Craig Venter's Human Longevity, Inc.). This course will teach students the basic skill sets to formulate their own ideas, design experiments to test them and explains the next steps to translat | |||||
Lernziel | The overall goal of this course is to be able to analyse current therapeutic interventions to identify an unmet need in molecular biology of aging and apply scientific thinking to discover new mechanisms that could be used as a novel therapeutic intervention. Learning objectives include: 1. Evaluate the current problem of our aging population, the impact of age-dependent diseases and current strategies to prevent these age-dependent diseases. 2. Analyse/compare current molecular/genetic strategies that address these aging problems. 3. Analyse case studies about biotech companies in the aging sector. Apply the scientific methods to formulate basic research questions to address these problems. 4. Generate own hypotheses (educated guess/idea), design experiments to test them, and map out the next steps to translate them. | |||||
Inhalt | Overview of aging and age-related diseases. Key discoveries in molecular biology of aging. Case studies of biotech companies addressing age-related complications. Brief introduction from bench to bedside with focus on start-up companies. | |||||
Voraussetzungen / Besonderes | No compulsory prerequisites, but student should have basic knowledge about genetics and molecular biology. | |||||
376-1103-00L | Frontiers in Nanotechnology | W | 4 KP | 4V | V. Vogel, weitere Dozierende | |
Kurzbeschreibung | Many disciplines are meeting at the nanoscale, from physics, chemistry to engineering, from the life sciences to medicine. The course will prepare students to communicate more effectively across disciplinary boundaries, and will provide them with deep insights into the various frontiers. | |||||
Lernziel | Building upon advanced technologies to create, visualize, analyze and manipulate nano-structures, as well as to probe their nano-chemistry, nano-mechanics and other properties within manmade and living systems, many exciting discoveries are currently made. They change the way we do science and result in so many new technologies. The goal of the course is to give Master and Graduate students from all interested departments an overview of what nanotechnology is all about, from analytical techniques to nanosystems, from physics to biology. Students will start to appreciate the extent to which scientific communities are meeting at the nanoscale. They will learn about the specific challenges and what is currently “sizzling” in the respective fields, and learn the vocabulary that is necessary to communicate effectively across departmental boundaries. Each lecturer will first give an overview of the state-of-the art in his/her field, and then describe the research highlights in his/her own research group. While preparing their Final Projects and discussing them in front of the class, the students will deepen their understanding of how to apply a range of new technologies to solve specific scientific problems and technical challenges. Exposure to the different frontiers will also improve their ability to conduct effective nanoscale research, recognize the broader significance of their work and to start collaborations. | |||||
Inhalt | Starting with the fabrication and analysis of nanoparticles and nanostructured materials that enable a variety of scientific and technical applications, we will transition to discussing biological nanosystems, how they work and what bioinspired engineering principles can be derived, to finally discussing biomedical applications and potential health risk issues. Scientific aspects as well as the many of the emerging technologies will be covered that start impacting so many aspects of our lives. This includes new phenomena in physics, advanced materials, novel technologies and new methods to address major medical challenges. | |||||
Skript | All the enrolled students will get access to a password protected website where they can find pdf files of the lecture notes, and typically 1-2 journal articles per lecture that cover selected topics. | |||||
376-1177-00L | Human Factors I | W | 3 KP | 2V | M. Menozzi Jäckli, R. Huang, M. Siegrist | |
Kurzbeschreibung | Every day humans interact with various systems. Strategies of interaction, individual needs, physical & mental abilities, and system properties are important factors in controlling the quality and performance in interaction processes. In the lecture, factors are investigated by basic scientific approaches. Discussed topics are important for optimizing people's satisfaction & overall performance. | |||||
Lernziel | The goal of the lecture is to empower students in better understanding the applied theories, principles, and methods in various applications. Students are expected to learn about how to enable an efficient and qualitatively high standing interaction between human and the environment, considering costs, benefits, health, and safety as well. Thus, an ergonomic design and evaluation process of products, tasks, and environments may be promoted in different disciplines. The goal is achieved in addressing a broad variety of topics and embedding the discussion in macroscopic factors such as the behavior of consumers and objectives of economy. | |||||
Inhalt | - Physiological, physical, and cognitive factors in sensation and perception - Body spaces and functional anthropometry, Digital Human Models - Experimental techniques in assessing human performance and well-being - Human factors and ergonomics in system designs, product development and innovation - Human information processing and biological cybernetics - Interaction among consumers, environments, behavior, and tasks | |||||
Literatur | - Gavriel Salvendy, Handbook of Human Factors and Ergonomics, 4th edition (2012), is available on NEBIS as electronic version and for free to ETH students - Further textbooks are introduced in the lecture - Brouchures, checklists, key articles etc. are uploaded in ILIAS | |||||
376-1179-00L | Applications of Cybernetics in Ergonomics | W | 1 KP | 1U | M. Menozzi Jäckli, Y.‑Y. Hedinger Huang, R. Huang | |
Kurzbeschreibung | Cybernetics systems have been studied and applied in various research fields, such as applications in the ergonomics domain. Research interests include the man-machine interaction (MMI) topic which involving the performance in multi-model interactions, quantification in gestalt principles in product development; or the information processing matter. | |||||
Lernziel | To learn and practice cybernetics principles in interface designs and product development. | |||||
Inhalt | - Fitt's law applied in manipulation tasks - Hick-Hyman law applied in design of the driver assistance systems - Vigilance applied in quality inspection - Accommodation/vergence crosslink function - Cross-link models in neurobiology- the ocular motor control system - Human performance in optimization of production lines | |||||
Literatur | Gavriel Salvendy, Handbook of Human Factors and Ergonomics, 4th edition (2012) | |||||
376-1219-00L | Rehabilitation Engineering II: Rehabilitation of Sensory and Vegetative Functions | W | 3 KP | 2V | R. Riener, O. Lambercy | |
Kurzbeschreibung | Rehabilitation Engng is the application of science and technology to ameliorate the handicaps of individuals with disabilities to reintegrate them into society.The goal is to present classical and new rehabilitation engineering principles applied to compensate or enhance motor, sensory, and cognitive deficits. Focus is on the restoration and treatment of the human sensory and vegetative system. | |||||
Lernziel | Provide knowledge on the anatomy and physiology of the human sensory system, related dysfunctions and pathologies, and how rehabilitation engineering can provide sensory restoration and substitution. This lecture is independent from Rehabilitation Engineering I. Thus, both lectures can be visited in arbitrary order. | |||||
Inhalt | Introduction, problem definition, overview Rehabilitation of visual function - Anatomy and physiology of the visual sense - Technical aids (glasses, sensor substitution) - Retina and cortex implants Rehabilitation of hearing function - Anatomy and physiology of the auditory sense - Hearing aids - Cochlea Implants Rehabilitation and use of kinesthetic and tactile function - Anatomy and physiology of the kinesthetic and tactile sense - Tactile/haptic displays for motion therapy (incl. electrical stimulation) - Role of displays in motor learning Rehabilitation of vestibular function - Anatomy and physiology of the vestibular sense - Rehabilitation strategies and devices (e.g. BrainPort) Rehabilitation of vegetative Functions - Cardiac Pacemaker - Phrenic stimulation, artificial breathing aids - Bladder stimulation, artificial sphincter Brain stimulation and recording - Deep brain stimulation for patients with Parkinson, epilepsy, depression - Brain-Computer Interfaces | |||||
Literatur | Introductory Books: An Introduction to Rehabilitation Engineering. R. A. Cooper, H. Ohnabe, D. A. Hobson (Eds.). Taylor & Francis, 2007. Principles of Neural Science. E. R. Kandel, J. H. Schwartz, T. M Jessell (Eds.). Mc Graw Hill, New York, 2000. Force and Touch Feedback for Virtual Reality. G. C. Burdea (Ed.). Wiley, New York, 1996 (available on NEBIS). Human Haptic Perception, Basics and Applications. M. Grunwald (Ed.). Birkhäuser, Basel, 2008. The Sense of Touch and Its Rendering, Springer Tracts in Advanced Robotics 45, A. Bicchi et al.(Eds). Springer-Verlag Berlin, 2008. Interaktive und autonome Systeme der Medizintechnik - Funktionswiederherstellung und Organersatz. Herausgeber: J. Werner, Oldenbourg Wissenschaftsverlag 2005. Neural prostheses - replacing motor function after desease or disability. Eds.: R. Stein, H. Peckham, D. Popovic. New York and Oxford: Oxford University Press. Advances in Rehabilitation Robotics - Human-Friendly Technologies on Movement Assistance and Restoration for People with Disabilities. Eds: Z.Z. Bien, D. Stefanov (Lecture Notes in Control and Information Science, No. 306). Springer Verlag Berlin 2004. Intelligent Systems and Technologies in Rehabilitation Engineering. Eds: H.N.L. Teodorescu, L.C. Jain (International Series on Computational Intelligence). CRC Press Boca Raton, 2001. Selected Journal Articles and Web Links: Abbas, J., Riener, R. (2001) Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function. Neuromodulation 4, pp. 187-195. Bach-y-Rita P., Tyler M., and Kaczmarek K (2003). Seeing with the brain. International journal of human-computer-interaction, 15(2):285-295. Burdea, G., Popescu, V., Hentz, V., and Colbert, K. (2000): Virtual reality-based orthopedic telerehabilitation, IEEE Trans. Rehab. Eng., 8, pp. 430-432 Colombo, G., Jörg, M., Schreier, R., Dietz, V. (2000) Treadmill training of paraplegic patients using a robotic orthosis. Journal of Rehabilitation Research and Development, vol. 37, pp. 693-700. Hayward, V. (2008): A Brief Taxonomy of Tactile Illusions and Demonstrations That Can Be Done In a Hardware Store. Brain Research Bulletin, Vol 75, No 6, pp 742-752 Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T. (1998): Robot-aided neurorehabilitation, IEEE Trans. Rehab. Eng., 6, pp. 75-87 Levesque. V. (2005). Blindness, technology and haptics. Technical report, McGill University. Available at: Link Quintern, J. (1998) Application of functional electrical stimulation in paraplegic patients. NeuroRehabilitation 10, pp. 205-250. Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10. Riener, R. (1999) Model-based development of neuroprostheses for paraplegic patients. Royal Philosophical Transactions: Biological Sciences 354, pp. 877-894. The vOICe. Link. VideoTact, ForeThought Development, LLC. Link | |||||
Voraussetzungen / Besonderes | Target Group: Students of higher semesters and PhD students of - D-MAVT, D-ITET, D-INFK, D-HEST - Biomedical Engineering, Robotics, Systems and Control - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome This lecture is independent from Rehabilitation Engineering I. Thus, both lectures can be visited in arbitrary order. | |||||
376-1279-00L | Virtual Reality in Medicine Findet dieses Semester nicht statt. | W | 3 KP | 2V | R. Riener | |
Kurzbeschreibung | Virtual Reality has the potential to support medical training and therapy. This lecture will derive the technical principles of multi-modal (audiovisual, haptic, tactile etc.) input devices, displays and rendering techniques. Examples are presented in the fields of surgical training, intra-operative augmentation, and rehabilitation. The lecture is accompanied by practical courses and excursions. | |||||
Lernziel | Provide theoretical and practical knowledge of new principles and applications of multi-modal simulation and interface technologies in medical education, therapy, and rehabilitation. | |||||
Inhalt | Virtual Reality has the potential to provide descriptive and practical information for medical training and therapy while relieving the patient and/or the physician. Multi-modal interactions between the user and the virtual environment facilitate the generation of high-fidelity sensory impressions, by using not only visual and auditory modalities, but also kinesthetic, tactile, and even olfactory feedback. On the basis of the existing physiological constraints, this lecture will derive the technical requirements and principles of multi-modal input devices, displays, and rendering techniques. Several examples are presented that are currently being developed or already applied for surgical training, intra-operative augmentation, and rehabilitation. The lecture will be accompanied by several practical courses on graphical and haptic display devices as well as excursions to facilities equipped with large-scale VR equipment. Target Group: Students of higher semesters and PhD students of - D-HEST, D-MAVT, D-ITET, D-INFK, D-PHYS - Robotics, Systems and Control Master - Biomedical Engineering/Movement Science and Sport - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome! | |||||
Literatur | Book: Virtual Reality in Medicine. Riener, Robert; Harders, Matthias; 2012 Springer. | |||||
Voraussetzungen / Besonderes | The course language is English. Basic experience in Information Technology and Computer Science will be of advantage More details will be announced in the lecture. | |||||
376-1351-00L | Micro/Nanotechnology and Microfluidics for Biomedical Applications | W | 2 KP | 2V | E. Delamarche | |
Kurzbeschreibung | This course is an introduction to techniques in micro/nanotechnology and to microfluidics. It reviews how many familiar devices are built and can be used for research and biomedical applications. Transistors for DNA sequencing, beamers for patterning proteins, hard-disk technology for biosensing and scanning microfluidics for analyzing tissue sections are just a few examples of the covered topics. | |||||
Lernziel | The main objective of the course is to introduce micro/nanotechnology and microfluidics to students having a background in the life sciences. The course should familiarize the students with the techniques used in micro/nanotechnology and show them how micro/nanotechnology pervades throughout life sciences. Microfluidics will be emphasized due to their increasing importance in research and medical applications. The second objective is to have life students less intimidated by micro/nanotechnology and make them able to link instruments and techniques to specific problems that they might have in their projects/studies. This will also help students getting access to the ETHZ/IBM Nanotech Center infrastructure if needed. | |||||
Inhalt | Mostly formal lectures (2 × 45 min), with a 2 hour visit and introduction to cleanroom and micro/nanotechnology instruments, last 3 sessions would be dedicated to the presentation and evaluation of projects by students (3 students per team). | |||||
Voraussetzungen / Besonderes | Nanotech center and lab visit at IBM would be mandatory, as well as attending the student project presentations. | |||||
376-1504-00L | Physical Human Robot Interaction (pHRI) Number of participants limited to 26. | W | 4 KP | 2V + 2U | R. Gassert, O. Lambercy | |
Kurzbeschreibung | This course focuses on the emerging, interdisciplinary field of physical human-robot interaction, bringing together themes from robotics, real-time control, human factors, haptics, virtual environments, interaction design and other fields to enable the development of human-oriented robotic systems. | |||||
Lernziel | The objective of this course is to give an introduction to the fundamentals of physical human robot interaction, through lectures on the underlying theoretical/mechatronics aspects and application fields, in combination with a hands-on lab tutorial. The course will guide students through the design and evaluation process of such systems. By the end of this course, you should understand the critical elements in human-robot interactions - both in terms of engineering and human factors - and use these to evaluate and de- sign safe and efficient assistive and rehabilitative robotic systems. Specifically, you should be able to: 1) identify critical human factors in physical human-robot interaction and use these to derive design requirements; 2) compare and select mechatronic components that optimally fulfill the defined design requirements; 3) derive a model of the device dynamics to guide and optimize the selection and integration of selected components into a functional system; 4) design control hardware and software and implement and test human-interactive control strategies on the physical setup; 5) characterize and optimize such systems using both engineering and psychophysical evaluation metrics; 6) investigate and optimize one aspect of the physical setup and convey and defend the gained insights in a technical presentation. | |||||
Inhalt | This course provides an introduction to fundamental aspects of physical human-robot interaction. After an overview of human haptic, visual and auditory sensing, neurophysiology and psychophysics, principles of human-robot interaction systems (kinematics, mechanical transmissions, robot sensors and actuators used in these systems) will be introduced. Throughout the course, students will gain knowledge of interaction control strategies including impedance/admittance and force control, haptic rendering basics and issues in device design for humans such as transparency and stability analysis, safety hardware and procedures. The course is organized into lectures that aim to bring students up to speed with the basics of these systems, readings on classical and current topics in physical human-robot interaction, laboratory sessions and lab visits. Students will attend periodic laboratory sessions where they will implement the theoretical aspects learned during the lectures. Here the salient features of haptic device design will be identified and theoretical aspects will be implemented in a haptic system based on the haptic paddle (Link), by creating simple dynamic haptic virtual environments and understanding the performance limitations and causes of instabilities (direct/virtual coupling, friction, damping, time delays, sampling rate, sensor quantization, etc.) during rendering of different mechanical properties. | |||||
Skript | Will be distributed through the document repository before the lectures. Link | |||||
Literatur | Abbott, J. and Okamura, A. (2005). Effects of position quantization and sampling rate on virtual-wall passivity. Robotics, IEEE Transactions on, 21(5):952 - 964. Adams, R. and Hannaford, B. (1999). Stable haptic interaction with virtual environments. Robotics and Automation, IEEE Transactions on, 15(3):465 -474. Buerger, S. and Hogan, N. (2007). Complementary stability and loop shaping for improved human ndash;robot interaction. Robotics, IEEE Transactions on, 23(2):232 -244. Burdea, G. and Brooks, F. (1996). Force and touch feedback for virtual reality. John Wiley & Sons New York NY. Colgate, J. and Brown, J. (1994). Factors affecting the z-width of a haptic display. In Robotics and Automation, 1994. Proceedings., 1994 IEEE International Conference on, pages 3205 -3210 vol.4. Diolaiti, N., Niemeyer, G., Barbagli, F., and Salisbury, J. (2006). Stability of haptic rendering: Discretization, quantization, time delay, and coulomb effects. Robotics, IEEE Transactions on, 22(2):256 -268. Gillespie, R. and Cutkosky, M. (1996). Stable user-specific haptic rendering of the virtual wall. In Proceedings of the ASME International Mechanical Engineering Congress and Exhibition, volume 58, pages 397-406. Hannaford, B. and Ryu, J.-H. (2002). Time-domain passivity control of haptic interfaces. Robotics and Automation, IEEE Transactions on, 18(1):1 -10. Hashtrudi-Zaad, K. and Salcudean, S. (2001). Analysis of control architectures for teleoperation systems with impedance/admittance master and slave manipulators. The International Journal of Robotics Research, 20(6):419. Hayward, V. and Astley, O. (1996). Performance measures for haptic interfaces. In ROBOTICS RESEARCH-INTERNATIONAL SYMPOSIUM-, volume 7, pages 195-206. Citeseer. Hayward, V. and Maclean, K. (2007). Do it yourself haptics: part i. Robotics Automation Magazine, IEEE, 14(4):88 -104. Leskovsky, P., Harders, M., and Szeekely, G. (2006). Assessing the fidelity of haptically rendered deformable objects. In Haptic Interfaces for Virtual Environment and Teleoperator Systems, 2006 14th Symposium on, pages 19 - 25. MacLean, K. and Hayward, V. (2008). Do it yourself haptics: Part ii [tutorial]. Robotics Automation Magazine, IEEE, 15(1):104 -119. Mahvash, M. and Hayward, V. (2003). Passivity-based high-fidelity haptic rendering of contact. In Robotics and Automation, 2003. Proceedings. ICRA '03. IEEE International Conference on, volume 3, pages 3722 - 3728 vol.3. Mehling, J., Colgate, J., and Peshkin, M. (2005). Increasing the impedance range of a haptic display by adding electrical damping. In Eurohaptics Conference, 2005 and Symposium on Haptic Interfaces for Virtual Environment and Teleoperator Systems, 2005. World Haptics 2005. First Joint, pages 257 - 262. Okamura, A., Richard, C., and Cutkosky, M. (2002). Feeling is believing: Using a force-feedback joystick to teach dynamic systems. JOURNAL OF ENGINEERING EDUCATION-WASHINGTON-, 91(3):345-350. O'Malley, M. and Goldfarb, M. (2004). The effect of virtual surface stiffness on the haptic perception of detail. Mechatronics, IEEE/ASME Transactions on, 9(2):448 -454. Richard, C. and Cutkosky, M. (2000). The effects of real and computer generated friction on human performance in a targeting task. In Proceedings of the ASME Dynamic Systems and Control Division, volume 69, page 2. Salisbury, K., Conti, F., and Barbagli, F. (2004). Haptic rendering: Introductory concepts. Computer Graphics and Applications, IEEE, 24(2):24-32. Weir, D., Colgate, J., and Peshkin, M. (2008). Measuring and increasing z-width with active electrical damping. In Haptic interfaces for virtual environment and teleoperator systems, 2008. haptics 2008. symposium on, pages 169 -175. Yasrebi, N. and Constantinescu, D. (2008). Extending the z-width of a haptic device using acceleration feedback. Haptics: Perception, Devices and Scenarios, pages 157-162. | |||||
Voraussetzungen / Besonderes | Notice: The registration is limited to 26 students There are 4 credit points for this lecture. The lecture will be held in English. The students are expected to have basic control knowledge from previous classes. Link | |||||
376-1622-00L | Practical Methods in Tissue Engineering Number of participants limited to 16 | W | 5 KP | 4P | K. Würtz-Kozak, O. Krupkova, M. Zenobi-Wong | |
Kurzbeschreibung | The goal of this course is to teach MSc students the necessary skills for doing research in the fields of tissue engineering and regenerative medicine. | |||||
Lernziel | Practical exercises and demonstrations on topics including sterile cell culture, light microscopy and histology, protein and gene expression analysis, and viability assays are covered. The advantages of 3D cell cultures will be discussed and practical work on manufacturing and evaluating hydrogels and scaffolds for tissue engineering will be performed in small groups. In addition to practical lab work, the course will teach skills in data acquisition/analysis. | |||||
376-1651-00L | Clinical and Movement Biomechanics | W | 4 KP | 3G | S. Lorenzetti, R. List, N. Singh | |
Kurzbeschreibung | Measurement and modeling of the human movement during daily activities and in a clinical environment. | |||||
Lernziel | The students are able to analyse the human movement from a technical point of view, to process the data and perform modeling with a focus towards clinical application. | |||||
Inhalt | This course includes study design, measurement techniques, clinical testing, accessing movement data and anysis as well as modeling with regards to human movement. | |||||
376-1985-00L | Trauma Biomechanics | W | 4 KP | 2V + 1U | K.‑U. Schmitt, M. H. Muser | |
Kurzbeschreibung | Trauma-Biomechanik ist ein interdiszipliäres Fach, das sich mit der Biomechanik von Verletzungen sowie Möglichkeiten zur Prävention von Verletzungen beschäftigt. Die Vorlesung stellt die Grundlagen der Trauma-Biomechanik dar. | |||||
Lernziel | Vermittlung von Grundlagen der Trauma-Biomechanik. | |||||
Inhalt | Die Vorlesung beschäftigt sich mit Verletzungen des menschlichen Körpers und den zugrunde liegenden Verletzungsmechanismen. Hierbei bilden Verletzungen, die im Strassenverkehr erlitten werden, den Schwerpunkt. Weitere Vorlesungsthemen sind: Crash-Tests und die dazugehörige Messtechnik (z. B. Dummys), sowie aktuelle Themen der Trauma-Biomechanik. | |||||
Skript | Unterlagen werden zur Verfügung gestellt. | |||||
Literatur | Schmitt K-U, Niederer P, M. Muser, Walz F: "Trauma Biomechanics - An Introduction to Injury Biomechanics" bzw. "Trauma-Biomechanik - Einführung in die Biomechanik von Verletzungen", beide Springer Verlag. | |||||
376-1974-00L | Colloquium in Biomechanics | W | 2 KP | 2K | B. Helgason, S. J. Ferguson, R. Müller, J. G. Snedeker, W. R. Taylor, K. Würtz-Kozak, M. Zenobi-Wong | |
Kurzbeschreibung | Current topics in biomechanics presented by speakers from academia and industry. | |||||
Lernziel | Getting insight into actual areas and problems of biomechanics. | |||||
401-0629-00L | Applied Biostatistics | W | 4 KP | 3G | M. Müller | |
Kurzbeschreibung | Principles and main methods in biostatistics with emphasis on practical aspects. Experimental and observational studies. Regression and analysis of variance. Introduction into survival analysis. | |||||
Lernziel | Getting an overwiew of the problems and statistical methods used in health sciences. Practise in using the software R to analyze data and interpreting the sults. | |||||
Inhalt | Experimental and observational studies. Relative risks and odds ratios. Diagnostic tests, ROC analysis. Multiple linear and logistic regression, analysis of variance. Introduction into survival analysis. | |||||
Skript | see teaching document repository | |||||
Literatur | Le, Chap T. and Eberly, L.: Introductory Biostatistics. Wiley Interscience, 2014. Norman, G. and Streiner, D.: Biostatistics. The Bare Essentials. pmph USA. 3th edition 2008. Rosner B: Fundamentals of Biostatistics. Duxbury Press, 7th edition, 2010. | |||||
Voraussetzungen / Besonderes | The statistical package R will be used in the exercises. If you are unfamiliar with R, I highly recommend the online R course etutoR. | |||||
402-0674-00L | Physics in Medical Research: From Atoms to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |
Kurzbeschreibung | Scanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells. | |||||
Lernziel | The lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour. As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced. The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes. High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering. Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body. Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function. 3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented. Visiting clinical research in a leading university hospital will show the usefulness of the lecture series. | |||||
535-0423-00L | Drug Delivery and Drug Targeting | W | 2 KP | 1.5V | J.‑C. Leroux, A. Spyrogianni Roveri | |
Kurzbeschreibung | Die Studierenden erwerben einen Überblick über derzeit aktuelle Prinzipien, Methoden und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Damit sind die Studierenden in der Lage, das Gebiet gemäss wissenschaftlichen Kriterien zu verstehen und zu beurteilen. | |||||
Lernziel | Die Studierenden verfügen über einen Überblick über derzeit aktuelle Prinzipien und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Im Vordergrund der Lehrveranstaltung steht die Entwicklung von Fähigkeiten zum Verständnis der betreffenden Technologien und Methoden, ebenso wie der Möglichkeiten und Grenzen ihres therapeutischen Einsatzes. Im Zentrum stehen therapeutische Peptide, Proteine, Nukleinsäuren und Impfstoffe. | |||||
Inhalt | Der Kurs behandelt folgende Themen: Arzneistoff-targeting und Freigabeprinzipien, makromolekulare Arzneistofftransporter, Liposomen, Mizellen, Mikro/Nanopartikel, Gele und Implantate, Anwendung von Impfstoffen, Abgabe im Gastrointestinaltrakt, synthetische Transporter für Arzneistoffe auf Nukleinsäurebasis, ophthalmische Vehikel und neue Trends in transdermaler und nasaler Arzneistofffreigabe. | |||||
Skript | Ausgewählte Skripten, Vorlesungsunterlagen und unterstützendes Material werden entweder direkt an der Vorlesung ausgegeben oder sind über das Web zugänglich: Link Diese Website enthält auch zusätzliche Unterlagen zu peroralen Abgabesystemen, zur gastrointestinalen Passage von Arzneiformen, transdermalen Systemen und über Abgabesysteme für alternative Absorptionswege. Diese Stoffgebiete werden speziell in der Vorlesung Galenische Pharmazie II behandelt. | |||||
Literatur | A.M. Hillery, K. Park. Drug Delivery: Fundamentals & Applications, second edition, CRC Press, Boca Raton, FL, 2017. B. Wang B, L. Hu, T.J. Siahaan. Drug Delivery - Principles and Applications, second edition, John Wiley & Sons, Hoboken NJ, 2016. Y. Perrie, T. Rhades. Pharmaceutics - Drug Delivery and Targeting, second edition, Pharmaceutical Press, London and Chicago, 2012. Weitere Literatur in der Vorlesung. | |||||
551-0317-00L | Immunology I | W | 3 KP | 2V | A. Oxenius, M. Kopf | |
Kurzbeschreibung | Einführung in strukturelle und funktionelle Eigenschaften des Immunsystems. Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort. | |||||
Lernziel | Einführung in strukturelle und funktionelle Eigenschaften des Immunsystems. Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort. | |||||
Inhalt | - Einleitung und historischer Hintergrund - Angeborene und adaptive Immunantwort, Zellen und Organe des Immunsystems - B Zellen und Antikörper - Generation von Diversität - Antigen-Präsentation und Histoinkompatibilitätsantigene (MHC) - Thymus und T Zellselektion - Autoimmunität - Zytotoxische T Zellen und NK Zellen - Th1 und Th2 Zellen, regulatorische T Zellen - Allergien - Hypersensitivititäten - Impfungen und immun-therapeutische Interventionen | |||||
Skript | Die Studenten haben elekronischen Zugriff auf die Vorlesungsunterlagen. Der Link ist unter "Lernmaterialien" zu finden. | |||||
Literatur | - Kuby, Immunology, 7th edition, Freemen + Co., New York, 2009 | |||||
Voraussetzungen / Besonderes | Immunology I (WS) und Immunology II (SS) werden in einer Sessionsprüfung im Anschluss an Immunology II als eine Lerneinheit geprüft. | |||||
551-0319-00L | Cellular Biochemistry (Part I) | W | 3 KP | 2V | U. Kutay, R. I. Enchev, B. Kornmann, M. Peter, I. Zemp, weitere Dozierende | |
Kurzbeschreibung | Concepts and molecular mechanisms underlying the biochemistry of the cell, providing advanced insights into structure, function and regulation of individual cell components. Particular emphasis will be put on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes such as intracellular transport, cell division & growth, and cell migration. | |||||
Lernziel | The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterisation of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain the integration of different molecules and signaling pathways into complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, cell division and cell growth. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer. | |||||
Inhalt | Structural and functional details of individual cell components, regulation of their interactions, and various aspects of the regulation and compartmentalisation of biochemical processes. Topics include: biophysical and electrical properties of membranes; viral membranes; structural and functional insights into intracellular transport and targeting; vesicular trafficking and phagocytosis; post-transcriptional regulation of gene expression. | |||||
Skript | Scripts and additional material will be provided during the semester. Please contact Dr. Alicia Smith for assistance with the learning materials. (Link) | |||||
Literatur | Recommended supplementary literature (review articles and selected primary literature) will be provided during the course. | |||||
Voraussetzungen / Besonderes | To attend this course the students must have a solid basic knowledge in chemistry, biochemistry and general biology. The course will be taught in English. | |||||
636-0108-00L | Biological Engineering and Biotechnology Attention: This course was offered in previous semesters with the number: 636-0003-00L "Biological Engineering and Biotechnology". Students that already passed course 636-0003-00L cannot receive credits for course 636-0108-00L. | W | 4 KP | 3V | M. Fussenegger | |
Kurzbeschreibung | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||
Lernziel | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||
Inhalt | 1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development. | |||||
Skript | Handout during the course. | |||||
752-3105-00L | Physiology Guided Food Structure and Process Design | W | 3 KP | 2V | E. J. Windhab, B. Le Révérend, T. Wooster | |
Kurzbeschreibung | A “cook-and look” approach to process design is no longer applicable in the current environmental, nutritional and competitive constraints. The modern R&D chemical/food engineer should have a clear focus on the desired structure that needs to be achieved to design a process line or a processing equipment, coupled with in depth knowledge of the processed materials. | |||||
Lernziel | The objective of this course is to highlight the intimate links between human physiology and product sensory and nutritional functions. To optimize these functions, an understanding of the physiological functions that interact and encode the actions of those product structures must be well understood. Therefore the objective of this course is for students to be equipped with a skill set that will encompass basic digestion and sensory physiology knowledge and food structures. The students will be exposed to this interplay all along the GI tract, including taste, aroma and texture perception, swallowing mechanics and gastro intestinal digestion with an engineering or physical sciences angle. | |||||
Vertiefung in Molekulare Gesundheitswissenschaften | ||||||
Pflichtfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-0300-00L | Translational Science for Health and Medicine | O | 3 KP | 2G | J. Goldhahn, G. von Krogh, C. Wolfrum | |
Kurzbeschreibung | Translational science is a cross disciplinary scientific research that is motivated by the need for practical applications that help people. The course should help to clarify basics of translational science, illustrate successful applications and should enable students to integrate key features into their future projects. | |||||
Lernziel | After completing this course, students will be able to understand: Principles of translational science (including project planning, ethics application, basics of resource management and interdisciplinary communication) | |||||
Inhalt | What is translational science and what is it not? How to identify need? - Disease concepts and consequences for research - Basics about incidence, prevalence etc., and orphan indications How to choose the appropriate research type and methodology - Ethical considerations including ethics application - Pros and cons of different types of research - Coordination of complex approaches incl. timing and resources How to measure success? - Outcome variables - Improving the translational process Challenges of communication? How independent is translational science? - Academic boundary conditions vs. industrial influences Positive and negative examples will be illustrated by distinguished guest speakers. | |||||
376-0302-01L | GCP Basic Course (Modul 1 and 2) Nur für Gesundheitswissenschaften und Technologie MSc. | O | 1 KP | 1G | G. Senti | |
Kurzbeschreibung | The basic course in "Good Clinical Practice" (GCP) contains of two full-time training days (Module 1 and Module 2) and addresses elementary aspects for the appropriate conduct of clinical trials and non-clinical research projects involving human beings. Successful participation will be confirmed by a certificate that is recognized by the Swiss authorities. | |||||
Lernziel | Students will get familiar with: - Key Ethics documents - (Inter)national Guidelines and Laws (e.g. ICH-GCP, DIN EN ISO 14155, TPA, HRA) - Sequence of research projects and project-involved parties - Planning of research projects (statistics, resources, study design, set-up of the study protocol) - Approval of research projects by Authorities (SwissEthics, Swissmedic, FOPH) - Roles and responsibilities of project-involved parties Students will learn how to: - Classify research projects according the risk-based approach of the HRA - Write a study protocol - Inform participating patients/study subjects - Obtain consent by participating patients/study subjects - Classify, document and report Adverse Events - Handle projects with biological material from humans and/or health- related personal data | |||||
Inhalt | Module 1: Research and Research Ethics, Guidelines, (inter)national Legislation, Development of therapeutic products, Methodology (Study Design), Study documents (Study protocol, Investigator's Brochure, Patient Information Leaflet, Informed Consent Form) Module 2: Roles and Responsibilities, Approval procedures, Notification and Reporting, Study documentation, Research with biological material and health-related data, data protection, data retention | |||||
Wahlfächer | ||||||
Wahlfächer I | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
551-0309-00L | Concepts in Modern Genetics | W | 6 KP | 4V | Y. Barral, D. Bopp, A. Hajnal, M. Stoffel, O. Voinnet | |
Kurzbeschreibung | Concepts of modern genetics and genomics, including principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference. | |||||
Lernziel | This course focuses on the concepts of classical and modern genetics and genomics. | |||||
Inhalt | The topics include principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference. | |||||
Skript | Scripts and additional material will be provided during the semester. | |||||
551-0317-00L | Immunology I | W | 3 KP | 2V | A. Oxenius, M. Kopf | |
Kurzbeschreibung | Einführung in strukturelle und funktionelle Eigenschaften des Immunsystems. Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort. | |||||
Lernziel | Einführung in strukturelle und funktionelle Eigenschaften des Immunsystems. Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort. | |||||
Inhalt | - Einleitung und historischer Hintergrund - Angeborene und adaptive Immunantwort, Zellen und Organe des Immunsystems - B Zellen und Antikörper - Generation von Diversität - Antigen-Präsentation und Histoinkompatibilitätsantigene (MHC) - Thymus und T Zellselektion - Autoimmunität - Zytotoxische T Zellen und NK Zellen - Th1 und Th2 Zellen, regulatorische T Zellen - Allergien - Hypersensitivititäten - Impfungen und immun-therapeutische Interventionen | |||||
Skript | Die Studenten haben elekronischen Zugriff auf die Vorlesungsunterlagen. Der Link ist unter "Lernmaterialien" zu finden. | |||||
Literatur | - Kuby, Immunology, 7th edition, Freemen + Co., New York, 2009 | |||||
Voraussetzungen / Besonderes | Immunology I (WS) und Immunology II (SS) werden in einer Sessionsprüfung im Anschluss an Immunology II als eine Lerneinheit geprüft. | |||||
Wahlfächer II | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
327-2125-00L | Microscopy Training SEM I - Introduction to SEM Number of participants limited to 9. Master students will have priority over PhD students. PhD students may still enrol, but will be asked for a fee (Link). | W | 2 KP | 3P | S. Rodighiero, A. G. Bittermann, L. Grafulha Morales, K. Kunze, J. Reuteler | |
Kurzbeschreibung | Der Einführungskurs in Rasterelektronenmikroskopie (SEM) betont praktisches Lernen. Die Studierenden haben die Möglichkeit an zwei Elektronenmikroskopen ihre eigenen Proben oder Standard-Testproben zu untersuchen, sowie von ScopeM-Wissenschafler vorbereitete Übungen zu lösen. | |||||
Lernziel | - Set-up, align and operate a SEM successfully and safely. - Accomplish imaging tasks successfully and optimize microscope performances. - Master the operation of a low-vacuum and field-emission SEM and EDX instrument. - Perform sample preparation with corresponding techniques and equipment for imaging and analysis - Acquire techniques in obtaining secondary electron and backscatter electron micrographs - Perform EDX qualitative and semi-quantitative analysis | |||||
Inhalt | During the course, students learn through lectures, demonstrations, and hands-on sessions how to setup and operate SEM instruments, including low-vacuum and low-voltage applications. This course gives basic skills for students new to SEM. At the end of the course, students with no prior experience are able to align a SEM, to obtain secondary electron (SE) and backscatter electron (BSE) micrographs and to perform energy dispersive X-ray spectroscopy (EDX) qualitative and semi-quantitative analysis. The procedures to better utilize SEM to solve practical problems and to optimize SEM analysis for a wide range of materials will be emphasized. - Discussion of students' sample/interest - Introduction and discussion on Electron Microscopy and instrumentation - Lectures on electron sources, electron lenses and probe formation - Lectures on beam/specimen interaction, image formation, image contrast and imaging modes. - Lectures on sample preparation techniques for EM - Brief description and demonstration of the SEM microscope - Practice on beam/specimen interaction, image formation, image contrast (and image processing) - Student participation on sample preparation techniques - Scanning Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities - Lecture and demonstrations on X-ray micro-analysis (theory and detection), qualitative and semi-quantitative EDX and point analysis, linescans and spectral mapping - Practice on real-world samples and report results | |||||
Literatur | - Detailed course manual - Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 - Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007 | |||||
Voraussetzungen / Besonderes | No mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite. | |||||
327-2126-00L | Microscopy Training TEM I - Introduction to TEM Number of participants limited to 6. Master students will have priority over PhD students. PhD students may still enrol, but will be asked for a fee (Link). | W | 2 KP | 3P | S. Rodighiero, E. J. Barthazy Meier, A. G. Bittermann, F. Gramm | |
Kurzbeschreibung | Der Einführungskurs in Transmissionselektronenmikroskopie (TEM) bietet neuen Nutzern die Möglichkeit theoretisches Wissen und praktische Kenntnisse in TEM zu erwerben | |||||
Lernziel | - Overview of TEM theory, instrumentation, operation and applications. - Alignment and operation of a TEM, as well as acquisition and interpretation of images, diffraction patterns, accomplishing basic tasks successfully. - Knowledge of electron imaging modes (including Scanning Transmission Electron Microscopy), magnification calibration, and image acquisition using CCD cameras. - To set up the TEM to acquire diffraction patterns, perform camera length calibration, as well as measure and interpret diffraction patterns. - Overview of techniques for specimen preparation. | |||||
Inhalt | Using two Transmission Electron Microscopes the students learn how to align a TEM, select parameters for acquisition of images in bright field (BF) and dark field (DF), perform scanning transmission electron microscopy (STEM) imaging, phase contrast imaging, and acquire electron diffraction patterns. The participants will also learn basic and advanced use of digital cameras and digital imaging methods. - Introduction and discussion on Electron Microscopy and instrumentation. - Lectures on electron sources, electron lenses and probe formation. - Lectures on beam/specimen interaction, image formation, image contrast and imaging modes. - Lectures on sample preparation techniques for EM. - Brief description and demonstration of the TEM microscope. - Practice on beam/specimen interaction, image formation, Image contrast (and image processing). - Demonstration of Transmission Electron Microscopes and imaging modes (Phase contrast, BF, DF, STEM). - Student participation on sample preparation techniques. - Transmission Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities. - TEM alignment, calibration, correction to improve image contrast and quality. - Electron diffraction. - Practice on real-world samples and report results. | |||||
Literatur | - Detailed course manual - Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 - Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007 | |||||
Voraussetzungen / Besonderes | No mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite. | |||||
376-0121-00L | Multiscale Bone Biomechanics Number of participants limited to 25. | W | 6 KP | 4S | R. Müller | |
Kurzbeschreibung | The seminar provides state-of-the-art insight to the biomechanical function of bone from molecules, to cells, tissue and up to the organ. Multiscale imaging and simulation allows linking different levels of hierarchy, where systems biology helps understanding the mechanobiological response of bone to loading and injury in scenarios relevant for personalized health and translational medicine. | |||||
Lernziel | The learning objectives include 1. advanced knowledge of the state-of-the-are in multiscale bone biomechanics; 2. basic understanding of the biological principles governing bone in health, disease and treatment from molecules, to cells, tissue and up to the organ; 3. good understanding of the prevalent biomechanical testing and imaging techniques on the various levels of bone hierarchy; 4. practical implementation of state-of-the-art multiscale simulation techniques; 5. improved programing skills through the use of 4th generation scripting language; 6. hands on experience in designing solutions for clinical and industrial problems; 7. encouragement of critical thinking and creating an environment for independent and self-directed studying. | |||||
Inhalt | Bone is one of the most investigated biological materials due to its primary function of providing skeletal stability. Bone is susceptible to different local stimuli including mechanical forces and has great capabilities in adapting its mechanical properties to the changes in its environment. Nevertheless, aging or hormonal changes can make bone lose its ability to remodel appropriately, with loss of strength and increased fracture risk as a result, leading to devastating diseases such as osteoporosis. To better understand the biomechanical function of bone, one has to understand the hierarchical organization of this fascinating material down from the molecules, to the cells, tissue and up to the organ. Multiscale imaging and simulation allows to link these different levels of hierarchy. Incorporating systems biology approaches, not only biomechanical strength of the material can be assessed but also the mechanobiological response of the bone triggered by loading and injury in scenarios relevant for personalized health and translational medicine. Watching cells working together to build and repair bone in a coordinated fashion is a spectacle, which will need dynamic image content and deep discussions in the lecture room to probe the imagination of the individual student interested in the topic. For the seminar, concepts of video lectures will be used in a flipped class room setup, where students can study the basic biology, engineering and mathematical concepts in video tutorials online. All videos and animations will be incorporated in an eSkript (eskript.ethz.ch) allowing studying and eventually even interactive course participation online. It is anticipated that the students need to prepare 2x45 minutes for the study of the actual lecture material. The Friday morning time slots will be used for students, who want to complete these assignments in a classroom setting. The student will have to study independently or in groups, but lecturer will be available for questions and answers during that time. In the Friday afternoon time slots, short clips with video/animation content will be used to introduce problems and discuss specific scientific findings using multiscale imaging and simulation technology. The students will have to form small groups to try to solve such problems and to present their solutions for advanced multiscale investigation of bone ranging from basic science to personalized health and onto translational medicine. | |||||
Skript | Material will be provided in Moodle and eScript (eskript.ethz.ch). | |||||
Voraussetzungen / Besonderes | Seminar will be held in English. | |||||
376-1151-00L | Translation of Basic Research Findings from Genetics and Molecular Mechanisms of Aging Number of participants limited to 30. | W | 3 KP | 2V | C. Ewald | |
Kurzbeschreibung | Recently, several start-up companies are aiming to translate basic molecular findings into new drugs/therapeutic interventions to slow aging or post-pone age-related diseases (e.g., Google founded Calico or Craig Venter's Human Longevity, Inc.). This course will teach students the basic skill sets to formulate their own ideas, design experiments to test them and explains the next steps to translat | |||||
Lernziel | The overall goal of this course is to be able to analyse current therapeutic interventions to identify an unmet need in molecular biology of aging and apply scientific thinking to discover new mechanisms that could be used as a novel therapeutic intervention. Learning objectives include: 1. Evaluate the current problem of our aging population, the impact of age-dependent diseases and current strategies to prevent these age-dependent diseases. 2. Analyse/compare current molecular/genetic strategies that address these aging problems. 3. Analyse case studies about biotech companies in the aging sector. Apply the scientific methods to formulate basic research questions to address these problems. 4. Generate own hypotheses (educated guess/idea), design experiments to test them, and map out the next steps to translate them. | |||||
Inhalt | Overview of aging and age-related diseases. Key discoveries in molecular biology of aging. Case studies of biotech companies addressing age-related complications. Brief introduction from bench to bedside with focus on start-up companies. | |||||
Voraussetzungen / Besonderes | No compulsory prerequisites, but student should have basic knowledge about genetics and molecular biology. | |||||
376-1622-00L | Practical Methods in Tissue Engineering Number of participants limited to 16 | W | 5 KP | 4P | K. Würtz-Kozak, O. Krupkova, M. Zenobi-Wong | |
Kurzbeschreibung | The goal of this course is to teach MSc students the necessary skills for doing research in the fields of tissue engineering and regenerative medicine. | |||||
Lernziel | Practical exercises and demonstrations on topics including sterile cell culture, light microscopy and histology, protein and gene expression analysis, and viability assays are covered. The advantages of 3D cell cultures will be discussed and practical work on manufacturing and evaluating hydrogels and scaffolds for tissue engineering will be performed in small groups. In addition to practical lab work, the course will teach skills in data acquisition/analysis. | |||||
551-0223-00L | Immunology III | W | 4 KP | 2V | M. Kopf, M. Bachmann, S. B. Freigang, J. Kisielow, S. R. Leibundgut, A. Oxenius, R. Spörri | |
Kurzbeschreibung | Diese Vorlesung liefert einen detaillierten Einblick in die - Entwicklung von T Zellen und B Zellen - Dynamik einer Immunantwort bei akuten und chronischen Infektionen - Mechanismen von Immunpathologie - neue Impfstoffstrategien | |||||
Lernziel | Sie verstehen - die Entwicklung, Aktivierung, und Differenzierung verschiedener Typen von T Zellen und deren Effektormechanismen während einer Immunantwort - die Erkennung von pathogenen Mikroorganismen und molekulare Ereignisse nach Infektion einer Zelle - Ereignisse und Signale für die Reifung von naiven B Zellen zu antikörperproduzierenden Plasmazellen und Gedächtniszellen, - Optimierung von B Zellantworten durch das intelligente Design neuer Impfstoffe | |||||
Inhalt | o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg) o NK T cells and responses to lipid antigens o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17 o Overview of cytokines and their effector function o Co-stimulation (signals 1-3) o Dendritic cells o Evolution of the "Danger" concept o Cells expressing Pattern Recognition Receptors and their downstream signals o T cell function and dysfunction in acute and chronic viral infections | |||||
Literatur | Unterlagen zur Vorlesung sind erhältlich bei: Link | |||||
Voraussetzungen / Besonderes | Immunology I and II recommended but not compulsory | |||||
551-0512-00L | Current Topics in Molecular and Cellular Neurobiology Number of participants limited to 8. | W | 2 KP | 1S | U. Suter | |
Kurzbeschreibung | The course is a literature seminar or "journal club". Each Friday a student, or a member of the Suter Lab in the Institute of Molecular Health Sciences, will present a paper from the recent literature. | |||||
Lernziel | The course introduces you to recent developments in the fields of cellular and molecular neurobiology. It also supports you to develop your skills in critically reading the scientific literature. You should be able to grasp what the authors wanted to learn i.e. their goals, why the authors chose the experimental approach they used, the strengths and weaknesses of the experiments and the data presented, and how the work fits into the wider literature in the field. You will present one paper yourself, which provides you with practice in public speaking. | |||||
Inhalt | You will present one paper yourself. Give an introduction to the field of the paper, then show and comment on the main results (all the papers we present are available online, so you can show original figures with a beamer). Finish with a summary of the main points and a discussion of their significance. You are expected to take part in the discussion and to ask questions. To prepare for this you should read all the papers beforehand (they will be announced a week in advance of the presentation). | |||||
Skript | Presentations will be made available after the seminars. | |||||
Voraussetzungen / Besonderes | You must attend at least 80% of the journal clubs, and give a presentation of your own. At the end of the semester there will be a 30 minute oral exam on the material presented during the semester. The grade will be based on the exam (45%), your presentation (45%), and a contribution based on your active participation in discussion of other presentations (10%). | |||||
551-0571-00L | From DNA to Diversity (University of Zurich) Der Kurs muss direkt an der UZH belegt werden. UZH Modulkürzel: BIO336 Beachten Sie die Einschreibungstermine an der UZH: Link | W | 2 KP | 2V | A. Hajnal, D. Bopp | |
Kurzbeschreibung | The evolution of the various body-plans is investigated by means of comparison of developmentally essential control genes of molecularly analysed model organisms. | |||||
Lernziel | By the end of this module, each student should be able to - recognize the universal principles underlying the development of different animal body plans. - explain how the genes encoding the molecular toolkit have evolved to create animal diversity. - relate changes in gene structure or function to evolutionary changes in animal development. Key skills: By the end of this module, each student should be able to - present and discuss a relevant evolutionary topic in an oral presentation - select and integrate key concepts in animal evolution from primary literature - participate in discussions on topics presented by others | |||||
551-1003-00L | Methoden der Biologischen Analytik | W | 3 KP | 3G | R. Aebersold, M. Badertscher, K. Weis | |
Kurzbeschreibung | 529-1042-00 Grundlagen der wichtigsten Trennmethoden und der Interpretation von Molekülspektren. 551-1003-00 Der Kurs befasst sich mit den Methoden und ausgewählten Anwendungen von Methoden der Nukleinsäuresequenzierung, der massenspektrometrischen Analyse von Proteinen und Proteomen und Licht-und Fluoreszenz gestützten Methoden der Mikroskopie. | |||||
Lernziel | 529-1042-00 Kenntnis der notwendigen Grundlagen und der Anwendungsmöglichkeiten für den Einsatz von relevanten spektroskopischen und Trennmethoden in der analytisch-chemischen Praxis. 551-1003-00 Kenntnis der notwendigen Grundlagen und der Anwendungsmöglichkeiten der Methoden für die Bestimmung von Nukleinsäuresequenzen, der massenspektrometrischen Analyse von Proteinen und Proteomen und Licht-und Fluoreszenz gestützten Methoden der Mikroskopie. | |||||
Inhalt | 529-1042-00 Anwendungsorientierte Grundlagen der organischen Instrumentalanalytik und des empirischen Einsatzes von Methoden der Strukturaufklärung (Massenspektrometrie, NMR-, IR-, UV/VIS-Spektroskopie). Grundlagen und Anwendung chromatographischer und elektrophoretischer Trennverfahren. Praxisnahe Anwendung und Vertiefung des Grundwissens anhand von Übungen. 551-1003-00 Der Kurs setzt sich zusammen aus Vorlesungen, die die theoretischen und technischen Grundlagen der betreffenden analytischen Methoden vermitteln und Übungen, die sich mit den Anwendungen der analytischen Methoden in der modernen experimentellen Biologie befassen. | |||||
Skript | 529-1042-00 Ein umfangreiches Skript ist im HCI-Shop erhältlich. Eine Kurzfassung des Teils "Spektroskopie" definiert die für die Prüfung dieses Teils relevanten Themen. | |||||
Literatur | 529-1042-00 - Pretsch E., Bühlmann P., Badertscher M. Structure Determination of Organic Compounds, 5th revised and enlarged English edition, Springer-Verlag, Berlin 2009; - Pretsch E., Bühlmann P., Badertscher M., Spektroskopische Daten zur Strukturaufklärung organischer Verbindungen, fünfte Auflage, Springer-Verlag, Berlin 2010; - D.A. Skoog, J.J. Leary, Instrumentelle Analytik, Grundlagen, Geräte, Anwendungen, Springer, Berlin, 1996; - K. Cammann, Instrumentelle Analytische Chemie, Verfahren, Anwendungen, Qualitätssicherung, Spektrum Akademischer Verlag, Heidelberg, 2001; - R. Kellner, J.-M. Mermet, M. Otto, H.M. Widmer, Analytical Chemistry, Wiley-VCH Verlag, Weinheim, 1998; - K. Robards, P.R.Haddad, P.E. Jackson, Principles and practice of modern chromatographic methods, Academic Press, London, 1994; | |||||
Voraussetzungen / Besonderes | 529-1042-00 Voraussetzungen: - 529-1001-01 V "Allgemeine Chemie I (für Biol./Pharm.Wiss.)" - 529-1001-00 P "Allgemeine Chemie I (für Biol./Pharm.Wiss.)" - 529-1011-00 G "Organische Chemie I (für Biol./Pharm.Wiss.)" | |||||
551-1105-00L | Glycobiology | W | 4 KP | 2V | M. Aebi, T. Hennet | |
Kurzbeschreibung | Structural principles, nomenclature and different classes of glycosylation. The different pathways of N- and O-linked protein glycosylation and glycolipid biosynthesis in prokaryotes and eukaryotes are discussed. Specific glycan binding proteins and their role in deciphering the glycan code are presented. The role of glycans in infectious diseases, antigen mimicry and autoimmunity are discussed. | |||||
Lernziel | Detailed knowledge in 1) the different areas of prokaryotic and eukaryotic glycobiology, in particular in the biosynthesis of glycoproteins and glycolipids, 2) the cellular machinery required for these pathways, 3) the principles of carbohydrate/protein interaction, 4) the function of lectins, 5) the role of glycans in infectious disease. | |||||
Inhalt | Structure and linkages; analytical approaches; N-linked protein glycosylation (ER, Golgi); glycan-assisted protein folding and quality control; O-linked protein glycosylation; glucosaminoglycans; glycolipids; prokaryotic glycosylation pathways; lectins; glycans and infectious disease | |||||
Skript | handouts | |||||
Literatur | Introduction to Glycobiology; M.E.Taylor, K.Drickamer, Oxford University Press, 2003 Essentials of Glycobiology (second edition); A.Varki et al. Cold Spring Harbor Laboratory Press, 2009 | |||||
Voraussetzungen / Besonderes | The course will be in English. It will include the preparation of short essays (marked) about defined topics in Glycobiology. | |||||
551-1145-00L | Viral and non-Viral Vectors for Human Gene-Therapy - from Pathogens to Safe Medical Applications Findet dieses Semester nicht statt. Der Kurs muss direkt an der UZH belegt werden. UZH Modulkürzel: BIO708 Beachten Sie die Einschreibungstermine an der UZH: Link | W | 2 KP | 3V | Uni-Dozierende | |
Kurzbeschreibung | Basic aspects of virology, the viral mechanisms for transfer of genetic material into cells, different vector-systems and target cells, animal models, specific applications for inborn diseases of the immune system and of metabolism, adverse effects, and new developments of vector systems will be taught. | |||||
Lernziel | Knowledge of important viral and non-viral vector systems. Knowledge of application in human diseases. Knowledge of limiting factors. | |||||
551-1153-00L | Systems Biology of Metabolism Number of participants limited to 15. | W | 4 KP | 2V | U. Sauer, N. Zamboni, M. Zampieri | |
Kurzbeschreibung | Starting from contemporary biological problems related to metabolism, the course focuses on systems biological approaches to address them. In a problem-oriented, this-is-how-it-is-done manner, we thereby teach modern methods and concepts. | |||||
Lernziel | Develop a deeper understanding of how relevant biological problems can be solved, thereby providing advanced insights to key experimental and computational methods in systems biology. | |||||
Inhalt | The course will be given as a mixture of lectures, studies of original research and guided discussions that focus on current research topics. For each particular problem studied, we will work out how the various methods work and what their capabilities/limits are. The problem areas range from microbial metabolism to cancer cell metabolism and from metabolic networks to regulation networks in populations and single cells. Key methods to be covered are various modeling approaches, metabolic flux analyses, metabolomics and other omics. | |||||
Skript | Script and original publications will be supplied during the course. | |||||
Voraussetzungen / Besonderes | The course extends many of the generally introduced concepts and methods of the Concept Course in Systems Biology. It requires a good knowledge of biochemistry and basics of mathematics and chemistry. | |||||
551-1171-00L | Immunology: from Milestones to Current Topics | W | 4 KP | 2S | B. Ludewig, J. Kisielow, M. Kopf, A. Oxenius, Uni-Dozierende | |
Kurzbeschreibung | Milestones in Immunology: on old concepts and modern experiments | |||||
Lernziel | The course will cover six grand topics in immunology (B cells, innate immunity, antigen presentation, tumor immunity, thymus and T cells, cytotoxic T cells and NK cells) and for each grand topic four hours will be allocated. During the first double hour, historical milestone papers will be presented by the supervisor providing an overview on the development of the conceptional framework and critical technological advances. The students will also prepare themselves for this double lecture by reading the historical milestone papers and contributing to the discussion. In the following lecture up to four students will present each a recent high impact research paper which emerged from the landmark achievements of the previously discussed milestone concepts. | |||||
Inhalt | Milestones and current topics of innate immunity, antigen presentatino, B cells, thymus and T cells, cytotoxic T cells and NK cells, and tumor immunology. | |||||
Skript | Original and review articles will be distributed by the lecturer. | |||||
Literatur | Literaturunterlagen werden vor Beginn des Kurses auf folgender website zugänglich sein: Moodle Course Link | |||||
551-1303-00L | Cellular Biochemistry of Health and Disease Number of participants limited to 20. | W | 4 KP | 2S | P. Picotti, Y. Barral, J. Fernandes de Matos, V. Korkhov, B. Kornmann, R. Kroschewski, M. Peter, A. E. Smith, K. Weis | |
Kurzbeschreibung | During this Masters level seminar style course, students will explore current research topics in cellular biochemistry focused on the structure, function and regulation of selected cell components, and the consequences of dysregulation for pathologies. | |||||
Lernziel | Students will work with experts toward a critical analysis of cutting-edge research in the domain of cellular biochemistry, with emphasis on normal cellular processes and the consequences of their dysregulation. At the end of the course, students will be able to introduce, present, evaluate, critically discuss and write about recent scientific articles in the research area of cellular biochemistry. | |||||
Inhalt | Guided by an expert in the field, students will engage in classical round-table style discussions of current literature with occasional frontal presentations. Students will alternate as discussion leaders throughout the semester, with the student leader responsible to briefly summarize key general knowledge and context of the assigned primary research paper. Together with the faculty expert, all students will participate in discussion of the primary paper, including the foundation of the biological question, specific questions addressed, key methods, key results, remaining gaps and research implications. | |||||
Literatur | The literature will be provided during the course | |||||
Voraussetzungen / Besonderes | The course will be taught in English. | |||||
551-1323-00L | Grundlagen der Biologie II: Biochemie und Molekularbiologie | W | 4 KP | 4V | K. Locher, N. Ban, R. Glockshuber, E. Weber-Ban | |
Kurzbeschreibung | Die Vorlesung vermittelt die Grundlagen der Biochemie und Molekularbiologie mit Betonung der chemischen und biophysikalischen Aspekte. | |||||
Lernziel | Behandelt werden Struktur-Funktionsbeziehungen in Proteinen und Nukleinsäuren, Konzepte der Proteinfaltung und der biochemischen Katalyse, die wichtigsten an zellulärer Energiegewinnung und -Speicherung beteiligten Stoffwechselvorgänge, die Biosynthese von Aminosäuren, Zucker, Nukleotiden, Fetten und Steroiden, sowie eine detaillierte Diskussion von Replikation, Transkription und Translation. | |||||
Skript | kein Skript | |||||
Literatur | obligatorisch: "Biochemistry", Autoren: Berg/Tymoczko/Stryer, 8th edition, Palgrave Macmillan, International edition (wird bei der Polybuchhandlung als englische Version vorbestellt werden) | |||||
Voraussetzungen / Besonderes | Einige Vorlesungseinheiten werden in englischer Sprache gehalten. | |||||
636-0017-00L | Computational Biology | W | 6 KP | 3G + 2A | C. Magnus, T. Stadler, T. Vaughan | |
Kurzbeschreibung | The aim of the course is to provide up-to-date knowledge on how we can study biological processes using genetic sequencing data. Computational algorithms extracting biological information from genetic sequence data are discussed, and statistical tools to understand this information in detail are introduced. | |||||
Lernziel | Attendees will learn which information is contained in genetic sequencing data and how to extract information from this data using computational tools. The main concepts introduced are: * stochastic models in molecular evolution * phylogenetic & phylodynamic inference * maximum likelihood and Bayesian statistics Attendees will apply these concepts to a number of applications yielding biological insight into: * epidemiology * pathogen evolution * macroevolution of species | |||||
Inhalt | The course consists of four parts. We first introduce modern genetic sequencing technology, and algorithms to obtain sequence alignments from the output of the sequencers. We then present methods for direct alignment analysis using approaches such as BLAST and GWAS. Second, we introduce mechanisms and concepts of molecular evolution, i.e. we discuss how genetic sequences change over time. Third, we employ evolutionary concepts to infer ancestral relationships between organisms based on their genetic sequences, i.e. we discuss methods to infer genealogies and phylogenies. Lastly, we introduce the field of phylodynamics. The aim of phylodynamics is to understand and quantify the population dynamic processes (such as transmission in epidemiology or speciation & extinction in macroevolution) based on a phylogeny. Throughout the class, the models and methods are illustrated on different datasets giving insight into the epidemiology and evolution of a range of infectious diseases (e.g. HIV, HCV, influenza, Ebola). Applications of the methods to the field of macroevolution provide insight into the evolution and ecology of different species clades. Students will be trained in the algorithms and their application both on paper and in silico as part of the exercises. | |||||
Skript | Lecture slides will be available on moodle. | |||||
Literatur | The course is not based on any of the textbooks below, but they are excellent choices as accompanying material: * Yang, Z. 2006. Computational Molecular Evolution. * Felsenstein, J. 2004. Inferring Phylogenies. * Semple, C. & Steel, M. 2003. Phylogenetics. * Drummond, A. & Bouckaert, R. 2015. Bayesian evolutionary analysis with BEAST. | |||||
Voraussetzungen / Besonderes | Basic knowledge in linear algebra, analysis, and statistics will be helpful. Programming in R will be required for the "Central Element". We provide an R tutorial and help sessions during the first two weeks of class to learn the required skills. | |||||
636-0108-00L | Biological Engineering and Biotechnology Attention: This course was offered in previous semesters with the number: 636-0003-00L "Biological Engineering and Biotechnology". Students that already passed course 636-0003-00L cannot receive credits for course 636-0108-00L. | W | 4 KP | 3V | M. Fussenegger | |
Kurzbeschreibung | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||
Lernziel | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||
Inhalt | 1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development. | |||||
Skript | Handout during the course. | |||||
636-0507-00L | Synthetic Biology II | W | 4 KP | 4A | S. Panke, Y. Benenson, J. Stelling | |
Kurzbeschreibung | 7 months biological design project, during which the students are required to give presentations on advanced topics in synthetic biology (specifically genetic circuit design) and then select their own biological system to design. The system is subsequently modeled, analyzed, and experimentally implemented. Results are presented at an international student competition at the MIT (Cambridge). | |||||
Lernziel | The students are supposed to acquire a deep understanding of the process of biological design including model representation of a biological system, its thorough analysis, and the subsequent experimental implementation of the system and the related problems. | |||||
Inhalt | Presentations on advanced synthetic biology topics (eg genetic circuit design, adaptation of systems dynamics, analytical concepts, large scale de novo DNA synthesis), project selection, modeling of selected biological system, design space exploration, sensitivity analysis, conversion into DNA sequence, (DNA synthesis external,) implementation and analysis of design, summary of results in form of scientific presentation and poster, presentation of results at the iGEM international student competition (Link). | |||||
Skript | Handouts during course | |||||
Voraussetzungen / Besonderes | The final presentation of the project is typically at the MIT (Cambridge, US). Other competing schools include regularly Imperial College, Cambridge University, Harvard University, UC Berkeley, Princeton Universtiy, CalTech, etc. This project takes place between end of Spring Semester and beginning of Autumn Semester. Registration in April. Please note that the number of ECTS credits and the actual work load are disconnected. | |||||
701-1703-00L | Evolutionary Medicine for Infectious Diseases | W | 3 KP | 2G | A. Hall | |
Kurzbeschreibung | This course explores infectious disease from both the host and pathogen perspective. Through short lectures, reading and active discussion, students will identify areas where evolutionary thinking can improve our understanding of infectious diseases and, ultimately, our ability to treat them effectively. | |||||
Lernziel | Students will learn to (i) identify evolutionary explanations for the origins and characteristics of infectious diseases in a range of organisms and (ii) evaluate ways of integrating evolutionary thinking into improved strategies for treating infections of humans and animals. This will incorporate principles that apply across any host-pathogen interaction, as well as system-specific mechanistic information, with particular emphasis on bacteria and viruses. | |||||
Inhalt | We will cover several topics where evolutionary thinking is relevant to understanding or treating infectious diseases. This includes: (i) determinants of pathogen host range and virulence, (ii) dynamics of host-parasite coevolution, (iii) pathogen adaptation to evade or suppress immune responses, (iv) antimicrobial resistance, (v) evolution-proof medicine. For each topic there will be a short (< 20 minutes) introductory lecture, before students independently research the primary literature and develop discussion points and questions, followed by interactive discussion in class. | |||||
Literatur | The focus is on primary literature, but for some parts the following text books provide good background information: Schmid Hempel 2011 Evolutionary Parasitology Stearns & Medzhitov 2016 Evolutionary Medicine | |||||
Voraussetzungen / Besonderes | A basic understanding of evolutionary biology, microbiology or parasitology will be advantageous but is not essential. | |||||
752-3105-00L | Physiology Guided Food Structure and Process Design | W | 3 KP | 2V | E. J. Windhab, B. Le Révérend, T. Wooster | |
Kurzbeschreibung | A “cook-and look” approach to process design is no longer applicable in the current environmental, nutritional and competitive constraints. The modern R&D chemical/food engineer should have a clear focus on the desired structure that needs to be achieved to design a process line or a processing equipment, coupled with in depth knowledge of the processed materials. | |||||
Lernziel | The objective of this course is to highlight the intimate links between human physiology and product sensory and nutritional functions. To optimize these functions, an understanding of the physiological functions that interact and encode the actions of those product structures must be well understood. Therefore the objective of this course is for students to be equipped with a skill set that will encompass basic digestion and sensory physiology knowledge and food structures. The students will be exposed to this interplay all along the GI tract, including taste, aroma and texture perception, swallowing mechanics and gastro intestinal digestion with an engineering or physical sciences angle. | |||||
752-4009-00L | Molecular Biology of Foodborne Pathogens | W | 3 KP | 2V | M. Loessner, M. Schuppler | |
Kurzbeschreibung | The course offers detailed information on selected foodborne pathogens and toxin producing organisms; the focus lies on relevant molecular biological aspects of pathogenicity and virulence, as well as on the occurrence and survival of these organisms in foods. | |||||
Lernziel | Detailed and current status of research and insights into the molecular basis of foodborne diseases, with focus on interactions of the microorganism or the toxins they produce with the human system. Understanding the relationship between specific types of food and the associated pathogens and microbial risks. Another focus lies on the currently available methods and techniques useful for the various purposes, i.e., detection, differentiation (typing), and antimicrobial agents. | |||||
Inhalt | Molecular biology of infectious foodborne pathogens (Listeria, Vibrio, E. coli, Campylobacter, etc) and toxin-producing organisms (Bacillus, Clostridium, Staphylococcus). How and under which conditions will toxins and virulence factors be produced, and how do they work? How is the interaction between the human host and the microbial pathogen? What are the roles of food and the environment ? What can be done to interfere with the potential risks? Which methods are best suited for what approach? Last, but not least, the role of bacteriophages in microbial pathogenicity will be highlighted, in addition to various applications of bacteriophage for both diagnostics and antimicrobial intervention. | |||||
Skript | Electronic copies of the presentation slides (PDF) and additional material will be made available for download to registered students. | |||||
Literatur | Recommendations will be given in the first lecture | |||||
Voraussetzungen / Besonderes | Lectures (2 hours) will be held as a single session of approximately 60+ minutes (10:15 until approx. 11:15 h), without break ! | |||||
752-6101-00L | Dietary Etiologies of Chronic Disease | W | 3 KP | 2V | M. B. Zimmermann | |
Kurzbeschreibung | To have the student gain understanding of the links between the diet and the etiology and progression of chronic diseases, including diabetes, gastrointestinal diseases, kidney disease, cardiovascular disease, arthritis and food allergies. | |||||
Lernziel | To examine and understand the protective effect of foods and food ingredients in the maintenance of health and the prevention of chronic disease, as well as the progression of complications of the chronic diseases. | |||||
Inhalt | The course evaluates food and food ingredients in relation to primary and secondary prevention of chronic diseases including diabetes, gastrointestinal diseases, kidney disease, cardiovascular disease, arthritis and food allergies. | |||||
Skript | There is no script. Powerpoint presentations will be made available on-line to students. | |||||
Literatur | To be provided by the individual lecturers, at their discretion. | |||||
Voraussetzungen / Besonderes | No compulsory prerequisites, but prior completion of Introduction to Nutritional Science and Advanced Topics in Nutritional Science is strongly advised. | |||||
752-6105-00L | Epidemiology and Prevention Information für UZH Studierende: Die Lerneinheit kann nur an der ETH belegt werden. Die Belegung des Moduls CS16_101 an der UZH ist nicht möglich. Beachten Sie die Einschreibungstermine an der ETH für UZH Studierende: Link | W | 3 KP | 2V | M. Puhan, R. Heusser | |
Kurzbeschreibung | The module „Epidemiology and prevention“ describes the process of scientific discovery from the detection of a disease and its causes, to the development and evaluation of preventive and treatment interventions and to improved population health. | |||||
Lernziel | The overall goal of the course is to introduce students to epidemiological thinking and methods, which are criticial pillars for medical and public health research. Students will also become aware on how epidemiological facts are used in prevention, practice and politics. | |||||
Inhalt | The module „Epidemiology and prevention“ follows an overall framework that describes the course of scientific discovery from the detection of a disease to the development of prevention and treatment interventions and their evaluation in clinical trials and real world settings. We will discuss study designs in the context of existing knowledge and the type of evidence needed to advance knowledge. Examples form nutrition, chronic and infectious diseases will be used in order to show the underlying concepts and methods. | |||||
Vertiefung in Neurowissenschaften | ||||||
Pflichtfächer | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-0300-00L | Translational Science for Health and Medicine | O | 3 KP | 2G | J. Goldhahn, G. von Krogh, C. Wolfrum | |
Kurzbeschreibung | Translational science is a cross disciplinary scientific research that is motivated by the need for practical applications that help people. The course should help to clarify basics of translational science, illustrate successful applications and should enable students to integrate key features into their future projects. | |||||
Lernziel | After completing this course, students will be able to understand: Principles of translational science (including project planning, ethics application, basics of resource management and interdisciplinary communication) | |||||
Inhalt | What is translational science and what is it not? How to identify need? - Disease concepts and consequences for research - Basics about incidence, prevalence etc., and orphan indications How to choose the appropriate research type and methodology - Ethical considerations including ethics application - Pros and cons of different types of research - Coordination of complex approaches incl. timing and resources How to measure success? - Outcome variables - Improving the translational process Challenges of communication? How independent is translational science? - Academic boundary conditions vs. industrial influences Positive and negative examples will be illustrated by distinguished guest speakers. | |||||
376-0302-01L | GCP Basic Course (Modul 1 and 2) Nur für Gesundheitswissenschaften und Technologie MSc. | O | 1 KP | 1G | G. Senti | |
Kurzbeschreibung | The basic course in "Good Clinical Practice" (GCP) contains of two full-time training days (Module 1 and Module 2) and addresses elementary aspects for the appropriate conduct of clinical trials and non-clinical research projects involving human beings. Successful participation will be confirmed by a certificate that is recognized by the Swiss authorities. | |||||
Lernziel | Students will get familiar with: - Key Ethics documents - (Inter)national Guidelines and Laws (e.g. ICH-GCP, DIN EN ISO 14155, TPA, HRA) - Sequence of research projects and project-involved parties - Planning of research projects (statistics, resources, study design, set-up of the study protocol) - Approval of research projects by Authorities (SwissEthics, Swissmedic, FOPH) - Roles and responsibilities of project-involved parties Students will learn how to: - Classify research projects according the risk-based approach of the HRA - Write a study protocol - Inform participating patients/study subjects - Obtain consent by participating patients/study subjects - Classify, document and report Adverse Events - Handle projects with biological material from humans and/or health- related personal data | |||||
Inhalt | Module 1: Research and Research Ethics, Guidelines, (inter)national Legislation, Development of therapeutic products, Methodology (Study Design), Study documents (Study protocol, Investigator's Brochure, Patient Information Leaflet, Informed Consent Form) Module 2: Roles and Responsibilities, Approval procedures, Notification and Reporting, Study documentation, Research with biological material and health-related data, data protection, data retention | |||||
Wahlfächer | ||||||
Wahlfächer I | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-1305-00L | Development of the Nervous System | W | 3 KP | 2V | E. Stoeckli, weitere Dozierende | |
Kurzbeschreibung | Der Kurs behandelt die Entwicklung des Nervensystems (NS) mit Schwergewicht auf Neurogenese und Migration, Axonwachstum, Synapsenbildung, mol. & zell. Mechanismen und Krankheiten des sich entwickelnden NS. | |||||
Lernziel | Ziel ist, einen vertieften Einblick in die normale Entwicklung des Nervensystems zu verschaffen auf Grund molekularer, zellulärer und biochemischer Ansätze. | |||||
Inhalt | Das Hauptmerk liegt auf der Entwicklung des NS: Frühentwicklung des Nervensystems, zelluläre Prozesse, Nervenfaserwachstum, Bildung von Synapsen und neuronaler Schaltkreise. | |||||
Skript | Muss vom OLAT runtergeladen werden: Link unter BIO344 | |||||
Literatur | Diese Vorlesung setzt das Lesen von Buchkapiteln, Handouts und Originalliteratur voraus. Weitere Informationen dazu werden in den verschiedenen Vorlesungsstunden abgegeben bzw. sind im OLAT vermerkt. | |||||
Voraussetzungen / Besonderes | Prüfung: anfangs Januar 2018 Repetition: Ende Februar 2018 | |||||
376-1305-01L | Structure, Plasticity and Repair of the Nervous System | W | 3 KP | 2V | G. Schratt, L. Filli, W. von der Behrens, weitere Dozierende | |
Kurzbeschreibung | Der Kurs behandelt die Struktur, Plastizität und Regeneration des adulten Nervensystems (NS) mit Schwerpunkt auf: sensorische Systeme, kognitive Funktionen, Lernen und Gedächtnis, molekulare und zelluläre Mechanismen, Tiermodelle und Krankheiten des NS. | |||||
Lernziel | Basierend auf molekularen, zellulären und biochemischen Ansätzen soll ein vertiefter Einblick in die Struktur, Plastizität und Regeneration des Nervensystems verschafft werden. | |||||
Inhalt | Das Hauptmerk liegt auf der Struktur, Plastizität und Regeneration des NS: Biologie des erwachsenen Nervensystems, Strukturelle Plastizität des adulten Nervensystems, Regeneration und Reparatur, Netzwerke und Nervenfasern, Regeneration, pathologischer Zellverlust. | |||||
Skript | ETH-Studenten: Skript wird auf Moodle zur Verfügung gestellt Link Einschreibeschlüssel wird zu Beginn der Vorlesung zur Verfügung gestellt. UZH-Studenten: Skript wird auf OLAT zur Verfügung gestellt Link | |||||
Literatur | Diese Vorlesung setzt das Lesen von Buchkapiteln, Handouts und Originalliteratur voraus. Weitere Informationen dazu werden in den verschiedenen Vorlesungsstunden abgegeben bzw. sind im Moodle / OLAT vermerkt. | |||||
551-0309-00L | Concepts in Modern Genetics | W | 6 KP | 4V | Y. Barral, D. Bopp, A. Hajnal, M. Stoffel, O. Voinnet | |
Kurzbeschreibung | Concepts of modern genetics and genomics, including principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference. | |||||
Lernziel | This course focuses on the concepts of classical and modern genetics and genomics. | |||||
Inhalt | The topics include principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference. | |||||
Skript | Scripts and additional material will be provided during the semester. | |||||
Wahlfächer II | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
227-0447-00L | Image Analysis and Computer Vision | W | 6 KP | 3V + 1U | L. Van Gool, O. Göksel, E. Konukoglu | |
Kurzbeschreibung | Light and perception. Digital image formation. Image enhancement and feature extraction. Unitary transformations. Color and texture. Image segmentation and deformable shape matching. Motion extraction and tracking. 3D data extraction. Invariant features. Specific object recognition and object class recognition. | |||||
Lernziel | Overview of the most important concepts of image formation, perception and analysis, and Computer Vision. Gaining own experience through practical computer and programming exercises. | |||||
Inhalt | The first part of the course starts off from an overview of existing and emerging applications that need computer vision. It shows that the realm of image processing is no longer restricted to the factory floor, but is entering several fields of our daily life. First it is investigated how the parameters of the electromagnetic waves are related to our perception. Also the interaction of light with matter is considered. The most important hardware components of technical vision systems, such as cameras, optical devices and illumination sources are discussed. The course then turns to the steps that are necessary to arrive at the discrete images that serve as input to algorithms. The next part describes necessary preprocessing steps of image analysis, that enhance image quality and/or detect specific features. Linear and non-linear filters are introduced for that purpose. The course will continue by analyzing procedures allowing to extract additional types of basic information from multiple images, with motion and depth as two important examples. The estimation of image velocities (optical flow) will get due attention and methods for object tracking will be presented. Several techniques are discussed to extract three-dimensional information about objects and scenes. Finally, approaches for the recognition of specific objects as well as object classes will be discussed and analyzed. | |||||
Skript | Course material Script, computer demonstrations, exercises and problem solutions | |||||
Voraussetzungen / Besonderes | Prerequisites: Basic concepts of mathematical analysis and linear algebra. The computer exercises are based on Linux and C. The course language is English. | |||||
227-1037-00L | Introduction to Neuroinformatics | W | 6 KP | 2V + 1U | V. Mante, M. Cook, B. Grewe, G. Indiveri, K. A. Martin | |
Kurzbeschreibung | The course provides an introduction to the functional properties of neurons. Particularly the description of membrane electrical properties (action potentials, channels), neuronal anatomy, synaptic structures, and neuronal networks. Simple models of computation, learning, and behavior will be explained. Some artificial systems (robot, chip) are presented. | |||||
Lernziel | Understanding computation by neurons and neuronal circuits is one of the great challenges of science. Many different disciplines can contribute their tools and concepts to solving mysteries of neural computation. The goal of this introductory course is to introduce the monocultures of physics, maths, computer science, engineering, biology, psychology, and even philosophy and history, to discover the enchantments and challenges that we all face in taking on this major 21st century problem and how each discipline can contribute to discovering solutions. | |||||
Inhalt | This course considers the structure and function of biological neural networks at different levels. The function of neural networks lies fundamentally in their wiring and in the electro-chemical properties of nerve cell membranes. Thus, the biological structure of the nerve cell needs to be understood if biologically-realistic models are to be constructed. These simpler models are used to estimate the electrical current flow through dendritic cables and explore how a more complex geometry of neurons influences this current flow. The active properties of nerves are studied to understand both sensory transduction and the generation and transmission of nerve impulses along axons. The concept of local neuronal circuits arises in the context of the rules governing the formation of nerve connections and topographic projections within the nervous system. Communication between neurons in the network can be thought of as information flow across synapses, which can be modified by experience. We need an understanding of the action of inhibitory and excitatory neurotransmitters and neuromodulators, so that the dynamics and logic of synapses can be interpreted. Finally, the neural architectures of feedforward and recurrent networks will be discussed in the context of co-ordination, control, and integration of sensory and motor information in neural networks. | |||||
227-1045-00L | Readings in Neuroinformatics (University of Zurich) No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH. UZH Module Code: INI431 Mind the enrolment deadlines at UZH: Link | W | 3 KP | 1S | G. Indiveri, M. Cook, D. Kiper, K. A. Martin | |
Kurzbeschreibung | Thirteen major areas of research have been selected, which cover the key concepts that have led to our current ideas of how the nervous system is built and functions. We will read both original papers and explore the conceptual the links between them and discuss the 'sociology' of science, the pursuit of basic science questions over a century of research." | |||||
Lernziel | It is a commonplace that scientists rarely cite literature that is older than 10 years and when they do, they usually cite one paper that serves as the representative for a larger body of work that has long since been incorporated anonymously in textbooks. Worse than that, many authors have not even read the papers they cite in their own publications. This course, ‘Foundations of Neuroscience’ is one antidote. Thirteen major areas of research have been selected, which cover the key concepts that have led to our current ideas of how the nervous system is built and functions. Unusually, we will explore these areas of research by reading the original publications, instead of reading someone else’s digested summary from a textbook or review. By doing this, we will learn how the discoveries were made, what instrumentation was used, how the scientists interpreted their own findings, and how their work, often over many decades and linked together with related findings from many different scientists, generate the current views of mechanism and structure of the nervous system. To give one concrete example, in 1890 Roy and Sherrington showed that there was a neural activity-dependent regulation of blood flow in the brain. One hundred years later, Ogawa discovered that they could use Nuclear Magnetic Resonance (NMR) to measure a blood oxygen-level dependent (BOLD) signal, which they showed was neural activity-dependent. This discovery led to the development of human functional Magnetic Resonance Imaging (fMRI), which has revolutionized neuropsychology and neuropsychiatry. We will read both these original papers and explore the conceptual the links between them and discuss the ‘sociology’ of science, which in this case, the pursuit of basic science questions over a century of research, led to an explosion in applications. We will also explore the personalities of the scientists and the context in which they made their seminal discoveries. Each week the course members will be given original papers to read for homework, they will have to write a short abstract for each paper. We will then meet weekly with the course leader (KACM) and an assistant for an hour-or-so long interactive seminar. An intimate knowledge of the papers will be assumed so that the discussion does not center simply on an explication of the contents of the papers. Assessment will in the form of a written exam in which the students will be given a paper and asked to write a short abstract of the contents. | |||||
Inhalt | It is a commonplace that scientists rarely cite literature that is older than 10 years and when they do, they usually cite one paper that serves as the representative for a larger body of work that has long since been incorporated anonymously in textbooks. Worse than that many authors have not even read the papers they cite in their own publications. This course, ‘Foundations of Neuroscience’ is one antidote. Thirteen major areas of research have been selected, which cover the key concepts that have led to our current ideas of how the nervous system is built and functions. Unusually, we will explore these areas of research by reading the original publications, instead of reading someone else’s digested summary from a textbook or review. By doing this, we will learn how the discoveries were made, what instrumentation was used, how the scientists interpreted their own findings, and how their work, often over many decades and by many different scientists, linked together to generate the current view of mechanism and structure. We will also explore the personalities of the scientists and the context in which they made their seminal discoveries. To give one concrete example, in 1890 Roy and Sherrington showed that there was a neural activity-dependent regulation of blood flow in the brain. One hundred years later, Ogawa discovered that they could use Nuclear Magnetic Resonance (NMR) to measure a blood oxygen-level dependent (BOLD) signal, which they showed was neural activity-dependent. This discovery led to the development of human functional Magnetic Resonance Imaging (fMRI), which has revolutionized neuropsychology and neuropsychiatry. We will read both these original papers and explore the conceptual links between them and discuss the ‘sociology’ of science, which in this case, the pursuit of basic science questions over a century of research, led to an explosion in applications. Each week the course members will be given between 2 and 4 papers to read for homework and we will then meet weekly for an hour long interactive seminar. An intimate knowledge of the papers will be assumed so that the discussion does not center simply on an explication of the contents of the papers. Assessment will be done continuously as the individual students are asked to explain a figure, technique, or concept. | |||||
227-1047-00L | Consciousness: From Philosophy to Neuroscience (University of Zurich) No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH. UZH Module Code: INI410 Mind the enrolment deadlines at UZH: Link | W | 3 KP | 2V | D. Kiper, A. Gamma | |
Kurzbeschreibung | This seminar reviews the philosophical and phenomenological as well as the neurobiological aspects of consciousness. The subjective features of consciousness are explored, and modern research into its neural substrate, particularly in the visual domain, is explained. Emphasis is placed on students developing their own thinking through a discussion-centered course structure. | |||||
Lernziel | The course's goal is to give an overview of the contemporary state of consciousness research, with emphasis on the contributions brought by modern cognitive neuroscience. We aim to clarify concepts, explain their philosophical and scientific backgrounds, and to present experimental protocols that shed light on on a variety of consciousness related issues. | |||||
Inhalt | The course includes discussions of scientific as well as philosophical articles. We review current schools of thought, models of consciousness, and proposals for the neural correlate of consciousness (NCC). | |||||
Skript | None | |||||
Literatur | We display articles pertaining to the issues we cover in the class on the course's webpage. | |||||
Voraussetzungen / Besonderes | Since we are all experts on consciousness, we expect active participation and discussions! | |||||
327-2125-00L | Microscopy Training SEM I - Introduction to SEM Number of participants limited to 9. Master students will have priority over PhD students. PhD students may still enrol, but will be asked for a fee (Link). | W | 2 KP | 3P | S. Rodighiero, A. G. Bittermann, L. Grafulha Morales, K. Kunze, J. Reuteler | |
Kurzbeschreibung | Der Einführungskurs in Rasterelektronenmikroskopie (SEM) betont praktisches Lernen. Die Studierenden haben die Möglichkeit an zwei Elektronenmikroskopen ihre eigenen Proben oder Standard-Testproben zu untersuchen, sowie von ScopeM-Wissenschafler vorbereitete Übungen zu lösen. | |||||
Lernziel | - Set-up, align and operate a SEM successfully and safely. - Accomplish imaging tasks successfully and optimize microscope performances. - Master the operation of a low-vacuum and field-emission SEM and EDX instrument. - Perform sample preparation with corresponding techniques and equipment for imaging and analysis - Acquire techniques in obtaining secondary electron and backscatter electron micrographs - Perform EDX qualitative and semi-quantitative analysis | |||||
Inhalt | During the course, students learn through lectures, demonstrations, and hands-on sessions how to setup and operate SEM instruments, including low-vacuum and low-voltage applications. This course gives basic skills for students new to SEM. At the end of the course, students with no prior experience are able to align a SEM, to obtain secondary electron (SE) and backscatter electron (BSE) micrographs and to perform energy dispersive X-ray spectroscopy (EDX) qualitative and semi-quantitative analysis. The procedures to better utilize SEM to solve practical problems and to optimize SEM analysis for a wide range of materials will be emphasized. - Discussion of students' sample/interest - Introduction and discussion on Electron Microscopy and instrumentation - Lectures on electron sources, electron lenses and probe formation - Lectures on beam/specimen interaction, image formation, image contrast and imaging modes. - Lectures on sample preparation techniques for EM - Brief description and demonstration of the SEM microscope - Practice on beam/specimen interaction, image formation, image contrast (and image processing) - Student participation on sample preparation techniques - Scanning Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities - Lecture and demonstrations on X-ray micro-analysis (theory and detection), qualitative and semi-quantitative EDX and point analysis, linescans and spectral mapping - Practice on real-world samples and report results | |||||
Literatur | - Detailed course manual - Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 - Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007 | |||||
Voraussetzungen / Besonderes | No mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite. | |||||
327-2126-00L | Microscopy Training TEM I - Introduction to TEM Number of participants limited to 6. Master students will have priority over PhD students. PhD students may still enrol, but will be asked for a fee (Link). | W | 2 KP | 3P | S. Rodighiero, E. J. Barthazy Meier, A. G. Bittermann, F. Gramm | |
Kurzbeschreibung | Der Einführungskurs in Transmissionselektronenmikroskopie (TEM) bietet neuen Nutzern die Möglichkeit theoretisches Wissen und praktische Kenntnisse in TEM zu erwerben | |||||
Lernziel | - Overview of TEM theory, instrumentation, operation and applications. - Alignment and operation of a TEM, as well as acquisition and interpretation of images, diffraction patterns, accomplishing basic tasks successfully. - Knowledge of electron imaging modes (including Scanning Transmission Electron Microscopy), magnification calibration, and image acquisition using CCD cameras. - To set up the TEM to acquire diffraction patterns, perform camera length calibration, as well as measure and interpret diffraction patterns. - Overview of techniques for specimen preparation. | |||||
Inhalt | Using two Transmission Electron Microscopes the students learn how to align a TEM, select parameters for acquisition of images in bright field (BF) and dark field (DF), perform scanning transmission electron microscopy (STEM) imaging, phase contrast imaging, and acquire electron diffraction patterns. The participants will also learn basic and advanced use of digital cameras and digital imaging methods. - Introduction and discussion on Electron Microscopy and instrumentation. - Lectures on electron sources, electron lenses and probe formation. - Lectures on beam/specimen interaction, image formation, image contrast and imaging modes. - Lectures on sample preparation techniques for EM. - Brief description and demonstration of the TEM microscope. - Practice on beam/specimen interaction, image formation, Image contrast (and image processing). - Demonstration of Transmission Electron Microscopes and imaging modes (Phase contrast, BF, DF, STEM). - Student participation on sample preparation techniques. - Transmission Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities. - TEM alignment, calibration, correction to improve image contrast and quality. - Electron diffraction. - Practice on real-world samples and report results. | |||||
Literatur | - Detailed course manual - Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 - Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990 - Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007 | |||||
Voraussetzungen / Besonderes | No mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite. | |||||
376-0221-00L | Methods and Concepts in Human Systems Neuroscience and Motor Control Maximale Teilnehmerzahl: 18 | W | 4 KP | 3P | N. Wenderoth | |
Kurzbeschreibung | This course provides hands-on experience with measurement and analysis methods relevant for Humans Systems Neuroscience and Motor control (nerve/brain stimulation, EMG, EEG, psycho-physical paradigms etc). Students read scientific material, set up experiments, perform measurements in the lab, analyse data, apply statistics and write short reports or essays. | |||||
Lernziel | This course will prepare students for experimental work as it is typically done during the master thesis. The goal is to gain hands-on experience with measurement and analysis methods relevant for Humans Systems Neuroscience and Motor control (ifor example peripheral nerve stimulation, electrical and magnetic brain stimulation, EMG, EEG, psycho-physical paradigms etc). Students will learn how to perform small scientific projects in this area. Students will work individually or in small groups and solve scientific problems which require them to perform measurements in human participants, extract relevant readouts from the data, apply appropriate statistics and interpret the results. They will also be required to write small essays and reports and they will get feedback on their writing throughout the course. | |||||
Voraussetzungen / Besonderes | Students are required to have successfully completed the course "Neural control of movement and motor learning" and to have basic knowledge of applied statistics. Self-study material about applied statistics will be available at the beginning of the course and statistical knowledge will be tested (central element) in the second course week. Passing this test is a requirement for continuing the course. Students will have to solve scientific problems, requiring them to independently study scientific material, apply statistics and report their results in the form of written reports and essays. Assessments will be made on the basis of the completed theoretical and practical work that will be performed either in small groups or individually. | |||||
376-1151-00L | Translation of Basic Research Findings from Genetics and Molecular Mechanisms of Aging Number of participants limited to 30. | W | 3 KP | 2V | C. Ewald | |
Kurzbeschreibung | Recently, several start-up companies are aiming to translate basic molecular findings into new drugs/therapeutic interventions to slow aging or post-pone age-related diseases (e.g., Google founded Calico or Craig Venter's Human Longevity, Inc.). This course will teach students the basic skill sets to formulate their own ideas, design experiments to test them and explains the next steps to translat | |||||
Lernziel | The overall goal of this course is to be able to analyse current therapeutic interventions to identify an unmet need in molecular biology of aging and apply scientific thinking to discover new mechanisms that could be used as a novel therapeutic intervention. Learning objectives include: 1. Evaluate the current problem of our aging population, the impact of age-dependent diseases and current strategies to prevent these age-dependent diseases. 2. Analyse/compare current molecular/genetic strategies that address these aging problems. 3. Analyse case studies about biotech companies in the aging sector. Apply the scientific methods to formulate basic research questions to address these problems. 4. Generate own hypotheses (educated guess/idea), design experiments to test them, and map out the next steps to translate them. | |||||
Inhalt | Overview of aging and age-related diseases. Key discoveries in molecular biology of aging. Case studies of biotech companies addressing age-related complications. Brief introduction from bench to bedside with focus on start-up companies. | |||||
Voraussetzungen / Besonderes | No compulsory prerequisites, but student should have basic knowledge about genetics and molecular biology. | |||||
376-1177-00L | Human Factors I | W | 3 KP | 2V | M. Menozzi Jäckli, R. Huang, M. Siegrist | |
Kurzbeschreibung | Every day humans interact with various systems. Strategies of interaction, individual needs, physical & mental abilities, and system properties are important factors in controlling the quality and performance in interaction processes. In the lecture, factors are investigated by basic scientific approaches. Discussed topics are important for optimizing people's satisfaction & overall performance. | |||||
Lernziel | The goal of the lecture is to empower students in better understanding the applied theories, principles, and methods in various applications. Students are expected to learn about how to enable an efficient and qualitatively high standing interaction between human and the environment, considering costs, benefits, health, and safety as well. Thus, an ergonomic design and evaluation process of products, tasks, and environments may be promoted in different disciplines. The goal is achieved in addressing a broad variety of topics and embedding the discussion in macroscopic factors such as the behavior of consumers and objectives of economy. | |||||
Inhalt | - Physiological, physical, and cognitive factors in sensation and perception - Body spaces and functional anthropometry, Digital Human Models - Experimental techniques in assessing human performance and well-being - Human factors and ergonomics in system designs, product development and innovation - Human information processing and biological cybernetics - Interaction among consumers, environments, behavior, and tasks | |||||
Literatur | - Gavriel Salvendy, Handbook of Human Factors and Ergonomics, 4th edition (2012), is available on NEBIS as electronic version and for free to ETH students - Further textbooks are introduced in the lecture - Brouchures, checklists, key articles etc. are uploaded in ILIAS | |||||
376-1179-00L | Applications of Cybernetics in Ergonomics | W | 1 KP | 1U | M. Menozzi Jäckli, Y.‑Y. Hedinger Huang, R. Huang | |
Kurzbeschreibung | Cybernetics systems have been studied and applied in various research fields, such as applications in the ergonomics domain. Research interests include the man-machine interaction (MMI) topic which involving the performance in multi-model interactions, quantification in gestalt principles in product development; or the information processing matter. | |||||
Lernziel | To learn and practice cybernetics principles in interface designs and product development. | |||||
Inhalt | - Fitt's law applied in manipulation tasks - Hick-Hyman law applied in design of the driver assistance systems - Vigilance applied in quality inspection - Accommodation/vergence crosslink function - Cross-link models in neurobiology- the ocular motor control system - Human performance in optimization of production lines | |||||
Literatur | Gavriel Salvendy, Handbook of Human Factors and Ergonomics, 4th edition (2012) | |||||
376-1414-00L | Current Topics in Brain Research (HS) | W | 1 KP | 1.5K | I. Mansuy, F. Helmchen, S. Jessberger, M. E. Schwab, weitere Dozierende | |
Kurzbeschreibung | Es werden verschiedene wissenschaftliche Gäste aus dem In-und Ausland eingeladen, die Ihre aktuellen Forschungsdaten präsentieren und diskutieren. | |||||
Lernziel | Förderung des Austauschs von wissenschaftlichen Erkenntnissen und Daten sowie der Kommunikation und Zusammenarbeit unter den Forschenden. Für Studierende: Kritische Auseinandersetzung mit der aktuellen Forschung. Studierende, welche den Kreditpunkt für dieses Kolloqium erhalten möchten, wählen einen Vortrag aus und schreiben einen kritischen Aufsatz über die vorgestellte Forschungsarbeit. | |||||
Inhalt | Verschiedene wissenschaftliche Gäste aus den Bereichen Molekulares Bewusstsein, Neurochemie, Neuromorphologie und Neurophysiologie berichten über ihre neuesten wissenschaftlichen Erkenntnisse. | |||||
Skript | kein Skript | |||||
Literatur | keine | |||||
376-1504-00L | Physical Human Robot Interaction (pHRI) Number of participants limited to 26. | W | 4 KP | 2V + 2U | R. Gassert, O. Lambercy | |
Kurzbeschreibung | This course focuses on the emerging, interdisciplinary field of physical human-robot interaction, bringing together themes from robotics, real-time control, human factors, haptics, virtual environments, interaction design and other fields to enable the development of human-oriented robotic systems. | |||||
Lernziel | The objective of this course is to give an introduction to the fundamentals of physical human robot interaction, through lectures on the underlying theoretical/mechatronics aspects and application fields, in combination with a hands-on lab tutorial. The course will guide students through the design and evaluation process of such systems. By the end of this course, you should understand the critical elements in human-robot interactions - both in terms of engineering and human factors - and use these to evaluate and de- sign safe and efficient assistive and rehabilitative robotic systems. Specifically, you should be able to: 1) identify critical human factors in physical human-robot interaction and use these to derive design requirements; 2) compare and select mechatronic components that optimally fulfill the defined design requirements; 3) derive a model of the device dynamics to guide and optimize the selection and integration of selected components into a functional system; 4) design control hardware and software and implement and test human-interactive control strategies on the physical setup; 5) characterize and optimize such systems using both engineering and psychophysical evaluation metrics; 6) investigate and optimize one aspect of the physical setup and convey and defend the gained insights in a technical presentation. | |||||
Inhalt | This course provides an introduction to fundamental aspects of physical human-robot interaction. After an overview of human haptic, visual and auditory sensing, neurophysiology and psychophysics, principles of human-robot interaction systems (kinematics, mechanical transmissions, robot sensors and actuators used in these systems) will be introduced. Throughout the course, students will gain knowledge of interaction control strategies including impedance/admittance and force control, haptic rendering basics and issues in device design for humans such as transparency and stability analysis, safety hardware and procedures. The course is organized into lectures that aim to bring students up to speed with the basics of these systems, readings on classical and current topics in physical human-robot interaction, laboratory sessions and lab visits. Students will attend periodic laboratory sessions where they will implement the theoretical aspects learned during the lectures. Here the salient features of haptic device design will be identified and theoretical aspects will be implemented in a haptic system based on the haptic paddle (Link), by creating simple dynamic haptic virtual environments and understanding the performance limitations and causes of instabilities (direct/virtual coupling, friction, damping, time delays, sampling rate, sensor quantization, etc.) during rendering of different mechanical properties. | |||||
Skript | Will be distributed through the document repository before the lectures. Link | |||||
Literatur | Abbott, J. and Okamura, A. (2005). Effects of position quantization and sampling rate on virtual-wall passivity. Robotics, IEEE Transactions on, 21(5):952 - 964. Adams, R. and Hannaford, B. (1999). Stable haptic interaction with virtual environments. Robotics and Automation, IEEE Transactions on, 15(3):465 -474. Buerger, S. and Hogan, N. (2007). Complementary stability and loop shaping for improved human ndash;robot interaction. Robotics, IEEE Transactions on, 23(2):232 -244. Burdea, G. and Brooks, F. (1996). Force and touch feedback for virtual reality. John Wiley & Sons New York NY. Colgate, J. and Brown, J. (1994). Factors affecting the z-width of a haptic display. In Robotics and Automation, 1994. Proceedings., 1994 IEEE International Conference on, pages 3205 -3210 vol.4. Diolaiti, N., Niemeyer, G., Barbagli, F., and Salisbury, J. (2006). Stability of haptic rendering: Discretization, quantization, time delay, and coulomb effects. Robotics, IEEE Transactions on, 22(2):256 -268. Gillespie, R. and Cutkosky, M. (1996). Stable user-specific haptic rendering of the virtual wall. In Proceedings of the ASME International Mechanical Engineering Congress and Exhibition, volume 58, pages 397-406. Hannaford, B. and Ryu, J.-H. (2002). Time-domain passivity control of haptic interfaces. Robotics and Automation, IEEE Transactions on, 18(1):1 -10. Hashtrudi-Zaad, K. and Salcudean, S. (2001). Analysis of control architectures for teleoperation systems with impedance/admittance master and slave manipulators. The International Journal of Robotics Research, 20(6):419. Hayward, V. and Astley, O. (1996). Performance measures for haptic interfaces. In ROBOTICS RESEARCH-INTERNATIONAL SYMPOSIUM-, volume 7, pages 195-206. Citeseer. Hayward, V. and Maclean, K. (2007). Do it yourself haptics: part i. Robotics Automation Magazine, IEEE, 14(4):88 -104. Leskovsky, P., Harders, M., and Szeekely, G. (2006). Assessing the fidelity of haptically rendered deformable objects. In Haptic Interfaces for Virtual Environment and Teleoperator Systems, 2006 14th Symposium on, pages 19 - 25. MacLean, K. and Hayward, V. (2008). Do it yourself haptics: Part ii [tutorial]. Robotics Automation Magazine, IEEE, 15(1):104 -119. Mahvash, M. and Hayward, V. (2003). Passivity-based high-fidelity haptic rendering of contact. In Robotics and Automation, 2003. Proceedings. ICRA '03. IEEE International Conference on, volume 3, pages 3722 - 3728 vol.3. Mehling, J., Colgate, J., and Peshkin, M. (2005). Increasing the impedance range of a haptic display by adding electrical damping. In Eurohaptics Conference, 2005 and Symposium on Haptic Interfaces for Virtual Environment and Teleoperator Systems, 2005. World Haptics 2005. First Joint, pages 257 - 262. Okamura, A., Richard, C., and Cutkosky, M. (2002). Feeling is believing: Using a force-feedback joystick to teach dynamic systems. JOURNAL OF ENGINEERING EDUCATION-WASHINGTON-, 91(3):345-350. O'Malley, M. and Goldfarb, M. (2004). The effect of virtual surface stiffness on the haptic perception of detail. Mechatronics, IEEE/ASME Transactions on, 9(2):448 -454. Richard, C. and Cutkosky, M. (2000). The effects of real and computer generated friction on human performance in a targeting task. In Proceedings of the ASME Dynamic Systems and Control Division, volume 69, page 2. Salisbury, K., Conti, F., and Barbagli, F. (2004). Haptic rendering: Introductory concepts. Computer Graphics and Applications, IEEE, 24(2):24-32. Weir, D., Colgate, J., and Peshkin, M. (2008). Measuring and increasing z-width with active electrical damping. In Haptic interfaces for virtual environment and teleoperator systems, 2008. haptics 2008. symposium on, pages 169 -175. Yasrebi, N. and Constantinescu, D. (2008). Extending the z-width of a haptic device using acceleration feedback. Haptics: Perception, Devices and Scenarios, pages 157-162. | |||||
Voraussetzungen / Besonderes | Notice: The registration is limited to 26 students There are 4 credit points for this lecture. The lecture will be held in English. The students are expected to have basic control knowledge from previous classes. Link | |||||
551-0317-00L | Immunology I | W | 3 KP | 2V | A. Oxenius, M. Kopf | |
Kurzbeschreibung | Einführung in strukturelle und funktionelle Eigenschaften des Immunsystems. Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort. | |||||
Lernziel | Einführung in strukturelle und funktionelle Eigenschaften des Immunsystems. Grundlegendes Verständnis der Mechanismen und der Regulation einer Immunantwort. | |||||
Inhalt | - Einleitung und historischer Hintergrund - Angeborene und adaptive Immunantwort, Zellen und Organe des Immunsystems - B Zellen und Antikörper - Generation von Diversität - Antigen-Präsentation und Histoinkompatibilitätsantigene (MHC) - Thymus und T Zellselektion - Autoimmunität - Zytotoxische T Zellen und NK Zellen - Th1 und Th2 Zellen, regulatorische T Zellen - Allergien - Hypersensitivititäten - Impfungen und immun-therapeutische Interventionen | |||||
Skript | Die Studenten haben elekronischen Zugriff auf die Vorlesungsunterlagen. Der Link ist unter "Lernmaterialien" zu finden. | |||||
Literatur | - Kuby, Immunology, 7th edition, Freemen + Co., New York, 2009 | |||||
Voraussetzungen / Besonderes | Immunology I (WS) und Immunology II (SS) werden in einer Sessionsprüfung im Anschluss an Immunology II als eine Lerneinheit geprüft. | |||||
551-0319-00L | Cellular Biochemistry (Part I) | W | 3 KP | 2V | U. Kutay, R. I. Enchev, B. Kornmann, M. Peter, I. Zemp, weitere Dozierende | |
Kurzbeschreibung | Concepts and molecular mechanisms underlying the biochemistry of the cell, providing advanced insights into structure, function and regulation of individual cell components. Particular emphasis will be put on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes such as intracellular transport, cell division & growth, and cell migration. | |||||
Lernziel | The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterisation of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain the integration of different molecules and signaling pathways into complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, cell division and cell growth. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer. | |||||
Inhalt | Structural and functional details of individual cell components, regulation of their interactions, and various aspects of the regulation and compartmentalisation of biochemical processes. Topics include: biophysical and electrical properties of membranes; viral membranes; structural and functional insights into intracellular transport and targeting; vesicular trafficking and phagocytosis; post-transcriptional regulation of gene expression. | |||||
Skript | Scripts and additional material will be provided during the semester. Please contact Dr. Alicia Smith for assistance with the learning materials. (Link) | |||||
Literatur | Recommended supplementary literature (review articles and selected primary literature) will be provided during the course. | |||||
Voraussetzungen / Besonderes | To attend this course the students must have a solid basic knowledge in chemistry, biochemistry and general biology. The course will be taught in English. | |||||
551-1145-00L | Viral and non-Viral Vectors for Human Gene-Therapy - from Pathogens to Safe Medical Applications Findet dieses Semester nicht statt. Der Kurs muss direkt an der UZH belegt werden. UZH Modulkürzel: BIO708 Beachten Sie die Einschreibungstermine an der UZH: Link | W | 2 KP | 3V | Uni-Dozierende | |
Kurzbeschreibung | Basic aspects of virology, the viral mechanisms for transfer of genetic material into cells, different vector-systems and target cells, animal models, specific applications for inborn diseases of the immune system and of metabolism, adverse effects, and new developments of vector systems will be taught. | |||||
Lernziel | Knowledge of important viral and non-viral vector systems. Knowledge of application in human diseases. Knowledge of limiting factors. | |||||
752-4009-00L | Molecular Biology of Foodborne Pathogens | W | 3 KP | 2V | M. Loessner, M. Schuppler | |
Kurzbeschreibung | The course offers detailed information on selected foodborne pathogens and toxin producing organisms; the focus lies on relevant molecular biological aspects of pathogenicity and virulence, as well as on the occurrence and survival of these organisms in foods. | |||||
Lernziel | Detailed and current status of research and insights into the molecular basis of foodborne diseases, with focus on interactions of the microorganism or the toxins they produce with the human system. Understanding the relationship between specific types of food and the associated pathogens and microbial risks. Another focus lies on the currently available methods and techniques useful for the various purposes, i.e., detection, differentiation (typing), and antimicrobial agents. | |||||
Inhalt | Molecular biology of infectious foodborne pathogens (Listeria, Vibrio, E. coli, Campylobacter, etc) and toxin-producing organisms (Bacillus, Clostridium, Staphylococcus). How and under which conditions will toxins and virulence factors be produced, and how do they work? How is the interaction between the human host and the microbial pathogen? What are the roles of food and the environment ? What can be done to interfere with the potential risks? Which methods are best suited for what approach? Last, but not least, the role of bacteriophages in microbial pathogenicity will be highlighted, in addition to various applications of bacteriophage for both diagnostics and antimicrobial intervention. | |||||
Skript | Electronic copies of the presentation slides (PDF) and additional material will be made available for download to registered students. | |||||
Literatur | Recommendations will be given in the first lecture | |||||
Voraussetzungen / Besonderes | Lectures (2 hours) will be held as a single session of approximately 60+ minutes (10:15 until approx. 11:15 h), without break ! | |||||
752-6403-00L | Nutrition and Performance | W | 2 KP | 2V | S. Mettler, M. B. Zimmermann | |
Kurzbeschreibung | The course introduces basic concepts of the interaction between nutrition and exercise and cognitive performance. | |||||
Lernziel | To understand the potential effects of nutrition on exercise performance, with a focus on concepts and principles of nutrition before, during and after exercise. | |||||
Inhalt | The course will cover elementary aspects of sports nutrition physiology, including carbohydrate, glycogen, fat, protein and energy metabolism. A main focus will be to understand nutritional aspects before exercise to be prepared for intensive exercise bouts, how exercise performance can be supported by nutrition during exercise and how recovery can be assisted by nutrition after exercise. Although this is a scientific course, it is a goal of the course to translate basic sports nutrition science into practical sports nutrition examples. | |||||
Skript | Lecture slides and required handouts will be available on the ETH website. | |||||
Literatur | Information on further reading will be announced during the lecture. There will be some mandatory as well as voluntary readings. | |||||
Voraussetzungen / Besonderes | General knowledge about nutrition, human biology, physiology and biochemistry is a prerequisite for this course. The course builds on basic nutrition and biochemistry knowledge to address exercise and performance related aspects of nutrition. The course is designed for 3rd year Bachelor students, Master students and postgraduate students (MAS/CAS). Language: English It is strongly recommended to attend the lectures. The lecture (including the handouts) is not designed for distance education. | |||||
Praktika und Semesterarbeiten Praktika und Semesterarbeiten NUR für folgende Vertiefungen: - Bewegungswissenschaften und Sport - Gesundheitstechnologien - Molekulare Gesundheitswissenschaften - Neurowissenschaften | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-2110-00L | Internship 12 Weeks (Research or Job Oriented) | W | 15 KP | 34P | Professor/innen | |
Kurzbeschreibung | Practical Training Internships are either research-oriented for exercising scientific (laboratory) methods or job-related for giving insight into the future world of work (industry, services, school). | |||||
Lernziel | Students should exercise scientific working and/or get realistic insights into future jobs. | |||||
Voraussetzungen / Besonderes | This version of internships lasts for at least 12 weeks full time equivalent. | |||||
376-2111-00L | Internship 8 Weeks (Research or Job Oriented) | W | 10 KP | 23P | Professor/innen | |
Kurzbeschreibung | Practical Training Internships are either research-oriented for exercising scientific (laboratory) methods or job-related for giving insight into the future world of work (industry, services, school). | |||||
Lernziel | Students should exercise scientific working and/or get realistic insights into future jobs. | |||||
Voraussetzungen / Besonderes | This version of internships lasts for at least 8 weeks full time equivalent. | |||||
376-2112-00L | Internship 4 Weeks (Research or Job Oriented) | W | 5 KP | 11P | Professor/innen | |
Kurzbeschreibung | Practical Training Internships are either research-oriented for exercising scientific (laboratory) methods or job-related for giving insight into the future world of work (industry, services, school). | |||||
Lernziel | Students should exercise scientific working and/or get realistic insights into future jobs. | |||||
Voraussetzungen / Besonderes | This version of internships lasts for at least 4 weeks full time equivalent. | |||||
GESS Wissenschaft im Kontext | ||||||
» siehe Studiengang Wissenschaft im Kontext: Typ A: Förderung allgemeiner Reflexionsfähigkeiten | ||||||
» siehe Studiengang Wissenschaft im Kontext: Sprachkurse ETH/UZH | ||||||
» Empfehlungen aus dem Bereich Wissenschaft im Kontext (Typ B) für das D-HEST. | ||||||
Forschungs-Praktikum | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-2100-00L | Research Internship | O | 15 KP | 36A | Professor/innen | |
Kurzbeschreibung | 12-week internship intended for exercising (independent) scientific working. | |||||
Lernziel | Students shall exercise scientific working as preparation for their master thesis. | |||||
Voraussetzungen / Besonderes | The Research Internship lasts for at least 12 weeks full time equivalent. It can be combined with the Master Thesis. | |||||
Master-Arbeit | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-2000-00L | Master's Thesis Zur Master-Arbeit wird nur zugelassen, wer: a. das Bachelor-Studium erfolgreich abgeschlossen hat; b. allfällige Auflagen für die Zulassung zum Master-Studiengang erfüllt hat. | O | 30 KP | 71D | Betreuer/innen | |
Kurzbeschreibung | 6-months research study with topics from the chosen major within the field of Health Sciences and Technology. In general, it includes the study of existing literature, the specification of the research question, the choice of the methodological approach, the collection, analysis and interpretation of data, and the written and oral reporting of the findings. | |||||
Lernziel | The students shall demonstrate their ability to carry out a structured, scientific piece of work independently. | |||||
Voraussetzungen / Besonderes | The Master Thesis can only be started after the Bachelor Degree was obtained and/or master admission requirements have been fulfilled. | |||||
Auflagen-Lerneinheiten Das untenstehende Lernangebot gilt nur für MSc Studierende mit Zulassungsauflagen. | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
406-0253-AAL | Mathematics I & II Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle andere Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen. | E- | 13 KP | 28R | A. Cannas da Silva | |
Kurzbeschreibung | Mathematics I covers mathematical concepts and techniques necessary to model, solve and discuss scientific problems - notably through ordinary differential equations. Main focus of Mathematics II: multivariable calculus and partial differential equations. | |||||
Lernziel | Mathematics is of ever increasing importance to the Natural Sciences and Engineering. The key is the so-called mathematical modelling cycle, i.e. the translation of problems from outside of mathematics into mathematics, the study of the mathematical problems (often with the help of high level mathematical software packages) and the interpretation of the results in the original environment. The goal of Mathematics I and II is to provide the mathematical foundations relevant for this paradigm. Differential equations are by far the most important tool for modelling and are therefore a main focus of both of these courses. | |||||
Inhalt | 1. Linear Algebra and Complex Numbers: systems of linear equations, Gauss-Jordan elimination, matrices, determinants, eigenvalues and eigenvectors, cartesian and polar forms for complex numbers, complex powers, complex roots, fundamental theorem of algebra. 2. Single-Variable Calculus: review of differentiation, linearisation, Taylor polynomials, maxima and minima, antiderivative, fundamental theorem of calculus, integration methods, improper integrals. 3. Ordinary Differential Equations: separable ordinary differential equations (ODEs), integration by substitution, 1st and 2nd order linear ODEs, homogeneous systems of linear ODEs with constant coefficients, introduction to 2-dimensional dynamical systems. 4. Multivariable Differential Calculus: functions of several variables, partial differentiation, curves and surfaces in space, scalar and vector fields, gradient, curl and divergence. 5. Multivariable Integral Calculus: multiple integrals, line and surface integrals, work and flow, Green, Gauss and Stokes theorems, applications. 6. Partial Differential Equations: separation of variables, Fourier series, heat equation, wave equation, Laplace equation, Fourier transform. | |||||
Literatur | - Bretscher, O.: Linear Algebra with Applications (Pearson Prentice Hall). - Thomas, G. B.: Thomas' Calculus, Part 1 - Early Transcendentals (Pearson Addison-Wesley). - Thomas, G. B.: Thomas' Calculus, Parts 2 (Pearson Addison-Wesley). - Kreyszig, E.: Advanced Engineering Mathematics (John Wiley & Sons). | |||||
Voraussetzungen / Besonderes | Prerequisites: familiarity with the basic notions from Calculus, in particular those of function and derivative. Assistance: Tuesdays and Wednesdays 17-19h, in Room HG E 41. | |||||
376-0203-AAL | Movement and Sport Biomechanics Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle anderen Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen! | E- | 4 KP | 3R | S. Lorenzetti, W. R. Taylor | |
Kurzbeschreibung | Learning to view the human body as a (bio-) mechanical system. Making the connections between everyday movements and sports activity with injury, discomfort, prevention and rehabilitation. | |||||
Lernziel | "Students are able to describe the human body as a mechanical system. They analyse and describe human movement according to the laws of mechanics." | |||||
Inhalt | Movement- and sports biomechanics deals with the attributes of the human body and their link to mechanics. The course includes topics such as functional anatomy, biomechanics of daily activities (gait, running, etc.) and looks at movement in sport from a mechanical point of view. Furthermore, simple reflections on the loading analysis of joints in various situations are discussed. Additionally, questions covering the statics and dynamics of rigid bodies, and inverse dynamics, relevant to biomechanics are investigated. | |||||
406-0062-AAL | Physics I Belegung ist NUR erlaubt für MSc Studierende, die diese Lerneinheit als Auflagenfach verfügt haben. Alle andere Studierenden (u.a. auch Mobilitätsstudierende, Doktorierende) können diese Lerneinheit NICHT belegen. | E- | 5 KP | 11R | A. Vaterlaus | |
Kurzbeschreibung | Introduction to the concepts and tools in physics: mechanics of point-like and rigid bodies, elasticity theory, elements of hydrostatics and hydrodynamics, periodic motion and mechanical waves. | |||||
Lernziel | Introduction to the scientific methodology. The student should develop his/her capability to turn physical observations into mathematical models, and to solve the latter. The student should acquire an overview over the basic concepts in mechanics. | |||||
Inhalt | Book: Physics for Scientists and Engineers, Douglas C. Giancoli, Pearson Education (2009), ISBN: 978-0-13-157849-4 Chapters: 1, 2, 3, 4, 5, 6 (without: 6-5, 6-6, 6-8), 7, 8 (without 8-9), 9, 10 (without 10-10), 11 (without 11-7), 13 (without 13-13, 13-14), 14 (without 14-6), 15 (without 15-3, 15-5) | |||||
Literatur | see "Content" Friedhelm Kuypers Physik für Ingenieure und Naturwissenschaftler Band 1: Mechanik und Thermodynamik Wiley-VCH Verlag, 2002, 544 S, ca.: Fr. 68.- |