Suchergebnis: Katalogdaten im Frühjahrssemester 2019

Biologie Master Information
Wahlvertiefungen
Wahlvertiefung: Ökologie und Evolution
Obligatorische Konzeptkurse
NummerTitelTypECTSUmfangDozierende
701-0323-00LPlant EcologyO3 KP2VJ.  Alexander, S. P. Hart
KurzbeschreibungThis class focuses on ecological processes involved with plant life, mechanisms of plant adaptation, plant-animal and plant-soil interactions, plant strategies and implications for the structure and function of plant communities. The discussion of original research examples familiarises students with research questions and methods; they learn to evaluate results and interpretations.
LernzielStudents will be able to:
- propose methods to study ecological processes involved with plant life, and how these processes depend on internal and external factors;
- analyse benefits and costs of plant adaptations;
- explain plant strategies with relevant traits and trade-offs;
- explain and predict the assembly of plant communities;
- explain implications of plant strategies for animals, microbes and ecosystem functions;
- evaluate studies in plant ecology regarding research questions, assumptions, methods, as well as the reliability and relevance of results.
InhaltPlants represent the matrix of natural communities. The structure and dynamics of plant populations drives the function of ecosystems. This course presents essential processes and plant traits involved with plant life. We focus on research questions that have been of special interest to plant ecologists as well as current topical questions. We use original research examples to discuss how ecological questions are studied and how results are interpreted.
- Growth: what determines the production of a plant?
- Nutrients: consumption or recycling: opposite strategies and feedbacks on soils;
- Clonality: collaboration and division of labour in plants;
- Plasticity: benefits and costs of plant intelligence;
- Flowering and pollination: how expensive is sex?
- Seed types, dispersal, seed banks and germination: strategies and trade-offs in the persistence of plant populations;
- Development and structure of plant populations;
- Stress, disturbance and competition as drivers of different plant strategies;
- Herbivory: plant-animal feedbacks and functioning of grazing ecosystems
- Fire: impacts on plants, vegetation and ecosystems.
- Plant functional types and rules in the assembly of plant communities.
SkriptHandouts and further reading will be available electronically at the beginning of the semester.
Voraussetzungen / BesonderesPrerequisites
- General knowledge of plant biology
- Basic knowledge of plant sytematics
- General ecological concepts
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
701-0310-00LNaturschutz und Naturschutzbiologie Information W2 KP2GF. Knaus
KurzbeschreibungIn dieser Vorlesung setzen sich die Studierenden mit biologisch-ökologischen Konzepten, philosophischen Grundlagen und praktischen Umsetzungsmöglichkeiten des Naturschutzes auseinander. Anhand konkreter Beispiele werden sie sich unterschiedlicher Betrachtungsweisen und Wertvorstellungen im Zusammenhang mit naturschützerischen Aktivitäten bewusst.
LernzielStudierende dieser Vorlesung können:
- die zeitliche Entwicklung und den aktuellen Zustand der Biodiversität nachvollziehen und mögliche weitere Entwicklungen abschätzen
- die ökonomischen, rechtlichen, politischen und philosophischen Grundlagen des Naturschutzes darlegen
- verschiedene Möglichkeiten aufzeigen, wie Naturschutz in der Praxis umgesetzt werden kann
- normative Elemente im Naturschutz identifizieren und kritisch hinterfragen
- ein Naturschutzprojekt von A-Z analysieren und evaluieren
InhaltDie Vorlesung deckt folgende Inhalte ab:
- Beschreiben und analysieren des historischen, aktuellen und zukünftigen menschlichen Einflusses auf die Biodiversität.
- Erkunden unterschiedlicher Ansätze des Naturschutzes und deren Umsetzungsinstrumente wie Arten- und Lebensraumschutz, Vertragsnaturschutz, Renaturierungen, Natur- und Nationalparks.
- Betrachten von ethisch-moralischen, gesetzlichen, ökonomischen, praktischen und anderen Beweggründen für den Naturschutz.
- Kennenlernen von relevanten Theorien rund um den Naturschutz, z.B. Verletzlichkeit von kleinen Populationen, Ecosystem Services, Biodiversität, etc.
- Kennenlernen von praktischen Beispielen auf Exkursionen, selbständiges analysieren und bewerten von konkreten Naturschutzprojekten.
SkriptKein Skript
LiteraturKüster H. 1999: Geschichte der Landschaft in Mitteleuropa. Von der Eiszeit bis zur Gegenwart. Beck, München, Germany. 424p.
Piechocki R. 2010: Landschaft, Heimat, Wildnis. Schutz der Natur - aber welcher und warum? Beck'sche Reihe, Beck, München, Germany. 266p.
Primack R.B. 2008: A primer of Conservation Biology. Fourth Edition. Sinauer Associates, Sunderland MA, USA. 349p.
Voraussetzungen / BesonderesKenntnisse aus den folgenden LV sind vorausgesetzt:
- Allgemeine Biologie I
- Allgemeine Biologie II
- Biologie III: Ökologie
- Biologie IV: Diversität der Pflanzen und Tiere
701-1450-00LConservation GeneticsW3 KP4GR. Holderegger, M. C. Fischer, F. Gugerli
KurzbeschreibungThe course deals with knowledge in conservation genetics and its practical applications. It introduces the genetic theories of conservation genetics, such as inbreeding depression in small populations or fragmentation. The course also shows how genetic methods are used in conservation Management, and it critically discusses the benefits and limits of conservation genetics.
LernzielGenetic and evolutionary argumentation is an important feature of conservation biology. The course equips students with knowledge on conservation genetics and its applications in conservation management. The course introduces the main theories of conservation genetics and shows how genetic methods are used in conservation Management, and it critically discusses the benefits and limits of conservation genetics. Practical examples from animals and plants are presented.
InhaltThere are 4 hours of lectures, presentations and group works per week. Students also have to spend about 3 hours per week on preparatory work for the following week. Every week, one subject will be presented by one of three lecturers.

Overview of themes:
Barcoding, eDNA and genetic monitoring; effects of small population size: genetic drift and inbreeding; neutral and adaptive genetic diversity; hybridization; gene flow, fragmentation and connectivity.

Specific topics:
(1) Species and individual identification: barcoding; eDNA; population size estimation; habitat use and genetic monitoring.
(2) Small population size; bottlenecks; genetic drift; inbreeding and inbreeding depression; effective population size.
(3) Adaptive genetic diversity; neutral and adaptive genetic variation; importance of adaptive genetic diversity; methods to measure adaptive genetic variation.
(4) Hybridization; gene introgression; gene flow across species boundaries.
(5) Half day excursion: practical example of conservation genetics on fragmentation.
(6) Discussion and evaluation of excursion; historical and contemporary gene flow and dispersal; fragmentation and connectivity.
(7) Written examination.
SkriptNo script; handouts and material for downloading will be provided.
LiteraturThere is no textbook for this course, but the following books are (partly) recommended:
Allendorf F.W., Luikart G.; Aitken S.N. 2013. Conservation and the Genetics of Populations, 2nd edition. Wiley, Oxford.
Frankham R., Ballou J.D., Briscoe D.A. 2010. Introduction to Conservation Genetics, 2nd edition. Cambridge University Press, Cambridge.

Targeted to practitioners in conservation management is the following book in German:
Holderegger R., Segelbacher G. (eds.). 2016. Naturschutzgenetik. Ein Handbuch für die Praxis. Haupt, Bern.
Voraussetzungen / BesonderesRequirements:
Students must have a good background in genetics as well as in ecology and evolution. The courses "Population and Quantitative Genetics" or "Evolutionary Genetics" should have been attended.

Examination:
A final written examination on the content of the course and an excursion are integral parts of the course.

Teaching forms:
The course needs the active participation of students. It consists of lectures, group works, presentations, discussions, readings and a half-day excursion.
701-1424-00LGuarda-Workshop in Evolutionary Biology Information
Der Kurs hat eine Teilnehmerbeschränkung. Um sich für den Kurs anzumelden, müssen Sie sich sowohl über mystudies als auch über die Webseite der Universität Basel http://evolution.unibas.ch/teaching/guarda/index.htm einschreiben.
W3 KP4PS. Bonhoeffer
KurzbeschreibungDieser Kurs ist fuer Studenten mit grossem Interesse an evolutionaerer Biologie. Das Ziel des Kurses ist es in kleinen Teams von 4-5 Studenten eigenstaendig wissenschaftliche Projekte zu entwickeln. Die Studenten werden angeleitet von Prof. D. Ebert (Basel) und Prof. S. Bonhoeffer (ETHZ). Zusaetzlich werden jedes Jahr zwei international angesehene Experten eingeladen.
LernzielSiehe Link http://evolution.unibas.ch/teaching/guarda/index.htm
InhaltSiehe link http://evolution.unibas.ch/teaching/guarda/index.htm
Skriptkeines
Literaturkeine
Voraussetzungen / BesonderesDa der Kurs nur eine begrenzte Teilnehmerzahl erlaubt, ist die Anmeldung fuer den Kurs notwendig. Bitte melden Sie sich ueber die Kurs-Website (siehe Link http://evolution.unibas.ch/teaching/guarda/index.htm) an.
551-0216-00LMykologischer Feldkurs Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 8
W3 KP3.5PA. Leuchtmann
KurzbeschreibungExkursionen zum Sammeln von Pilzen und anschliessendes Studium der Funde im Kursraum. Hauptfokus sind Kleinpilze (Ascomyceten): sie erhalten einen Einblick in die Vielfalt der Formen und eine Einführung ins Bestimmen. Zudem wird auf die Ökologie und Funktion der Pilze in ausgewählten Habitaten eingegangen, sowie ausgewählte Beispiele von einheimischen Speise- und Giftpilzen gezeigt.
LernzielErweiterung und Vertiefung der systematisch-taxonomischen Kenntnisse der Pilze, mit Fokus auf Ascomyceten. Teilnehmer kennen ökologische Funktionen der Pilze als Mutualisten, Saprobionten oder Parasiten von Pflanzen in verschiedenen Ökosystemen.
InhaltEinführung ins Reich der Pilze, Merkmale der Pilze und Überblick über deren systematische Gliederung. Exkursionen zum Sammeln von Ascomyceten in ausgewählten Lebensräumen. Kennenlernen von notwendigen Sammel- und Präparationstechniken, Einführung in die Ökologie und Funktion der Pilze, Untersuchung und Bestimmen von Pilzen mit optischen Hilfsmitteln im Kursraum, Einblick in Formenvielfalt ausgewählter Pilzgruppen (Ascomyecten), Beispiele von Gift- und Speisepilzen.
SkriptKursunterlagen werden abgegeben
LiteraturSpezialliteratur für die Bestimmung der Familien, Gattungen und Arten der mitteleuropäischen Mykoflora.
Voraussetzungen / BesonderesDer Kurs ist auf maximal 8 Teilnehmende beschränkt. Schriftliche Anmeldung erforderlich. Das Kursgeld von Fr. 180.- muss von den Kursteilnehmern übernommen werden. Vor dem Kurs (Freitag 23. Aug. 2019) findet eine halbtägige Einführung in Zürich statt, deren Besuch ist obligatorisch.
751-4802-00LSystembezogene Bekämpfung herbivorer Insekten IIW2 KP2GD. Mazzi
KurzbeschreibungIm Zentrum stehen Kenntnisse und Fähigkeiten zur Beurteilung von Massnahmen zur Lenkung von Schädlingspopulationen im Spannungsfeld Ökonomie-Ökologie-Gesellschaft. Ein vielfältiges Spektrum von Strategien wird erarbeitet, von natürlichen Gegenspielern, natürlichen und synthetischen Produkten bis zu physikalischen und genetischen Verfahren sowie neuen Forschungsansätzen.
LernzielDie Studierenden erreichen ein gutes Verständnis über verfügbare und potentielle künftige Lenkungsmassnahmen von Schädlingspopulationen in Agrarökosystemen, und können die Handlungsoptionen beurteilen im Spannungsfeld Oekologie - Oekonomie - Gesellschaft. Sie gewinnen zusätzliche Fähigkeiten, kontroverse wissenschaftliche Themen argumentativ aufzuarbeiten und zu debattieren.
SkriptDie Präsentationsunterlagen werden zur Verfügung gestellt.
LiteraturHinweise auf Literatur werden in der Lehrveranstaltung gegeben.
Voraussetzungen / BesonderesDer erste Teil der Veranstaltung "Systembezogene Bekämpfung herbivorer Insekten I" (im HS durchgeführt) ist nicht Voraussetzung zum Verständnis des zweiten Teils.
751-5110-00LInsects in AgroecosystemsW2 KP2VC. De Moraes, M. Fenske, D. Lucas Gomes Marques Barbosa
KurzbeschreibungThis class will focus on insect-plant interactions in agroecosystems, and how the unique man-made agricultural community effects insect populations leading to pest outbreaks. Key concepts in pest prediction and management will be discussed from an ecological perspective.
LernzielAt the end of this course, students will understand what biotic and abiotic factors contribute to pest outbreaks, why some modern pest management techniques have failed over time, and the trade-offs associated with the use of different pest control methods. Our approach will allow students to apply their knowledge to a variety of pest management situations. Additionally, students will learn about current research goals in agroecology and how these goals are being addressed by scientists engaged in agricultural research.
InhaltThe focus of this course will be on understanding how the ecologies of agricultural systems differ from natural ecosystems, and how these difference affect the population dynamics of insect pests and natural enemies. Each section of the course is centered around a basic ecological, biological or engineering theme such as host shift, physiological time, or sampling techniques. Different management techniques will be discussed, as well as the ecological basis behind why these techniques work and why they sometimes fail. The role of insects in spreading economically important plant diseases will also be discussed. Recent advances in research will also be addressed throughout the course and reinforced with periodic readings of primary literature.
SkriptProvided to students through ILIAS
LiteraturSelected required readings (peer reviewed literature, selected book chapters).
701-1418-00LModelling Course in Population and Evolutionary Biology Information Belegung eingeschränkt - Details anzeigen
Number of participants limited to 20.

Priority is given to MSc Biology and Environmental Sciences students.
W4 KP6PS. Bonhoeffer, V. Müller
KurzbeschreibungDieser Kurs ist eine praktische Einfuehrung in die mathematische/computerorientierte Modellierung biologischer Prozesse mit Schwerpunkt auf evolutionsbiologischen und populationsbiologischen Fragestellungen. Die Modelle werden in der Open Source software R entwickelt.
LernzielDen Teilnehmern soll der Nutzen der Modellierung als ein Hilfsmittel zur Untersuchung biologischer Fragestellungen vermittelt werden. Die einfacheren Module orientieren sich mehrheitlich an Beispielen aus der ehemaligen Vorlesung "Oekologie und Evolution: Populationen" (Skript von der Kurswebseite zugaenglich). Die fortgeschrittenen Module orientieren sich an aktuellen Forschungsthemen. Hierbei werden auch Fragestellungen untersucht, die zwar konzeptionell und methodisch auf Evolutions- und Populations-biologischen Ansaetzen beruhen, aber sich mit anderen Bereichen der Biologie befassen.
Inhaltsiehe www.tb.ethz.ch/education/learningmaterials/modelingcourse.html
SkriptDetaillierte Handouts für alle Module sind an der Webseite des Kurses zu finden. Zusaetzlich ist das Skript für die frühere Vorlesung "Oekologie und Evolution: Populationen" auch zugaenglich, und enthaelt weitere relevante Informationen.
Voraussetzungen / BesonderesDer Kurs basiert auf der Open Source Software R. Programmiererfahrung in R ist nuetzlich, aber keine Voraussetzung. Ebenso ist der Kurs 701-1708-00L Infectious Disease Dynamics nützlich, aber keine Voraussetzung.
701-1452-00LWildlife Conservation and Management
Findet dieses Semester nicht statt.
W2 KP2GNoch nicht bekannt
KurzbeschreibungThe course deals with major issues in wildlife conservation and management, the emphasis being on the underlying population processes. Topics include species interactions (predation, herbivory), conservation challenges in a landscape-ecological context, and the social background (values, policies, etc.). The course consists of seminar-type lectures, lab exercises, home reading, and a field trip.
LernzielReview major issues in wildlife conservation and management; understand the underlying ecological principles, particularly population processes; link them to principles of landscape ecology; be aware of human aspects and the distinction of scientific questions from questions rooting in society's value system; understand principles of policy formulation; become acquainted with simple modelling procedures; get some experience with field methods and field situations.
InhaltThe course deals with major issues in wildlife conservation and management with a focus on temperate regions as far as the topics go, but with a general view on principles. There will be an emphasis on population processes as the basis for management, and on applying this knowledge to problems of declining, small and harvestable populations, and population interactions such as predation, competition and herbivory. Aspects of how society's value system (stakeholder values, beliefs, laws) shape management goals and how valuation and science interact in policy formulation, will also be addressed. Conservation-oriented topics will be illustrated mainly with amphibian and reptile examples.

The course consists of lectures with seminar-type discussion parts, preceded by home reading of pertinent literature, occasional lab exercises (using spreadsheets Excel or Open Office Calc, and SPSS/R), and a two-days field trip.

Provisional program, sequence may change (WS=W. Suter, UH=U. Hofer):

1. Introduction; science & policy (WS)
2. Issues and methods in wildlife research (WS)
3. Population parameters in harvested species (WS)
4. Sustainable harvest (WS)
5. Conservation of vertebrates: Objectives, perspectives (UH)
6. Knowledge of species: Example indigenous reptiles (UH)
7. Evaluation of populations: population size (UH)
8. Evaluation of habitats: habitat use, habitat quality (UH)
9. Evaluation of landscapes: connectivity (UH)
10. Management issue 1: herbivory (WS)
11. Management issue 2: predation (WS)

Field trip:
Possibly 19-20 May, 2017
Provisional program: Day 1: Reptiles in subalpine environments - visit good reptile sites; evening-Day 2: visit to main large predator study area in western Alps, presentations by and discussions of human-large predator conflicts with researchers
SkriptThe course will partly be based on 'Mills, L.S. 2013. Conservation of Wildlife Populations. Demography, Genetics, and Management. Chichester: Wiley-Blackwell. 326 pp.', and several chapters are strongly recommended. The book can be obtained from http://www.polybuchhandlung.ch/studium/index.php3)

Other literature/information will be provided as handouts or is available online.
Literaturother useful books:

Fryxell, J.M., Sinclair, A.R.E. & Caughley, G. 2014. Wildlife Ecology, Conservation, and Management. 3rd edition. Chichester: Wiley-Blackwell. 528 pp.

Owen-Smith, N. 2007. Introduction to Modeling in Wildlife and Resource Conservation. Malden: Blackwell Publishing. 332 pp.

Conroy, M.J. & Carroll, J.P. 2009. Quantitative Conservation of Vertebrates. Southern Gate: Wiley-Blackwell. 342 pp.
Voraussetzungen / BesonderesThe course builds on the Bachelor course '701-0305-00 G Ökologie der Wirbeltiere', and on subjects taught in courses such as '701-0310-00 G Naturschutz und Stadtbioökologie' and '701-0553-00 G Landschaftsökologie', or similar. Reading Fryxell et al. 2014 (see literature) would also provide an excellent background. Participants in the course are expected to have a fair level of background knowledge.
701-0364-00LFlora, Vegetation und Böden der Alpen Belegung eingeschränkt - Details anzeigen W3 KP1V + 2PA. Widmer, R. Kretzschmar
KurzbeschreibungVorlesung: Umweltfaktoren und Beziehungen Pflanze-Umwelt im Lebensraum "Alpen"; Entstehung der Flora der Alpen; Höhenstufen und ihre wichtigen Vegetationen.
Exkursion: Standorte auf verschiedenen Ausgangsgesteinen in der subalpinen und alpinen Stufe; Aufbau und Eigenschaften der Böden, Auswirkungen auf die Pflanzen, wichtige Pflanzengesellschaften und Arten.
LernzielKennenlernen der Umweltfaktoren und der Beziehungen Pflanze-Umwelt (insbesondere Klima und Boden) im Lebensraum "Alpen".
InhaltVorlesung: Umweltfaktoren in den Alpen; Anpassungen der Pflanzen; Verbreitungsmuster; Entstehung der Alpenflora; Höhenstufen; wichtige Vegetationen.
Exkursion in die Region Davos: Standorte auf verschiedenen Ausgangsgesteinen (Dolomit, saures und basisches Silikat, Serpentinit) in der subalpinen und alpinen Stufe; Aufbau und Eigenschaften der Böden, Auswirkungen auf die Pflanzen, wichtige Pflanzengesellschaften und Arten der entsprechenden Standorte.
SkriptAnstelle eines Skriptes wird das Buch von E. Landolt angeboten (siehe Literatur). Für die Exkursion wird ein Exkursionsführer abgegeben.
LiteraturLandolt E. 2003: Unsere Alpenflora. 7.Aufl., SAC-Verlag.
Voraussetzungen / BesonderesVoraussetzungen:
Solide Grundkenntnisse in systematischer Botanik; erfolgreiche Absolvierung der Lehrveranstaltung "Systematische Biologie: Pflanzen" (Nr. 701-0360-00). Im Weiteren ist die vorgängige Teilnahme am Blockkurs "Pflanzendiversität" (Nr. 701-2314-00L), resp. der beiden Einzelkurse "Pflanzendiversität: kollin und montan" (701-0314-00L) und "Pflanzendiversität: subalpin und alpin" (701-0314-01L), empfohlen.

Besonderes:
Die Veranstaltung besteht aus der Vorlesung ("Flora und Vegetation der Alpen", FS, Mo 17-18, CHN G42) und der viertägigen Exkursion ("Böden und Vegetation der Alpen") im Juli (Mittwoch 3. bis Samstag 6.7.2019).

Die Prüfung umfasst den Stoff von Vorlesung und Exkursion.

Die Reisekosten werden von der ETH übernommen; die Departemente Biologie und Umweltsystemwissenschaften leisten einen Kostenbeitrag für die Unterkunft, die restlichen Kosten für die Unterkunft (inkl. Vollpension) sowie den Exkursionsführer von 190 Fr. müssen von den Teilnehmenden übernommen werden.

Die Exkursionen finden in den Bergen statt. Die Teilnehmenden müssen geländegängig sein, auch in steilem Gelände. Bei Bedenken bitten wir um Kontaktaufnahme, dann werden wir die Situation analysieren und besprechen.
701-1708-00LInfectious Disease DynamicsW4 KP2VS. Bonhoeffer, R. D. Kouyos, R. R. Regös, T. Stadler
KurzbeschreibungThis course introduces into current research on the population biology of infectious diseases. The course discusses the most important mathematical tools and their application to relevant diseases of human, natural or managed populations.
LernzielAttendees will learn about:
* the impact of important infectious pathogens and their evolution on human, natural and managed populations
* the population biological impact of interventions such as treatment or vaccination
* the impact of population structure on disease transmission

Attendees will learn how:
* the emergence spread of infectious diseases is described mathematically
* the impact of interventions can be predicted and optimized with mathematical models
* population biological models are parameterized from empirical data
* genetic information can be used to infer the population biology of the infectious disease

The course will focus on how the formal methods ("how") can be used to derive biological insights about the host-pathogen system ("about").
InhaltAfter an introduction into the history of infectious diseases and epidemiology the course will discuss basic epidemiological models and the mathematical methods of their analysis. We will then discuss the population dynamical effects of intervention strategies such as vaccination and treatment. In the second part of the course we will introduce into more advanced topics such as the effect of spatial population structure, explicit contact structure, host heterogeneity, and stochasticity. In the final part of the course we will introduce basic concepts of phylogenetic analysis in the context of infectious diseases.
SkriptSlides and script of the lecture will be available online.
LiteraturThe course is not based on any of the textbooks below, but they are excellent choices as accompanying material:
* Keeling & Rohani, Modeling Infectious Diseases in Humans and Animals, Princeton Univ Press 2008
* Anderson & May, Infectious Diseases in Humans, Oxford Univ Press 1990
* Murray, Mathematical Biology, Springer 2002/3
* Nowak & May, Virus Dynamics, Oxford Univ Press 2000
* Holmes, The Evolution and Emergence of RNA Viruses, Oxford Univ Press 2009
Voraussetzungen / BesonderesBasic knowledge of population dynamics and population genetics as well as linear algebra and analysis will be an advantage.
701-1410-01LQuantitative Approaches to Plant Population and Community EcologyW2 KP2VS. P. Hart
KurzbeschreibungThis course presents leading problems in plant population and community ecology and modern tools to address them. Topics include the nature of species coexistence, the factors regulating the success and spread of plant invasions, and community responses to human impacts. Students are engaged in discussions of primary literature and develop new scientific skills through practical exercises.
LernzielStudents will attain deep insight into topics at the cutting edge of plant ecology/evolutionary research, whilst developing specific skills that can later be applied to basic and applied ecological problems.
751-4505-00LPlant Pathology IIW2 KP2GB. McDonald
KurzbeschreibungPlant Pathology II focuses on disease control in agroecosystems based on biological control, pesticide applications and breeding of resistant crop cultivars. The genetics of pathogen-plant interactions will be explored in detail as a basis for understanding the development of boom-and-bust cycles and methods that may be used to prevent the evolution of pathogen virulence and fungicide resistance.
LernzielAn understanding of the how biological control, pesticides and plant breeding can be used to achieve sustainable disease control. An understanding of the genetic basis of pathogen-plant interactions and appropriate methods for using resistance to control diseases in agroecosystems.
InhaltPlant Pathology II will focus on disease control in agroecosystems based on biological control, pesticide applications and breeding of resistant crop cultivars. The genetics of pathogen-plant interactions will be explored in detail as a basis for understanding the development of boom-and-bust cycles and methods that may be used to prevent the evolution of pathogen virulence and fungicide resistance.

Lecture Topics and Tentative Schedule

Week 1 Biological control: biofumigation, disease declines, suppressive soils.

Week 2 Biological control: competitive exclusion, hyperparasitism.

Week 3 Chemical control: History of fungicides in Europe, fungicide properties, application methods.

Week 4 Fungicide categories and modes of action, antibiotics, fungicide development, fungicide safety and risk assessment (human health).

Week 5 Resistance to fungicides. Genetics of fungicide resistance, ABC transporters, risk assessment, fitness costs. FRAC risk assessment model vs. population genetic risk assessment model.

Week 6 Genetics of pathogen-plant interaction: genetics of pathogens, genetics of plant resistance, major gene and quantitative resistance, acquired resistance. Flor's GFG hypothesis and the quadratic check, the receptor and elicitor model of GFG, the guard model of GFG.

Week 7 Resistance gene structure and genome distribution, conservation of LRR motifs across eukaryotes. Genetic basis of quantitative resistance. QTLs and QRLs. Connections between MGR and QR. Durability of QR.

Week 8 Genetic resistance: Costs, benefits and risks.

Week 9 Non-host resistance. Types of NHR. NHR in Arabidopsis with powdery mildews. NHR in maize and rice. Avirulence genes and pathogen elicitors. PAMPs, effectors, type-III secretion systems, harpins in bacteria. Fungal avirulence genes.

Week 10 Easter holiday no class.

Week 11 Sechselauten holiday no class.

Week 12 Host-specific toxins. GFG for toxins and connection to apoptosis. Fitness costs of virulence alleles. Diversifying selection in NIP1.

Week 13 Boom and bust cycles for resistance genes and fungicides and coevolutionary processes. Pathogen genetic structure and evolutionary potential. Genetic structure of pathogen populations in agroecosystems, risk assessment for pathogen evolution and breeding strategies for durable resistance.

Week 14 Resistance gene and fungicide deployment strategies for agroecosystems.

Week 15 Genetic engineering approaches to achieve disease resistant crops.
SkriptLecture notes will be available for purchase at the cost of reproduction.
LiteraturLecture notes will be available for purchase at the cost of reproduction.
Voraussetzungen / BesonderesPlant Pathology I provides a good preparation for Plant Pathology II, but is not a prerequisite for this course.
701-1462-00LEvolution of Social Behavior and Biological Communication Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 24
W3 KP2VM. Mescher
KurzbeschreibungThis course addresses presents core concepts in the study of behavior and biological communication from a Darwinian perspective, with a focus on the evolution of sociality and the emergence of higher-level biological organization. It will entail lectures and discussion of selected readings from relevant primary and secondary literature.
LernzielStudents will become familiar with the application of Darwinian evolutionary theory to the study of behavior, communication, and social organization. They will also gain insight into the relevance of these topics for broader intellectual questions in biology, as well as for the organization of human societies.
InhaltThis course will begin with an exploration of key concepts, including the central role of information in biology and Darwinian explanations for the emergence of adaptation and functional complexity in biological systems. We will then discuss the application of these concepts to the study of behavior and communication, with a focus on the evolution of social interactions. Significant attention will also be given to the evolution of cooperation among individual organisms and the emergence and maintenance of complex social organization. Finally, we will discuss the implications of the material covered for understanding human behavior and for the organization of human societies, including implications for implementing collective action to address global environmental challenges. These topics will be covered by lectures and discussion of relevant readings selected by the instructor. Evaluations will be based on in-class or take-home examinations, as well as participation in classroom discussions.
701-1426-00LAdvanced Evolutionary GeneticsW3 KP4GT. Städler, P. C. Brunner
KurzbeschreibungThe field of evolutionary genetics rests on genetic and evolutionary principles, (often) mathematical models, and molecular data. The explosion in the availability of genome-wide data makes competencies in "making sense" of such data more and more relevant. This course will cover selected topics that are both fundamental and/or currently very active research fields.
LernzielThis course deals with (some of) the conceptual foundations of evolutionary genetics in the age of genomics, going well beyond the introductory material that is part of the BSc curriculum. The principal aim is for students to gain a thorough appreciation for the underlying ideas and models of key evolutionary processes, and to witness how these are being tested and refined vis-à-vis the recent deluge of genome-wide sequence data. The course focuses on theoretical concepts and ways to infer the action of evolutionary processes from molecular data; as such it is also designed to facilitate understanding of the burgeoning scientific literature in molecular ecology and evolution. These aims require students to be actively engaged in reading original papers, discussing ideas and data among themselves, and presenting their interpretations in group talks.
InhaltThere are 4 hours of lectures, student presentations, and/or group work per week. Students are expected to spend 4 additional hours per week on preparatory study for the following week. Every week, one subject will be presented and overseen by one of the two lecturers.

Each weekly topic will be introduced by a lecture (max. 2 x 45 minutes), highlighting key concepts and historically important papers. The (slight) majority of the time will be spent with group presentations based on recent important papers, and discussions of the relevant concepts.

Specific proposed topics (subject to change):
(1) The coalescent in structured populations (e.g. spatial sampling and its genealogical consequences, demographic inference from sequence data, spurious bottlenecks).
(2) Population subdivision: evolutionary processes and measures (e.g. spatial models, absolute and relative measures of divergence, Jost's (2008) fundamental insights and their reception).
(3) Speciation genetics and modes of species divergence (e.g. intrinsic postzygotic barriers, Dobzhansky-Muller incompatibilities, snowball effect, genomic islands of divergence).
(4) The interplay of linkage, recombination, and selection (e.g. selective sweeps, background selection, Hill-Robertson interference, adaptation).
(5) Evolutionary consequences of mating systems (e.g. clonal vs. sexual reproduction, bottlenecks, colonizing potential, efficacy of natural selection).
(6) Genomics of virulence evolution (e.g. pathogenicity islands, mobile genetic elements, chromosomal rearrangements).
SkriptNo script; handouts and material for downloading will be provided.
LiteraturThere is no textbook for this course. Relevant literature will be provided for each weekly session, selected mostly from the primary research literature.
Voraussetzungen / BesonderesRequirements:
Students must have a good background in genetics, basic population genetics, as well as evolutionary biology. At a minimum, either the course "Population and Quantitative Genetics" or the course "Ecological Genetics" should have been attended, and ideally, both of these ("Evolutionary Genetics" in the D-BIOL curriculum).

Teaching Forms:
The course consists of lectures, readings, group work, student presentations, and discussions. Active participation and preparation of students is critical for a successful learning experience and outcome.
701-0362-00LBöden und Vegetation der Alpen Belegung eingeschränkt - Details anzeigen
Voraussetzungen sind die bestandenen Prüfungen in "Bodenchemie" (701-0533-00L; R. Kretzschmar, D.I. Christl) und "Pedosphäre" (701-0501-00L; R. Kretzschmar). Falls gleichwertige Voraussetzungen (z.B. von anderen Hochschulen) vorliegen, muss eine Teilnahme zuvor mit den Dozenten abgesprochen werden.
W2 KP2PA. Widmer, R. Kretzschmar
KurzbeschreibungExkursion: Kennen der Beziehungen Pflanzen-Umwelt (insbesondere Klima und Boden) in den Alpen (am Beispiel der Region Davos); Standorte auf verschiedenen Ausgangsgesteinen (Dolomit, saures und basisches Silikat, Serpentinit) in der subalpinen und alpinen Stufe; Aufbau und Eigenschaften der Böden, Auswirkungen auf die Pflanzen, wichtige Pflanzengesellschaften und Arten der entsprechenden Standorte.
LernzielKennen der Beziehungen Pflanzen-Umwelt (insbesondere Klima und Boden) in den Alpen (am Beispiel der Region Davos).
InhaltExkursion in die Region von Davos: Standorte auf verschiedenen Ausgangsgesteinen (Dolomit, saures und basisches Silikat, Serpentinit) in der subalpinen und alpinen Stufe; Aufbau und Eigenschaften der Böden, Auswirkungen auf die Pflanzen, wichtige Pflanzengesellschaften und Arten der entsprechenden Standorte.
SkriptEin Exkursionsführer wird abgegeben.
LiteraturLandolt E. 2003: Unsere Alpenflora. 7.Aufl., SAC-Verlag.
Voraussetzungen / BesonderesVoraussetzungen /Besonderes:
Diese Lehrveranstaltung kann nur mit bestandenen Prüfungen in "Bodenchemie" (701-0533-00L; R. Kretzschmar, D.I. Christl) und "Pedosphäre" (701-0501-00L; R. Kretzschmar) belegt werden. Falls gleichwertige Voraussetzungen (z.B. von anderen Hochschulen) vorliegen, muss eine Teilnahme zuvor mit den Dozenten abgesprochen werden. Studierende, die auch die Vorlesung "Flora und Vegetation der Alpen" (701-0364-00V; A. Widmer) belegen, können diese Lehrveranstaltung nicht zusätzlich belegen

Besonderes
Die viertägigen Exkursion in der Region Davos findet statt vom Mittwoch, 3. Juli bis Samstag, 6. Juli 2019. Die Reisekosten werden von der ETH Zürich übernommen; die Departemente Biologie und Umweltsystemwissenschaften leisten einen Beitrag an die Unterkunftskosten; die restlichen Kosten (Unterkunft inkl. Vollpension und Exkursionsführer) von 190 Fr. müssen von den Teilnehmenden übernommen werden.

Die Exkursionen finden in den Bergen statt. Die Teilnehmenden müssen deshalb geländegängig sein, auch in steilem Gelände. Bei Bedenken bitten wir um rechtzeitige Kontaktaufnahme, damit wir die Situation vorgängig analysieren und besprechen können.
Zusätzliche Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0314-00LMicrobiology (Part II)W3 KP2VW.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli
KurzbeschreibungAdvanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
LernzielThis concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
InhaltAdvanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references will be provided during the lectures.
Voraussetzungen / BesonderesEnglish
Wahlvertiefung: Neurowissenschaften
Wahlpflicht Konzeptkurse
Siehe D-BIOL Master-Wegleitung
NummerTitelTypECTSUmfangDozierende
551-0326-00LCell Biology Information W6 KP4VS. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz
KurzbeschreibungThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Lernziel-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
551-0318-00LImmunology IIW3 KP2VA. Oxenius, M. Kopf, S. R. Leibundgut, E. Wetter Slack, weitere Dozierende
KurzbeschreibungEinführung in die zellulären und molekularen Grundlagen des Immunsystems und die Immunreaktionen gegen verschiedene Pathogene, Tumore, Transplantate, und körpereigene Strukturen (Autoimmunität)
LernzielDie Vorlesung soll ein grundlegendes Verständnis vermitteln über:
- die Interaktion der verschiedenen Immunzellen auf zellulärer und molekularer Ebene?
- Erkennung und Abwehr ausgewählter Viren, Bakterien, und Parasiten.
- Abwehr von Tumoren.
- Mechanismen der Toleranz für körpereigene Moleküle.
- Funktion des Immunsystems im Darm und warum kommensale Bakterien keine Immunantwort auslösen.
- Immunpathologie und entzündliche Erkrankungen.
InhaltZiel dieser Vorlesung ist das Verständnis:
> Wie Pathogene vom unspezifischen Immunystem erkannt werden
> Wie Pathogene vom Immunsystem bekämpft werden
> Immunantworten der Haut, Lung, und Darms
> Tumorimmunologie
> Migration von Immunzellen
> Toleranz und Autoimmunität
> das Gedächtnis von T Zellen
SkriptDie Vorlesungsunterlagen der Dozenten sind verfügbar in Moodle
LiteraturEmpfohlen: Kuby Immunology (Freeman)
551-0320-00LCellular Biochemistry (Part II)W3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
227-1034-00LComputational Vision (University of Zurich) Information
No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH.
UZH Module Code: INI402

Mind the enrolment deadlines at UZH:
https://www.uzh.ch/cmsssl/en/studies/application/mobilitaet.html
W6 KP2V + 1UD. Kiper
KurzbeschreibungThis course focuses on neural computations that underlie visual perception. We study how visual signals are processed in the retina, LGN and visual cortex. We study the morpholgy and functional architecture of cortical circuits responsible for pattern, motion, color, and three-dimensional vision.
LernzielThis course considers the operation of circuits in the process of neural computations. The evolution of neural systems will be considered to demonstrate how neural structures and mechanisms are optimised for energy capture, transduction, transmission and representation of information. Canonical brain circuits will be described as models for the analysis of sensory information. The concept of receptive fields will be introduced and their role in coding spatial and temporal information will be considered. The constraints of the bandwidth of neural channels and the mechanisms of normalization by neural circuits will be discussed.
The visual system will form the basis of case studies in the computation of form, depth, and motion. The role of multiple channels and collective computations for object recognition will
be considered. Coordinate transformations of space and time by cortical and subcortical mechanisms will be analysed. The means by which sensory and motor systems are integrated to allow for adaptive behaviour will be considered.
InhaltThis course considers the operation of circuits in the process of neural computations. The evolution of neural systems will be considered to demonstrate how neural structures and mechanisms are optimised for energy capture, transduction, transmission and representation of information. Canonical brain circuits will be described as models for the analysis of sensory information. The concept of receptive fields will be introduced and their role in coding spatial and temporal information will be considered. The constraints of the bandwidth of neural channels and the mechanisms of normalization by neural circuits will be discussed.
The visual system will form the basis of case studies in the computation of form, depth, and motion. The role of multiple channels and collective computations for object recognition will
be considered. Coordinate transformations of space and time by cortical and subcortical mechanisms will be analysed. The means by which sensory and motor systems are integrated to allow for adaptive behaviour will be considered.
LiteraturBooks: (recommended references, not required)
1. An Introduction to Natural Computation, D. Ballard (Bradford Books, MIT Press) 1997.
2. The Handbook of Brain Theorie and Neural Networks, M. Arbib (editor), (MIT Press) 1995.
227-1046-00LComputer Simulations of Sensory Systems Information W3 KP2V + 1UT. Haslwanter
KurzbeschreibungThis course deals with computer simulations of the human auditory, visual, and balance system. The lecture will cover the physiological and mechanical mechanisms of these sensory systems. And in the exercises, the simulations will be implemented with Python (or Matlab). The simulations will be such that their output could be used as input for actual neuro-sensory prostheses.
LernzielOur sensory systems provide us with information about what is happening in the world surrounding us. Thereby they transform incoming mechanical, electromagnetic, and chemical signals into “action potentials”, the language of the central nervous system.
The main goal of this lecture is to describe how our sensors achieve these transformations, how they can be reproduced with computational tools. For example, our auditory system performs approximately a “Fourier transformation” of the incoming sound waves; our early visual system is optimized for finding edges in images that are projected onto our retina; and our balance system can be well described with a “control system” that transforms linear and rotational movements into nerve impulses.
In the exercises that go with this lecture, we will use Python to reproduce the transformations achieved by our sensory systems. The goal is to write programs whose output could be used as input for actual neurosensory prostheses: such prostheses have become commonplace for the auditory system, and are under development for the visual and the balance system. For the corresponding exercises, at least some basic programing experience is required!!
InhaltThe following topics will be covered:
• Introduction into the signal processing in nerve cells.
• Introduction into Python.
• Simplified simulation of nerve cells (Hodgkins-Huxley model).
• Description of the auditory system, including the application of Fourier transforms on recorded sounds.
• Description of the visual system, including the retina and the information processing in the visual cortex. The corresponding exercises will provide an introduction to digital image processing.
• Description of the mechanics of our balance system, and the “Control System”-language that can be used for an efficient description of the corresponding signal processing (essentially Laplace transforms and control systems).
SkriptFor each module additional material will be provided on the e-learning platform "moodle". The main content of the lecture is also available as a wikibook, under http://en.wikibooks.org/wiki/Sensory_Systems
LiteraturOpen source information is available as wikibook http://en.wikibooks.org/wiki/Sensory_Systems

For good overviews I recommend:
• L. R. Squire, D. Berg, F. E. Bloom, Lac S. du, A. Ghosh, and N. C. Spitzer. Fundamental Neuroscience, Academic Press - Elsevier, 2012 [ISBN: 9780123858702].
This book covers the biological components, from the functioning of an individual ion channels through the various senses, all the way to consciousness. And while it does not cover the computational aspects, it nevertheless provides an excellent overview of the underlying neural processes of sensory systems.

• Principles of Neural Science (5th Ed, 2012), by Eric Kandel, James Schwartz, Thomas Jessell, Steven Siegelbaum, A.J. Hudspeth
ISBN 0071390111 / 9780071390118
THE standard textbook on neuroscience.

• P Wallisch, M Lusignan, M. Benayoun, T. I. Baker, A. S. Dickey, and N. G. Hatsopoulos. MATLAB for Neuroscientists, Academic Press, 2009.
Compactly written, it provides a short introduction to MATLAB, as well as a very good overview of MATLAB’s functionality, focusing on applications in different areas of neuroscience.

• G. Mather. Foundations of Sensation and Perception, 2nd Ed Psychology Press, 2009 [ISBN: 978-1-84169-698-0 (hardcover), oder 978-1-84169-699-7 (paperback)]
A coherent, up-to-date introduction to the basic facts and theories concerning human sensory perception.
Voraussetzungen / BesonderesSince I have to gravel from Linz, Austria, to Zurich to give this lecture, I plan to hold this lecture in blocks (every 2nd week).
227-0390-00LElements of MicroscopyW4 KP3GM. Stampanoni, G. Csúcs, A. Sologubenko
KurzbeschreibungThe lecture reviews the basics of microscopy by discussing wave propagation, diffraction phenomena and aberrations. It gives the basics of light microscopy, introducing fluorescence, wide-field, confocal and multiphoton imaging. It further covers 3D electron microscopy and 3D X-ray tomographic micro and nanoimaging.
LernzielSolid introduction to the basics of microscopy, either with visible light, electrons or X-rays.
InhaltIt would be impossible to imagine any scientific activities without the help of microscopy. Nowadays, scientists can count on very powerful instruments that allow investigating sample down to the atomic level.
The lecture includes a general introduction to the principles of microscopy, from wave physics to image formation. It provides the physical and engineering basics to understand visible light, electron and X-ray microscopy.
During selected exercises in the lab, several sophisticated instrument will be explained and their capabilities demonstrated.
LiteraturAvailable Online.
376-1306-00LClinical Neuroscience Information W3 KP3GG. Schratt, Uni-Dozierende
KurzbeschreibungThe lecture series "Clinical Neuroscience" presents a comprehensive, condensed overview of the most important neurological diseases, their clinical presentation, diagnosis, therapy options and possible causes. Patient demonstrations (Übungen) follow every lecture that is dedicated to a particular disease.
LernzielBy the end of this module students should be able to:
- demonstrate their understanding and deep knowledge concerning the main neurological diseases
- identify and explain the different clinical presentation of these diseases, the methodology of diagnosis and the current therapies available
- summarize and critically review scientific literature efficiently and effectively
376-1414-01LCurrent Topics in Brain Research (FS)W1 KP1.5KI. Mansuy, F. Helmchen, weitere Dozierende
KurzbeschreibungEs werden verschiedene wissenschaftliche Gäste aus dem In-und Ausland eingeladen, um ihre aktuellen Forschungsdaten zu präsentieren und diskutieren.
LernzielEs soll der Austausch von wissenschaftlichen Erkenntnissen und Daten sowie die Kommunikation und Zusammenarbeit zwischen den Forschenden gefördert werden. Studierende, welche den Kurs belegen, besuchen während eines Semesters alle Seminare und schreiben einen kritischen Report über ein Seminar ihrer Wahl. Die Anleitung dazu erhalten eingeschriebene Studierende von Prof. Isabelle Mansuy / Dr. Silvia Schelbert.
InhaltVerschiedene wissenschaftliche Gäste aus den Bereichen Molekulares Bewusstsein, Neurochemie, Neuromorphologie und Neurophysiologie berichten über ihre neuesten wissenschaftlichen Erkenntnisse.
Skriptkein Skript
Literaturkeine Literatur
Zusätzliche Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0326-00LCell Biology Information W6 KP4VS. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz
KurzbeschreibungThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Lernziel-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
551-0318-00LImmunology IIW3 KP2VA. Oxenius, M. Kopf, S. R. Leibundgut, E. Wetter Slack, weitere Dozierende
KurzbeschreibungEinführung in die zellulären und molekularen Grundlagen des Immunsystems und die Immunreaktionen gegen verschiedene Pathogene, Tumore, Transplantate, und körpereigene Strukturen (Autoimmunität)
LernzielDie Vorlesung soll ein grundlegendes Verständnis vermitteln über:
- die Interaktion der verschiedenen Immunzellen auf zellulärer und molekularer Ebene?
- Erkennung und Abwehr ausgewählter Viren, Bakterien, und Parasiten.
- Abwehr von Tumoren.
- Mechanismen der Toleranz für körpereigene Moleküle.
- Funktion des Immunsystems im Darm und warum kommensale Bakterien keine Immunantwort auslösen.
- Immunpathologie und entzündliche Erkrankungen.
InhaltZiel dieser Vorlesung ist das Verständnis:
> Wie Pathogene vom unspezifischen Immunystem erkannt werden
> Wie Pathogene vom Immunsystem bekämpft werden
> Immunantworten der Haut, Lung, und Darms
> Tumorimmunologie
> Migration von Immunzellen
> Toleranz und Autoimmunität
> das Gedächtnis von T Zellen
SkriptDie Vorlesungsunterlagen der Dozenten sind verfügbar in Moodle
LiteraturEmpfohlen: Kuby Immunology (Freeman)
551-0320-00LCellular Biochemistry (Part II)W3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
Wahlvertiefung: Mikrobiologie und Immunologie
Obligatorische Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0314-00LMicrobiology (Part II)O3 KP2VW.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli
KurzbeschreibungAdvanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
LernzielThis concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
InhaltAdvanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references will be provided during the lectures.
Voraussetzungen / BesonderesEnglish
551-0318-00LImmunology IIO3 KP2VA. Oxenius, M. Kopf, S. R. Leibundgut, E. Wetter Slack, weitere Dozierende
KurzbeschreibungEinführung in die zellulären und molekularen Grundlagen des Immunsystems und die Immunreaktionen gegen verschiedene Pathogene, Tumore, Transplantate, und körpereigene Strukturen (Autoimmunität)
LernzielDie Vorlesung soll ein grundlegendes Verständnis vermitteln über:
- die Interaktion der verschiedenen Immunzellen auf zellulärer und molekularer Ebene?
- Erkennung und Abwehr ausgewählter Viren, Bakterien, und Parasiten.
- Abwehr von Tumoren.
- Mechanismen der Toleranz für körpereigene Moleküle.
- Funktion des Immunsystems im Darm und warum kommensale Bakterien keine Immunantwort auslösen.
- Immunpathologie und entzündliche Erkrankungen.
InhaltZiel dieser Vorlesung ist das Verständnis:
> Wie Pathogene vom unspezifischen Immunystem erkannt werden
> Wie Pathogene vom Immunsystem bekämpft werden
> Immunantworten der Haut, Lung, und Darms
> Tumorimmunologie
> Migration von Immunzellen
> Toleranz und Autoimmunität
> das Gedächtnis von T Zellen
SkriptDie Vorlesungsunterlagen der Dozenten sind verfügbar in Moodle
LiteraturEmpfohlen: Kuby Immunology (Freeman)
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
701-1310-00LEnvironmental MicrobiologyW3 KP2VM. H. Schroth, M. Lever
KurzbeschreibungMicroorganisms catalyze a large number of reactions that are of great importance to terrestrial and aquatic environments. To improve our understanding of the dynamics of a specific environment, it is important to gain a better understanding of microbial structures and their functions under varying environmental conditions.
LernzielStudents will learn basic concepts in microbial ecology. Qualitative and quantitative concepts will be presented to assess microbial communities and associated processes in terrestrial and aquatic environments. Microbial diversity in such ecosystems will be illustrated in discussions of selected habitats.
InhaltLectures will cover general concepts of environmental microbiology including (i) quantification of microbial processes, (ii) energy fluxes in microbial ecosystems, (iii) application of state-of-the-art microbiological and molecular tools, and (iv) use of isotope methods for identification of microbial structures and functions.
Topics to illustrate the microbial diversity of terrestrial and aquatic ecosystems will include (i) interactions between microbes and mineral/metallic solid phases, (ii) microbial carbon and nutrient cycling, (iii) microbial processes involved in the turnover of greenhouse gases, (iv) biofilms and microbial mats, (v) bioremediation, (vi) microorganisms in extreme habitats, and (vii) microbial evolution and astrobiology.
Skriptavailable at time of lecture - will be distributed electronically as pdf's
LiteraturBrock Biology of Microorganisms, Madigan M. et al., Pearson, 14th ed., 2015
551-1100-00LInfectious Agents: From Molecular Biology to Disease
Number of participants limited to 22.
Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures.
(if you missed the deadline, please come to the first date to see, if there are any slots left)
W4 KP2SW.‑D. Hardt, L. Eberl, U. F. Greber, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander
KurzbeschreibungLiterature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.
LernzielWorking with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.
Inhaltfor each model pathogen (or key technology):
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
SkriptTeachers will provide the research papers to be discussed.
Students will prepare handouts for the rest of the group for their assigned seminar.
LiteraturTeachers will provide the research papers to be discussed.
Voraussetzungen / BesonderesRestricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to micro_secr@micro.biol.ethz.ch and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.
The first seminar date will serve to form groups of students and assign a paper to each group.
551-1118-00LCutting Edge Topics: Immunology and Infection Biology II Information W2 KP1SA. Oxenius, B. Becher, C. Halin Winter, N. C. Joller, M. Kopf, S. R. Leibundgut, C. Münz, F. Sallusto, R. Spörri, M. van den Broek, Uni-Dozierende
KurzbeschreibungWöchentliches Seminar über aktuelle Themen der Immunologie und Infektionsbiologie. International renommierte Experten referieren über ihre aktuellen Forschungsresultate mit anschliessender offener Diskussion.
LernzielWöchentliches Seminar über aktuelle Themen der Immunologie und Infektionsbiologie. International renommierte Experten referieren über ihre aktuellen Forschungsresultate mit anschliessender offener Diskussion.
Ziel der Veranstaltung ist die Konfrontation von Studenten und Doktoranden mit aktuellen Forschungsthemen und mit wissenschaftlicher Vortragsform. Studenten und Doktoranden wird die Gelegenheit geboten, sich mit diversen Themen vertieft auseinander zu setzen, welche oft in den Konzeptkursen nur knapp präsentiert werden und mit Experten auf dem Gebiet zu diskutieren.
InhaltImmunologie und Infektionsbiologie.
Die speziellen Themen variieren jedes Semester und hängen von den eingeladenen Experten ab.
551-1104-00LAusgewählte Kapitel der Mykologie im WaldW2 KP1VI. L. Brunner, M. Peter Baltensweiler, D. H. Rigling
KurzbeschreibungLebensweisen und Funktionen von symbiotischen, saproben und pathogenen Pilzen, Lebensgemeinschaften der Mykorrhiza und funktionelle Aspekte der Mykorrhizadiversität, Evolution und phylogenetische Aspekte der Pflanzen-Pilz Interaktionen, inter- und intraspezifische Myzelinteraktionen, Rolle der Pilze bei Nährstofferschliessung und Verwitterung.
LernzielVertiefte Kenntnisse der Biologie und Ökologie der Pilze im Wald. Selbständige Auseinandersetzung mit aktueller Literatur.
InhaltVertiefte Behandlung ausgewählter Themen der Pilze im Ökosystem Wald: Lebensweisen und Funktionen von symbiotischen, saproben und pathogenen Pilzen, Lebensgemeinschaften der Mykorrhiza und funktionelle Aspekte der Mykorrhizadiversität, Evolution und phylogenetische Aspekte der Pflanzen-Pilz Interaktionen, Inter- und intraspezifische Myzelinteraktionen, Rolle der Pilze bei Nährstofferschliessung und Verwitterung.
Die Grundlagen werden in Vorlesungen vermittelt. Daneben selbständige Vertiefung des Stoffes mit Hilfe aktueller Literatur und Präsentationen.
SkriptUnterlagen zum Kurs werden abgegeben.
LiteraturSmith S.E. and Read D.J. 1997. Mycorrhizal Symbiosis. Academic Press, 2nd ed., pp. 605.
551-0216-00LMykologischer Feldkurs Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 8
W3 KP3.5PA. Leuchtmann
KurzbeschreibungExkursionen zum Sammeln von Pilzen und anschliessendes Studium der Funde im Kursraum. Hauptfokus sind Kleinpilze (Ascomyceten): sie erhalten einen Einblick in die Vielfalt der Formen und eine Einführung ins Bestimmen. Zudem wird auf die Ökologie und Funktion der Pilze in ausgewählten Habitaten eingegangen, sowie ausgewählte Beispiele von einheimischen Speise- und Giftpilzen gezeigt.
LernzielErweiterung und Vertiefung der systematisch-taxonomischen Kenntnisse der Pilze, mit Fokus auf Ascomyceten. Teilnehmer kennen ökologische Funktionen der Pilze als Mutualisten, Saprobionten oder Parasiten von Pflanzen in verschiedenen Ökosystemen.
InhaltEinführung ins Reich der Pilze, Merkmale der Pilze und Überblick über deren systematische Gliederung. Exkursionen zum Sammeln von Ascomyceten in ausgewählten Lebensräumen. Kennenlernen von notwendigen Sammel- und Präparationstechniken, Einführung in die Ökologie und Funktion der Pilze, Untersuchung und Bestimmen von Pilzen mit optischen Hilfsmitteln im Kursraum, Einblick in Formenvielfalt ausgewählter Pilzgruppen (Ascomyecten), Beispiele von Gift- und Speisepilzen.
SkriptKursunterlagen werden abgegeben
LiteraturSpezialliteratur für die Bestimmung der Familien, Gattungen und Arten der mitteleuropäischen Mykoflora.
Voraussetzungen / BesonderesDer Kurs ist auf maximal 8 Teilnehmende beschränkt. Schriftliche Anmeldung erforderlich. Das Kursgeld von Fr. 180.- muss von den Kursteilnehmern übernommen werden. Vor dem Kurs (Freitag 23. Aug. 2019) findet eine halbtägige Einführung in Zürich statt, deren Besuch ist obligatorisch.
551-1132-00LAllgemeine Virologie Information
Findet dieses Semester nicht statt.
W2 KP1V
KurzbeschreibungEinführung in die Grundlagen der Virologie, welche die Charakterisierung von Viren, die Interaktionen der Viren mit infizierten Zellen, Wirten und Populationen, die Grundlagen des Schutzes vor Infektion und die Virusdiagnostik beinhaltet.
LernzielEinführung in die Grundlagen der Virologie.
InhaltGrundlagen der Virologie. Charakterisierung von Viren. Virus-Zell-Interaktionen. Virus-Wirt-Interaktionen. Virus-Population-Interaktionen. Schutz vor Virusinfektion. Virusdiagnostik.
SkriptDie Vorlesung ist auf dem Lehrbuch "Allgemeine Virologie" von Kurt Tobler, Mathias Ackermann und Cornel Fraefel aufgebaut.

Die Präsentationsfolien und ausgewählte Primärliteratur werden 24 bis 48 Stunden vor den Lektionen als .pdf-Dateien bereitgestellt.
LiteraturKurt Tobler, Mathias Ackermann und Cornel Fraefel,
Allgemeine Virologie, 2016,
1. Auflage UTB-Band-Nr.:4516 Haupt Verlag Bern
ISBN: 978-3-8252-4516-0
Voraussetzungen / BesonderesGrundkenntnisse in Molekularbiologie, Zellbiologie und Immunologie
551-0140-00LEpigeneticsW4 KP2VA. Wutz, U. Grossniklaus, R. Paro, R. Santoro
KurzbeschreibungEpigenetik untersucht die Vererbung von Merkmalen, die nicht auf eine Veränderung der DNA Sequenz zurückgeführt werden kann. Die Vorlesung gibt einen Überblick über epigenetische Phänomene und erklärt die zugrundeliegenden molekularen Mechanismen. Die Rolle von epigenetischen Prozessen bei der Krebsentstehung und anderen Krankheiten wird diskutiert.
LernzielDas Ziel des Kurses ist das Verständnis von epigenetischen Mechanismen und deren Funktion in der Entwicklung von Organismen, bei Regenerationsprozessen oder bei der Entstehung von Krankheiten.
InhaltThemen
- Historischer Überblick, Konzepte und Vergleich Genetik vs. Epigenetik
- Biologie von Chromatin: Struktur und Funktion, Organisation im Kern und die Rolle von Histon Modifikationen bei Prozessen wie Transkription und Replikation.
- DNA-Methylierung als epigenetische Modifikation
- Weitergabe epigenetischer Modifikationen während der Zellteilung: das Zellgedächtnis
- Stabilität/Revertierbarkeit epigenetischer Modifikationen: zelluläre Plastizität und Stammzellen.
- Genomisches Imprinting in Pflanzen und in Säugern
- X Chromosom Inaktivierung und Dosiskompensation
- Positionseffekte, Paramutationen und Transvektion
- RNA-induziertes Gensilencing
- die Rolle von epigenetischen Prozessen bei der Krebsentstehung oder der Zellalterung.
751-4904-00LMikrobielle SchädlingsbekämpfungW2 KP2GJ. Enkerli, G. Grabenweger, S. Kuske Pradal
KurzbeschreibungDie Vorlesung vermittelt konzeptionelle, sowie biologische und ökologische Grundlagen in mikrobieller Schädlingsbekämpfung. Anhand von Beispielen werden die Methoden und Techniken zur Entwicklung und Überwachung von mikrobiellen Schädlingsbekämpfungsmitteln erarbeitet.
LernzielKennenlernen der wichtigsten Gruppen von insektenpathogenen Mikroorganismen und deren Eigenschaften. Vertraut werden mit den nötigen Schritten für die Entwicklung von Schädlingsbekämpfungsmitteln. Verstehen der Techniken und Methoden, die für das Überwachen von Feldapplikationen benützt werden, und Kennen der Registrierungsanforderungen für mikrobielle Schädlingsbekämpfungsmittel.
InhaltDie in der biologischen Schädlingsbekämpfung gebrauchten Definitionen und generell verwendete Ausdrücke werden erarbeitet. Ferner werden biologische und ökologische Aspekte aller Arthropoden-pathogenen Gruppen (Viren, Bakterien Pilze und Nematoden) und ihre Vor- und Nachteile in Bezug auf biologische Schädlingsbekämpfung diskutiert. Ein Schwergewicht wird dabei auf die Pilzgruppen Hypocreales und Entomophtorales gelegt. Anhand von Beispielen wird aufgezeigt, wie Projekte in biologischer Schädlingsbekämpfung aufgebaut werden können, wie Pathogene appliziert werden und wie die Effizienz, Effekte auf Nicht-Zielorganismen, Persistenz und Verbreitung überwacht werden. Im Weiteren werden die nötigen Schritte in der Entwicklung eines Produktes, kommerzielle Aspekte und die Registrierungsanforderungen besprochen.
SkriptDie grundlegenden Aspekte werden als Skript (Präsentationsunterlagen) abgegeben.
LiteraturHinweise auf zusätzliche Literatur werde in der Lehrveranstaltung gegeben.
551-1126-00LTechnologies in Molecular MicrobiologyW4 KP2VH.‑M. Fischer, B. Christen, M. Christen, weitere Dozierende
KurzbeschreibungThe lecture course provides an advanced understanding of modern techniques used in molecular microbiology. Current technologies and research directions in molecular microbiology including applied aspects will be illustrated with paper discussions. The format is a lecture course enriched by group activities.
LernzielThe lecture course aims at providing principles of modern techniques used in molecular microbiology. Emphasis is on genetic, biochemical, and cellular analysis including also bioinformatics aspects. Discussion of a set of commonly applied technologies will assist students in evaluating current research in molecular microbiology and choosing appropriate methods for their own demands.
InhaltImportant genetic, biochemical, biophysical, bioinformatic and structural analysis methods will be presented that are used to gain a deeper understanding of the molecular principles and mechanisms underlying basic physiological processes in prokaryotes. Applied aspects of molecular microbiology and current research in this area will also be covered.

List of topics:
- Analysis of genes, genomes and transcriptomes
- Analysis of proteins, proteomes and microbial systems
- Synthetic biology
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references, relevant papers and handouts will be provided during the lectures.
Voraussetzungen / BesonderesThe following lecturers will contribute to the course:

Prof. Beat Christen (ETH)
Dr. Matthias Christen (ETH)
Prof. Hans-Martin Fischer (ETH)
Dr. Jonas Grossmann (FGCZ)
Dr. Florian Freimoser (Agroscope)
Dr. Bernd Roschitzki (FGCZ)
Dr. Roman Spörri (ETH)
227-0390-00LElements of MicroscopyW4 KP3GM. Stampanoni, G. Csúcs, A. Sologubenko
KurzbeschreibungThe lecture reviews the basics of microscopy by discussing wave propagation, diffraction phenomena and aberrations. It gives the basics of light microscopy, introducing fluorescence, wide-field, confocal and multiphoton imaging. It further covers 3D electron microscopy and 3D X-ray tomographic micro and nanoimaging.
LernzielSolid introduction to the basics of microscopy, either with visible light, electrons or X-rays.
InhaltIt would be impossible to imagine any scientific activities without the help of microscopy. Nowadays, scientists can count on very powerful instruments that allow investigating sample down to the atomic level.
The lecture includes a general introduction to the principles of microscopy, from wave physics to image formation. It provides the physical and engineering basics to understand visible light, electron and X-ray microscopy.
During selected exercises in the lab, several sophisticated instrument will be explained and their capabilities demonstrated.
LiteraturAvailable Online.
701-1708-00LInfectious Disease DynamicsW4 KP2VS. Bonhoeffer, R. D. Kouyos, R. R. Regös, T. Stadler
KurzbeschreibungThis course introduces into current research on the population biology of infectious diseases. The course discusses the most important mathematical tools and their application to relevant diseases of human, natural or managed populations.
LernzielAttendees will learn about:
* the impact of important infectious pathogens and their evolution on human, natural and managed populations
* the population biological impact of interventions such as treatment or vaccination
* the impact of population structure on disease transmission

Attendees will learn how:
* the emergence spread of infectious diseases is described mathematically
* the impact of interventions can be predicted and optimized with mathematical models
* population biological models are parameterized from empirical data
* genetic information can be used to infer the population biology of the infectious disease

The course will focus on how the formal methods ("how") can be used to derive biological insights about the host-pathogen system ("about").
InhaltAfter an introduction into the history of infectious diseases and epidemiology the course will discuss basic epidemiological models and the mathematical methods of their analysis. We will then discuss the population dynamical effects of intervention strategies such as vaccination and treatment. In the second part of the course we will introduce into more advanced topics such as the effect of spatial population structure, explicit contact structure, host heterogeneity, and stochasticity. In the final part of the course we will introduce basic concepts of phylogenetic analysis in the context of infectious diseases.
SkriptSlides and script of the lecture will be available online.
LiteraturThe course is not based on any of the textbooks below, but they are excellent choices as accompanying material:
* Keeling & Rohani, Modeling Infectious Diseases in Humans and Animals, Princeton Univ Press 2008
* Anderson & May, Infectious Diseases in Humans, Oxford Univ Press 1990
* Murray, Mathematical Biology, Springer 2002/3
* Nowak & May, Virus Dynamics, Oxford Univ Press 2000
* Holmes, The Evolution and Emergence of RNA Viruses, Oxford Univ Press 2009
Voraussetzungen / BesonderesBasic knowledge of population dynamics and population genetics as well as linear algebra and analysis will be an advantage.
751-4505-00LPlant Pathology IIW2 KP2GB. McDonald
KurzbeschreibungPlant Pathology II focuses on disease control in agroecosystems based on biological control, pesticide applications and breeding of resistant crop cultivars. The genetics of pathogen-plant interactions will be explored in detail as a basis for understanding the development of boom-and-bust cycles and methods that may be used to prevent the evolution of pathogen virulence and fungicide resistance.
LernzielAn understanding of the how biological control, pesticides and plant breeding can be used to achieve sustainable disease control. An understanding of the genetic basis of pathogen-plant interactions and appropriate methods for using resistance to control diseases in agroecosystems.
InhaltPlant Pathology II will focus on disease control in agroecosystems based on biological control, pesticide applications and breeding of resistant crop cultivars. The genetics of pathogen-plant interactions will be explored in detail as a basis for understanding the development of boom-and-bust cycles and methods that may be used to prevent the evolution of pathogen virulence and fungicide resistance.

Lecture Topics and Tentative Schedule

Week 1 Biological control: biofumigation, disease declines, suppressive soils.

Week 2 Biological control: competitive exclusion, hyperparasitism.

Week 3 Chemical control: History of fungicides in Europe, fungicide properties, application methods.

Week 4 Fungicide categories and modes of action, antibiotics, fungicide development, fungicide safety and risk assessment (human health).

Week 5 Resistance to fungicides. Genetics of fungicide resistance, ABC transporters, risk assessment, fitness costs. FRAC risk assessment model vs. population genetic risk assessment model.

Week 6 Genetics of pathogen-plant interaction: genetics of pathogens, genetics of plant resistance, major gene and quantitative resistance, acquired resistance. Flor's GFG hypothesis and the quadratic check, the receptor and elicitor model of GFG, the guard model of GFG.

Week 7 Resistance gene structure and genome distribution, conservation of LRR motifs across eukaryotes. Genetic basis of quantitative resistance. QTLs and QRLs. Connections between MGR and QR. Durability of QR.

Week 8 Genetic resistance: Costs, benefits and risks.

Week 9 Non-host resistance. Types of NHR. NHR in Arabidopsis with powdery mildews. NHR in maize and rice. Avirulence genes and pathogen elicitors. PAMPs, effectors, type-III secretion systems, harpins in bacteria. Fungal avirulence genes.

Week 10 Easter holiday no class.

Week 11 Sechselauten holiday no class.

Week 12 Host-specific toxins. GFG for toxins and connection to apoptosis. Fitness costs of virulence alleles. Diversifying selection in NIP1.

Week 13 Boom and bust cycles for resistance genes and fungicides and coevolutionary processes. Pathogen genetic structure and evolutionary potential. Genetic structure of pathogen populations in agroecosystems, risk assessment for pathogen evolution and breeding strategies for durable resistance.

Week 14 Resistance gene and fungicide deployment strategies for agroecosystems.

Week 15 Genetic engineering approaches to achieve disease resistant crops.
SkriptLecture notes will be available for purchase at the cost of reproduction.
LiteraturLecture notes will be available for purchase at the cost of reproduction.
Voraussetzungen / BesonderesPlant Pathology I provides a good preparation for Plant Pathology II, but is not a prerequisite for this course.
551-1700-00LIntroduction to Flow Cytometry Belegung eingeschränkt - Details anzeigen
Number of participants limited to 24.
W2 KP1VJ. Kisielow, L. Tortola, weitere Dozierende
KurzbeschreibungThe lecture provides an introduction to flow cytometry. We will cover the technology basics, experimental design, data acquisition and analysis of flow and mass cytometry. In addition, various research applications will be discussed. The format is a lecture course enriched by a visit to the ETH Flow Cytometry Core Facility and practical demonstration of the use of analysis and sorting instruments.
LernzielThe goal of this course is to provide the basic knowledge of flow and mass cytometry required for planning and execution of cytometric experiments.
InhaltThe lecture course aims at teaching principles of flow cytometry. The emphasis is on theoretical principles (signal detection, fluorochromes, signal spill-over and compensation) as well as practical aspects of experimental design and performance (sample preparation, controls, data acquisition and analysis).
List of topics:
- Principles of Flow Cytometry
- Signal processing
- Compensation and Controls
- Data analysis, gating and presentation
- Panel design
- Sorting
- Mass cytometry
- High-dimensional data analysis
- Practical demonstration (hardware and software)
Modern flow cytometric techniques for immunophenotyping, analysis of proliferation, cell cycle, apoptosis and cell signalling will be introduced.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references on immunophenotyping, analysis of proliferation, cell cycle, apoptosis and cell signalling will be discussed during the lectures.
Zusätzliche Masterkurse
NummerTitelTypECTSUmfangDozierende
551-0512-00LCurrent Topics in Molecular and Cellular Neurobiology Belegung eingeschränkt - Details anzeigen
Findet dieses Semester nicht statt.
Number of participants limited to 8
W2 KP1SU. Suter
KurzbeschreibungThe course is a literature seminar or "journal club". Each Friday a student, or a member of the Suter Lab in the Institute of Molecular Health Sciences, will present a paper from the recent literature.
LernzielThe course introduces you to recent developments in the fields of cellular and molecular neurobiology. It also supports you to develop your skills in critically reading the scientific literature. You should be able to grasp what the authors wanted to learn e.g. their goals, why the authors chose the experimental approach they used, the strengths and weaknesses of the experiments and the data presented, and how the work fits into the wider literature in the field. You will present one paper yourself, which provides you with practice in public speaking.
InhaltYou will present one paper yourself. Give an introduction to the field of the paper, then show and comment on the main results (all the papers we present are available online, so you can show original figures with a beamer). Finish with a summary of the main points and a discussion of their significance.
You are expected to take part in the discussion and to ask questions. To prepare for this you should read all the papers beforehand (they will be announced a week in advance of the presentation).
SkriptPresentations will be made available after the seminars.
LiteraturWe cover a range of themes related to development and neurobiology. Before starting your preparations, you are required to check with Laura Montani (laura.montani@biol.ethz.ch), who helps you with finding an appropriate paper.
Voraussetzungen / BesonderesYou must attend at least 80% of the journal clubs, and give a presentation of your own. At the end of the semester there will be a 30 minute oral exam on the material presented during the semester. The grade will be based on the exam (45%), your presentation (45%), and a contribution based on your active participation in discussion of other presentations (10%).
551-0224-00LAdvanced Proteomics Belegung eingeschränkt - Details anzeigen
Für Masterstudierende ab 2. Semester, Doktorierende und Postdoktorierende
W4 KP6GR. Aebersold, L. Gillet, M. Gstaiger, A. Leitner, P. Pedrioli
KurzbeschreibungZiel dieses Kurses ist es, etablierte und neue Technologien der Protein- und Proteome-Analyse kennenzulernen in Bezug auf ihre Anwendung in Biologie, Biotechnologie und Medizin.
Format: Einführung durch Dozent mit anschliessender Diskussion, unterstützt durch Literaturarbeit und Übungen.
LernzielIm Kurs werden sowohl die bereits etablierten als auch die neuesten derzeit entstehenden Technologien und Methoden in der Protein- und Proteomanlayse diskutiert im Hinblick auf ihre Anwendung in der Biologie, Biotechnologie, Medizin und Systembiologie.
InhaltBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Voraussetzungen / BesonderesNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students http://www.rektorat.ethz.ch/students/admission/auditors/index_EN
Zusätzliche Konzeptkurse
NummerTitelTypECTSUmfangDozierende
752-4006-00LLebensmittel-Mikrobiologie IIW3 KP2VM. Loessner, J. Klumpp
KurzbeschreibungVermittlung von (teilweise vertieften) Basiskenntnissen ueber Methoden fuer Nachweis und die Differenzierung von (nicht nur lebensmittelrelevanten) Mikroorganismen; Herstellung von Lebensmitteln mit Mikroorganismen; Haltbarmachung und Lebensmittelsicherheit; kurzer Ueberblick ueber gesetzliche Regelungen und Hygienemassnahmen.
LernzielDer zweite Teil dieser 1 Jahres-Vorlesung vermittelt (teilweise vertiefte) Basiskenntnisse ueber verschiedene Methoden (klassisch und molekularbiologisch)fuer den Nachweis und die Differenzierung von (nicht nur lebensmittelrelevanten) Mikroorganismen; die Herstellung von Lebensmitteln mit Mikroorganismen; verschiedene Ansaetze zur Haltbarmachung und Lebensmittelsicherheit; und einen kurzen Ueberblick ueber gesetzliche Regelungen und Hygienemassnahmen.
InhaltNachweis und Differenzierung von Mikroorganismen
Kulturmethoden, Mikroskopischer Nachweis, Anreicherung und Separation, Nachweis intrazellulärer Metaboliten und Enzyme, Immunologische Methoden, Gensonden und Microarrays, Nukleinsäureamplifikation, Expression von Reportergenen, Typisierungsmethoden

Herstellung von Lebensmitteln mit Mikroorganismen
Fermentierte pflanzliche Produkte, Brot und Sauerteig, Fermentierte (alkoholische) Getränke, Fermentierte Milchprodukte, Probiotika, Fermentierte Fleischprodukte, Traditionelle Fermentationsprodukte, Kaffee, Tee, Kakao, Tabak; Störungen der Fermentation (Viren, Antibiotika, Desinfektionsmittel)

Haltbarmachung I: Physikalische Verfahren
Erniedrigung der Wasseraktivität, Erniedrigung der Temperatur, Hitzebehandlung, Hochdruckbehandlung, Bestrahlung

Haltbarmachung II. Chemische Verfahren
Natürliche antimikrobielle Stoffe, Räuchern, Konservierungsstoffe, Erniedrigung des pH Wertes, Schutzgas- und Vakuumverpackung

Haltbarmachung III. Biologische Verfahren
Zusatz von Enzymen, Schutzkulturen, Starter- und Reifungskulturen

Qualitätssicherung und Kontrolle
Gesetzliche Kriterien & Verordnungen, Betriebs- & Personalhygiene, Reinigung & Desinfektion, GHP & HACCP
SkriptElektronische PDF Kopien der Praesentationsfolien werden an die Studenten abgegeben
LiteraturHinweise in der ersten Vorlesungsstunde
Voraussetzungen / BesonderesDie Vorlesung "Lebensmittelmikrobiologie I" (oder eine ähnliche Veranstaltung) wird inhaltlich vorausgesetzt
529-0732-00LProteins and LipidsW6 KP3GD. Hilvert
KurzbeschreibungAn overview of the relationship between protein sequence, conformation and function.
LernzielOverview of the relationship between protein sequence, conformation and function.
InhaltProteins, structures and properties, (bio)synthesis of polypeptides, protein folding and design, protein engineering, chemical modification of proteins, proteomics.
LiteraturGeneral Literature:
- T.E. Creighton: Proteins: Structures and Molecular Properties, 2nd Edition, H.W. Freeman and Company, New York, 1993.
- C. Branden, J. Tooze , Introduction to Protein Structure, Garland Publishing, New York, 1991.
- J. M. Berg, J. L. Tymoczko, L. Stryer: Biochemistry, 5th edition, H.W. Freeman and Company, New York, 2002.
- G.A. Petsko, D. Ringe: Protein Structure and Function, New Science Press Ltd., London, 2004.

Original Literature:
Citations from the original literature relevant to the individual lectures will be assigned weekly.
551-0326-00LCell Biology Information W6 KP4VS. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz
KurzbeschreibungThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Lernziel-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
551-0324-00LSystems Biology Information W6 KP4VR. Aebersold, B. Christen, M. Claassen, U. Sauer
KurzbeschreibungIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Lernziel- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
InhaltOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Skriptno script
LiteraturThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
551-0320-00LCellular Biochemistry (Part II)W3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-0307-01LMolecular and Structural Biology II: From Gene to Protein
D-BIOL students are obliged to take part I and part II as a two-semester course.
W3 KP2VN. Ban, F. Allain, S. Jonas, M. Pilhofer
KurzbeschreibungThis course will cover advanced topics in molecular biology and biochemistry with emphasis on the structure and function of cellular assemblies involved in expression and maintenance of genetic information. We will cover the architecture and the function of molecules involved in DNA replication, transcription, translation, nucleic acid packaging in viruses, RNA processing, and CRISPER/CAS system.
LernzielStudents will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes ranging from DNA replication, transcription and translation. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation.
InhaltAdvanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies.
SkriptUpdated handouts will be provided during the class.
LiteraturThe lecture will be based on the latest literature. Additional suggested
literature:
Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed.
(1995). Garland, New York.
Wahlvertiefung: Zellbiologie
Obligatorische Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0326-00LCell Biology Information O6 KP4VS. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz
KurzbeschreibungThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Lernziel-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
Wahlpflicht Konzeptkurse
Siehe D-BIOL Master-Wegleitung
NummerTitelTypECTSUmfangDozierende
551-0324-00LSystems Biology Information W6 KP4VR. Aebersold, B. Christen, M. Claassen, U. Sauer
KurzbeschreibungIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Lernziel- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
InhaltOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Skriptno script
LiteraturThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
551-0320-00LCellular Biochemistry (Part II)W3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-0318-00LImmunology IIW3 KP2VA. Oxenius, M. Kopf, S. R. Leibundgut, E. Wetter Slack, weitere Dozierende
KurzbeschreibungEinführung in die zellulären und molekularen Grundlagen des Immunsystems und die Immunreaktionen gegen verschiedene Pathogene, Tumore, Transplantate, und körpereigene Strukturen (Autoimmunität)
LernzielDie Vorlesung soll ein grundlegendes Verständnis vermitteln über:
- die Interaktion der verschiedenen Immunzellen auf zellulärer und molekularer Ebene?
- Erkennung und Abwehr ausgewählter Viren, Bakterien, und Parasiten.
- Abwehr von Tumoren.
- Mechanismen der Toleranz für körpereigene Moleküle.
- Funktion des Immunsystems im Darm und warum kommensale Bakterien keine Immunantwort auslösen.
- Immunpathologie und entzündliche Erkrankungen.
InhaltZiel dieser Vorlesung ist das Verständnis:
> Wie Pathogene vom unspezifischen Immunystem erkannt werden
> Wie Pathogene vom Immunsystem bekämpft werden
> Immunantworten der Haut, Lung, und Darms
> Tumorimmunologie
> Migration von Immunzellen
> Toleranz und Autoimmunität
> das Gedächtnis von T Zellen
SkriptDie Vorlesungsunterlagen der Dozenten sind verfügbar in Moodle
LiteraturEmpfohlen: Kuby Immunology (Freeman)
376-0209-00LMolecular Disease MechanismsW6 KP4VC. Wolfrum, H. Gahlon, M. Kopf
KurzbeschreibungIn this course the mechanisms of disease development will be studied. Main topics will be:

1. Influence of environmental factors with an emphasis on inflammation and the immune response.
2. Mechanisms underlying disease progression in metabolic disorders, integrating genetic and environmental factors.
3. Mechanisms underlying disease progression in cancer, integrating genetic and environment
LernzielTo understand the mechanisms governing disease development with a special emphasis on genetic and environmental associated components
SkriptAll information can be found at:

https://moodle-app2.let.ethz.ch/course/view.php?id=690

The enrollment key will be provided by email
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
551-1100-00LInfectious Agents: From Molecular Biology to Disease
Number of participants limited to 22.
Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures.
(if you missed the deadline, please come to the first date to see, if there are any slots left)
W4 KP2SW.‑D. Hardt, L. Eberl, U. F. Greber, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander
KurzbeschreibungLiterature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.
LernzielWorking with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.
Inhaltfor each model pathogen (or key technology):
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
SkriptTeachers will provide the research papers to be discussed.
Students will prepare handouts for the rest of the group for their assigned seminar.
LiteraturTeachers will provide the research papers to be discussed.
Voraussetzungen / BesonderesRestricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to micro_secr@micro.biol.ethz.ch and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.
The first seminar date will serve to form groups of students and assign a paper to each group.
551-0512-00LCurrent Topics in Molecular and Cellular Neurobiology Belegung eingeschränkt - Details anzeigen
Findet dieses Semester nicht statt.
Number of participants limited to 8
W2 KP1SU. Suter
KurzbeschreibungThe course is a literature seminar or "journal club". Each Friday a student, or a member of the Suter Lab in the Institute of Molecular Health Sciences, will present a paper from the recent literature.
LernzielThe course introduces you to recent developments in the fields of cellular and molecular neurobiology. It also supports you to develop your skills in critically reading the scientific literature. You should be able to grasp what the authors wanted to learn e.g. their goals, why the authors chose the experimental approach they used, the strengths and weaknesses of the experiments and the data presented, and how the work fits into the wider literature in the field. You will present one paper yourself, which provides you with practice in public speaking.
InhaltYou will present one paper yourself. Give an introduction to the field of the paper, then show and comment on the main results (all the papers we present are available online, so you can show original figures with a beamer). Finish with a summary of the main points and a discussion of their significance.
You are expected to take part in the discussion and to ask questions. To prepare for this you should read all the papers beforehand (they will be announced a week in advance of the presentation).
SkriptPresentations will be made available after the seminars.
LiteraturWe cover a range of themes related to development and neurobiology. Before starting your preparations, you are required to check with Laura Montani (laura.montani@biol.ethz.ch), who helps you with finding an appropriate paper.
Voraussetzungen / BesonderesYou must attend at least 80% of the journal clubs, and give a presentation of your own. At the end of the semester there will be a 30 minute oral exam on the material presented during the semester. The grade will be based on the exam (45%), your presentation (45%), and a contribution based on your active participation in discussion of other presentations (10%).
551-1118-00LCutting Edge Topics: Immunology and Infection Biology II Information W2 KP1SA. Oxenius, B. Becher, C. Halin Winter, N. C. Joller, M. Kopf, S. R. Leibundgut, C. Münz, F. Sallusto, R. Spörri, M. van den Broek, Uni-Dozierende
KurzbeschreibungWöchentliches Seminar über aktuelle Themen der Immunologie und Infektionsbiologie. International renommierte Experten referieren über ihre aktuellen Forschungsresultate mit anschliessender offener Diskussion.
LernzielWöchentliches Seminar über aktuelle Themen der Immunologie und Infektionsbiologie. International renommierte Experten referieren über ihre aktuellen Forschungsresultate mit anschliessender offener Diskussion.
Ziel der Veranstaltung ist die Konfrontation von Studenten und Doktoranden mit aktuellen Forschungsthemen und mit wissenschaftlicher Vortragsform. Studenten und Doktoranden wird die Gelegenheit geboten, sich mit diversen Themen vertieft auseinander zu setzen, welche oft in den Konzeptkursen nur knapp präsentiert werden und mit Experten auf dem Gebiet zu diskutieren.
InhaltImmunologie und Infektionsbiologie.
Die speziellen Themen variieren jedes Semester und hängen von den eingeladenen Experten ab.
551-1310-00LA Problem-Based Approach to Cellular Biochemistry Belegung eingeschränkt - Details anzeigen
Number of participants limited to 15.
W6 KP2GM. Peter, E. Dultz, M. Gstaiger, V. Korkhov, V. Panse, A. E. Smith
KurzbeschreibungIndependent, guided acquisition of an overview over a defined area of research, identification of important open questions, development of an experimental strategy to address a defined question, and formulation of this strategy within the framework of a research grant.
LernzielThe students will learn to acquire independently an overview over a defined area of research, and to identify important open questions. In addition, they will learn to develop an experimental strategy to address a defined question, and to formulate this strategy within the framework of a research grant.
InhaltThe students will work in groups of two to three, in close contact with a tutor (ETH Prof or senior scientist). A research overview with open questions and a research grant will be developed independently by the students, with guidance from the tutor through regular mandatory meetings. The students will write both the research overview with open questions and the grant in short reports, and present them to their colleagues.
LiteraturThe identification of appropriate literature is a component of the course.
Voraussetzungen / BesonderesThis course will be taught in english, and requires extensive independent work.
551-0140-00LEpigeneticsW4 KP2VA. Wutz, U. Grossniklaus, R. Paro, R. Santoro
KurzbeschreibungEpigenetik untersucht die Vererbung von Merkmalen, die nicht auf eine Veränderung der DNA Sequenz zurückgeführt werden kann. Die Vorlesung gibt einen Überblick über epigenetische Phänomene und erklärt die zugrundeliegenden molekularen Mechanismen. Die Rolle von epigenetischen Prozessen bei der Krebsentstehung und anderen Krankheiten wird diskutiert.
LernzielDas Ziel des Kurses ist das Verständnis von epigenetischen Mechanismen und deren Funktion in der Entwicklung von Organismen, bei Regenerationsprozessen oder bei der Entstehung von Krankheiten.
InhaltThemen
- Historischer Überblick, Konzepte und Vergleich Genetik vs. Epigenetik
- Biologie von Chromatin: Struktur und Funktion, Organisation im Kern und die Rolle von Histon Modifikationen bei Prozessen wie Transkription und Replikation.
- DNA-Methylierung als epigenetische Modifikation
- Weitergabe epigenetischer Modifikationen während der Zellteilung: das Zellgedächtnis
- Stabilität/Revertierbarkeit epigenetischer Modifikationen: zelluläre Plastizität und Stammzellen.
- Genomisches Imprinting in Pflanzen und in Säugern
- X Chromosom Inaktivierung und Dosiskompensation
- Positionseffekte, Paramutationen und Transvektion
- RNA-induziertes Gensilencing
- die Rolle von epigenetischen Prozessen bei der Krebsentstehung oder der Zellalterung.
551-0224-00LAdvanced Proteomics Belegung eingeschränkt - Details anzeigen
Für Masterstudierende ab 2. Semester, Doktorierende und Postdoktorierende
W4 KP6GR. Aebersold, L. Gillet, M. Gstaiger, A. Leitner, P. Pedrioli
KurzbeschreibungZiel dieses Kurses ist es, etablierte und neue Technologien der Protein- und Proteome-Analyse kennenzulernen in Bezug auf ihre Anwendung in Biologie, Biotechnologie und Medizin.
Format: Einführung durch Dozent mit anschliessender Diskussion, unterstützt durch Literaturarbeit und Übungen.
LernzielIm Kurs werden sowohl die bereits etablierten als auch die neuesten derzeit entstehenden Technologien und Methoden in der Protein- und Proteomanlayse diskutiert im Hinblick auf ihre Anwendung in der Biologie, Biotechnologie, Medizin und Systembiologie.
InhaltBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Voraussetzungen / BesonderesNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students http://www.rektorat.ethz.ch/students/admission/auditors/index_EN
551-1126-00LTechnologies in Molecular MicrobiologyW4 KP2VH.‑M. Fischer, B. Christen, M. Christen, weitere Dozierende
KurzbeschreibungThe lecture course provides an advanced understanding of modern techniques used in molecular microbiology. Current technologies and research directions in molecular microbiology including applied aspects will be illustrated with paper discussions. The format is a lecture course enriched by group activities.
LernzielThe lecture course aims at providing principles of modern techniques used in molecular microbiology. Emphasis is on genetic, biochemical, and cellular analysis including also bioinformatics aspects. Discussion of a set of commonly applied technologies will assist students in evaluating current research in molecular microbiology and choosing appropriate methods for their own demands.
InhaltImportant genetic, biochemical, biophysical, bioinformatic and structural analysis methods will be presented that are used to gain a deeper understanding of the molecular principles and mechanisms underlying basic physiological processes in prokaryotes. Applied aspects of molecular microbiology and current research in this area will also be covered.

List of topics:
- Analysis of genes, genomes and transcriptomes
- Analysis of proteins, proteomes and microbial systems
- Synthetic biology
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references, relevant papers and handouts will be provided during the lectures.
Voraussetzungen / BesonderesThe following lecturers will contribute to the course:

Prof. Beat Christen (ETH)
Dr. Matthias Christen (ETH)
Prof. Hans-Martin Fischer (ETH)
Dr. Jonas Grossmann (FGCZ)
Dr. Florian Freimoser (Agroscope)
Dr. Bernd Roschitzki (FGCZ)
Dr. Roman Spörri (ETH)
551-0338-00LCurrent Approaches in Single Cell Analysis (University of Zurich)
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BIO256

Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/mobilitaet.html
W2 KP1VUni-Dozierende
KurzbeschreibungIn this lecture, we will discuss the most important single cell
approaches, the questions they can address and current developments. We will cover single cell: genomics, transcriptomics, proteomics (CyTOF mass cytometry), metabolomics and highly multiplexed imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data.
LernzielOn completion of this module the students should be able to:
- explain the basic principles of single cell analysis techniques
- identify and justify the limitations of the current single cell
technologies and suggest reasonable improvements
- know the basic challenges in data analysis imposed by the complex
multi parameter data.
Key skills:
On completion of this module the students should be able to:
- summarize and discuss the impact these technologies have on biology
and medicine
- design biological and biomedical experiments for which single cell
analysis is essential
InhaltCurrently single cell analysis approaches revolutionize the way we study and understand biological systems. In all biological and biomedical settings, cell populations and tissues are highly heterogeneous; this heterogeneity plays a critical role in basic biological processes such as cell cycle, development and organismic function, but is also a major player in disease, e.g. for cancer development, diagnosis and treatment.
Currently, single cell analysis techniques are rapidly developing and
find broad application, as the single cell measurements not only enable
to study cell specific functions, but often reveal unexpected biological
mechanisms in so far (assumed) well understood biological processes.
In this lecture, we will discuss the most important single cell approaches, the questions they can address and current developments. We will cover single cell genomics, single cell transcriptomics, single cell proteomics (CyTOF mass cytometry), single cell metabolomics and highly multiplexed single cell imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data.
551-1404-00LRNA and Proteins: Post-Transcriptional Regulation of Gene Expression (University of Zurich)
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BCH252

Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/mobilitaet.html
W3 KP2VUni-Dozierende
KurzbeschreibungThe course introduces the cellular processes and molecular mechanisms involved in regulating genome expression at the post-transcriptional level.
Topics will include :
-RNA processing, and transport;
-protein synthesis and translational control, trafficking and degradation;
-RNA-guided regulation (RNA interference, microRNAs);
-molecular surveillance and quality control mechanisms
Lernziel-Outline the cellular processes
used by eukaryotic and prokaryotic cells
to control gene expression at the post-
transcriptional level.
-Describe the molecular mechanisms
underlying post-transcriptional gene
regulation
-Identify experimental approaches
used to study post-transcriptional gene
regulation and describe their strengths
and weaknesses.
551-1412-00LMolecular and Structural Biology IV: Visualizing Macromolecules by X-Ray Crystallography and EMW4 KP2VN. Ban, D. Böhringer, T. Ishikawa, M. A. Leibundgut, K. Locher, M. Pilhofer, K. Wüthrich, weitere Dozierende
KurzbeschreibungThis course provides an in-depth discussion of two main methods to determine the 3D structures of macromolecules and complexes at high resolution: X-ray crystallography and cryo-electron microscopy. Both techniques result in electron density maps that are interpreted by atomic models.
LernzielStudents will obtain the theoretical background to understand structure determination techniques employed in X-ray crystallography and electron microscopy, including diffraction theory, crystal growth and analysis, reciprocal space calculations, interpretation of electron density, structure building and refinement as well as validation. The course will also provide an introduction into the use of cryo-electron tomography to visualize complex cellular substructures at sub-nanometer resolutions, effectively bridging the resolution gap between optical microscopy and single particle cryo-electron microscopy. Lectures will be complemented with practical sessions where students will have a chance to gain hands on experience with sample preparation, data processing and structure building and refinement.
InhaltFebruary 22 Lecture 1 Prof. Dr. Kurt Wüthrich
History of Structural Molecular Biology

March 1 Lecture 2 Prof. Dr. Kaspar Locher
X-ray diffraction from macromolecular crystals

March 8 Lecture 3 Prof. Dr. Kaspar Locher
Data collection and statistics, phasing methods

March 15 Lecture 4 Prof. Dr. Nenad Ban
Crystal symmetry and space groups

March 22 Lecture 5 Ban Lab
Practical session with X-ray data processing

March 29 Lecture 6 Prof. Dr. Takashi Ishikawa
Principle of cryo-EM for biological macromolecules I, including hardware of TEM and detectors, image formation principle (phase contrast, spherical aberration, CTF), 3D reconstruction (central-section theorem, backprojection, missing information)

April 5 Lecture 7 Dr. Daniel Boehringer
Single particle analysis, including principle (projection matching, random conical tilt, angular reconstitution)

April 12 Lecture 8 Ban Lab
Practical session including specimen preparation (cryo, negative stain, visit to ScopeM

May 3 Lecture 9
Prof. Dr. M. Pilhofer
Tomography I, including basics and subtomogram averaging

May 10 Lecture 10 Ban Lab
Practical session with example initial EM data processing

May 17 Lecture 11 Prof. Dr. Martin Pilhofer
Practical session (including recent techniques, including cryo-FIB)

May 24 Lecture 12 Prof. Dr. Nenad Ban
EM and X-ray structure building, refinement, validation and interpretation

May 31 Lecture 13 Ban Lab
Practical session with model building and refinemen
551-1414-00LMolecular and Structural Biology V: Studying Macromolecules by NMR and EPRW4 KP2VF. Allain, A. D. Gossert, G. Jeschke, K. Wüthrich
KurzbeschreibungThe course provides an overview of experimental methods for studying function and structure of macromolecules at atomic resolution in solution. The two main methods used are Nuclear Magnetic Resonance (NMR) spectroscopy and Electron Paramagnetic Resonance (EPR) spectroscopy.
LernzielInsight into the methodology, areas of application and limitations of these two methods for studying biological macromolecules. Practical exercises with spectra to have hands on understanding of the methodology.
InhaltPart I: Historical overview of structural biology.
Part II: Basic concepts of NMR and initial examples of applications.
2D NMR and isotope labeling for studying protein function and molecular interactions at atomic level.
Studies of dynamic processes of proteins in solution.
Approaches to study large particles.
Methods for determination of protein structures in solution.
Part III: NMR methods for structurally characterizing RNA and protein-RNA complexes.
Part IV: EPR of biomolecules
Literatur1) Wüthrich, K. NMR of Proteins and Nucleic Acids, Wiley-Interscience.
2) Dominguez et al, Prog Nucl Magn Reson Spectrosc. 2011 Feb;58(1-2):1-61.
3) Duss O et al, Methods Enzymol. 2015;558:279-331.
551-1700-00LIntroduction to Flow Cytometry Belegung eingeschränkt - Details anzeigen
Number of participants limited to 24.
W2 KP1VJ. Kisielow, L. Tortola, weitere Dozierende
KurzbeschreibungThe lecture provides an introduction to flow cytometry. We will cover the technology basics, experimental design, data acquisition and analysis of flow and mass cytometry. In addition, various research applications will be discussed. The format is a lecture course enriched by a visit to the ETH Flow Cytometry Core Facility and practical demonstration of the use of analysis and sorting instruments.
LernzielThe goal of this course is to provide the basic knowledge of flow and mass cytometry required for planning and execution of cytometric experiments.
InhaltThe lecture course aims at teaching principles of flow cytometry. The emphasis is on theoretical principles (signal detection, fluorochromes, signal spill-over and compensation) as well as practical aspects of experimental design and performance (sample preparation, controls, data acquisition and analysis).
List of topics:
- Principles of Flow Cytometry
- Signal processing
- Compensation and Controls
- Data analysis, gating and presentation
- Panel design
- Sorting
- Mass cytometry
- High-dimensional data analysis
- Practical demonstration (hardware and software)
Modern flow cytometric techniques for immunophenotyping, analysis of proliferation, cell cycle, apoptosis and cell signalling will be introduced.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references on immunophenotyping, analysis of proliferation, cell cycle, apoptosis and cell signalling will be discussed during the lectures.
376-1306-00LClinical Neuroscience Information W3 KP3GG. Schratt, Uni-Dozierende
KurzbeschreibungThe lecture series "Clinical Neuroscience" presents a comprehensive, condensed overview of the most important neurological diseases, their clinical presentation, diagnosis, therapy options and possible causes. Patient demonstrations (Übungen) follow every lecture that is dedicated to a particular disease.
LernzielBy the end of this module students should be able to:
- demonstrate their understanding and deep knowledge concerning the main neurological diseases
- identify and explain the different clinical presentation of these diseases, the methodology of diagnosis and the current therapies available
- summarize and critically review scientific literature efficiently and effectively
701-1708-00LInfectious Disease DynamicsW4 KP2VS. Bonhoeffer, R. D. Kouyos, R. R. Regös, T. Stadler
KurzbeschreibungThis course introduces into current research on the population biology of infectious diseases. The course discusses the most important mathematical tools and their application to relevant diseases of human, natural or managed populations.
LernzielAttendees will learn about:
* the impact of important infectious pathogens and their evolution on human, natural and managed populations
* the population biological impact of interventions such as treatment or vaccination
* the impact of population structure on disease transmission

Attendees will learn how:
* the emergence spread of infectious diseases is described mathematically
* the impact of interventions can be predicted and optimized with mathematical models
* population biological models are parameterized from empirical data
* genetic information can be used to infer the population biology of the infectious disease

The course will focus on how the formal methods ("how") can be used to derive biological insights about the host-pathogen system ("about").
InhaltAfter an introduction into the history of infectious diseases and epidemiology the course will discuss basic epidemiological models and the mathematical methods of their analysis. We will then discuss the population dynamical effects of intervention strategies such as vaccination and treatment. In the second part of the course we will introduce into more advanced topics such as the effect of spatial population structure, explicit contact structure, host heterogeneity, and stochasticity. In the final part of the course we will introduce basic concepts of phylogenetic analysis in the context of infectious diseases.
SkriptSlides and script of the lecture will be available online.
LiteraturThe course is not based on any of the textbooks below, but they are excellent choices as accompanying material:
* Keeling & Rohani, Modeling Infectious Diseases in Humans and Animals, Princeton Univ Press 2008
* Anderson & May, Infectious Diseases in Humans, Oxford Univ Press 1990
* Murray, Mathematical Biology, Springer 2002/3
* Nowak & May, Virus Dynamics, Oxford Univ Press 2000
* Holmes, The Evolution and Emergence of RNA Viruses, Oxford Univ Press 2009
Voraussetzungen / BesonderesBasic knowledge of population dynamics and population genetics as well as linear algebra and analysis will be an advantage.
Wahlvertiefung: Molekulare Gesundheitswissenschaften
Obligatorische Konzeptkurse
NummerTitelTypECTSUmfangDozierende
376-0209-00LMolecular Disease MechanismsO6 KP4VC. Wolfrum, H. Gahlon, M. Kopf
KurzbeschreibungIn this course the mechanisms of disease development will be studied. Main topics will be:

1. Influence of environmental factors with an emphasis on inflammation and the immune response.
2. Mechanisms underlying disease progression in metabolic disorders, integrating genetic and environmental factors.
3. Mechanisms underlying disease progression in cancer, integrating genetic and environment
LernzielTo understand the mechanisms governing disease development with a special emphasis on genetic and environmental associated components
SkriptAll information can be found at:

https://moodle-app2.let.ethz.ch/course/view.php?id=690

The enrollment key will be provided by email
Wahlpflicht Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0326-00LCell Biology Information W6 KP4VS. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz
KurzbeschreibungThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Lernziel-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
551-1310-00LA Problem-Based Approach to Cellular Biochemistry Belegung eingeschränkt - Details anzeigen
Number of participants limited to 15.
W6 KP2GM. Peter, E. Dultz, M. Gstaiger, V. Korkhov, V. Panse, A. E. Smith
KurzbeschreibungIndependent, guided acquisition of an overview over a defined area of research, identification of important open questions, development of an experimental strategy to address a defined question, and formulation of this strategy within the framework of a research grant.
LernzielThe students will learn to acquire independently an overview over a defined area of research, and to identify important open questions. In addition, they will learn to develop an experimental strategy to address a defined question, and to formulate this strategy within the framework of a research grant.
InhaltThe students will work in groups of two to three, in close contact with a tutor (ETH Prof or senior scientist). A research overview with open questions and a research grant will be developed independently by the students, with guidance from the tutor through regular mandatory meetings. The students will write both the research overview with open questions and the grant in short reports, and present them to their colleagues.
LiteraturThe identification of appropriate literature is a component of the course.
Voraussetzungen / BesonderesThis course will be taught in english, and requires extensive independent work.
551-0512-00LCurrent Topics in Molecular and Cellular Neurobiology Belegung eingeschränkt - Details anzeigen
Findet dieses Semester nicht statt.
Number of participants limited to 8
W2 KP1SU. Suter
KurzbeschreibungThe course is a literature seminar or "journal club". Each Friday a student, or a member of the Suter Lab in the Institute of Molecular Health Sciences, will present a paper from the recent literature.
LernzielThe course introduces you to recent developments in the fields of cellular and molecular neurobiology. It also supports you to develop your skills in critically reading the scientific literature. You should be able to grasp what the authors wanted to learn e.g. their goals, why the authors chose the experimental approach they used, the strengths and weaknesses of the experiments and the data presented, and how the work fits into the wider literature in the field. You will present one paper yourself, which provides you with practice in public speaking.
InhaltYou will present one paper yourself. Give an introduction to the field of the paper, then show and comment on the main results (all the papers we present are available online, so you can show original figures with a beamer). Finish with a summary of the main points and a discussion of their significance.
You are expected to take part in the discussion and to ask questions. To prepare for this you should read all the papers beforehand (they will be announced a week in advance of the presentation).
SkriptPresentations will be made available after the seminars.
LiteraturWe cover a range of themes related to development and neurobiology. Before starting your preparations, you are required to check with Laura Montani (laura.montani@biol.ethz.ch), who helps you with finding an appropriate paper.
Voraussetzungen / BesonderesYou must attend at least 80% of the journal clubs, and give a presentation of your own. At the end of the semester there will be a 30 minute oral exam on the material presented during the semester. The grade will be based on the exam (45%), your presentation (45%), and a contribution based on your active participation in discussion of other presentations (10%).
551-0140-00LEpigeneticsW4 KP2VA. Wutz, U. Grossniklaus, R. Paro, R. Santoro
KurzbeschreibungEpigenetik untersucht die Vererbung von Merkmalen, die nicht auf eine Veränderung der DNA Sequenz zurückgeführt werden kann. Die Vorlesung gibt einen Überblick über epigenetische Phänomene und erklärt die zugrundeliegenden molekularen Mechanismen. Die Rolle von epigenetischen Prozessen bei der Krebsentstehung und anderen Krankheiten wird diskutiert.
LernzielDas Ziel des Kurses ist das Verständnis von epigenetischen Mechanismen und deren Funktion in der Entwicklung von Organismen, bei Regenerationsprozessen oder bei der Entstehung von Krankheiten.
InhaltThemen
- Historischer Überblick, Konzepte und Vergleich Genetik vs. Epigenetik
- Biologie von Chromatin: Struktur und Funktion, Organisation im Kern und die Rolle von Histon Modifikationen bei Prozessen wie Transkription und Replikation.
- DNA-Methylierung als epigenetische Modifikation
- Weitergabe epigenetischer Modifikationen während der Zellteilung: das Zellgedächtnis
- Stabilität/Revertierbarkeit epigenetischer Modifikationen: zelluläre Plastizität und Stammzellen.
- Genomisches Imprinting in Pflanzen und in Säugern
- X Chromosom Inaktivierung und Dosiskompensation
- Positionseffekte, Paramutationen und Transvektion
- RNA-induziertes Gensilencing
- die Rolle von epigenetischen Prozessen bei der Krebsentstehung oder der Zellalterung.
701-1350-00LCase Studies in Environment and HealthW4 KP2VK. McNeill, N. Borduas-Dedekind, T. Julian
KurzbeschreibungThis course will focus on a few individual chemicals and pathogens from different standpoints: their basic chemistry or biology, their environmental behavior, (eco)toxicology, and human health impacts. The course will draw out the common points in each chemical or pathogen's history.
LernzielThis course aims to illustrate how the individual properties of chemicals and pathogens along with societal pressures lead to environmental and human health crises. The ultimate goal of the course is to identify common aspects that will improve prediction of environmental crises before they occur. Students are expected to participate actively in the course, which includes the critical reading of the pertinent literature and class presentations.
InhaltEach semester will feature case studies of chemicals and pathogens that have had a profound effect on human health and the environment. The instructors will present eight of these and the students will present approx. six in groups of three or four. Students will be expected to contribute to the discussion and, on selected topics, to lead the discussion.
SkriptHandouts will be provided as needed.
LiteraturHandouts will be provided as needed.
551-1100-00LInfectious Agents: From Molecular Biology to Disease
Number of participants limited to 22.
Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures.
(if you missed the deadline, please come to the first date to see, if there are any slots left)
W4 KP2SW.‑D. Hardt, L. Eberl, U. F. Greber, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander
KurzbeschreibungLiterature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.
LernzielWorking with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.
Inhaltfor each model pathogen (or key technology):
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
SkriptTeachers will provide the research papers to be discussed.
Students will prepare handouts for the rest of the group for their assigned seminar.
LiteraturTeachers will provide the research papers to be discussed.
Voraussetzungen / BesonderesRestricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to micro_secr@micro.biol.ethz.ch and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.
The first seminar date will serve to form groups of students and assign a paper to each group.
227-0396-00LEXCITE Interdisciplinary Summer School on Bio-Medical Imaging Information Belegung eingeschränkt - Details anzeigen
The school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process.

Students have to apply for acceptance by April 22, 2019. To apply a curriculum vitae and an application letter need to be submitted. The notification of acceptance will be given by May 24, 2019. Further information can be found at: www.excite.ethz.ch.
W4 KP6GS. Kozerke, G. Csúcs, J. Klohs-Füchtemeier, S. F. Noerrelykke, M. P. Wolf
KurzbeschreibungTwo-week summer school organized by EXCITE (Center for EXperimental & Clinical Imaging TEchnologies Zurich) on biological and medical imaging. The course covers X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, infrared and optical microscopy, electron microscopy, image processing and analysis.
LernzielStudents understand basic concepts and implementations of biological and medical imaging. Based on relative advantages and limitations of each method they can identify preferred procedures and applications. Common foundations and conceptual differences of the methods can be explained.
InhaltTwo-week summer school on biological and medical imaging. The course covers concepts and implementations of X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, infrared and optical microscopy and electron microscopy. Multi-modal and multi-scale imaging and supporting technologies such as image analysis and modeling are discussed. Dedicated modules for physical and life scientists taking into account the various backgrounds are offered.
SkriptHand-outs, Web links
Voraussetzungen / BesonderesThe school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process. To apply a curriculum vitae, a statement of purpose and applicants references need to be submitted. Further information can be found at: http://www.excite.ethz.ch/education/summer-school.html
227-0946-00LMolecular Imaging - Basic Principles and Biomedical ApplicationsW2 KP2VM. Rudin
KurzbeschreibungConcept: What is molecular imaging.
Discussion/comparison of the various imaging modalities used in molecular imaging.
Design of target specific probes: specificity, delivery, amplification strategies.
Biomedical Applications.
LernzielMolecular Imaging is a rapidly emerging discipline that translates concepts developed in molecular biology and cellular imaging to in vivo imaging in animals and ultimatly in humans. Molecular imaging techniques allow the study of molecular events in the full biological context of an intact organism and will therefore become an indispensable tool for biomedical research.
InhaltConcept: What is molecular imaging.
Discussion/comparison of the various imaging modalities used in molecular imaging.
Design of target specific probes: specificity, delivery, amplification strategies.
Biomedical Applications.
551-1132-00LAllgemeine Virologie Information
Findet dieses Semester nicht statt.
W2 KP1V
KurzbeschreibungEinführung in die Grundlagen der Virologie, welche die Charakterisierung von Viren, die Interaktionen der Viren mit infizierten Zellen, Wirten und Populationen, die Grundlagen des Schutzes vor Infektion und die Virusdiagnostik beinhaltet.
LernzielEinführung in die Grundlagen der Virologie.
InhaltGrundlagen der Virologie. Charakterisierung von Viren. Virus-Zell-Interaktionen. Virus-Wirt-Interaktionen. Virus-Population-Interaktionen. Schutz vor Virusinfektion. Virusdiagnostik.
SkriptDie Vorlesung ist auf dem Lehrbuch "Allgemeine Virologie" von Kurt Tobler, Mathias Ackermann und Cornel Fraefel aufgebaut.

Die Präsentationsfolien und ausgewählte Primärliteratur werden 24 bis 48 Stunden vor den Lektionen als .pdf-Dateien bereitgestellt.
LiteraturKurt Tobler, Mathias Ackermann und Cornel Fraefel,
Allgemeine Virologie, 2016,
1. Auflage UTB-Band-Nr.:4516 Haupt Verlag Bern
ISBN: 978-3-8252-4516-0
Voraussetzungen / BesonderesGrundkenntnisse in Molekularbiologie, Zellbiologie und Immunologie
376-1306-00LClinical Neuroscience Information W3 KP3GG. Schratt, Uni-Dozierende
KurzbeschreibungThe lecture series "Clinical Neuroscience" presents a comprehensive, condensed overview of the most important neurological diseases, their clinical presentation, diagnosis, therapy options and possible causes. Patient demonstrations (Übungen) follow every lecture that is dedicated to a particular disease.
LernzielBy the end of this module students should be able to:
- demonstrate their understanding and deep knowledge concerning the main neurological diseases
- identify and explain the different clinical presentation of these diseases, the methodology of diagnosis and the current therapies available
- summarize and critically review scientific literature efficiently and effectively
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 KP2GA. Ferrari, K. Würtz-Kozak, M. Zenobi-Wong
KurzbeschreibungThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
LernzielThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
InhaltTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include osteogenesis (bones), chondrogenesis (cartilage), and tendogenesis (tendons). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Skriptn/a
LiteraturTopical Scientific Manuscripts
551-0364-00LFunctional Genomics
Information for UZH students:
Enrolment to this course unit only possible at ETH. No enrolment to module BIO 254 at UZH.

Please mind the ETH enrolment deadlines for UZH students: Link
W3 KP2VC. von Mering, C. Beyer, B. Bodenmiller, M. Gstaiger, H. Rehrauer, R. Schlapbach, K. Shimizu, N. Zamboni, weitere Dozierende
KurzbeschreibungFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data.
LernzielFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data. Such data provide the basis for systems biology efforts to elucidate the structure, dynamics and regulation of cellular networks.
InhaltThe curriculum of the Functional Genomics course emphasizes an in depth understanding of new technology platforms for modern genomics and advanced genetics, including the application of functional genomics approaches such as advanced microarrays, proteomics, metabolomics, clustering and classification. Students will learn quality controls and standards (benchmarking) that apply to the generation of quantitative data and will be able to analyze and interpret these data. The training obtained in the Functional Genomics course will be immediately applicable to experimental research and design of systems biology projects.
Voraussetzungen / BesonderesThe Functional Genomics course will be taught in English.
551-0338-00LCurrent Approaches in Single Cell Analysis (University of Zurich)
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BIO256

Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/mobilitaet.html
W2 KP1VUni-Dozierende
KurzbeschreibungIn this lecture, we will discuss the most important single cell
approaches, the questions they can address and current developments. We will cover single cell: genomics, transcriptomics, proteomics (CyTOF mass cytometry), metabolomics and highly multiplexed imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data.
LernzielOn completion of this module the students should be able to:
- explain the basic principles of single cell analysis techniques
- identify and justify the limitations of the current single cell
technologies and suggest reasonable improvements
- know the basic challenges in data analysis imposed by the complex
multi parameter data.
Key skills:
On completion of this module the students should be able to:
- summarize and discuss the impact these technologies have on biology
and medicine
- design biological and biomedical experiments for which single cell
analysis is essential
InhaltCurrently single cell analysis approaches revolutionize the way we study and understand biological systems. In all biological and biomedical settings, cell populations and tissues are highly heterogeneous; this heterogeneity plays a critical role in basic biological processes such as cell cycle, development and organismic function, but is also a major player in disease, e.g. for cancer development, diagnosis and treatment.
Currently, single cell analysis techniques are rapidly developing and
find broad application, as the single cell measurements not only enable
to study cell specific functions, but often reveal unexpected biological
mechanisms in so far (assumed) well understood biological processes.
In this lecture, we will discuss the most important single cell approaches, the questions they can address and current developments. We will cover single cell genomics, single cell transcriptomics, single cell proteomics (CyTOF mass cytometry), single cell metabolomics and highly multiplexed single cell imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data.
551-1404-00LRNA and Proteins: Post-Transcriptional Regulation of Gene Expression (University of Zurich)
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BCH252

Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/mobilitaet.html
W3 KP2VUni-Dozierende
KurzbeschreibungThe course introduces the cellular processes and molecular mechanisms involved in regulating genome expression at the post-transcriptional level.
Topics will include :
-RNA processing, and transport;
-protein synthesis and translational control, trafficking and degradation;
-RNA-guided regulation (RNA interference, microRNAs);
-molecular surveillance and quality control mechanisms
Lernziel-Outline the cellular processes
used by eukaryotic and prokaryotic cells
to control gene expression at the post-
transcriptional level.
-Describe the molecular mechanisms
underlying post-transcriptional gene
regulation
-Identify experimental approaches
used to study post-transcriptional gene
regulation and describe their strengths
and weaknesses.
636-0111-00LSynthetic Biology I
Attention: This course was offered in previous semesters with the number: 636-0002-00L "Synthetic Biology I". Students that already passed course 636-0002-00L cannot receive credits for course 636-0111-00L.
W4 KP3GS. Panke, J. Stelling
KurzbeschreibungTheoretical & practical introduction into the design of dynamic biological systems at different levels of abstraction, ranging from biological fundamentals of systems design (introduction to bacterial gene regulation, elements of transcriptional & translational control, advanced genetic engineering) to engineering design principles (standards, abstractions) mathematical modelling & systems desig
LernzielAfter the course, students will be able to theoretically master the biological and engineering fundamentals required for biological design to be able to participate in the international iGEM competition (see www.syntheticbiology.ethz.ch).
InhaltThe overall goal of the course is to familiarize the students with the potential, the requirements and the problems of designing dynamic biological elements that are of central importance for manipulating biological systems, primarily (but not exclusively) prokaryotic systems. Next, the students will be taken through a number of successful examples of biological design, such as toggle switches, pulse generators, and oscillating systems, and apply the biological and engineering fundamentals to these examples, so that they get hands-on experience on how to integrate the various disciplines on their way to designing biological systems.
SkriptHandouts during classes.
LiteraturMark Ptashne, A Genetic Switch (3rd ed), Cold Spring Haror Laboratory Press
Uri Alon, An Introduction to Systems Biology, Chapman & Hall
Voraussetzungen / Besonderes1) Though we do not place a formal requirement for previous participation in particular courses, we expect all participants to be familiar with a certain level of biology and of mathematics. Specifically, there will be material for self study available on http://www.bsse.ethz.ch/bpl/education/index as of mid January, and everybody is expected to be fully familiar with this material BEFORE THE CLASS BEGINS to be able to follow the different lectures. Please contact sven.panke@bsse.ethz.ch for access to material
2) The course is also thought as a preparation for the participation in the international iGEM synthetic biology summer competition (www.syntheticbiology.ethz.ch, http://www.igem.org). This competition is also the contents of the course Synthetic Biology II. http://www.bsse.ethz.ch/bpl/education/index
551-1700-00LIntroduction to Flow Cytometry Belegung eingeschränkt - Details anzeigen
Number of participants limited to 24.
W2 KP1VJ. Kisielow, L. Tortola, weitere Dozierende
KurzbeschreibungThe lecture provides an introduction to flow cytometry. We will cover the technology basics, experimental design, data acquisition and analysis of flow and mass cytometry. In addition, various research applications will be discussed. The format is a lecture course enriched by a visit to the ETH Flow Cytometry Core Facility and practical demonstration of the use of analysis and sorting instruments.
LernzielThe goal of this course is to provide the basic knowledge of flow and mass cytometry required for planning and execution of cytometric experiments.
InhaltThe lecture course aims at teaching principles of flow cytometry. The emphasis is on theoretical principles (signal detection, fluorochromes, signal spill-over and compensation) as well as practical aspects of experimental design and performance (sample preparation, controls, data acquisition and analysis).
List of topics:
- Principles of Flow Cytometry
- Signal processing
- Compensation and Controls
- Data analysis, gating and presentation
- Panel design
- Sorting
- Mass cytometry
- High-dimensional data analysis
- Practical demonstration (hardware and software)
Modern flow cytometric techniques for immunophenotyping, analysis of proliferation, cell cycle, apoptosis and cell signalling will be introduced.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references on immunophenotyping, analysis of proliferation, cell cycle, apoptosis and cell signalling will be discussed during the lectures.
701-1708-00LInfectious Disease DynamicsW4 KP2VS. Bonhoeffer, R. D. Kouyos, R. R. Regös, T. Stadler
KurzbeschreibungThis course introduces into current research on the population biology of infectious diseases. The course discusses the most important mathematical tools and their application to relevant diseases of human, natural or managed populations.
LernzielAttendees will learn about:
* the impact of important infectious pathogens and their evolution on human, natural and managed populations
* the population biological impact of interventions such as treatment or vaccination
* the impact of population structure on disease transmission

Attendees will learn how:
* the emergence spread of infectious diseases is described mathematically
* the impact of interventions can be predicted and optimized with mathematical models
* population biological models are parameterized from empirical data
* genetic information can be used to infer the population biology of the infectious disease

The course will focus on how the formal methods ("how") can be used to derive biological insights about the host-pathogen system ("about").
InhaltAfter an introduction into the history of infectious diseases and epidemiology the course will discuss basic epidemiological models and the mathematical methods of their analysis. We will then discuss the population dynamical effects of intervention strategies such as vaccination and treatment. In the second part of the course we will introduce into more advanced topics such as the effect of spatial population structure, explicit contact structure, host heterogeneity, and stochasticity. In the final part of the course we will introduce basic concepts of phylogenetic analysis in the context of infectious diseases.
SkriptSlides and script of the lecture will be available online.
LiteraturThe course is not based on any of the textbooks below, but they are excellent choices as accompanying material:
* Keeling & Rohani, Modeling Infectious Diseases in Humans and Animals, Princeton Univ Press 2008
* Anderson & May, Infectious Diseases in Humans, Oxford Univ Press 1990
* Murray, Mathematical Biology, Springer 2002/3
* Nowak & May, Virus Dynamics, Oxford Univ Press 2000
* Holmes, The Evolution and Emergence of RNA Viruses, Oxford Univ Press 2009
Voraussetzungen / BesonderesBasic knowledge of population dynamics and population genetics as well as linear algebra and analysis will be an advantage.
Wahlvertiefung: Biochemie
Obligatorische Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0320-00LCellular Biochemistry (Part II)O3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
Obligatorische Masterkurs
NummerTitelTypECTSUmfangDozierende
551-1310-00LA Problem-Based Approach to Cellular Biochemistry Belegung eingeschränkt - Details anzeigen
Number of participants limited to 15.
O6 KP2GM. Peter, E. Dultz, M. Gstaiger, V. Korkhov, V. Panse, A. E. Smith
KurzbeschreibungIndependent, guided acquisition of an overview over a defined area of research, identification of important open questions, development of an experimental strategy to address a defined question, and formulation of this strategy within the framework of a research grant.
LernzielThe students will learn to acquire independently an overview over a defined area of research, and to identify important open questions. In addition, they will learn to develop an experimental strategy to address a defined question, and to formulate this strategy within the framework of a research grant.
InhaltThe students will work in groups of two to three, in close contact with a tutor (ETH Prof or senior scientist). A research overview with open questions and a research grant will be developed independently by the students, with guidance from the tutor through regular mandatory meetings. The students will write both the research overview with open questions and the grant in short reports, and present them to their colleagues.
LiteraturThe identification of appropriate literature is a component of the course.
Voraussetzungen / BesonderesThis course will be taught in english, and requires extensive independent work.
Wahlpflicht Konzeptkurse
Siehe D-BIOL Master-Wegleitung
NummerTitelTypECTSUmfangDozierende
551-0326-00LCell Biology Information W6 KP4VS. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz
KurzbeschreibungThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Lernziel-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
551-0307-01LMolecular and Structural Biology II: From Gene to Protein
D-BIOL students are obliged to take part I and part II as a two-semester course.
W3 KP2VN. Ban, F. Allain, S. Jonas, M. Pilhofer
KurzbeschreibungThis course will cover advanced topics in molecular biology and biochemistry with emphasis on the structure and function of cellular assemblies involved in expression and maintenance of genetic information. We will cover the architecture and the function of molecules involved in DNA replication, transcription, translation, nucleic acid packaging in viruses, RNA processing, and CRISPER/CAS system.
LernzielStudents will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes ranging from DNA replication, transcription and translation. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation.
InhaltAdvanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies.
SkriptUpdated handouts will be provided during the class.
LiteraturThe lecture will be based on the latest literature. Additional suggested
literature:
Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed.
(1995). Garland, New York.
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
551-0140-00LEpigeneticsW4 KP2VA. Wutz, U. Grossniklaus, R. Paro, R. Santoro
KurzbeschreibungEpigenetik untersucht die Vererbung von Merkmalen, die nicht auf eine Veränderung der DNA Sequenz zurückgeführt werden kann. Die Vorlesung gibt einen Überblick über epigenetische Phänomene und erklärt die zugrundeliegenden molekularen Mechanismen. Die Rolle von epigenetischen Prozessen bei der Krebsentstehung und anderen Krankheiten wird diskutiert.
LernzielDas Ziel des Kurses ist das Verständnis von epigenetischen Mechanismen und deren Funktion in der Entwicklung von Organismen, bei Regenerationsprozessen oder bei der Entstehung von Krankheiten.
InhaltThemen
- Historischer Überblick, Konzepte und Vergleich Genetik vs. Epigenetik
- Biologie von Chromatin: Struktur und Funktion, Organisation im Kern und die Rolle von Histon Modifikationen bei Prozessen wie Transkription und Replikation.
- DNA-Methylierung als epigenetische Modifikation
- Weitergabe epigenetischer Modifikationen während der Zellteilung: das Zellgedächtnis
- Stabilität/Revertierbarkeit epigenetischer Modifikationen: zelluläre Plastizität und Stammzellen.
- Genomisches Imprinting in Pflanzen und in Säugern
- X Chromosom Inaktivierung und Dosiskompensation
- Positionseffekte, Paramutationen und Transvektion
- RNA-induziertes Gensilencing
- die Rolle von epigenetischen Prozessen bei der Krebsentstehung oder der Zellalterung.
551-1100-00LInfectious Agents: From Molecular Biology to Disease
Number of participants limited to 22.
Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures.
(if you missed the deadline, please come to the first date to see, if there are any slots left)
W4 KP2SW.‑D. Hardt, L. Eberl, U. F. Greber, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander
KurzbeschreibungLiterature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.
LernzielWorking with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.
Inhaltfor each model pathogen (or key technology):
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
SkriptTeachers will provide the research papers to be discussed.
Students will prepare handouts for the rest of the group for their assigned seminar.
LiteraturTeachers will provide the research papers to be discussed.
Voraussetzungen / BesonderesRestricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to micro_secr@micro.biol.ethz.ch and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.
The first seminar date will serve to form groups of students and assign a paper to each group.
551-1402-00LMolecular and Structural Biology VI: Biophysical Analysis of Macromolecular Mechanisms
This course is strongly recommended for the Masters Major "Biology and Biophysics".
W4 KP2VR. Glockshuber, T. Ishikawa, S. Jonas, B. Schuler, D. Veprintsev, E. Weber-Ban
KurzbeschreibungThe course is focussed on biophysical methods for characterising conformational transitions and reaction mechanisms of proteins and biological mecromolecules, with focus on methods that have not been covered in the Biology Bachelor Curriculum.
LernzielThe goal of the course is to give the students a broad overview on biopyhsical techniques available for studying conformational transitions and complex reaction mechanisms of biological macromolecules. The course is particularly suited for students enrolled in the Majors "Structural Biology and Biophysics", "Biochemistry" and "Chemical Biology" of the Biology MSc curriculum, as well as for MSc students of Chemistry and Interdisciplinary Natural Sciences".
InhaltThe biophysical methods covered in the course include advanced reaction kinetics, methods for the thermodynamic and kinetic analysis of protein-ligand interactions, static and dynamic light scattering, analytical ultracentrifugation, spectroscopic techniques such as fluorescence anisotropy, fluorescence resonance energy transfer (FRET) and single molecule fluorescence spectrosopy, modern electron microscopy techniques, atomic force microscopy, and isothermal and differential scanning calorimetry.
SkriptCourse material from the individual lecturers wil be made available at the sharepoint website

https://team.biol.ethz.ch/e-learn/551-1402-00L
Voraussetzungen / BesonderesFinished BSc curriculum in Biology, Chemistry or Interdisciplinary Natural Sciences. The course is also adequate for doctoral students with research projects in structural biology, biophysics, biochemistry and chemical biology.
551-0224-00LAdvanced Proteomics Belegung eingeschränkt - Details anzeigen
Für Masterstudierende ab 2. Semester, Doktorierende und Postdoktorierende
W4 KP6GR. Aebersold, L. Gillet, M. Gstaiger, A. Leitner, P. Pedrioli
KurzbeschreibungZiel dieses Kurses ist es, etablierte und neue Technologien der Protein- und Proteome-Analyse kennenzulernen in Bezug auf ihre Anwendung in Biologie, Biotechnologie und Medizin.
Format: Einführung durch Dozent mit anschliessender Diskussion, unterstützt durch Literaturarbeit und Übungen.
LernzielIm Kurs werden sowohl die bereits etablierten als auch die neuesten derzeit entstehenden Technologien und Methoden in der Protein- und Proteomanlayse diskutiert im Hinblick auf ihre Anwendung in der Biologie, Biotechnologie, Medizin und Systembiologie.
InhaltBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Voraussetzungen / BesonderesNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students http://www.rektorat.ethz.ch/students/admission/auditors/index_EN
551-0364-00LFunctional Genomics
Information for UZH students:
Enrolment to this course unit only possible at ETH. No enrolment to module BIO 254 at UZH.

Please mind the ETH enrolment deadlines for UZH students: Link
W3 KP2VC. von Mering, C. Beyer, B. Bodenmiller, M. Gstaiger, H. Rehrauer, R. Schlapbach, K. Shimizu, N. Zamboni, weitere Dozierende
KurzbeschreibungFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data.
LernzielFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data. Such data provide the basis for systems biology efforts to elucidate the structure, dynamics and regulation of cellular networks.
InhaltThe curriculum of the Functional Genomics course emphasizes an in depth understanding of new technology platforms for modern genomics and advanced genetics, including the application of functional genomics approaches such as advanced microarrays, proteomics, metabolomics, clustering and classification. Students will learn quality controls and standards (benchmarking) that apply to the generation of quantitative data and will be able to analyze and interpret these data. The training obtained in the Functional Genomics course will be immediately applicable to experimental research and design of systems biology projects.
Voraussetzungen / BesonderesThe Functional Genomics course will be taught in English.
551-1126-00LTechnologies in Molecular MicrobiologyW4 KP2VH.‑M. Fischer, B. Christen, M. Christen, weitere Dozierende
KurzbeschreibungThe lecture course provides an advanced understanding of modern techniques used in molecular microbiology. Current technologies and research directions in molecular microbiology including applied aspects will be illustrated with paper discussions. The format is a lecture course enriched by group activities.
LernzielThe lecture course aims at providing principles of modern techniques used in molecular microbiology. Emphasis is on genetic, biochemical, and cellular analysis including also bioinformatics aspects. Discussion of a set of commonly applied technologies will assist students in evaluating current research in molecular microbiology and choosing appropriate methods for their own demands.
InhaltImportant genetic, biochemical, biophysical, bioinformatic and structural analysis methods will be presented that are used to gain a deeper understanding of the molecular principles and mechanisms underlying basic physiological processes in prokaryotes. Applied aspects of molecular microbiology and current research in this area will also be covered.

List of topics:
- Analysis of genes, genomes and transcriptomes
- Analysis of proteins, proteomes and microbial systems
- Synthetic biology
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references, relevant papers and handouts will be provided during the lectures.
Voraussetzungen / BesonderesThe following lecturers will contribute to the course:

Prof. Beat Christen (ETH)
Dr. Matthias Christen (ETH)
Prof. Hans-Martin Fischer (ETH)
Dr. Jonas Grossmann (FGCZ)
Dr. Florian Freimoser (Agroscope)
Dr. Bernd Roschitzki (FGCZ)
Dr. Roman Spörri (ETH)
227-0396-00LEXCITE Interdisciplinary Summer School on Bio-Medical Imaging Information Belegung eingeschränkt - Details anzeigen
The school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process.

Students have to apply for acceptance by April 22, 2019. To apply a curriculum vitae and an application letter need to be submitted. The notification of acceptance will be given by May 24, 2019. Further information can be found at: www.excite.ethz.ch.
W Dr4 KP6GS. Kozerke, G. Csúcs, J. Klohs-Füchtemeier, S. F. Noerrelykke, M. P. Wolf
KurzbeschreibungTwo-week summer school organized by EXCITE (Center for EXperimental & Clinical Imaging TEchnologies Zurich) on biological and medical imaging. The course covers X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, infrared and optical microscopy, electron microscopy, image processing and analysis.
LernzielStudents understand basic concepts and implementations of biological and medical imaging. Based on relative advantages and limitations of each method they can identify preferred procedures and applications. Common foundations and conceptual differences of the methods can be explained.
InhaltTwo-week summer school on biological and medical imaging. The course covers concepts and implementations of X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, infrared and optical microscopy and electron microscopy. Multi-modal and multi-scale imaging and supporting technologies such as image analysis and modeling are discussed. Dedicated modules for physical and life scientists taking into account the various backgrounds are offered.
SkriptHand-outs, Web links
Voraussetzungen / BesonderesThe school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process. To apply a curriculum vitae, a statement of purpose and applicants references need to be submitted. Further information can be found at: http://www.excite.ethz.ch/education/summer-school.html
227-0390-00LElements of MicroscopyW4 KP3GM. Stampanoni, G. Csúcs, A. Sologubenko
KurzbeschreibungThe lecture reviews the basics of microscopy by discussing wave propagation, diffraction phenomena and aberrations. It gives the basics of light microscopy, introducing fluorescence, wide-field, confocal and multiphoton imaging. It further covers 3D electron microscopy and 3D X-ray tomographic micro and nanoimaging.
LernzielSolid introduction to the basics of microscopy, either with visible light, electrons or X-rays.
InhaltIt would be impossible to imagine any scientific activities without the help of microscopy. Nowadays, scientists can count on very powerful instruments that allow investigating sample down to the atomic level.
The lecture includes a general introduction to the principles of microscopy, from wave physics to image formation. It provides the physical and engineering basics to understand visible light, electron and X-ray microscopy.
During selected exercises in the lab, several sophisticated instrument will be explained and their capabilities demonstrated.
LiteraturAvailable Online.
551-0338-00LCurrent Approaches in Single Cell Analysis (University of Zurich)
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BIO256

Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/mobilitaet.html
W2 KP1VUni-Dozierende
KurzbeschreibungIn this lecture, we will discuss the most important single cell
approaches, the questions they can address and current developments. We will cover single cell: genomics, transcriptomics, proteomics (CyTOF mass cytometry), metabolomics and highly multiplexed imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data.
LernzielOn completion of this module the students should be able to:
- explain the basic principles of single cell analysis techniques
- identify and justify the limitations of the current single cell
technologies and suggest reasonable improvements
- know the basic challenges in data analysis imposed by the complex
multi parameter data.
Key skills:
On completion of this module the students should be able to:
- summarize and discuss the impact these technologies have on biology
and medicine
- design biological and biomedical experiments for which single cell
analysis is essential
InhaltCurrently single cell analysis approaches revolutionize the way we study and understand biological systems. In all biological and biomedical settings, cell populations and tissues are highly heterogeneous; this heterogeneity plays a critical role in basic biological processes such as cell cycle, development and organismic function, but is also a major player in disease, e.g. for cancer development, diagnosis and treatment.
Currently, single cell analysis techniques are rapidly developing and
find broad application, as the single cell measurements not only enable
to study cell specific functions, but often reveal unexpected biological
mechanisms in so far (assumed) well understood biological processes.
In this lecture, we will discuss the most important single cell approaches, the questions they can address and current developments. We will cover single cell genomics, single cell transcriptomics, single cell proteomics (CyTOF mass cytometry), single cell metabolomics and highly multiplexed single cell imaging. Finally, we will also discuss the latest approaches for the analysis of such generated highly multiplexed single cell data.
551-1412-00LMolecular and Structural Biology IV: Visualizing Macromolecules by X-Ray Crystallography and EMW4 KP2VN. Ban, D. Böhringer, T. Ishikawa, M. A. Leibundgut, K. Locher, M. Pilhofer, K. Wüthrich, weitere Dozierende
KurzbeschreibungThis course provides an in-depth discussion of two main methods to determine the 3D structures of macromolecules and complexes at high resolution: X-ray crystallography and cryo-electron microscopy. Both techniques result in electron density maps that are interpreted by atomic models.
LernzielStudents will obtain the theoretical background to understand structure determination techniques employed in X-ray crystallography and electron microscopy, including diffraction theory, crystal growth and analysis, reciprocal space calculations, interpretation of electron density, structure building and refinement as well as validation. The course will also provide an introduction into the use of cryo-electron tomography to visualize complex cellular substructures at sub-nanometer resolutions, effectively bridging the resolution gap between optical microscopy and single particle cryo-electron microscopy. Lectures will be complemented with practical sessions where students will have a chance to gain hands on experience with sample preparation, data processing and structure building and refinement.
InhaltFebruary 22 Lecture 1 Prof. Dr. Kurt Wüthrich
History of Structural Molecular Biology

March 1 Lecture 2 Prof. Dr. Kaspar Locher
X-ray diffraction from macromolecular crystals

March 8 Lecture 3 Prof. Dr. Kaspar Locher
Data collection and statistics, phasing methods

March 15 Lecture 4 Prof. Dr. Nenad Ban
Crystal symmetry and space groups

March 22 Lecture 5 Ban Lab
Practical session with X-ray data processing

March 29 Lecture 6 Prof. Dr. Takashi Ishikawa
Principle of cryo-EM for biological macromolecules I, including hardware of TEM and detectors, image formation principle (phase contrast, spherical aberration, CTF), 3D reconstruction (central-section theorem, backprojection, missing information)

April 5 Lecture 7 Dr. Daniel Boehringer
Single particle analysis, including principle (projection matching, random conical tilt, angular reconstitution)

April 12 Lecture 8 Ban Lab
Practical session including specimen preparation (cryo, negative stain, visit to ScopeM

May 3 Lecture 9
Prof. Dr. M. Pilhofer
Tomography I, including basics and subtomogram averaging

May 10 Lecture 10 Ban Lab
Practical session with example initial EM data processing

May 17 Lecture 11 Prof. Dr. Martin Pilhofer
Practical session (including recent techniques, including cryo-FIB)

May 24 Lecture 12 Prof. Dr. Nenad Ban
EM and X-ray structure building, refinement, validation and interpretation

May 31 Lecture 13 Ban Lab
Practical session with model building and refinemen
551-1414-00LMolecular and Structural Biology V: Studying Macromolecules by NMR and EPRW4 KP2VF. Allain, A. D. Gossert, G. Jeschke, K. Wüthrich
KurzbeschreibungThe course provides an overview of experimental methods for studying function and structure of macromolecules at atomic resolution in solution. The two main methods used are Nuclear Magnetic Resonance (NMR) spectroscopy and Electron Paramagnetic Resonance (EPR) spectroscopy.
LernzielInsight into the methodology, areas of application and limitations of these two methods for studying biological macromolecules. Practical exercises with spectra to have hands on understanding of the methodology.
InhaltPart I: Historical overview of structural biology.
Part II: Basic concepts of NMR and initial examples of applications.
2D NMR and isotope labeling for studying protein function and molecular interactions at atomic level.
Studies of dynamic processes of proteins in solution.
Approaches to study large particles.
Methods for determination of protein structures in solution.
Part III: NMR methods for structurally characterizing RNA and protein-RNA complexes.
Part IV: EPR of biomolecules
Literatur1) Wüthrich, K. NMR of Proteins and Nucleic Acids, Wiley-Interscience.
2) Dominguez et al, Prog Nucl Magn Reson Spectrosc. 2011 Feb;58(1-2):1-61.
3) Duss O et al, Methods Enzymol. 2015;558:279-331.
Zusätzliche Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0326-00LCell Biology Information W6 KP4VS. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz
KurzbeschreibungThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Lernziel-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
551-0324-00LSystems Biology Information W6 KP4VR. Aebersold, B. Christen, M. Claassen, U. Sauer
KurzbeschreibungIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Lernziel- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
InhaltOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Skriptno script
LiteraturThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
529-0732-00LProteins and LipidsW6 KP3GD. Hilvert
KurzbeschreibungAn overview of the relationship between protein sequence, conformation and function.
LernzielOverview of the relationship between protein sequence, conformation and function.
InhaltProteins, structures and properties, (bio)synthesis of polypeptides, protein folding and design, protein engineering, chemical modification of proteins, proteomics.
LiteraturGeneral Literature:
- T.E. Creighton: Proteins: Structures and Molecular Properties, 2nd Edition, H.W. Freeman and Company, New York, 1993.
- C. Branden, J. Tooze , Introduction to Protein Structure, Garland Publishing, New York, 1991.
- J. M. Berg, J. L. Tymoczko, L. Stryer: Biochemistry, 5th edition, H.W. Freeman and Company, New York, 2002.
- G.A. Petsko, D. Ringe: Protein Structure and Function, New Science Press Ltd., London, 2004.

Original Literature:
Citations from the original literature relevant to the individual lectures will be assigned weekly.
551-0314-00LMicrobiology (Part II)W3 KP2VW.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli
KurzbeschreibungAdvanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
LernzielThis concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
InhaltAdvanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references will be provided during the lectures.
Voraussetzungen / BesonderesEnglish
551-0318-00LImmunology IIW3 KP2VA. Oxenius, M. Kopf, S. R. Leibundgut, E. Wetter Slack, weitere Dozierende
KurzbeschreibungEinführung in die zellulären und molekularen Grundlagen des Immunsystems und die Immunreaktionen gegen verschiedene Pathogene, Tumore, Transplantate, und körpereigene Strukturen (Autoimmunität)
LernzielDie Vorlesung soll ein grundlegendes Verständnis vermitteln über:
- die Interaktion der verschiedenen Immunzellen auf zellulärer und molekularer Ebene?
- Erkennung und Abwehr ausgewählter Viren, Bakterien, und Parasiten.
- Abwehr von Tumoren.
- Mechanismen der Toleranz für körpereigene Moleküle.
- Funktion des Immunsystems im Darm und warum kommensale Bakterien keine Immunantwort auslösen.
- Immunpathologie und entzündliche Erkrankungen.
InhaltZiel dieser Vorlesung ist das Verständnis:
> Wie Pathogene vom unspezifischen Immunystem erkannt werden
> Wie Pathogene vom Immunsystem bekämpft werden
> Immunantworten der Haut, Lung, und Darms
> Tumorimmunologie
> Migration von Immunzellen
> Toleranz und Autoimmunität
> das Gedächtnis von T Zellen
SkriptDie Vorlesungsunterlagen der Dozenten sind verfügbar in Moodle
LiteraturEmpfohlen: Kuby Immunology (Freeman)
551-0307-01LMolecular and Structural Biology II: From Gene to Protein
D-BIOL students are obliged to take part I and part II as a two-semester course.
W3 KP2VN. Ban, F. Allain, S. Jonas, M. Pilhofer
KurzbeschreibungThis course will cover advanced topics in molecular biology and biochemistry with emphasis on the structure and function of cellular assemblies involved in expression and maintenance of genetic information. We will cover the architecture and the function of molecules involved in DNA replication, transcription, translation, nucleic acid packaging in viruses, RNA processing, and CRISPER/CAS system.
LernzielStudents will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes ranging from DNA replication, transcription and translation. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation.
InhaltAdvanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies.
SkriptUpdated handouts will be provided during the class.
LiteraturThe lecture will be based on the latest literature. Additional suggested
literature:
Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed.
(1995). Garland, New York.
Wahlvertiefung: Pflanzenbiologie
Obligatorische Masterkurse
NummerTitelTypECTSUmfangDozierende
551-0120-01LPlant Biology Colloquium (Spring Semester)
Only compulsory for Master students who started their Master in Autumn Semester 2017 or later.

This compulsory course is required only once. It may be taken in autumn as course 551-0120-00 "Plant Biology Colloquium (Autumn Semester)" or in spring as course 551-0120-01 "Plant Biology Colloquium (Spring Semester)".
W2 KP1KC. Sánchez-Rodríguez, W. Gruissem, A. Rodriguez-Villalon, O. Voinnet, S. C. Zeeman
KurzbeschreibungCurrent topics in Molecular Plant Biology presented by internal and external speakers from accademia.
LernzielGetting insight into actual areas and challenges of Molecular Plant Biology.
Inhalthttp://www.impb.ethz.ch/news-and-events/colloquium-impb.html
Wahlpflicht Konzeptkurse
Siehe D-BIOL Master-Wegleitung
NummerTitelTypECTSUmfangDozierende
529-0732-00LProteins and LipidsW6 KP3GD. Hilvert
KurzbeschreibungAn overview of the relationship between protein sequence, conformation and function.
LernzielOverview of the relationship between protein sequence, conformation and function.
InhaltProteins, structures and properties, (bio)synthesis of polypeptides, protein folding and design, protein engineering, chemical modification of proteins, proteomics.
LiteraturGeneral Literature:
- T.E. Creighton: Proteins: Structures and Molecular Properties, 2nd Edition, H.W. Freeman and Company, New York, 1993.
- C. Branden, J. Tooze , Introduction to Protein Structure, Garland Publishing, New York, 1991.
- J. M. Berg, J. L. Tymoczko, L. Stryer: Biochemistry, 5th edition, H.W. Freeman and Company, New York, 2002.
- G.A. Petsko, D. Ringe: Protein Structure and Function, New Science Press Ltd., London, 2004.

Original Literature:
Citations from the original literature relevant to the individual lectures will be assigned weekly.
551-0324-00LSystems Biology Information W6 KP4VR. Aebersold, B. Christen, M. Claassen, U. Sauer
KurzbeschreibungIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Lernziel- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
InhaltOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Skriptno script
LiteraturThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
551-0320-00LCellular Biochemistry (Part II)W3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-0314-00LMicrobiology (Part II)W3 KP2VW.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli
KurzbeschreibungAdvanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
LernzielThis concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
InhaltAdvanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references will be provided during the lectures.
Voraussetzungen / BesonderesEnglish
551-0326-00LCell Biology Information W6 KP4VS. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz
KurzbeschreibungThis Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism.
Lernziel-To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project.
-To convey knowledge about neuron-glia interactions in health and disease.
- To provide information on different types of stem cells and their function in health and disease
-To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases
-To convey knowledge on the mechanisms underlying repair of injured tissues
-To provide the students with an overview of mitochondrial dynamics.
-Providing an understanding of RNA processing reactions and their regulations.
-To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses.
-To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level.
-Providing the background and context that foster cross-disciplinary scientific thinking.
551-0307-01LMolecular and Structural Biology II: From Gene to Protein
D-BIOL students are obliged to take part I and part II as a two-semester course.
W3 KP2VN. Ban, F. Allain, S. Jonas, M. Pilhofer
KurzbeschreibungThis course will cover advanced topics in molecular biology and biochemistry with emphasis on the structure and function of cellular assemblies involved in expression and maintenance of genetic information. We will cover the architecture and the function of molecules involved in DNA replication, transcription, translation, nucleic acid packaging in viruses, RNA processing, and CRISPER/CAS system.
LernzielStudents will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes ranging from DNA replication, transcription and translation. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation.
InhaltAdvanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies.
SkriptUpdated handouts will be provided during the class.
LiteraturThe lecture will be based on the latest literature. Additional suggested
literature:
Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed.
(1995). Garland, New York.
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
551-0140-00LEpigeneticsW4 KP2VA. Wutz, U. Grossniklaus, R. Paro, R. Santoro
KurzbeschreibungEpigenetik untersucht die Vererbung von Merkmalen, die nicht auf eine Veränderung der DNA Sequenz zurückgeführt werden kann. Die Vorlesung gibt einen Überblick über epigenetische Phänomene und erklärt die zugrundeliegenden molekularen Mechanismen. Die Rolle von epigenetischen Prozessen bei der Krebsentstehung und anderen Krankheiten wird diskutiert.
LernzielDas Ziel des Kurses ist das Verständnis von epigenetischen Mechanismen und deren Funktion in der Entwicklung von Organismen, bei Regenerationsprozessen oder bei der Entstehung von Krankheiten.
InhaltThemen
- Historischer Überblick, Konzepte und Vergleich Genetik vs. Epigenetik
- Biologie von Chromatin: Struktur und Funktion, Organisation im Kern und die Rolle von Histon Modifikationen bei Prozessen wie Transkription und Replikation.
- DNA-Methylierung als epigenetische Modifikation
- Weitergabe epigenetischer Modifikationen während der Zellteilung: das Zellgedächtnis
- Stabilität/Revertierbarkeit epigenetischer Modifikationen: zelluläre Plastizität und Stammzellen.
- Genomisches Imprinting in Pflanzen und in Säugern
- X Chromosom Inaktivierung und Dosiskompensation
- Positionseffekte, Paramutationen und Transvektion
- RNA-induziertes Gensilencing
- die Rolle von epigenetischen Prozessen bei der Krebsentstehung oder der Zellalterung.
551-0138-00LRegulation of Plant Primary MetabolismW2 KP1VS. C. Zeeman
KurzbeschreibungPlants are the primary producers of our ecosystem. This course will survey the pathways of plant metabolism. Emphasis will be placed on the mechanisms of carbon dioxide assimilation, carbohydrate metabolism, and the regulation of metabolic fluxes. The course will also highlight the classical and state-of-the-art research methods.
LernzielThe aim of the course is to confer a broad understanding of plant metabolism, to give insight into the methods of plant biology research, and to promote critical evaluation of scientific literature.
InhaltThe course will include a combination of lectures and coursework/active-learning exercises (e.g. research paper presentations)
551-0224-00LAdvanced Proteomics Belegung eingeschränkt - Details anzeigen
Für Masterstudierende ab 2. Semester, Doktorierende und Postdoktorierende
W4 KP6GR. Aebersold, L. Gillet, M. Gstaiger, A. Leitner, P. Pedrioli
KurzbeschreibungZiel dieses Kurses ist es, etablierte und neue Technologien der Protein- und Proteome-Analyse kennenzulernen in Bezug auf ihre Anwendung in Biologie, Biotechnologie und Medizin.
Format: Einführung durch Dozent mit anschliessender Diskussion, unterstützt durch Literaturarbeit und Übungen.
LernzielIm Kurs werden sowohl die bereits etablierten als auch die neuesten derzeit entstehenden Technologien und Methoden in der Protein- und Proteomanlayse diskutiert im Hinblick auf ihre Anwendung in der Biologie, Biotechnologie, Medizin und Systembiologie.
InhaltBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Voraussetzungen / BesonderesNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students http://www.rektorat.ethz.ch/students/admission/auditors/index_EN
751-4802-00LSystembezogene Bekämpfung herbivorer Insekten IIW2 KP2GD. Mazzi
KurzbeschreibungIm Zentrum stehen Kenntnisse und Fähigkeiten zur Beurteilung von Massnahmen zur Lenkung von Schädlingspopulationen im Spannungsfeld Ökonomie-Ökologie-Gesellschaft. Ein vielfältiges Spektrum von Strategien wird erarbeitet, von natürlichen Gegenspielern, natürlichen und synthetischen Produkten bis zu physikalischen und genetischen Verfahren sowie neuen Forschungsansätzen.
LernzielDie Studierenden erreichen ein gutes Verständnis über verfügbare und potentielle künftige Lenkungsmassnahmen von Schädlingspopulationen in Agrarökosystemen, und können die Handlungsoptionen beurteilen im Spannungsfeld Oekologie - Oekonomie - Gesellschaft. Sie gewinnen zusätzliche Fähigkeiten, kontroverse wissenschaftliche Themen argumentativ aufzuarbeiten und zu debattieren.
SkriptDie Präsentationsunterlagen werden zur Verfügung gestellt.
LiteraturHinweise auf Literatur werden in der Lehrveranstaltung gegeben.
Voraussetzungen / BesonderesDer erste Teil der Veranstaltung "Systembezogene Bekämpfung herbivorer Insekten I" (im HS durchgeführt) ist nicht Voraussetzung zum Verständnis des zweiten Teils.
751-5110-00LInsects in AgroecosystemsW2 KP2VC. De Moraes, M. Fenske, D. Lucas Gomes Marques Barbosa
KurzbeschreibungThis class will focus on insect-plant interactions in agroecosystems, and how the unique man-made agricultural community effects insect populations leading to pest outbreaks. Key concepts in pest prediction and management will be discussed from an ecological perspective.
LernzielAt the end of this course, students will understand what biotic and abiotic factors contribute to pest outbreaks, why some modern pest management techniques have failed over time, and the trade-offs associated with the use of different pest control methods. Our approach will allow students to apply their knowledge to a variety of pest management situations. Additionally, students will learn about current research goals in agroecology and how these goals are being addressed by scientists engaged in agricultural research.
InhaltThe focus of this course will be on understanding how the ecologies of agricultural systems differ from natural ecosystems, and how these difference affect the population dynamics of insect pests and natural enemies. Each section of the course is centered around a basic ecological, biological or engineering theme such as host shift, physiological time, or sampling techniques. Different management techniques will be discussed, as well as the ecological basis behind why these techniques work and why they sometimes fail. The role of insects in spreading economically important plant diseases will also be discussed. Recent advances in research will also be addressed throughout the course and reinforced with periodic readings of primary literature.
SkriptProvided to students through ILIAS
LiteraturSelected required readings (peer reviewed literature, selected book chapters).
751-4904-00LMikrobielle SchädlingsbekämpfungW2 KP2GJ. Enkerli, G. Grabenweger, S. Kuske Pradal
KurzbeschreibungDie Vorlesung vermittelt konzeptionelle, sowie biologische und ökologische Grundlagen in mikrobieller Schädlingsbekämpfung. Anhand von Beispielen werden die Methoden und Techniken zur Entwicklung und Überwachung von mikrobiellen Schädlingsbekämpfungsmitteln erarbeitet.
LernzielKennenlernen der wichtigsten Gruppen von insektenpathogenen Mikroorganismen und deren Eigenschaften. Vertraut werden mit den nötigen Schritten für die Entwicklung von Schädlingsbekämpfungsmitteln. Verstehen der Techniken und Methoden, die für das Überwachen von Feldapplikationen benützt werden, und Kennen der Registrierungsanforderungen für mikrobielle Schädlingsbekämpfungsmittel.
InhaltDie in der biologischen Schädlingsbekämpfung gebrauchten Definitionen und generell verwendete Ausdrücke werden erarbeitet. Ferner werden biologische und ökologische Aspekte aller Arthropoden-pathogenen Gruppen (Viren, Bakterien Pilze und Nematoden) und ihre Vor- und Nachteile in Bezug auf biologische Schädlingsbekämpfung diskutiert. Ein Schwergewicht wird dabei auf die Pilzgruppen Hypocreales und Entomophtorales gelegt. Anhand von Beispielen wird aufgezeigt, wie Projekte in biologischer Schädlingsbekämpfung aufgebaut werden können, wie Pathogene appliziert werden und wie die Effizienz, Effekte auf Nicht-Zielorganismen, Persistenz und Verbreitung überwacht werden. Im Weiteren werden die nötigen Schritte in der Entwicklung eines Produktes, kommerzielle Aspekte und die Registrierungsanforderungen besprochen.
SkriptDie grundlegenden Aspekte werden als Skript (Präsentationsunterlagen) abgegeben.
LiteraturHinweise auf zusätzliche Literatur werde in der Lehrveranstaltung gegeben.
751-4505-00LPlant Pathology IIW2 KP2GB. McDonald
KurzbeschreibungPlant Pathology II focuses on disease control in agroecosystems based on biological control, pesticide applications and breeding of resistant crop cultivars. The genetics of pathogen-plant interactions will be explored in detail as a basis for understanding the development of boom-and-bust cycles and methods that may be used to prevent the evolution of pathogen virulence and fungicide resistance.
LernzielAn understanding of the how biological control, pesticides and plant breeding can be used to achieve sustainable disease control. An understanding of the genetic basis of pathogen-plant interactions and appropriate methods for using resistance to control diseases in agroecosystems.
InhaltPlant Pathology II will focus on disease control in agroecosystems based on biological control, pesticide applications and breeding of resistant crop cultivars. The genetics of pathogen-plant interactions will be explored in detail as a basis for understanding the development of boom-and-bust cycles and methods that may be used to prevent the evolution of pathogen virulence and fungicide resistance.

Lecture Topics and Tentative Schedule

Week 1 Biological control: biofumigation, disease declines, suppressive soils.

Week 2 Biological control: competitive exclusion, hyperparasitism.

Week 3 Chemical control: History of fungicides in Europe, fungicide properties, application methods.

Week 4 Fungicide categories and modes of action, antibiotics, fungicide development, fungicide safety and risk assessment (human health).

Week 5 Resistance to fungicides. Genetics of fungicide resistance, ABC transporters, risk assessment, fitness costs. FRAC risk assessment model vs. population genetic risk assessment model.

Week 6 Genetics of pathogen-plant interaction: genetics of pathogens, genetics of plant resistance, major gene and quantitative resistance, acquired resistance. Flor's GFG hypothesis and the quadratic check, the receptor and elicitor model of GFG, the guard model of GFG.

Week 7 Resistance gene structure and genome distribution, conservation of LRR motifs across eukaryotes. Genetic basis of quantitative resistance. QTLs and QRLs. Connections between MGR and QR. Durability of QR.

Week 8 Genetic resistance: Costs, benefits and risks.

Week 9 Non-host resistance. Types of NHR. NHR in Arabidopsis with powdery mildews. NHR in maize and rice. Avirulence genes and pathogen elicitors. PAMPs, effectors, type-III secretion systems, harpins in bacteria. Fungal avirulence genes.

Week 10 Easter holiday no class.

Week 11 Sechselauten holiday no class.

Week 12 Host-specific toxins. GFG for toxins and connection to apoptosis. Fitness costs of virulence alleles. Diversifying selection in NIP1.

Week 13 Boom and bust cycles for resistance genes and fungicides and coevolutionary processes. Pathogen genetic structure and evolutionary potential. Genetic structure of pathogen populations in agroecosystems, risk assessment for pathogen evolution and breeding strategies for durable resistance.

Week 14 Resistance gene and fungicide deployment strategies for agroecosystems.

Week 15 Genetic engineering approaches to achieve disease resistant crops.
SkriptLecture notes will be available for purchase at the cost of reproduction.
LiteraturLecture notes will be available for purchase at the cost of reproduction.
Voraussetzungen / BesonderesPlant Pathology I provides a good preparation for Plant Pathology II, but is not a prerequisite for this course.
Zusätzliche Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0307-01LMolecular and Structural Biology II: From Gene to Protein
D-BIOL students are obliged to take part I and part II as a two-semester course.
W3 KP2VN. Ban, F. Allain, S. Jonas, M. Pilhofer
KurzbeschreibungThis course will cover advanced topics in molecular biology and biochemistry with emphasis on the structure and function of cellular assemblies involved in expression and maintenance of genetic information. We will cover the architecture and the function of molecules involved in DNA replication, transcription, translation, nucleic acid packaging in viruses, RNA processing, and CRISPER/CAS system.
LernzielStudents will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes ranging from DNA replication, transcription and translation. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation.
InhaltAdvanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies.
SkriptUpdated handouts will be provided during the class.
LiteraturThe lecture will be based on the latest literature. Additional suggested
literature:
Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed.
(1995). Garland, New York.
Wahlvertiefung: Systembiologie
Obligatorische Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0324-00LSystems Biology Information O6 KP4VR. Aebersold, B. Christen, M. Claassen, U. Sauer
KurzbeschreibungIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Lernziel- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
InhaltOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Skriptno script
LiteraturThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
Wahlpflicht Konzeptkurse
Siehe D-BIOL Master-Wegleitung
NummerTitelTypECTSUmfangDozierende
551-0320-00LCellular Biochemistry (Part II)W3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-0314-00LMicrobiology (Part II)W3 KP2VW.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli
KurzbeschreibungAdvanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
LernzielThis concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
InhaltAdvanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references will be provided during the lectures.
Voraussetzungen / BesonderesEnglish
Wahlpflicht Masterkurse I: Rechnergestütz
NummerTitelTypECTSUmfangDozierende
636-0702-00LStatistical Models in Computational BiologyW6 KP2V + 1U + 2AN. Beerenwinkel
KurzbeschreibungThe course offers an introduction to graphical models and their application to complex biological systems. Graphical models combine a statistical methodology with efficient algorithms for inference in settings of high dimension and uncertainty. The unifying graphical model framework is developed and used to examine several classical and topical computational biology methods.
LernzielThe goal of this course is to establish the common language of graphical models for applications in computational biology and to see this methodology at work for several real-world data sets.
InhaltGraphical models are a marriage between probability theory and graph theory. They combine the notion of probabilities with efficient algorithms for inference among many random variables. Graphical models play an important role in computational biology, because they explicitly address two features that are inherent to biological systems: complexity and uncertainty. We will develop the basic theory and the common underlying formalism of graphical models and discuss several computational biology applications. Topics covered include conditional independence, Bayesian networks, Markov random fields, Gaussian graphical models, EM algorithm, junction tree algorithm, model selection, Dirichlet process mixture, causality, the pair hidden Markov model for sequence alignment, probabilistic phylogenetic models, phylo-HMMs, microarray experiments and gene regulatory networks, protein interaction networks, learning from perturbation experiments, time series data and dynamic Bayesian networks. Some of the biological applications will be explored in small data analysis problems as part of the exercises.
Skriptno
Literatur- Airoldi EM (2007) Getting started in probabilistic graphical models. PLoS Comput Biol 3(12): e252. doi:10.1371/journal.pcbi.0030252
- Bishop CM. Pattern Recognition and Machine Learning. Springer, 2007.
- Durbin R, Eddy S, Krogh A, Mitchinson G. Biological Sequence Analysis. Cambridge university Press, 2004
401-0102-00LApplied Multivariate StatisticsW5 KP2V + 1UF. Sigrist
KurzbeschreibungMultivariate statistics analyzes data on several random variables simultaneously. This course introduces the basic concepts and provides an overview of classical and modern methods of multivariate statistics including visualization, dimension reduction, supervised and unsupervised learning for multivariate data. An emphasis is on applications and solving problems with the statistical software R.
LernzielAfter the course, you are able to:
- describe the various methods and the concepts behind them
- identify adequate methods for a given statistical problem
- use the statistical software R to efficiently apply these methods
- interpret the output of these methods
InhaltVisualization, multivariate outliers, the multivariate normal distribution, dimension reduction, principal component analysis, multidimensional scaling, factor analysis, cluster analysis, classification, multivariate tests and multiple testing
SkriptNone
Literatur1) "An Introduction to Applied Multivariate Analysis with R" (2011) by Everitt and Hothorn
2) "An Introduction to Statistical Learning: With Applications in R" (2013) by Gareth, Witten, Hastie and Tibshirani

Electronic versions (pdf) of both books can be downloaded for free from the ETH library.
Voraussetzungen / BesonderesThis course is targeted at students with a non-math background.

Requirements:
==========
1) Introductory course in statistics (min: t-test, regression; ideal: conditional probability, multiple regression)
2) Good understanding of R (if you don't know R, it is recommended that you study chapters 1,2,3,4, and 5 of "Introductory Statistics with R" from Peter Dalgaard, which is freely available online from the ETH library)

An alternative course with more emphasis on theory is 401-6102-00L "Multivariate Statistics" (only every second year).

401-0102-00L and 401-6102-00L are mutually exclusive. You can register for only one of these two courses.
227-0396-00LEXCITE Interdisciplinary Summer School on Bio-Medical Imaging Information Belegung eingeschränkt - Details anzeigen
The school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process.

Students have to apply for acceptance by April 22, 2019. To apply a curriculum vitae and an application letter need to be submitted. The notification of acceptance will be given by May 24, 2019. Further information can be found at: www.excite.ethz.ch.
W4 KP6GS. Kozerke, G. Csúcs, J. Klohs-Füchtemeier, S. F. Noerrelykke, M. P. Wolf
KurzbeschreibungTwo-week summer school organized by EXCITE (Center for EXperimental & Clinical Imaging TEchnologies Zurich) on biological and medical imaging. The course covers X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, infrared and optical microscopy, electron microscopy, image processing and analysis.
LernzielStudents understand basic concepts and implementations of biological and medical imaging. Based on relative advantages and limitations of each method they can identify preferred procedures and applications. Common foundations and conceptual differences of the methods can be explained.
InhaltTwo-week summer school on biological and medical imaging. The course covers concepts and implementations of X-ray imaging, magnetic resonance imaging, nuclear imaging, ultrasound imaging, infrared and optical microscopy and electron microscopy. Multi-modal and multi-scale imaging and supporting technologies such as image analysis and modeling are discussed. Dedicated modules for physical and life scientists taking into account the various backgrounds are offered.
SkriptHand-outs, Web links
Voraussetzungen / BesonderesThe school admits 60 MSc or PhD students with backgrounds in biology, chemistry, mathematics, physics, computer science or engineering based on a selection process. To apply a curriculum vitae, a statement of purpose and applicants references need to be submitted. Further information can be found at: http://www.excite.ethz.ch/education/summer-school.html
Wahlpflicht Masterkurse II: Biologie
NummerTitelTypECTSUmfangDozierende
551-1310-00LA Problem-Based Approach to Cellular Biochemistry Belegung eingeschränkt - Details anzeigen
Number of participants limited to 15.
W6 KP2GM. Peter, E. Dultz, M. Gstaiger, V. Korkhov, V. Panse, A. E. Smith
KurzbeschreibungIndependent, guided acquisition of an overview over a defined area of research, identification of important open questions, development of an experimental strategy to address a defined question, and formulation of this strategy within the framework of a research grant.
LernzielThe students will learn to acquire independently an overview over a defined area of research, and to identify important open questions. In addition, they will learn to develop an experimental strategy to address a defined question, and to formulate this strategy within the framework of a research grant.
InhaltThe students will work in groups of two to three, in close contact with a tutor (ETH Prof or senior scientist). A research overview with open questions and a research grant will be developed independently by the students, with guidance from the tutor through regular mandatory meetings. The students will write both the research overview with open questions and the grant in short reports, and present them to their colleagues.
LiteraturThe identification of appropriate literature is a component of the course.
Voraussetzungen / BesonderesThis course will be taught in english, and requires extensive independent work.
551-0364-00LFunctional Genomics
Information for UZH students:
Enrolment to this course unit only possible at ETH. No enrolment to module BIO 254 at UZH.

Please mind the ETH enrolment deadlines for UZH students: Link
W3 KP2VC. von Mering, C. Beyer, B. Bodenmiller, M. Gstaiger, H. Rehrauer, R. Schlapbach, K. Shimizu, N. Zamboni, weitere Dozierende
KurzbeschreibungFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data.
LernzielFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data. Such data provide the basis for systems biology efforts to elucidate the structure, dynamics and regulation of cellular networks.
InhaltThe curriculum of the Functional Genomics course emphasizes an in depth understanding of new technology platforms for modern genomics and advanced genetics, including the application of functional genomics approaches such as advanced microarrays, proteomics, metabolomics, clustering and classification. Students will learn quality controls and standards (benchmarking) that apply to the generation of quantitative data and will be able to analyze and interpret these data. The training obtained in the Functional Genomics course will be immediately applicable to experimental research and design of systems biology projects.
Voraussetzungen / BesonderesThe Functional Genomics course will be taught in English.
551-0224-00LAdvanced Proteomics Belegung eingeschränkt - Details anzeigen
Für Masterstudierende ab 2. Semester, Doktorierende und Postdoktorierende
W4 KP6GR. Aebersold, L. Gillet, M. Gstaiger, A. Leitner, P. Pedrioli
KurzbeschreibungZiel dieses Kurses ist es, etablierte und neue Technologien der Protein- und Proteome-Analyse kennenzulernen in Bezug auf ihre Anwendung in Biologie, Biotechnologie und Medizin.
Format: Einführung durch Dozent mit anschliessender Diskussion, unterstützt durch Literaturarbeit und Übungen.
LernzielIm Kurs werden sowohl die bereits etablierten als auch die neuesten derzeit entstehenden Technologien und Methoden in der Protein- und Proteomanlayse diskutiert im Hinblick auf ihre Anwendung in der Biologie, Biotechnologie, Medizin und Systembiologie.
InhaltBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Voraussetzungen / BesonderesNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students http://www.rektorat.ethz.ch/students/admission/auditors/index_EN
701-1418-00LModelling Course in Population and Evolutionary Biology Information Belegung eingeschränkt - Details anzeigen
Number of participants limited to 20.

Priority is given to MSc Biology and Environmental Sciences students.
W4 KP6PS. Bonhoeffer, V. Müller
KurzbeschreibungDieser Kurs ist eine praktische Einfuehrung in die mathematische/computerorientierte Modellierung biologischer Prozesse mit Schwerpunkt auf evolutionsbiologischen und populationsbiologischen Fragestellungen. Die Modelle werden in der Open Source software R entwickelt.
LernzielDen Teilnehmern soll der Nutzen der Modellierung als ein Hilfsmittel zur Untersuchung biologischer Fragestellungen vermittelt werden. Die einfacheren Module orientieren sich mehrheitlich an Beispielen aus der ehemaligen Vorlesung "Oekologie und Evolution: Populationen" (Skript von der Kurswebseite zugaenglich). Die fortgeschrittenen Module orientieren sich an aktuellen Forschungsthemen. Hierbei werden auch Fragestellungen untersucht, die zwar konzeptionell und methodisch auf Evolutions- und Populations-biologischen Ansaetzen beruhen, aber sich mit anderen Bereichen der Biologie befassen.
Inhaltsiehe www.tb.ethz.ch/education/learningmaterials/modelingcourse.html
SkriptDetaillierte Handouts für alle Module sind an der Webseite des Kurses zu finden. Zusaetzlich ist das Skript für die frühere Vorlesung "Oekologie und Evolution: Populationen" auch zugaenglich, und enthaelt weitere relevante Informationen.
Voraussetzungen / BesonderesDer Kurs basiert auf der Open Source Software R. Programmiererfahrung in R ist nuetzlich, aber keine Voraussetzung. Ebenso ist der Kurs 701-1708-00L Infectious Disease Dynamics nützlich, aber keine Voraussetzung.
551-1126-00LTechnologies in Molecular MicrobiologyW4 KP2VH.‑M. Fischer, B. Christen, M. Christen, weitere Dozierende
KurzbeschreibungThe lecture course provides an advanced understanding of modern techniques used in molecular microbiology. Current technologies and research directions in molecular microbiology including applied aspects will be illustrated with paper discussions. The format is a lecture course enriched by group activities.
LernzielThe lecture course aims at providing principles of modern techniques used in molecular microbiology. Emphasis is on genetic, biochemical, and cellular analysis including also bioinformatics aspects. Discussion of a set of commonly applied technologies will assist students in evaluating current research in molecular microbiology and choosing appropriate methods for their own demands.
InhaltImportant genetic, biochemical, biophysical, bioinformatic and structural analysis methods will be presented that are used to gain a deeper understanding of the molecular principles and mechanisms underlying basic physiological processes in prokaryotes. Applied aspects of molecular microbiology and current research in this area will also be covered.

List of topics:
- Analysis of genes, genomes and transcriptomes
- Analysis of proteins, proteomes and microbial systems
- Synthetic biology
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references, relevant papers and handouts will be provided during the lectures.
Voraussetzungen / BesonderesThe following lecturers will contribute to the course:

Prof. Beat Christen (ETH)
Dr. Matthias Christen (ETH)
Prof. Hans-Martin Fischer (ETH)
Dr. Jonas Grossmann (FGCZ)
Dr. Florian Freimoser (Agroscope)
Dr. Bernd Roschitzki (FGCZ)
Dr. Roman Spörri (ETH)
701-1708-00LInfectious Disease DynamicsW4 KP2VS. Bonhoeffer, R. D. Kouyos, R. R. Regös, T. Stadler
KurzbeschreibungThis course introduces into current research on the population biology of infectious diseases. The course discusses the most important mathematical tools and their application to relevant diseases of human, natural or managed populations.
LernzielAttendees will learn about:
* the impact of important infectious pathogens and their evolution on human, natural and managed populations
* the population biological impact of interventions such as treatment or vaccination
* the impact of population structure on disease transmission

Attendees will learn how:
* the emergence spread of infectious diseases is described mathematically
* the impact of interventions can be predicted and optimized with mathematical models
* population biological models are parameterized from empirical data
* genetic information can be used to infer the population biology of the infectious disease

The course will focus on how the formal methods ("how") can be used to derive biological insights about the host-pathogen system ("about").
InhaltAfter an introduction into the history of infectious diseases and epidemiology the course will discuss basic epidemiological models and the mathematical methods of their analysis. We will then discuss the population dynamical effects of intervention strategies such as vaccination and treatment. In the second part of the course we will introduce into more advanced topics such as the effect of spatial population structure, explicit contact structure, host heterogeneity, and stochasticity. In the final part of the course we will introduce basic concepts of phylogenetic analysis in the context of infectious diseases.
SkriptSlides and script of the lecture will be available online.
LiteraturThe course is not based on any of the textbooks below, but they are excellent choices as accompanying material:
* Keeling & Rohani, Modeling Infectious Diseases in Humans and Animals, Princeton Univ Press 2008
* Anderson & May, Infectious Diseases in Humans, Oxford Univ Press 1990
* Murray, Mathematical Biology, Springer 2002/3
* Nowak & May, Virus Dynamics, Oxford Univ Press 2000
* Holmes, The Evolution and Emergence of RNA Viruses, Oxford Univ Press 2009
Voraussetzungen / BesonderesBasic knowledge of population dynamics and population genetics as well as linear algebra and analysis will be an advantage.
636-0111-00LSynthetic Biology I
Attention: This course was offered in previous semesters with the number: 636-0002-00L "Synthetic Biology I". Students that already passed course 636-0002-00L cannot receive credits for course 636-0111-00L.
W4 KP3GS. Panke, J. Stelling
KurzbeschreibungTheoretical & practical introduction into the design of dynamic biological systems at different levels of abstraction, ranging from biological fundamentals of systems design (introduction to bacterial gene regulation, elements of transcriptional & translational control, advanced genetic engineering) to engineering design principles (standards, abstractions) mathematical modelling & systems desig
LernzielAfter the course, students will be able to theoretically master the biological and engineering fundamentals required for biological design to be able to participate in the international iGEM competition (see www.syntheticbiology.ethz.ch).
InhaltThe overall goal of the course is to familiarize the students with the potential, the requirements and the problems of designing dynamic biological elements that are of central importance for manipulating biological systems, primarily (but not exclusively) prokaryotic systems. Next, the students will be taken through a number of successful examples of biological design, such as toggle switches, pulse generators, and oscillating systems, and apply the biological and engineering fundamentals to these examples, so that they get hands-on experience on how to integrate the various disciplines on their way to designing biological systems.
SkriptHandouts during classes.
LiteraturMark Ptashne, A Genetic Switch (3rd ed), Cold Spring Haror Laboratory Press
Uri Alon, An Introduction to Systems Biology, Chapman & Hall
Voraussetzungen / Besonderes1) Though we do not place a formal requirement for previous participation in particular courses, we expect all participants to be familiar with a certain level of biology and of mathematics. Specifically, there will be material for self study available on http://www.bsse.ethz.ch/bpl/education/index as of mid January, and everybody is expected to be fully familiar with this material BEFORE THE CLASS BEGINS to be able to follow the different lectures. Please contact sven.panke@bsse.ethz.ch for access to material
2) The course is also thought as a preparation for the participation in the international iGEM synthetic biology summer competition (www.syntheticbiology.ethz.ch, http://www.igem.org). This competition is also the contents of the course Synthetic Biology II. http://www.bsse.ethz.ch/bpl/education/index
Wahlvertiefung: Molekular- und Strukturbiologie
Obligatorische Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0307-01LMolecular and Structural Biology II: From Gene to Protein
D-BIOL students are obliged to take part I and part II as a two-semester course.
O3 KP2VN. Ban, F. Allain, S. Jonas, M. Pilhofer
KurzbeschreibungThis course will cover advanced topics in molecular biology and biochemistry with emphasis on the structure and function of cellular assemblies involved in expression and maintenance of genetic information. We will cover the architecture and the function of molecules involved in DNA replication, transcription, translation, nucleic acid packaging in viruses, RNA processing, and CRISPER/CAS system.
LernzielStudents will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes ranging from DNA replication, transcription and translation. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation.
InhaltAdvanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies.
SkriptUpdated handouts will be provided during the class.
LiteraturThe lecture will be based on the latest literature. Additional suggested
literature:
Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed.
(1995). Garland, New York.
Wahlpflicht Konzeptkurse
Siehe D-BIOL Master-Wegleitung
NummerTitelTypECTSUmfangDozierende
529-0732-00LProteins and LipidsW6 KP3GD. Hilvert
KurzbeschreibungAn overview of the relationship between protein sequence, conformation and function.
LernzielOverview of the relationship between protein sequence, conformation and function.
InhaltProteins, structures and properties, (bio)synthesis of polypeptides, protein folding and design, protein engineering, chemical modification of proteins, proteomics.
LiteraturGeneral Literature:
- T.E. Creighton: Proteins: Structures and Molecular Properties, 2nd Edition, H.W. Freeman and Company, New York, 1993.
- C. Branden, J. Tooze , Introduction to Protein Structure, Garland Publishing, New York, 1991.
- J. M. Berg, J. L. Tymoczko, L. Stryer: Biochemistry, 5th edition, H.W. Freeman and Company, New York, 2002.
- G.A. Petsko, D. Ringe: Protein Structure and Function, New Science Press Ltd., London, 2004.

Original Literature:
Citations from the original literature relevant to the individual lectures will be assigned weekly.
551-0320-00LCellular Biochemistry (Part II)W3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-0314-00LMicrobiology (Part II)W3 KP2VW.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli
KurzbeschreibungAdvanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
LernzielThis concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
InhaltAdvanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references will be provided during the lectures.
Voraussetzungen / BesonderesEnglish
551-0324-00LSystems Biology Information W6 KP4VR. Aebersold, B. Christen, M. Claassen, U. Sauer
KurzbeschreibungIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Lernziel- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
InhaltOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Skriptno script
LiteraturThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
551-1402-00LMolecular and Structural Biology VI: Biophysical Analysis of Macromolecular Mechanisms
This course is strongly recommended for the Masters Major "Biology and Biophysics".
W4 KP2VR. Glockshuber, T. Ishikawa, S. Jonas, B. Schuler, D. Veprintsev, E. Weber-Ban
KurzbeschreibungThe course is focussed on biophysical methods for characterising conformational transitions and reaction mechanisms of proteins and biological mecromolecules, with focus on methods that have not been covered in the Biology Bachelor Curriculum.
LernzielThe goal of the course is to give the students a broad overview on biopyhsical techniques available for studying conformational transitions and complex reaction mechanisms of biological macromolecules. The course is particularly suited for students enrolled in the Majors "Structural Biology and Biophysics", "Biochemistry" and "Chemical Biology" of the Biology MSc curriculum, as well as for MSc students of Chemistry and Interdisciplinary Natural Sciences".
InhaltThe biophysical methods covered in the course include advanced reaction kinetics, methods for the thermodynamic and kinetic analysis of protein-ligand interactions, static and dynamic light scattering, analytical ultracentrifugation, spectroscopic techniques such as fluorescence anisotropy, fluorescence resonance energy transfer (FRET) and single molecule fluorescence spectrosopy, modern electron microscopy techniques, atomic force microscopy, and isothermal and differential scanning calorimetry.
SkriptCourse material from the individual lecturers wil be made available at the sharepoint website

https://team.biol.ethz.ch/e-learn/551-1402-00L
Voraussetzungen / BesonderesFinished BSc curriculum in Biology, Chemistry or Interdisciplinary Natural Sciences. The course is also adequate for doctoral students with research projects in structural biology, biophysics, biochemistry and chemical biology.
551-0224-00LAdvanced Proteomics Belegung eingeschränkt - Details anzeigen
Für Masterstudierende ab 2. Semester, Doktorierende und Postdoktorierende
W4 KP6GR. Aebersold, L. Gillet, M. Gstaiger, A. Leitner, P. Pedrioli
KurzbeschreibungZiel dieses Kurses ist es, etablierte und neue Technologien der Protein- und Proteome-Analyse kennenzulernen in Bezug auf ihre Anwendung in Biologie, Biotechnologie und Medizin.
Format: Einführung durch Dozent mit anschliessender Diskussion, unterstützt durch Literaturarbeit und Übungen.
LernzielIm Kurs werden sowohl die bereits etablierten als auch die neuesten derzeit entstehenden Technologien und Methoden in der Protein- und Proteomanlayse diskutiert im Hinblick auf ihre Anwendung in der Biologie, Biotechnologie, Medizin und Systembiologie.
InhaltBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Voraussetzungen / BesonderesNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students http://www.rektorat.ethz.ch/students/admission/auditors/index_EN
551-0364-00LFunctional Genomics
Information for UZH students:
Enrolment to this course unit only possible at ETH. No enrolment to module BIO 254 at UZH.

Please mind the ETH enrolment deadlines for UZH students: Link
W3 KP2VC. von Mering, C. Beyer, B. Bodenmiller, M. Gstaiger, H. Rehrauer, R. Schlapbach, K. Shimizu, N. Zamboni, weitere Dozierende
KurzbeschreibungFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data.
LernzielFunctional genomics is key to understanding the dynamic aspects of genome function and regulation. Functional genomics approaches use the wealth of data produced by large-scale DNA sequencing, gene expression profiling, proteomics and metabolomics. Today functional genomics is becoming increasingly important for the generation and interpretation of quantitative biological data. Such data provide the basis for systems biology efforts to elucidate the structure, dynamics and regulation of cellular networks.
InhaltThe curriculum of the Functional Genomics course emphasizes an in depth understanding of new technology platforms for modern genomics and advanced genetics, including the application of functional genomics approaches such as advanced microarrays, proteomics, metabolomics, clustering and classification. Students will learn quality controls and standards (benchmarking) that apply to the generation of quantitative data and will be able to analyze and interpret these data. The training obtained in the Functional Genomics course will be immediately applicable to experimental research and design of systems biology projects.
Voraussetzungen / BesonderesThe Functional Genomics course will be taught in English.
551-1100-00LInfectious Agents: From Molecular Biology to Disease
Number of participants limited to 22.
Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures.
(if you missed the deadline, please come to the first date to see, if there are any slots left)
W4 KP2SW.‑D. Hardt, L. Eberl, U. F. Greber, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander
KurzbeschreibungLiterature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich.
LernzielWorking with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology.
Inhaltfor each model pathogen (or key technology):
1. introduction to the pathogen
2. Discussion of one current research paper.
The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion.
SkriptTeachers will provide the research papers to be discussed.
Students will prepare handouts for the rest of the group for their assigned seminar.
LiteraturTeachers will provide the research papers to be discussed.
Voraussetzungen / BesonderesRestricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to micro_secr@micro.biol.ethz.ch and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt.
The first seminar date will serve to form groups of students and assign a paper to each group.
551-1404-00LRNA and Proteins: Post-Transcriptional Regulation of Gene Expression (University of Zurich)
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BCH252

Beachten Sie die Einschreibungstermine an der UZH: https://www.uzh.ch/cmsssl/de/studies/application/mobilitaet.html
W3 KP2VUni-Dozierende
KurzbeschreibungThe course introduces the cellular processes and molecular mechanisms involved in regulating genome expression at the post-transcriptional level.
Topics will include :
-RNA processing, and transport;
-protein synthesis and translational control, trafficking and degradation;
-RNA-guided regulation (RNA interference, microRNAs);
-molecular surveillance and quality control mechanisms
Lernziel-Outline the cellular processes
used by eukaryotic and prokaryotic cells
to control gene expression at the post-
transcriptional level.
-Describe the molecular mechanisms
underlying post-transcriptional gene
regulation
-Identify experimental approaches
used to study post-transcriptional gene
regulation and describe their strengths
and weaknesses.
551-1412-00LMolecular and Structural Biology IV: Visualizing Macromolecules by X-Ray Crystallography and EMW4 KP2VN. Ban, D. Böhringer, T. Ishikawa, M. A. Leibundgut, K. Locher, M. Pilhofer, K. Wüthrich, weitere Dozierende
KurzbeschreibungThis course provides an in-depth discussion of two main methods to determine the 3D structures of macromolecules and complexes at high resolution: X-ray crystallography and cryo-electron microscopy. Both techniques result in electron density maps that are interpreted by atomic models.
LernzielStudents will obtain the theoretical background to understand structure determination techniques employed in X-ray crystallography and electron microscopy, including diffraction theory, crystal growth and analysis, reciprocal space calculations, interpretation of electron density, structure building and refinement as well as validation. The course will also provide an introduction into the use of cryo-electron tomography to visualize complex cellular substructures at sub-nanometer resolutions, effectively bridging the resolution gap between optical microscopy and single particle cryo-electron microscopy. Lectures will be complemented with practical sessions where students will have a chance to gain hands on experience with sample preparation, data processing and structure building and refinement.
InhaltFebruary 22 Lecture 1 Prof. Dr. Kurt Wüthrich
History of Structural Molecular Biology

March 1 Lecture 2 Prof. Dr. Kaspar Locher
X-ray diffraction from macromolecular crystals

March 8 Lecture 3 Prof. Dr. Kaspar Locher
Data collection and statistics, phasing methods

March 15 Lecture 4 Prof. Dr. Nenad Ban
Crystal symmetry and space groups

March 22 Lecture 5 Ban Lab
Practical session with X-ray data processing

March 29 Lecture 6 Prof. Dr. Takashi Ishikawa
Principle of cryo-EM for biological macromolecules I, including hardware of TEM and detectors, image formation principle (phase contrast, spherical aberration, CTF), 3D reconstruction (central-section theorem, backprojection, missing information)

April 5 Lecture 7 Dr. Daniel Boehringer
Single particle analysis, including principle (projection matching, random conical tilt, angular reconstitution)

April 12 Lecture 8 Ban Lab
Practical session including specimen preparation (cryo, negative stain, visit to ScopeM

May 3 Lecture 9
Prof. Dr. M. Pilhofer
Tomography I, including basics and subtomogram averaging

May 10 Lecture 10 Ban Lab
Practical session with example initial EM data processing

May 17 Lecture 11 Prof. Dr. Martin Pilhofer
Practical session (including recent techniques, including cryo-FIB)

May 24 Lecture 12 Prof. Dr. Nenad Ban
EM and X-ray structure building, refinement, validation and interpretation

May 31 Lecture 13 Ban Lab
Practical session with model building and refinemen
551-1414-00LMolecular and Structural Biology V: Studying Macromolecules by NMR and EPRW4 KP2VF. Allain, A. D. Gossert, G. Jeschke, K. Wüthrich
KurzbeschreibungThe course provides an overview of experimental methods for studying function and structure of macromolecules at atomic resolution in solution. The two main methods used are Nuclear Magnetic Resonance (NMR) spectroscopy and Electron Paramagnetic Resonance (EPR) spectroscopy.
LernzielInsight into the methodology, areas of application and limitations of these two methods for studying biological macromolecules. Practical exercises with spectra to have hands on understanding of the methodology.
InhaltPart I: Historical overview of structural biology.
Part II: Basic concepts of NMR and initial examples of applications.
2D NMR and isotope labeling for studying protein function and molecular interactions at atomic level.
Studies of dynamic processes of proteins in solution.
Approaches to study large particles.
Methods for determination of protein structures in solution.
Part III: NMR methods for structurally characterizing RNA and protein-RNA complexes.
Part IV: EPR of biomolecules
Literatur1) Wüthrich, K. NMR of Proteins and Nucleic Acids, Wiley-Interscience.
2) Dominguez et al, Prog Nucl Magn Reson Spectrosc. 2011 Feb;58(1-2):1-61.
3) Duss O et al, Methods Enzymol. 2015;558:279-331.
Wahlvertiefung: Biologische Chemie
Obligatorische Konzeptkurse
NummerTitelTypECTSUmfangDozierende
529-0732-00LProteins and LipidsO6 KP3GD. Hilvert
KurzbeschreibungAn overview of the relationship between protein sequence, conformation and function.
LernzielOverview of the relationship between protein sequence, conformation and function.
InhaltProteins, structures and properties, (bio)synthesis of polypeptides, protein folding and design, protein engineering, chemical modification of proteins, proteomics.
LiteraturGeneral Literature:
- T.E. Creighton: Proteins: Structures and Molecular Properties, 2nd Edition, H.W. Freeman and Company, New York, 1993.
- C. Branden, J. Tooze , Introduction to Protein Structure, Garland Publishing, New York, 1991.
- J. M. Berg, J. L. Tymoczko, L. Stryer: Biochemistry, 5th edition, H.W. Freeman and Company, New York, 2002.
- G.A. Petsko, D. Ringe: Protein Structure and Function, New Science Press Ltd., London, 2004.

Original Literature:
Citations from the original literature relevant to the individual lectures will be assigned weekly.
Wahlpflicht Masterkurse
NummerTitelTypECTSUmfangDozierende
551-1402-00LMolecular and Structural Biology VI: Biophysical Analysis of Macromolecular Mechanisms
This course is strongly recommended for the Masters Major "Biology and Biophysics".
W4 KP2VR. Glockshuber, T. Ishikawa, S. Jonas, B. Schuler, D. Veprintsev, E. Weber-Ban
KurzbeschreibungThe course is focussed on biophysical methods for characterising conformational transitions and reaction mechanisms of proteins and biological mecromolecules, with focus on methods that have not been covered in the Biology Bachelor Curriculum.
LernzielThe goal of the course is to give the students a broad overview on biopyhsical techniques available for studying conformational transitions and complex reaction mechanisms of biological macromolecules. The course is particularly suited for students enrolled in the Majors "Structural Biology and Biophysics", "Biochemistry" and "Chemical Biology" of the Biology MSc curriculum, as well as for MSc students of Chemistry and Interdisciplinary Natural Sciences".
InhaltThe biophysical methods covered in the course include advanced reaction kinetics, methods for the thermodynamic and kinetic analysis of protein-ligand interactions, static and dynamic light scattering, analytical ultracentrifugation, spectroscopic techniques such as fluorescence anisotropy, fluorescence resonance energy transfer (FRET) and single molecule fluorescence spectrosopy, modern electron microscopy techniques, atomic force microscopy, and isothermal and differential scanning calorimetry.
SkriptCourse material from the individual lecturers wil be made available at the sharepoint website

https://team.biol.ethz.ch/e-learn/551-1402-00L
Voraussetzungen / BesonderesFinished BSc curriculum in Biology, Chemistry or Interdisciplinary Natural Sciences. The course is also adequate for doctoral students with research projects in structural biology, biophysics, biochemistry and chemical biology.
529-0941-00LIntroduction to Macromolecular ChemistryW4 KP3GD. Opris
KurzbeschreibungBasic definitions, types of polyreactions, constitution of homo- and copolymers, networks, configurative and conformative aspects, contour length, coil formation, mobility, glass temperature, rubber elasticity, molecular weight distribution, energetics of and examples for polyreactions.
LernzielUnderstanding the significance of molecular size, constitution, configuration and conformation of synthetic and natural macromolecules for their specific physical and chemical properties.
InhaltThis introductory course on macromolecular chemistry discusses definitions, introduces types of polyreactions, and compares chain and step-growth polymerizations. It also treats the constitution of polymers, homo- and copolymers, networks, configuration and conformation of polymers. Topics of interest are contour length, coil formation, the mobility in polymers, glass temperature, rubber elasticity, molecular weight distribution, energetics of polyreactions, and examples for polyreactions (polyadditions, polycondensations, polymerizations). Selected polymerization mechanisms and procedures are discussed whenever appropriate throughout the course. Some methods of molecular weight determination are introduced.
SkriptCourse materials (consisting of personal notes and distributed paper copies) are sufficient for exam preparation.
Voraussetzungen / BesonderesThe course will be taught in English. Complicated expressions will also be given in German. Questions are welcome in English or German. The written examination will be in English, answers in German are acceptable. A basic chemistry knowledge is required.

PhD students who need recognized credit points are required to pass the written exam.
529-0242-00LSupramolecular ChemistryW6 KP3GY. Yamakoshi, B. M. Lewandowski
KurzbeschreibungPrinzipien molekularer Erkennung: Komplexierung von Anionen, Kationen und technol. Anwendungen; Kompl. von Neutralmolekülen in wässr. Lösung; nichtkovalente Wechselwirkungen mit aromatischen Ringen; Wasserstoffbrückenbindungen; molekulare Selbstassoziation – ein chemischer Zugang zu Nanostrukturen; Thermodynamik und Kinetik von Komplexierungsprozessen; Synthese von Rezeptoren; Templateffekte.
LernzielZiel der Vorlesung ist das Verständnis von Natur und Stärke der nichtkovalenten zwischenmolekularen Wechselwirkungen sowie von Solvatationseffekten bei der Assoziation von Molekülen und/oder Ionen. Die Vorlesung (2 h) wird durch eine Übungsstunde (1 h) ergänzt, bei der die Synthese von Rezeptoren und andere synthetische Aspekte der Supramolekularen Chemie im Vordergrund stehen.
InhaltPrinzipien molekularer Erkennung: Komplexierung von Kationen und Anionen sowie entspr. technologische Anwendungen, Komplexierung von Neutralmolekülen in wässriger Lösung, nichtkovalente Wechselwirkungen mit aromatischen Ringen, Wasserstoffbrückenbindungen, Selbstassoziation von Molekülen – ein chemischer Zugang zu Nanostrukturen, Thermodynamik und Kinetik von Komplexierungsprozessen; Synthese von Rezeptoren; Templateffekte.
SkriptEin Skript kann zu Beginn der Vorlesung erworben werden. Übungsaufgaben und Lösungen werden über das Internet zur Verfügung gestellt.
LiteraturKeine Pflichtliteratur. Ergänzungsliteratur wird im Rahmen der Vorlesung und im Skript vorgestellt.
Voraussetzungen / BesonderesVoraussetzungen: organisch- und physikalisch-chemische Vorlesungen der ersten zwei Studienjahre.
551-0224-00LAdvanced Proteomics Belegung eingeschränkt - Details anzeigen
Für Masterstudierende ab 2. Semester, Doktorierende und Postdoktorierende
W4 KP6GR. Aebersold, L. Gillet, M. Gstaiger, A. Leitner, P. Pedrioli
KurzbeschreibungZiel dieses Kurses ist es, etablierte und neue Technologien der Protein- und Proteome-Analyse kennenzulernen in Bezug auf ihre Anwendung in Biologie, Biotechnologie und Medizin.
Format: Einführung durch Dozent mit anschliessender Diskussion, unterstützt durch Literaturarbeit und Übungen.
LernzielIm Kurs werden sowohl die bereits etablierten als auch die neuesten derzeit entstehenden Technologien und Methoden in der Protein- und Proteomanlayse diskutiert im Hinblick auf ihre Anwendung in der Biologie, Biotechnologie, Medizin und Systembiologie.
InhaltBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Voraussetzungen / BesonderesNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students http://www.rektorat.ethz.ch/students/admission/auditors/index_EN
551-1412-00LMolecular and Structural Biology IV: Visualizing Macromolecules by X-Ray Crystallography and EMW4 KP2VN. Ban, D. Böhringer, T. Ishikawa, M. A. Leibundgut, K. Locher, M. Pilhofer, K. Wüthrich, weitere Dozierende
KurzbeschreibungThis course provides an in-depth discussion of two main methods to determine the 3D structures of macromolecules and complexes at high resolution: X-ray crystallography and cryo-electron microscopy. Both techniques result in electron density maps that are interpreted by atomic models.
LernzielStudents will obtain the theoretical background to understand structure determination techniques employed in X-ray crystallography and electron microscopy, including diffraction theory, crystal growth and analysis, reciprocal space calculations, interpretation of electron density, structure building and refinement as well as validation. The course will also provide an introduction into the use of cryo-electron tomography to visualize complex cellular substructures at sub-nanometer resolutions, effectively bridging the resolution gap between optical microscopy and single particle cryo-electron microscopy. Lectures will be complemented with practical sessions where students will have a chance to gain hands on experience with sample preparation, data processing and structure building and refinement.
InhaltFebruary 22 Lecture 1 Prof. Dr. Kurt Wüthrich
History of Structural Molecular Biology

March 1 Lecture 2 Prof. Dr. Kaspar Locher
X-ray diffraction from macromolecular crystals

March 8 Lecture 3 Prof. Dr. Kaspar Locher
Data collection and statistics, phasing methods

March 15 Lecture 4 Prof. Dr. Nenad Ban
Crystal symmetry and space groups

March 22 Lecture 5 Ban Lab
Practical session with X-ray data processing

March 29 Lecture 6 Prof. Dr. Takashi Ishikawa
Principle of cryo-EM for biological macromolecules I, including hardware of TEM and detectors, image formation principle (phase contrast, spherical aberration, CTF), 3D reconstruction (central-section theorem, backprojection, missing information)

April 5 Lecture 7 Dr. Daniel Boehringer
Single particle analysis, including principle (projection matching, random conical tilt, angular reconstitution)

April 12 Lecture 8 Ban Lab
Practical session including specimen preparation (cryo, negative stain, visit to ScopeM

May 3 Lecture 9
Prof. Dr. M. Pilhofer
Tomography I, including basics and subtomogram averaging

May 10 Lecture 10 Ban Lab
Practical session with example initial EM data processing

May 17 Lecture 11 Prof. Dr. Martin Pilhofer
Practical session (including recent techniques, including cryo-FIB)

May 24 Lecture 12 Prof. Dr. Nenad Ban
EM and X-ray structure building, refinement, validation and interpretation

May 31 Lecture 13 Ban Lab
Practical session with model building and refinemen
551-1414-00LMolecular and Structural Biology V: Studying Macromolecules by NMR and EPRW4 KP2VF. Allain, A. D. Gossert, G. Jeschke, K. Wüthrich
KurzbeschreibungThe course provides an overview of experimental methods for studying function and structure of macromolecules at atomic resolution in solution. The two main methods used are Nuclear Magnetic Resonance (NMR) spectroscopy and Electron Paramagnetic Resonance (EPR) spectroscopy.
LernzielInsight into the methodology, areas of application and limitations of these two methods for studying biological macromolecules. Practical exercises with spectra to have hands on understanding of the methodology.
InhaltPart I: Historical overview of structural biology.
Part II: Basic concepts of NMR and initial examples of applications.
2D NMR and isotope labeling for studying protein function and molecular interactions at atomic level.
Studies of dynamic processes of proteins in solution.
Approaches to study large particles.
Methods for determination of protein structures in solution.
Part III: NMR methods for structurally characterizing RNA and protein-RNA complexes.
Part IV: EPR of biomolecules
Literatur1) Wüthrich, K. NMR of Proteins and Nucleic Acids, Wiley-Interscience.
2) Dominguez et al, Prog Nucl Magn Reson Spectrosc. 2011 Feb;58(1-2):1-61.
3) Duss O et al, Methods Enzymol. 2015;558:279-331.
Zusätzliche Konzeptkurse
NummerTitelTypECTSUmfangDozierende
551-0320-00LCellular Biochemistry (Part II)W3 KP2VY. Barral, R. Kroschewski, A. E. Smith
KurzbeschreibungThis course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes.
LernzielThe full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry.
The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection.
InhaltSpatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection.
LiteraturRecommended supplementary literature (review articles and selected primary literature) will be provided during the course.
Voraussetzungen / BesonderesTo attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English.
In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform.
551-0307-01LMolecular and Structural Biology II: From Gene to Protein
D-BIOL students are obliged to take part I and part II as a two-semester course.
W3 KP2VN. Ban, F. Allain, S. Jonas, M. Pilhofer
KurzbeschreibungThis course will cover advanced topics in molecular biology and biochemistry with emphasis on the structure and function of cellular assemblies involved in expression and maintenance of genetic information. We will cover the architecture and the function of molecules involved in DNA replication, transcription, translation, nucleic acid packaging in viruses, RNA processing, and CRISPER/CAS system.
LernzielStudents will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes ranging from DNA replication, transcription and translation. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation.
InhaltAdvanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies.
SkriptUpdated handouts will be provided during the class.
LiteraturThe lecture will be based on the latest literature. Additional suggested
literature:
Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed.
(1995). Garland, New York.