Suchergebnis: Katalogdaten im Frühjahrssemester 2015

Gesundheitswissenschaften und Technologie Master Information
Vertiefung in Gesundheit, Ernährung und Umwelt
Wahlfächer
Wahlfächer II
NummerTitelTypECTSUmfangDozierende
551-0314-00LMicrobiology (Part II) Information
Prerequisites: the basic Microbiobiology lecture "Grundlagen der Mikrobiologie, Teil Mikrobiologie" 551-0104-05L as the basis (Textbook: Brock, Microbiology).
W3 KP2VW.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli
KurzbeschreibungAdvanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
LernzielThis concept class will be based on common concepts (Grundlagen der Biologie IIB, Teil Mikrobiologie; 551-0104-05L) and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
InhaltAdvanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis.
SkriptUpdated handouts will be provided during the class.
LiteraturCurrent literature references will be provided during the lectures.
Voraussetzungen / BesonderesEnglish
701-1708-00LInfectious Disease DynamicsW4 KP2VS. Bonhoeffer, R. D. Kouyos, R. R. Regös, T. Stadler
KurzbeschreibungThis course introduces into current research on the population biology of infectious diseases. The course discusses the most important mathematical tools and their application to relevant diseases of human, natural or managed populations.
LernzielAttendees will learn about:
* the impact of important infectious pathogens and their evolution on human, natural and managed populations
* the population biological impact of interventions such as treatment or vaccination
* the impact of population structure on disease transmission

Attendees will learn how:
* the emergence spread of infectious diseases is described mathematically
* the impact of interventions can be predicted and optimized with mathematical models
* population biological models are parameterized from empirical data
* genetic information can be used to infer the population biology of the infectious disease

The course will focus on how the formal methods ("how") can be used to derive biological insights about the host-pathogen system ("about").
InhaltAfter an introduction into the history of infectious diseases and epidemiology the course will discuss basic epidemiological models and the mathematical methods of their analysis. We will then discuss the population dynamical effects of intervention strategies such as vaccination and treatment. In the second part of the course we will introduce into more advanced topics such as the effect of spatial population structure, explicit contact structure, host heterogeneity, and stochasticity. In the final part of the course we will introduce basic concepts of phylogenetic analysis in the context of infectious diseases.
SkriptSlides and script of the lecture will be available online.
LiteraturThe course is not based on any of the textbooks below, but they are excellent choices as accompanying material:
* Keeling & Rohani, Modeling Infectious Diseases in Humans and Animals, Princeton Univ Press 2008
* Anderson & May, Infectious Diseases in Humans, Oxford Univ Press 1990
* Murray, Mathematical Biology, Springer 2002/3
* Nowak & May, Virus Dynamics, Oxford Univ Press 2000
* Holmes, The Evolution and Emergence of RNA Viruses, Oxford Univ Press 2009
Voraussetzungen / BesonderesBasic knowledge of population dynamics and population genetics as well as linear algebra and analysis will be an advantage.
752-6102-00LNutrition and Chronic Disease (FS)W3 KP2VM. B. Zimmermann
KurzbeschreibungThe course teaches the links between the diet and the etiology and progression of chronic diseases.
LernzielTo examine and understand the protective effects of foods and food ingredients in the maintenance of health and the prevention of chronic disease, as well as the progression of complications of the chronic diseases.
InhaltThe course evaluates food and food ingredients in relation to primary and secondary prevention of chronic diseases including osteoporosis, cancer and obesity.
SkriptThere is no script. Powerpoint presentations and relevant literature will be made available online to students.
LiteraturObligatory course literature to be provided by the responsible lecturer and the individual lecturers.
Voraussetzungen / BesonderesNo compulsory prerequisites, but prior completion of Introduction to Nutritional Science (752-6001-00L) and Advanced Topics in Nutritional Science (752-6002-00L) is strongly adviced.
752-6302-00LPhysiology of EatingW3 KP2VW. Langhans, S. J. Lee, A. Mansouri
KurzbeschreibungIntroduction to the basic knowledge necessary for an understanding of the physiology and pathology of hunger, satiety, and body weight control, how this knowledge is generated, and how it helps improve nutritional advice for healthy people as well as nutritional guidelines for patients.
LernzielThis course requires basic knowledge in physiology and is designed to build on course HE03 “Selected Topics in Physiology Related to Nutrition.” The course covers psychological and physiological determinants of food selection and amount eaten. The aim is to introduce the students to (a) the basic knowledge necessary for an understanding of the physiology and pathology of hunger, satiety, and body weight control, (b) how new scientific knowledge in this area is generated, (c) how this basic knowledge helps improve nutritional advice for healthy people as well as nutritional guidelines for patients. Major topics are: Basic scientific concepts for the physiological study of eating in animals and humans; the psychopharmacology of reward; endocrine and metabolic controls of eating; the neural control of eating; psychological aspects of eating; eating behavior and energy balance; exercise, eating and body weight; epidemiology, clinical features and the treatment of psychiatric eating disorders; epidemiology, clinical features and the treatment of obesity, including related aspects of non-insulin dependent diabetes; mechanisms of cachexia and anorexia during illness; exogenous factors that influence eating, including pharmaceutical drugs, alcohol, coffee, etc.
SkriptHandouts will be provided
LiteraturLiterature will be discussed in class
701-0662-00LEnvironmental Impacts, Threshold Levels and Health Effects Information W3 KP2VC.‑T. Monn, M. Brink
KurzbeschreibungEs wird gezeigt, wie sich Umweltbelastungen auf die Gesundheit des Menschen und das Wohlbefinden auswirken. Dabei werden Methoden und Konzepte für die Bewertung von Belastungen gezeigt und diskutiert. Es werden exemplarisch die Gebiete Luftschadstoffe (z.B. Ozon, PM10 etc.) (1. Semesterhälfte) und Lärm (2. Semesterhälfte) behandelt.
Lernziel- Verstehen der Konzepte und Methoden der Expositionsmessung (Luft und Schall/Lärm)
- Kennen der Methoden für die Erforschung von gesundheitlichen Auswirkungen
- Kennen der Kriterien und Methoden für die Festlegung von Grenzwerten
InhaltLuftschadstoffe
- Aussenluft; Quellen der Luftschadstoffe; Ausbreitung
- Innenluft, Raumluft
- Konzepte des "Exposure Assessments", Messmethoden für Gase und Partikel
- Methoden für die Erfassung von gesundheitliche Auswirkungen (u.a. Epidemiologie)
- gesundheitliche Auswirkungen von Schadstoffen und Kriterien für Grenzwerte (PM-10 und Sommersmog (Ozon))

Lärm
- Grundlagen der Akustik, Schallmesstechnik, das Gehör
- Auditive Verarbeitung
- Lärm(Schall)-Berechnung und -Beurteilung
- Lärmwirkungen, Belastungs-Wirkungsbeziehungen
- Grundzüge der Lärmbekämpfung, Grenzwerte
- Lärmschutzpolitik
SkriptDie Vorlesungsunterlagen (Texte und Abb. der Vorlesung; ppt, pdf) werden jeweils einige Tage vor der Vorlesung per Email verschickt.
Literaturkeine spezielle. Verweise während Vorlesung.
701-1312-00LAdvanced EcotoxicologyW3 KP2VR. Eggen, E. Janssen, K. Schirmer, M. Suter
KurzbeschreibungThis course will take up the principles of environmental chemistry and ecotoxicology from the bachelor courses and deepen the understanding on selected topics. Linkages will be made between i) bioavailability and effects, ii) structures of compounds and modes of toxic action, iii) effects over various biological levels, moderated by environmental factors, iv) chemical and biological assessments
Lernziel- Understanding the key processes involved in fate, behavior and the bioaccumulation of (mainly) organic contaminants
- Overview on and understanding of mechanisms of toxicity
- linking structures and characteristics of compounds with effects
- processes in hazard assessment and risk assessment
- get insight in integrative approaches in ecotoxicology
InhaltUnits 1-3: Fate of contaminants, dynamic interactions with the (a)biotic environment, toxikokinetics
- physico-chemical properties
- partitioning processes in environmental compartments
- partitioning to biota
- bioavailability and bioaccumulation concepts
- partitioning in biota

Units 4-6: Toxicodynamics (effect of contaminants on biota)
- internal concentrations; dose-response concept
- molecular mechanisms of toxic actions - classification
- Exercise: databases and estimation of toxicity

Unit 7-10: Toxic effects: from molecular to ecosystems
- complex mechanisms and feedback loops
- mixtures and multiple stressors
- stress- and adaptive responses
- dynamic exposures
- confounding factors, food web interactions
- Exercise: linking compounds with modes of toxic action

Unit 11: metal ecotoxicology

Unit 12-14: integrative approaches and case studies
- bioassays, -omics, systems ecotoxicology, phenotypic anchoring
- in vivo versus in vitro biotesting
- linking chemical with biological analytics
- bioassay-directed fractionation and identification
- (inter) national case studies and linkage of learned with approaches in practice
SkriptParts of scripts will be distributed, otherwise copies of overheads and selected publications
LiteraturR.P. Schwarzenbach, P.M. Gschwend, D.M. Imboden, Environmental Organic Chemistry, third edition, Wiley, 2005

C.J. van Leeuwen, J.L.M. Hermens (Editoren), Risk Assessment of Chemicals: An Introduction, Kluwer, 1995

Principles of ecotoxicology, CH Walker, RM Sibly, SP Hopkin, DB Peakall, fourth edition, CRC Press, 2012
Voraussetzungen / BesonderesRequired:

1. Basics in environmental chemistry

2. Basics in environmental toxicology
701-1350-00LCase Studies in Environment and HealthW4 KP2VK. McNeill
KurzbeschreibungThis course will tell the story of a few individual chemicals from different standpoints: their basic chemistry, environmental behavior, ecotoxicology, human health impacts, and societal role. The goal of the course is to draw out the common points in each chemical's history to be able to better predict the environmental and human health impacts of new chemicals whose story is so far unknown.
LernzielThis course aims to illustrate how the individual molecular properties and societal pressures lead to environmental and human health crises. The ultimate goal of the course is to identify common aspects that will improve prediction of environmental crises before they occur. Students are expected to participate actively in the course, which includes the critical reading of the pertinent literature and class presentations.
InhaltEach semester will feature between three and five case studies of molecules, or classes of molecules, that have had a profound effect on human health and the environment. These case studies will be explored from different angles, including considering their environmental chemistry their toxicology and their societal role. Students will be expected to contribute to the discussion and, on selected topics, to lead the discussion.
SkriptHandouts will be provided as needed.
LiteraturHandouts will be provided as needed.
701-1704-01LHealth Impact Assessment: Concepts and Case StudiesW3 KP2VM. Winkler, C. Guéladio, L. Pérez Grau, M. Röösli, J. M. Utzinger
KurzbeschreibungThis course introduces the concept of health impact assessment (HIA) and discusses a suite of case studies in industrialised and developing countries. HIA pursues an inter- and multidisciplinary approach, employs qualitative and quantitative methods with the overarching goal to influence decision-making so that negative health effects of policies, programmes and projects can be minimized and posit
LernzielAfter successful completion of the course, students should be able to:
o critically reflect on the concept of HIA and the different steps from screening to implementation and monitoring; and
o apply specific tools and methodologies for HIA of policies, programmes and projects in different social, ecological and epidemiological settings.
InhaltThe course will present a broad set of tools and methods for the systematic and evidence-based judgment of potential health effects related to policies, programmes and projects. Methodological features will be introduced and applied to a variety of case studies in the public sector (e.g. traffic-related air pollution, passive smoking and waste water management) and private sector (e.g. water resource developments and extractive industries) all over the world.
SkriptHandouts will be distributed.
LiteraturWhenever possible, at least one peer-reviewed paper will be made available for each session.
701-1706-00LEnvironmental Neurotoxicology, Stress and Human Mental HealthW3 KP2VR. Nil
KurzbeschreibungThis lecture covers environmental factors with a potentially negative effect on human mental health and their underlying neurobiological effects. The environmental factors include chemical pollutants, non-medical drugs and stress.
LernzielKnowledge of key pharmacokinetic parameters and principles which are of relevance for environmental neurotoxicology

Knowledge of neurobiological principles in order to understand and evaluate neurotoxic effects

Knowledge of the main environmental pollutants with neurotoxic potential

Knowledge of the neurotoxic effects of stress and non-medical drugs with relevance to mental health
Inhalt1. Repetition of essentials in neurobiology and pharmacology/toxicology to allow conceptualising and synthesising of findings
- Basics of chemical neurotransmission and neurohormonal systems
- Basics of neurodevelopment and neural plasticity
- Basics of pharmacological/toxicological principles and parameters

2. Overview of environmental and non-medical substances with neurotoxic potential
- Relevant substances such as persistent organic pollutants (POPs), metals, industrial substances (PCB, PBDEs), solvents, non-medical drugs such as alcohol and others and their neurobiological effects
- Measurement and development of recent epidemiological human exposure

3. Specific evaluations of substances/substance classes with focus on neurobiological/mental health effects

4. Stress
- Stress: Stressors, psychophysiological stress reactions - concepts and hypotheses
- Mental health - epidemiology and recent developments
- Stress and mental health (depression, psychosis, anxiety)
- Specific stress related mental disorders (PTSD (post traumatic stress disorder), burnout) and related neurobehavioral hypotheses
SkriptNo script available. All lecture slides will be provided weekly on a ongoing basis before the single lectures.
752-1300-00LIntroduction to Molecular ToxicologyW3 KP2VS. J. Sturla
KurzbeschreibungIntroduction to chemical and biological interactions that govern the properties, disposition and biological influences of toxins.
LernzielThe objectives are for the student to establish a framework for examining adverse effects resulting from exposures to toxins by understanding key molecular mechanisms that give rise to toxic responses and disease processes.
InhaltEinführung in die Mechanismen zur Steuerung der chemischen Disposition und der biologischen Einflüsse von Giften. Geeignet für Bachelorstudenten in höheren Semestern und Masterstudenten sowie Doktorierende der Lebensmittelwissenschaft oder verwandten Bereichen (Chemie, Umweltwissenschaften, Pharmazie, etc.) Themengebiete sind: Dosis-Wirkungsrelation und Risikoanalyse, Absorption, Transport und Biotransformation von Fremdstoffen/Chemikalien; Kanzerogenese; Schädigung der DNS, Wiederherstellung und Mutation; Chemotherapie; Immunotoxikologie; Neurotoxikologie; und Systemtoxikologie. Diese fundamentalen Konzepte der molekularen Toxikologie werden anhand von Giftstoffen besprochen, die für Lebensmittel, Arzneistoffe und die Umwelt relevant sind.
LiteraturCasarett & Doull's Essentials of Toxicology, Second Edition. Curtis Kaassen and John B. Watkins III, 2010, McGraw-Hill.
Voraussetzungen / Besonderesorganic chemistry and biochemistry
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