Suchergebnis: Katalogdaten im Herbstsemester 2017

Medicinal and Industrial Pharmaceutical Sciences Master Information
Das 1. Semester dieses Studiengangs wird nicht mehr angeboten. Der Studiengang wird durch den Master in Pharmaceutical Sciences ersetzt.
Kompensationsfächer
NummerTitelTypECTSUmfangDozierende
535-0310-00LGlycobiology in Drug DevelopmentW1 KP1VV. I. Otto
KurzbeschreibungProtein-based drugs constitute around 25% of new approvals and most of them are glycoproteins. Using selected examples of prominent glycoprotein drugs, the course aims at providing insight into glycosylation-activity relationships and into biotechnological production and analytics.
LernzielStudents gain insight into the glycobiology of therapeutically used glycoproteins. This implies knowing and understanding
- the major types of protein-linked glycans and their biosynthesis
- the most important expression systems for production of recombinant glycoproteins
- methods used to alter or manipulate glycosylation
- the most prominent clinically used glycoproteins and how glycosylation influences their therapeutic profile.
- Current methods for the qualitative and quantitative characterization of glycoproteins
Students are able to apply this knowledge and propose solutions to biotechnological problems that involve protein glycosylation.
Inhaltlecture plan:
1. Introduction: Carbohydrates - one of life's principal molecular languages
2. Glucocerebrosidase and the biosynthesis of N-glycans
3. PSGL-1 and the biosynthesis of O-glycans
4. The glycoprotein hormones and the analysis of their glycosylation
5. Monoclonal antibodies and the modification of their therapeutic profile through glycoengineering
6. EPO "the same but different"
SkriptThe slides used for the lectures will be provided online
Literatur- Essentials of Glycobiology 2nd edition, A. Varki, R.D. Cummings et al., Cold Spring Harbor Laboratory Press, New York 2009.
- Posttranslational Modification of Protein Biopharmaceuticals, G. Walsh (ed.), Wiley VCH, Weinheim 2009.
- Gentechnik, Biotechnik. Grundlagen und Wirkstoffe, 2. Auflage, Dingermann, Winckler, Zündorf, Wissenschaftliche Verlagsgesellschaft Stuttgart, 2011.
Voraussetzungen / BesonderesRequirements: Basic knowledge in immunology, molecular biology, protein chemistry and analytics. Basic knowledge in pharmacology.
535-0300-00LMolecular Mechanisms of Drug Actions and Targets Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 24
W2 KP1VV. I. Otto, J. Scheuermann
KurzbeschreibungIm Schnitt wird ein Medikament pro Jahr vom Markt genommen. Anhand ausgewählter Beispiele solch gescheiterter Medikamente werden in diesem Kurs die modernen Erklärungen von Arzneimittelwirkungen, sowie die Aussagekraft (prä-)klinischer Studien analysiert und diskutiert. Auch werden die ethischen, gesellschaftlichen und wirtschaftlichen Erwartungen, die wir an neue Medikamente stellen, reflektiert.
LernzielKritische Auseinandersetzung mit den modernen Untersuchungsmethoden und Ansätzen zur Erklärung von Arzneimittelwirkungen. Diskussion ethischer, gesellschaftlicher, wirtschaftlicher und politischer Erwartungen an die Entwicklung neuer Medikamente.
InhaltIm Dezember 2006 brach Pfizer ihre gross angelegte Phase III-Studie (15'000 Probanden) zur Prävention von Atherosklerose und kardiovaskulären Erkrankungen mit Torcetrapib ab. 800 Millionen $ Entwicklungskosten und 21 Milliarden $ Börsenkapital wurden über Nacht wertlos. Das Scheitern von Torcetrapib hat Grenzen einer extrem reduktionistischen Betrachtungsweise von Atherosklerose und deren Beeinflussung durch Medikamente aufgezeigt. Es hat zudem verdeutlicht, welch hohe Anforderungen wir heute an eine sichere und breite Anwendbarkeit und somit den wirtschaftlichen Erfolg von Arzneimitteln stellen.
Torcetrapib ist kein Einzelfall. In den vergangenen 10 Jahren wurde durchschnittlich ein Medikament pro Jahr vom Markt genommen. Die Gründe waren mangelnde Wirksamkeit, unvorhergesehene, schwere Nebenwirkungen oder toxische Effekte. Dies zeigt, dass die gängigen Untersuchungen und das moderne Verständnis von Arzneimittelwirkungen oft nicht ausreichen, um deren Auswirkungen auf grössere Patientengruppen vorauszusagen.
Der Kurs ist diesem Themenkomplex gewidmet. Anhand von drei besonders aufschlussreichen Beispielen "gescheiterter" Medikamente werden die aufgetretenen Probleme, sowie die Konzepte und Aussagekraft präklinischer und klinischer Studien analysiert und reflektiert. Darüber hinaus werden ethische, gesellschaftliche, wirtschaftliche und politische Erwartungen an die Entwicklung neuer Medikamente kritisch beleuchtet und diskutiert.
SkriptVorlesungs- und Arbeitsunterlagen werden online zur Verfügung gestellt.
LiteraturLeseempfehlung: John Abramson, Overdo$ed America, Harper Perennial, New York 2008
Voraussetzungen / BesonderesVoraussetzungen: Grundwissen in Medizinischer Chemie und Pharmakologie. Fähigkeit, englisch geschriebene wissenschaftliche Publikationen zu lesen und zu verstehen.
535-0022-00LComputer-Assisted Drug DesignW1 KP1VG. Schneider
KurzbeschreibungThe lecture series provides an introduction to computer applications in medicinal chemistry. A focus is on molecular representations, property predictions, molecular similarity concepts, virtual screening techniques, and de novo drug design. All theoretical concepts and algorithms presented are illustrated by practical applications and case studies
LernzielThe students will learn how computer simulation generates ideas for drug design and development, understand the theoretical principles of property prediction and computer-generated compound generation, and understand possibilities and limitations of computer-assisted drug design in pharmaceutical chemistry. As a result, they are prepared for professional assessment of computer-assisted drug design studies in medicinal chemistry projects.
LiteraturRecommended textbooks:
1) G. Schneider, K.-H. Baringhaus (2008) "Molecular Design - Concepts and Applications", Wiley-VCH: Weinheim, New York.
2) H.-D. Höltje, W. Sippl, D. Rognan, G. Folkers (2008) "Molecular Modeling: Basic Principles and Applications", Wiley-VCH: Weinheim, New York.
3) G. Klebe (2009) "Wirkstoffdesign", Spektrum Akademischer Verlag: Heidelberg.
Voraussetzungen / BesonderesSuccessful participation in this course is required for a research project ("Forschungspraktikum") in the CADD group.
851-0180-00LResearch Ethics Belegung eingeschränkt - Details anzeigen
Number of participants limited to 40

Particularly suitable for students of D-BIOL, D-CHAB, D-HEST
W2 KP2GG. Achermann
KurzbeschreibungThis course enables students to:
• Identify and describe leading approaches to and key questions and concepts of research ethics;
• Identify, construct and evaluate moral arguments;
• Make well-reasoned decisions to ethical problems a scientist is likely to encounter;
• Analyze the theoretical foundations and disputes underlying contemporary debates on moral issues in research.
LernzielParticipants of the course Research Ethics will
• Develop an understanding of the role of certain moral concepts, principles and normative theories related to scientific research;
• Improve their moral reasoning skills (such as identifying and evaluating reasons, conclusions, assumptions, analogies, concepts and principles), and their ability to use these skills in assessing other people’s arguments, making decisions and constructing their own reasoning to the kinds of ethical problems a scientist is likely to encounter;
• Deepen their understanding of the debates on certain central moral issues in research, e.g. the use of animals in biomedical research.
InhaltI. Introduction to Moral Reasoning
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1. Ethics - the basics
- What is ethics? What ethics is not...
- Identification of moral issues (awareness): what constitutes an ethical question? Distinguishing ethical questions from other kinds of questions;
- Values (personal, cultural & ethical) & principles for ethical conduct in research;
- Descriptive and prescriptive ethics
- Ethical universalism, ethical relativism and cultural relativism
- What is research ethics and why is it important?
- Professional codes of conduct: functions and limitations

2. Normative Ethics
- Overview on important theories for research ethics: virtue theories, duty-based theories (rights theory, categorical imperative, prima facie duties), consequentialist theories, other theories;
- The plurality of ethical theories, moral pluralism and its consequences;

3. Moral reasoning I: Decision-making
- How (not) to approach ethical issues...; Is there a correct method for answering moral questions?
- Models of method in Applied Ethics: a) Top-down approaches; b) the reflective equilibrium; c) a bottom-up approach: casuistry (or reasoning-by-analogy);
- Is there a right answer?

4. Moral reasoning II: Arguments
- Why arguments? What is a good argument? The structure of (moral) arguments;
- Deductive and inductive arguments; Validity and soundness; strength and cogency;
- Assessing moral arguments

II. Research Ethics
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1. Research involving animals
- The moral status of animals: moral considerability, moral significance; morally relevant features;
- Representative views on the moral status of animals and resulting standpoints on the use of animals in biomedical research
- The 3 R's (replacement, reduction, refinement);
- Public policy in the context of moral disagreement
- The concept of dignity and the dignity of living beings in the Swiss constitution;
- The weighing/evaluation of interests: the procedure and criticism, the value of basic research and related problems in the weighing of interests;

2. Research involving human subjects
- History of research involving human subjects
- Basic ethical principles – the Belmont report
- Selection of study participants. The concept of vulnerability
- Assessment of risks and benefits of a research project
- Research ethics committees
- Information and consent; confidentiality and anonymity;
- Research projects involving biological material and health related data

3. Social responsibility
- What is social responsibility? Social responsibility: whose obligation?
- Public advocacy by researchers
SkriptCourse material (handouts, case studies, exercises, surveys and papers) will be available during the lectures and on the course homepage.
Voraussetzungen / BesonderesWhat are the requirements?
First and foremost your strong willingness to seriously achieve the main learning outcomes as indicated in the Course Catalogue (specific learning outcomes for each module will be provided at the beginning of the course). For successfully completing the course Research Ethics, the following commitment is absolutely necessary (but not sufficient) (observed success factors for many years!):
1. Your regular presence is absolutely required (so please no double, parallel enrollment for courses taking place at the identical time!) connected with your active participation during class, e.g. taking notes, contributing to discussions (in group as well as in plenary class), solving exercises.
2. Having the willingness and availability of the necessary time for regularly preparing the class (at least 1 hour per week, probably even more…). This includes e.g. the solving of exercises, the reading of ethics papers, and – of course – the preparation for the performance assessment during the semester.
3. Availability for writing the Performance assessment in the first part of the semester as well as the end-of-semester exam (the dates will be communicated in the first week of the semester).

Please carefully evaluate your situation for the autumn semester 2017 in respect of the necessary commitments.
351-0778-00LDiscovering Management
Entry level course in management for BSc, MSc and PHD students at all levels not belonging to D-MTEC. This course can be complemented with Discovering Management (Excercises) 351-0778-01.
W3 KP3GB. Clarysse, M. Ambühl, S. Brusoni, E. Fleisch, G. Grote, V. Hoffmann, T. Netland, G. von Krogh, F. von Wangenheim
KurzbeschreibungDiscovering Management offers an introduction to the field of business management and entrepreneurship for engineers and natural scientists. The module provides an overview of the principles of management, teaches knowledge about management that is highly complementary to the students' technical knowledge, and provides a basis for advancing the knowledge of the various subjects offered at D-MTEC.
LernzielDiscovering Management combines in an innovate format a set of lectures and an advanced business game. The learning model for Discovering Management involves 'learning by doing'. The objective is to introduce the students to the relevant topics of the management literature and give them a good introduction in entrepreneurship topics too. The course is a series of lectures on the topics of strategy, innovation, corporate finance, leadership, design thinking and corporate social responsibility. While the 14 different lectures provide the theoretical and conceptual foundations, the experiential learning outcomes result from the interactive business game. The purpose of the business game is to analyse the innovative needs of a large multinational company and develop a business case for the company to grow. This business case is as relevant to someone exploring innovation within an organisation as it is if you are planning to start your own business. By discovering the key aspects of entrepreneurial management, the purpose of the course is to advance students' understanding of factors driving innovation, entrepreneurship, and company success.
InhaltDiscovering Management aims to broaden the students' understanding of the principles of business management, emphasizing the interdependence of various topics in the development and management of a firm. The lectures introduce students not only to topics relevant for managing large corporations, but also touch upon the different aspects of starting up your own venture. The lectures will be presented by the respective area specialists at D-MTEC.
The course broadens the view and understanding of technology by linking it with its commercial applications and with society. The lectures are designed to introduce students to topics related to strategy, corporate innovation, leadership, corporate and entrepreneurial finance, value chain analysis, corporate social responsibility, and business model innovation. Practical examples from industry experts will stimulate the students to critically assess these issues. Creative skills will be trained by the business game exercise, a participant-centered learning activity, which provides students with the opportunity to place themselves in the role of Chief Innovation Officer of a large multinational company. As they learn more about the specific case and identify the challenge they are faced with, the students will have to develop an innovative business case for this multinational corporation. Doing so, this exercise will provide an insight into the context of managerial problem-solving and corporate innovation, and enhance the students' appreciation for the complex tasks companies and managers deal with. The business game presents a realistic model of a company and provides a valuable learning platform to integrate the increasingly important development of the skills and competences required to identify entrepreneurial opportunities, analyse the future business environment and successfully respond to it by taking systematic decisions, e.g. critical assessment of technological possibilities.
Voraussetzungen / BesonderesDiscovering Management is designed to suit the needs and expectations of Bachelor students at all levels as well as Master and PhD students not belonging to D-MTEC. By providing an overview of Business Management, this course is an ideal enrichment of the standard curriculum at ETH Zurich.
No prior knowledge of business or economics is required to successfully complete this course.
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