Suchergebnis: Katalogdaten im Frühjahrssemester 2019
Biologie Bachelor | ||||||
3. Studienjahr, 6. Semester | ||||||
Konzeptkurse | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
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529-0732-00L | Proteins and Lipids | W | 6 KP | 3G | D. Hilvert | |
Kurzbeschreibung | An overview of the relationship between protein sequence, conformation and function. | |||||
Lernziel | Overview of the relationship between protein sequence, conformation and function. | |||||
Inhalt | Proteins, structures and properties, (bio)synthesis of polypeptides, protein folding and design, protein engineering, chemical modification of proteins, proteomics. | |||||
Literatur | General Literature: - T.E. Creighton: Proteins: Structures and Molecular Properties, 2nd Edition, H.W. Freeman and Company, New York, 1993. - C. Branden, J. Tooze , Introduction to Protein Structure, Garland Publishing, New York, 1991. - J. M. Berg, J. L. Tymoczko, L. Stryer: Biochemistry, 5th edition, H.W. Freeman and Company, New York, 2002. - G.A. Petsko, D. Ringe: Protein Structure and Function, New Science Press Ltd., London, 2004. Original Literature: Citations from the original literature relevant to the individual lectures will be assigned weekly. | |||||
551-0324-00L | Systems Biology | W | 6 KP | 4V | R. Aebersold, B. Christen, M. Claassen, U. Sauer | |
Kurzbeschreibung | Introduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects. | |||||
Lernziel | - obtain an overview of global analytical methods - obtain an overview of computational methods in systems biology - understand the concepts of systems biology | |||||
Inhalt | Overview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology. | |||||
Skript | no script | |||||
Literatur | The course is not taught by a particular book, but some books are suggested for further reading: - Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005 | |||||
551-0320-00L | Cellular Biochemistry (Part II) | W | 3 KP | 2V | Y. Barral, R. Kroschewski, A. E. Smith | |
Kurzbeschreibung | This course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes. | |||||
Lernziel | The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection. | |||||
Inhalt | Spatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection. | |||||
Literatur | Recommended supplementary literature (review articles and selected primary literature) will be provided during the course. | |||||
Voraussetzungen / Besonderes | To attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English. In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform. | |||||
551-0314-00L | Microbiology (Part II) | W | 3 KP | 2V | W.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli | |
Kurzbeschreibung | Advanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Lernziel | This concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Inhalt | Advanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Skript | Updated handouts will be provided during the class. | |||||
Literatur | Current literature references will be provided during the lectures. | |||||
Voraussetzungen / Besonderes | English | |||||
551-0326-00L | Cell Biology | W | 6 KP | 4V | S. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz | |
Kurzbeschreibung | This Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism. | |||||
Lernziel | -To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project. -To convey knowledge about neuron-glia interactions in health and disease. - To provide information on different types of stem cells and their function in health and disease -To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases -To convey knowledge on the mechanisms underlying repair of injured tissues -To provide the students with an overview of mitochondrial dynamics. -Providing an understanding of RNA processing reactions and their regulations. -To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses. -To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level. -Providing the background and context that foster cross-disciplinary scientific thinking. | |||||
551-0318-00L | Immunology II | W | 3 KP | 2V | A. Oxenius, M. Kopf, S. R. Leibundgut, E. Slack, weitere Dozierende | |
Kurzbeschreibung | Einführung in die zellulären und molekularen Grundlagen des Immunsystems und die Immunreaktionen gegen verschiedene Pathogene, Tumore, Transplantate, und körpereigene Strukturen (Autoimmunität) | |||||
Lernziel | Die Vorlesung soll ein grundlegendes Verständnis vermitteln über: - die Interaktion der verschiedenen Immunzellen auf zellulärer und molekularer Ebene? - Erkennung und Abwehr ausgewählter Viren, Bakterien, und Parasiten. - Abwehr von Tumoren. - Mechanismen der Toleranz für körpereigene Moleküle. - Funktion des Immunsystems im Darm und warum kommensale Bakterien keine Immunantwort auslösen. - Immunpathologie und entzündliche Erkrankungen. | |||||
Inhalt | Ziel dieser Vorlesung ist das Verständnis: > Wie Pathogene vom unspezifischen Immunystem erkannt werden > Wie Pathogene vom Immunsystem bekämpft werden > Immunantworten der Haut, Lung, und Darms > Tumorimmunologie > Migration von Immunzellen > Toleranz und Autoimmunität > das Gedächtnis von T Zellen | |||||
Skript | Die Vorlesungsunterlagen der Dozenten sind verfügbar in Moodle | |||||
Literatur | Empfohlen: Kuby Immunology (Freeman) | |||||
376-0209-00L | Molecular Disease Mechanisms | W | 6 KP | 4V | C. Wolfrum, H. Gahlon, M. Kopf | |
Kurzbeschreibung | In this course the mechanisms of disease development will be studied. Main topics will be: 1. Influence of environmental factors with an emphasis on inflammation and the immune response. 2. Mechanisms underlying disease progression in metabolic disorders, integrating genetic and environmental factors. 3. Mechanisms underlying disease progression in cancer, integrating genetic and environment | |||||
Lernziel | To understand the mechanisms governing disease development with a special emphasis on genetic and environmental associated components | |||||
Skript | All information can be found at: Link The enrollment key will be provided by email | |||||
551-0307-01L | Molecular and Structural Biology II: From Gene to Protein D-BIOL students are obliged to take part I and part II as a two-semester course. | W | 3 KP | 2V | N. Ban, F. Allain, S. Jonas, M. Pilhofer | |
Kurzbeschreibung | This course will cover advanced topics in molecular biology and biochemistry with emphasis on the structure and function of cellular assemblies involved in expression and maintenance of genetic information. We will cover the architecture and the function of molecules involved in DNA replication, transcription, translation, nucleic acid packaging in viruses, RNA processing, and CRISPER/CAS system. | |||||
Lernziel | Students will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes ranging from DNA replication, transcription and translation. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation. | |||||
Inhalt | Advanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies. | |||||
Skript | Updated handouts will be provided during the class. | |||||
Literatur | The lecture will be based on the latest literature. Additional suggested literature: Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed. (1995). Garland, New York. |
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