Autumn Semester 2020 takes place in a mixed form of online and classroom teaching.
Please read the published information on the individual courses carefully.

Search result: Catalogue data in Autumn Semester 2016

Biology Master Information
Elective Major Subject Areas
Elective Major: Systems Biology
Elective Compulsory Master Courses I: Computation
NumberTitleTypeECTSHoursLecturers
636-0007-00LComputational Systems Biology Information W6 credits3V + 2UJ. Stelling
AbstractStudy of fundamental concepts, models and computational methods for the analysis of complex biological networks. Topics: Systems approaches in biology, biology and reaction network fundamentals, modeling and simulation approaches (topological, probabilistic, stoichiometric, qualitative, linear / nonlinear ODEs, stochastic), and systems analysis (complexity reduction, stability, identification).
ObjectiveThe aim of this course is to provide an introductory overview of mathematical and computational methods for the modeling, simulation and analysis of biological networks.
ContentBiology has witnessed an unprecedented increase in experimental data and, correspondingly, an increased need for computational methods to analyze this data. The explosion of sequenced genomes, and subsequently, of bioinformatics methods for the storage, analysis and comparison of genetic sequences provides a prominent example. Recently, however, an additional area of research, captured by the label "Systems Biology", focuses on how networks, which are more than the mere sum of their parts' properties, establish biological functions. This is essentially a task of reverse engineering. The aim of this course is to provide an introductory overview of corresponding computational methods for the modeling, simulation and analysis of biological networks. We will start with an introduction into the basic units, functions and design principles that are relevant for biology at the level of individual cells. Making extensive use of example systems, the course will then focus on methods and algorithms that allow for the investigation of biological networks with increasing detail. These include (i) graph theoretical approaches for revealing large-scale network organization, (ii) probabilistic (Bayesian) network representations, (iii) structural network analysis based on reaction stoichiometries, (iv) qualitative methods for dynamic modeling and simulation (Boolean and piece-wise linear approaches), (v) mechanistic modeling using ordinary differential equations (ODEs) and finally (vi) stochastic simulation methods.
Lecture notesLink
LiteratureU. Alon, An introduction to systems biology. Chapman & Hall / CRC, 2006.

Z. Szallasi et al. (eds.), System modeling in cellular biology. MIT Press, 2006.
636-0706-00LSpatio-Temporal Modelling in Biology Information W5 credits3GD. Iber
AbstractThis course focuses on modeling spatio-temporal problems in biology, in particular on the cell and tissue level. A wide range of mathematical techniques will be presented as part of the course, including concepts from non-linear dynamics (ODE and PDE models), stochastic techniques (SDE, Master equations, Monte Carlo simulations), and thermodynamic descriptions.
ObjectiveThe aim of the course is to introduce students to state-of-the-art mathematical modelling of spatio-temporal problems in biology. Students will learn how to chose from a wide range of modelling techniques and how to apply these to further our understanding of biological mechanisms. The course aims at equipping students with the tools and concepts to conduct successful research in this area; both classical as well as recent research work will be discussed.
Content1. Introduction to Modelling in Biology
2. Morphogen Gradients
3. Turing Pattern
4. Travelling Waves & Wave Pinning
5. Application Example 1: Dorso-ventral axis formation
6. Chemotaxis, Cell Adhesion & Migration
7. Introduction to Numerical Methods
8. Simulations on Growing Domains
9. Image-Based Modelling
10. Branching Processes
11. Cell-based Simulation Frameworks
12. Application Example 2: Limb Development
13. Summary
Lecture notesAll lecture material will be made available online
Link
LiteratureMurray, Mathematical Biology, Springer
Forgacs and Newman, Biological Physics of the Developing Embryo, CUP
Keener and Sneyd, Mathematical Physiology, Springer
Fall et al, Computational Cell Biology, Springer
Szallasi et al, System Modeling in Cellular Biology, MIT Press
Wolkenhauer, Systems Biology
Kreyszig, Engineering Mathematics, Wiley
Prerequisites / NoticeThe course builds on introductory courses in Computational Biology. The course assumes no background in biology but a good foundation regarding mathematical and computational techniques.
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