Search result: Catalogue data in Spring Semester 2019
|2. Year, 4. Semester|
|Cellular and Molecular Biology|
|551-1174-00L||Systems Biology||O||4 credits||2V + 2U||U. Sauer, K. M. Borgwardt, J. Stelling, N. Zamboni|
|Abstract||The course teaches computational methods and first hands-on applications by starting from biological problems/phenomena that students in the 4th semester are somewhat familiar with. During the exercises, students will obtain first experience with programming their own analyses/models for data analysis/interpretation.|
|Objective||We will teach little if any novel biological knowledge or analysis methods, but focus on training the ability of use existing knowledge (for example from enzyme kinetics, regulatory mechanisms or analytical methods) to understand biological problems that arise when considering molecular elements in their context and to translate some of these problems into a form that can be solved by computational methods. Specific goals are:|
- understand the limitations of intuitive reasoning
- obtain a first overview of computational approaches in systems biology
- train ability to translate biological problems into computational problems
- solve practical problems by programming with MATLAB
- make first experiences in computational interpretation of biological data
- understand typical abstractions in modeling molecular systems
|Content||During the first 7 weeks, the will focus on mechanistic modeling. Starting from simple enzyme kinetics, we will move through the dynamics of small pathways that also include regulation and end with flux balance analysis of a medium size metabolic network. During the second 7 weeks, the focus will shift to the analysis of larger data sets, such as metabolomics and transcriptomics that are often generated in biology. Here we will go through multivariate statistical methods that include clustering and principal component analysis, ending with first methods to learn networks from data.|
|Lecture notes||Kein Skript|
|Literature||The course is not taught by a particular book, but two books are suggested for further reading:|
- Systems Biology (Klipp, Herwig, Kowald, Wierling und Lehrach) Wiley-VCH 2009
- A First Course in Systems Biology (Eberhardt O. Voight) Garland Science 2012
|376-0152-00L||Anatomy and Physiology II||O||5 credits||4V||M. Ristow, K. De Bock, M. Kopf, L. Slomianka, C. Spengler|
|Abstract||Basic knowledge of the anatomy and physiology of the gastrointestinal tract, endocrine organs, urinary system and the reproductive system. Knowlewdge of the basic mechanisms of pathobiology. Study of all human tissues and selected organs by examining slides under the light microscope.|
|Objective||Foundations of human anatomy and physiology and basics of clinical pathophysiology|
|Content||Short overview of human anatomy, physiology and general pathology.|
Principles of histology and embryology. Anatomy and physiology: nervous system, muscle, sensory organs, circulatory system, respiratory system.
Anatomy and physiology: gastrointestinal tract, endocrine system, metabolism and thermoregulation, integumentary system, blood and immune system, urinary system, circadian rhythm, reproductive system, pregnancy and birth.
|Literature||Anatomie: Martini, Timmons, Tallitsch, "Anatomie", Pearson; oder Schiebler, Korf, "Anatomie", Steinkopff / Springer; oder Spornitz, "Anatomie und Physiologie, Lehrbuch und Atlas für Pflege-und Gesundheitsfachberufe", Springer|
Physiologie: Thews/Mutschler/Vaupel: Anatomie, Physiologie, Pathophysiologie des Menschen,
Wissenschaftliche Verlagsgesellschaft, Stuttgart
Schmidt/Lang/Thews: Physiologie des Menschen, Springer-Verlag, Heidelberg
|Prerequisites / Notice||Der Besuch der Anatomie und Physiologie I - Vorlesung ist Voraussetzung, da die Anatomie und Physiologie II - Vorlesung auf dem Wissen der im vorangegangenen Semester gelesenen Anatomie und Physiologie I - Vorlesung aufbaut.|
|529-0430-00L||Practical Course Physical Chemistry (for Biol./Pharm.Sci.)||O||3 credits||4P||E. C. Meister|
|Abstract||Practical introduction to important basic experimental methods in physical chemistry. Investigation of qualitative and quantitative relations between physico-chemical quantities of the systems under study.|
|Objective||The students have to carry out selected experiments in physical chemistry using important measurement methods and devices.|
The measured data have to be processed, mostly with the aid of computers, and considering error propagation and statistics.
Detailed laboratory reports have to be written to each experiment.
|Content||Basic physical chemistry experiments covering chemical thermodynamics and kinetics, electrochemistry, viscosity and optical spectroscopy.|
Computer simulation of physical-chemical phenomena.
|Lecture notes||Erich Meister, Grundpraktikum Physikalische Chemie: Theorie und Experimente, 2. Auflage, vdf Hochschul-Verlag an der ETH, Zürich, 2012.|
Supplementary material to experiments is available.
|701-0245-00L||Introduction to Evolutionary Biology||O||2 credits||2V||G. Velicer, S. Wielgoss|
|Abstract||This course introduces important questions about the evolutionary processes involved in the generation and maintenance of biological diversity across all domains of life and how evolutionary science investigates these questions.|
|Objective||This course introduces important questions about the evolutionary processes involved in the generation and maintenance of biological diversity across all domains of life and how evolutionary science investigates these questions. The topics covered range from different forms of selection, phylogenetic analysis, population genetics, life history theory, the evolution of sex, social evolution to human evolution. These topics are important for the understanding of a number of evolutionary problems in the basic and applied sciences.|
|Content||Topics likely to be covered in this course include research methods in evolutionary biology, adaptation, evolution of sex, evolutionary transitions, human evolution, infectious disease evolution, life history evolution, macroevolution, mechanisms of evolution, phylogenetic analysis, population dynamics, population genetics, social evolution, speciation and types of selection.|
Scott Freeman and Jon Herron
5th Edition, English.
|Prerequisites / Notice||The exam is based on lecture and textbook.|
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