Suchergebnis: Katalogdaten im Herbstsemester 2016
|Vertiefung in Gesundheit, Ernährung und Umwelt|
|701-0263-01L||Seminar in Evolutionary Ecology of Infectious Diseases||W||3 KP||2G||D. Croll, S. Bonhoeffer, R. R. Regös|
|Kurzbeschreibung||Students of this course will discuss current topics from the field of infectious disease biology. From a list of publications, each student chooses some themes that he/she is going to explain and discuss with all other participants and under supervision. The actual topics will change from year to year corresponding to the progress and new results occuring in the field.|
|Lernziel||This is an advanced course that will require significant student participation. Students will learn how to evaluate and present scientific literature and trace the development of ideas related to understanding the ecology and evolutionary biology of infectious diseases.|
|Inhalt||A core set of ~10 classic publications encompassing unifying themes in infectious disease ecology and evolution, such as virulence, resistance, metapopulations, networks, and competition will be presented and discussed. Pathogens will include bacteria, viruses and fungi. Hosts will include animals, plants and humans.|
|Skript||Publications and class notes can be downloaded from a web page announced during the lecture.|
|Literatur||Papers will be assigned and downloaded from a web page announced during the lecture.|
|701-1703-00L||Evolutionary Medicine for Infectious Diseases||W||3 KP||2G||A. Hall|
|Kurzbeschreibung||This course explores infectious disease from both the host and pathogen perspective. Through short lectures, reading and active discussion, students will identify areas where evolutionary thinking can improve our understanding of infectious diseases and, ultimately, our ability to treat them effectively.|
|Lernziel||Students will learn to (i) identify evolutionary explanations for the origins and characteristics of infectious diseases in a range of organisms and (ii) evaluate ways of integrating evolutionary thinking into improved strategies for treating infections of humans and animals. This will incorporate principles that apply across any host-pathogen interaction, as well as system-specific mechanistic information, with particular emphasis on bacteria and viruses.|
|Inhalt||We will cover several topics where evolutionary thinking is relevant to understanding or treating infectious diseases. This includes: (i) determinants of pathogen host range and virulence, (ii) dynamics of host-parasite coevolution, (iii) pathogen adaptation to evade or suppress immune responses, (iv) antimicrobial resistance, (v) evolution-proof medicine. For each topic there will be a short (< 30 minutes) introductory lecture, before students independently research the primary literature and develop half a page of discussion points and questions, followed by interactive discussion in class.|
|Literatur||Students will read the primary literature on each topic, and in places we will use the following books:|
Schmid Hempel 2011 Evolutionary Parasitology
Stearns & Medzhitov 2016 Evolutionary Medicine
|Voraussetzungen / Besonderes||A basic understanding of evolutionary biology, microbiology or parasitology will be advantageous but is not essential.|
|551-0223-00L||Immunology III||W||4 KP||2V||M. Kopf, M. Bachmann, J. Kisielow, A. Lanzavecchia, S. R. Leibundgut, A. Oxenius, R. Spörri|
|Kurzbeschreibung||Diese Vorlesung liefert einen detaillierten Einblick in die|
- Entwicklung von T Zellen und B Zellen
- Dynamik einer Immunantwort bei akuten und chronischen Infektionen
- Mechanismen von Immunpathologie
- neue Impfstoffstrategien
- die Entwicklung, Aktivierung, und Differenzierung verschiedener Typen von T Zellen und deren Effektormechanismen während einer Immunantwort
- die Erkennung von pathogenen Mikroorganismen und molekulare Ereignisse nach Infektion einer Zelle
- Ereignisse und Signale für die Reifung von naiven B Zellen zu antikörperproduzierenden Plasmazellen und Gedächtniszellen,
- Optimierung von B Zellantworten durch das intelligente Design neuer Impfstoffe
|Inhalt||o Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg)|
o NK T cells and responses to lipid antigens
o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17
o Overview of cytokines and their effector function
o Co-stimulation (signals 1-3)
o Dendritic cells
o Evolution of the "Danger" concept
o Cells expressing Pattern Recognition Receptors and their downstream signals
o T cell function and dysfunction in acute and chronic viral infections
|Literatur||Unterlagen zur Vorlesung sind erhältlich bei:|
|Voraussetzungen / Besonderes||Immunology I and II recommended but not compulsory|
|551-1171-00L||Immunology: from Milestones to Current Topics||W||4 KP||2S||B. Ludewig, J. Kisielow, M. Kopf, A. Oxenius, Uni-Dozierende|
|Kurzbeschreibung||Milestones in Immunology: on old concepts and modern experiments|
|Lernziel||The course will cover six grand topics in immunology (B cells, innate immunity, antigen presentation, tumor immunity, thymus and T cells, cytotoxic T cells and NK cells) and for each grand topic four hours will be allocated. During the first double hour, historical milestone papers will be presented by the supervisor providing an overview on the development of the conceptional framework and critical technological advances. The students will also prepare themselves for this double lecture by reading the historical milestone papers and contributing to the discussion. In the following lecture up to four students will present each a recent high impact research paper which emerged from the landmark achievements of the previously discussed milestone concepts.|
|Inhalt||Milestones and current topics of innate immunity, antigen presentatino, B cells, thymus and T cells, cytotoxic T cells and NK cells, and tumor immunology.|
|Skript||Original and review articles will be distributed by the lecturer.|
|Literatur||Literaturunterlagen werden vor Beginn des Kurses auf folgender website zugänglich sein: Moodle Course https://moodle-app2.let.ethz.ch/course/view.php?id=1002|
|752-4009-00L||Molecular Biology of Foodborne Pathogens||W||3 KP||2V||M. Loessner, M. Schuppler|
|Kurzbeschreibung||The course offers detailed information on selected foodborne pathogens and toxin producing organisms; the focus lies on relevant molecular biological aspects of pathogenicity and virulence, as well as on the occurrence and survival of these organisms in foods.|
|Lernziel||Detailed and current status of research and insights into the molecular basis of foodborne diseases, with focus on interactions of the microorganism or the toxins they produce with the human system. Understanding the relationship between specific types of food and the associated pathogens and microbial risks. Another focus lies on the currently available methods and techniques useful for the various purposes, i.e., detection, differentiation (typing), and antimicrobial agents.|
|Inhalt||Molecular biology of infectious foodborne pathogens (Listeria, Vibrio, E. coli, Campylobacter, etc) and toxin-producing organisms (Bacillus, Clostridium, Staphylococcus). How and under which conditions will toxins and virulence factors be produced, and how do they work? How is the interaction between the human host and the microbial pathogen? What are the roles of food and the environment ? What can be done to interfere with the potential risks? Which methods are best suited for what approach? Last, but not least, the role of bacteriophages in microbial pathogenicity will be highlighted, in addition to various applications of bacteriophage for both diagnsotics and antimicrobial intervention.|
|Skript||Electronic copies of the presentation slides (PDF) and additional material will be made available for download to registered students.|
|Literatur||Recommendations will be given in the first lecture|
|Voraussetzungen / Besonderes||Lectures (2 hours) will be held as a single session of approximately 60+ minutes (10:15 until approx. 11:15 h), with no break !|
|701-1471-00L||Ecological Parasitology |
Number of participants limited to 20.
Enrollment is limited to Master students of the study programme Environmental Sciences majoring Ecology and Evolution and to Master students of the study programme Biology majoring Ecology and Evolution (Elective Compulsory Master Courses), time of enrolment is decisive.
It is possible to enroll until September 12. The registration will only be effective once confirmed.
|W||3 KP||1V + 1P||O. E. Seppälä, H. Hartikainen, J. Jokela|
|Kurzbeschreibung||Course focuses on the ecology and evolution of macroparasites and their hosts. Through lectures and practical work, students learn about diversity and natural history of parasites, adaptations of parasites, ecology of host-parasite interactions, applied parasitology, and human macroparasites in the modern world.|
|Lernziel||1. Identify common macroparasites in aquatic organisms. |
2. Understand ecological and evolutionary processes in host-parasite interactions.
3. Conduct parasitological research.
1. Diversity and natural history of parasites (i.e. systematic groups and life-cycles).
2. Adaptations of parasites (e.g. evolution of life-cycles, host manipulation).
3. Ecology of host-parasite interactions (e.g. parasite communities, effects of environmental changes).
4. Applied parasitology (e.g. aquaculture and fisheries).
5. Human macroparasites (schistosomiasis, malaria).
1. Examination of parasites in fish (identification of species and description of parasite communities).
2. Examination of parasites in molluscs (identification and examination of host exploitation strategies).
3. Examination of parasites in amphipods (identification and examination of effects on hosts).
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