Suchergebnis: Katalogdaten im Frühjahrssemester 2020

Science, Technology, and Policy Master Information
Naturwissenschaftlich-technische Ergänzung (NUR für Reglement 2019)
Gesundheitswissenschaften und -technologie
NummerTitelTypECTSUmfangDozierende
376-1724-00LAppropriate Health System Design Information Belegung eingeschränkt - Details anzeigen
Maximale Teilnehmerzahl: 42
W3 KP2VW. Karlen
KurzbeschreibungThis course elaborates upon relevant aspects in the conception, implementation and distribution of health devices and systems that effectively meet peoples and societies' needs in a local context. Four key elements of appropriateness (usage, cost, durability and performance) that are integral to the engineering design process are extensively discussed and applied.
LernzielThe main goals are to
> Evaluate the appropriateness of health systems to the cultural, financial, environmental and medical context in which they will be applied
and
> Design health systems from a user's perspective for a specific context

At the end of the course, students can
> name, understand and describe the 4 main principles that define appropriate technology
> apply these principles to critically analyze and assess health systems and technology
> project him/herself into a unfamiliar person and context and create hypotheses as to that person's needs, requirements, and priorities
> modify specifications of existing systems to improve appropriateness
> discuss the challenges and illustrate the the ethical and societal consequences of proposed design modifications
> communicate effectively the results of his/her system analysis and implementation strategies to non-specialists
InhaltThe course will be interactive and involve roleplay. Please do not sign up for this course if you are not ready to leave your comfort zone in class. The lectures are divided in two parts:
The first part elaborates upon the important concepts of the design of health care devices and systems, and discusses implementation and dissemination strategies. We focus on communities such as low income households, the elderly, and patients with chronic illnesses that have special needs. Topics covered include point-of-care diagnostics, information and communication technologies, mobile health, user interactions, and also the social-cultural considerations.
The second part consists of elaboration of an appropriate device conducted by student groups. Each group will analyse an existing product or solution, critically assess its appropriateness according to the criteria learned in class, and provide explanations as to why the system succeeds or fails. The students will also present design improvements. Grading will be based on a written case report due in the middle of the semester and a final seminar presentation in form of a poster discussion and demo.
LiteraturWHO, "Medical Devices: Managing the Mismatch", 2010.
Link

PATH, "The IC2030 report. Reimagining Global Health," 2015. Link

R. Malkin and K. Von Oldenburg Beer, "Diffusion of novel healthcare technologies to resource poor settings," Annals of Biomedical Engineering, vol. 41, no. 9, pp. 1841:50, 2013.
Voraussetzungen / BesonderesTarget Group:
Students of higher semesters and doctoral students of
- D-MAVT, D-ITET, D-INFK, D-HEST
- Biomedical Engineering, Robotics, Systems and Control
- Medical Faculty, University of Zurich
Students of other departments, faculties, courses are also welcome
701-0662-00LEnvironmental Impacts, Threshold Levels and Health Effects Information W3 KP2VC.‑T. Monn, M. Brink
KurzbeschreibungEnvironmental impacts on human health and well-being will be discussed. Concepts and methods for exposure measurements and assessments will be shown. In the first part of the semester, air pollutants (for example for ozone, and fine particles).
In the second part, noise, its effects and control, will be covered.
Lernziel- to understand the basic concepts of an exposure assessment (air, noise)
- to know methods used in health effect research
- to know criteria and methods for setting threshold levels
InhaltAir Pollutants
- sources of pollutants (indoors and outdoors)
- concepts of an exposure assessment
- measurement methods for gases and particles
- health effect of pollutants (methods, most important pollutants, such as fine particles and ozone)

Noise
- Introduction to acoustics, Measurement, Hearing
- Auditory processing
- Exposure assessment of noise
- Noise effects, Exposure-effect relationships
- Basics of noise control and abatement, exposure limits
- Noise abatement policy
SkriptPresentations (ppt, pdf) will uploaded to a server, previous to the lecture.
Literatursee references in the scripts.
701-1350-00LCase Studies in Environment and HealthW4 KP2VK. McNeill, N. Borduas-Dedekind, T. Julian
KurzbeschreibungThis course will focus on a few individual chemicals and pathogens from different standpoints: their basic chemistry or biology, their environmental behavior, (eco)toxicology, and human health impacts. The course will draw out the common points in each chemical or pathogen's history.
LernzielThis course aims to illustrate how the individual properties of chemicals and pathogens along with societal pressures lead to environmental and human health crises. The ultimate goal of the course is to identify common aspects that will improve prediction of environmental crises before they occur. Students are expected to participate actively in the course, which includes the critical reading of the pertinent literature and class presentations.
InhaltEach class will feature the case study of a different chemical or pathogen that have had a profound effect on human health and the environment. The instructors will present eight to ten of these and the students will present a poster on their own pollutant or pathogen in groups of two. Students will be expected to contribute to the in class discussions and, on their selected topics, to lead the discussion.
SkriptHandouts will be provided as needed.
LiteraturHandouts will be provided as needed.
701-1704-01LHealth Impact Assessment: Concepts and Case StudiesW3 KP2VM. Winkler, C. Guéladio, M. Röösli, J. M. Utzinger
KurzbeschreibungThis course introduces the concept of health impact assessment (HIA) and discusses a suite of case studies in industrialised and developing countries. HIA pursues an inter- and multidisciplinary approach, employs qualitative and quantitative methods with the overarching goal to influence decision-making.
LernzielAfter successful completion of the course, students should be able to:
o critically reflect on the concept of HIA and the different steps from screening to implementation and monitoring; and
o apply specific tools and methodologies for HIA of policies, programmes and projects in different social, ecological and epidemiological settings.
InhaltThe course will present a broad set of tools and methods for the systematic and evidence-based judgment of potential health effects related to policies, programmes and projects. Methodological features will be introduced and applied to a variety of case studies in the public sector (e.g. traffic-related air pollution, passive smoking and waste water management) and private sector (e.g. water resource developments and extractive industries) all over the world.
SkriptHandouts will be distributed.
LiteraturWhenever possible, at least one peer-reviewed paper will be made available for each session.
701-1708-00LInfectious Disease DynamicsW4 KP2VS. Bonhoeffer, R. D. Kouyos, R. R. Regös, T. Stadler
KurzbeschreibungThis course introduces into current research on the population biology of infectious diseases. The course discusses the most important mathematical tools and their application to relevant diseases of human, natural or managed populations.
LernzielAttendees will learn about:
* the impact of important infectious pathogens and their evolution on human, natural and managed populations
* the population biological impact of interventions such as treatment or vaccination
* the impact of population structure on disease transmission

Attendees will learn how:
* the emergence spread of infectious diseases is described mathematically
* the impact of interventions can be predicted and optimized with mathematical models
* population biological models are parameterized from empirical data
* genetic information can be used to infer the population biology of the infectious disease

The course will focus on how the formal methods ("how") can be used to derive biological insights about the host-pathogen system ("about").
InhaltAfter an introduction into the history of infectious diseases and epidemiology the course will discuss basic epidemiological models and the mathematical methods of their analysis. We will then discuss the population dynamical effects of intervention strategies such as vaccination and treatment. In the second part of the course we will introduce into more advanced topics such as the effect of spatial population structure, explicit contact structure, host heterogeneity, and stochasticity. In the final part of the course we will introduce basic concepts of phylogenetic analysis in the context of infectious diseases.
SkriptSlides and script of the lecture will be available online.
LiteraturThe course is not based on any of the textbooks below, but they are excellent choices as accompanying material:
* Keeling & Rohani, Modeling Infectious Diseases in Humans and Animals, Princeton Univ Press 2008
* Anderson & May, Infectious Diseases in Humans, Oxford Univ Press 1990
* Murray, Mathematical Biology, Springer 2002/3
* Nowak & May, Virus Dynamics, Oxford Univ Press 2000
* Holmes, The Evolution and Emergence of RNA Viruses, Oxford Univ Press 2009
Voraussetzungen / BesonderesBasic knowledge of population dynamics and population genetics as well as linear algebra and analysis will be an advantage.
151-0630-00LNanorobotics Information W4 KP2V + 1US. Pané Vidal
KurzbeschreibungNanorobotics is an interdisciplinary field that includes topics from nanotechnology and robotics. The aim of this course is to expose students to the fundamental and essential aspects of this emerging field.
LernzielThe aim of this course is to expose students to the fundamental and essential aspects of this emerging field. These topics include basic principles of nanorobotics, building parts for nanorobotic systems, powering and locomotion of nanorobots, manipulation, assembly and sensing using nanorobots, molecular motors, and nanorobotics for nanomedicine.
376-0022-00LImaging and Computing in Medicine Information Belegung eingeschränkt - Details anzeigen W4 KP3GR. Müller, P. Christen, C. J. Collins
KurzbeschreibungImaging and computing methods are key to advances and innovation in medicine. This course introduces established fundamental as well as modern techniques and methods of imaging and computing in medicine.
Lernziel1. Understanding and practical implementation of biosignal processes methods for imaging
2. Understanding of imaging techniques including radiation imaging, radiographic imaging systems, computed tomography imaging, diagnostic ultrasound imaging, and magnetic resonance imaging
3. Knowledge of computing, programming, modelling and simulation fundamentals
4. Computational and systems thinking as well as scripting and programming skills
5. Understanding and practical implementation of emerging computational methods and their application in medicine including artificial intelligence, deep learning, big data, and complexity
6. Understanding of the emerging concept of personalised and in silico medicine
7. Encouragement of critical thinking and creating an environment for independent and self-directed studying
InhaltImaging and computing methods are key to advances and innovation in medicine. This course introduces established fundamental as well as modern techniques and methods of imaging and computing in medicine. For the imaging portion of the course, biosignal processing, radiation imaging, radiographic imaging systems, computed tomography imaging, diagnostic ultrasound imaging, and magnetic resonance imaging are covered. For the computing portion of the course, computing, programming, and modelling and simulation fundamentals are covered as well as their application in artificial intelligence and deep learning; complexity and systems medicine; big data and personalised medicine; and computational physiology and in silico medicine.
The course is structured as a seminar in three parts of 45 minutes with video lectures and a flipped classroom setup: in the first part (TORQUEs: Tiny, Open-with-Restrictions courses focused on QUality and Effectiveness), students study the basic concepts in short video lectures on the online learning platform Moodle. At the end of this first part, students must post a number of questions in the Moodle forum that will be addressed in the second part of the lectures using a flipped classroom concept. First, the lecturers may prepare additional teaching material to answer the posted questions and potentially discuss further questions (Q&A). Second, the students will form small groups to acquire additional knowledge online or from additionally distributed material and to present their findings to the rest of the class.
SkriptStored on Moodle.
Voraussetzungen / BesonderesLectures will be given in English.
376-1178-00LHuman Factors IIW3 KP2VM. Menozzi Jäckli, R. Huang, M. Siegrist
KurzbeschreibungStrategies, abilities and needs of human at work as well as properties of products and systems are factors controlling quality and performance in everyday interactions. In Human Factors II (HF II), cognitive aspects are in focus therefore complementing the more physical oriented approach in HF I. A basic scientific approach is adopted and relevant links to practice are illustrated.
LernzielThe goal of the lecture is to empower students in designing products and systems enabling an efficient and qualitatively high standing interaction between human and the environment, considering costs, benefits, health, well-being, and safety as well. The goal is achieved in addressing a broad variety of topics and embedding the discussion in macroscopic factors such as the behavior of consumers and objectives of economy.
InhaltCognitive factors in perception, information processing and action. Experimental techniques in assessing human performance and well-being, human factors and ergonomics in development of products and complex systems, innovation, decision taking, consumer behavior.
LiteraturSalvendy G. (ed), Handbook of Human Factors, Wiley & Sons, 2012
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 KP2GA. Ferrari, G. Shivashankar, M. Zenobi-Wong
KurzbeschreibungThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
LernzielThis course is designed to illuminate the importance of mechanobiological processes to life as well as to teach good experimental strategies to investigate mechanobiological phenomena.
InhaltTypically, cell differentiation is studied under static conditions (cells grown on rigid plastic tissue culture dishes in two-dimensions), an experimental approach that, while simplifying the requirements considerably, is short-sighted in scope. It is becoming increasingly apparent that many tissues modulate their developmental programs to specifically match the mechanical stresses that they will encounter in later life. Examples of known mechanosensitive developmental programs include osteogenesis (bones), chondrogenesis (cartilage), and tendogenesis (tendons). Furthermore, general forms of cell behavior such as migration, extracellular matrix deposition, and complex tissue differentiation are also regulated by mechanical stimuli. Mechanically-regulated cellular processes are thus ubiquitous, ongoing and of great clinical importance.

The overall importance of mechanobiology to humankind is illustrated by the fact that nearly 80% of our entire body mass arises from tissues originating from mechanosensitive developmental programs, principally bones and muscles. Unfortunately, our ability to regenerate mechanosensitive tissue diminishes in later life. As it is estimated that the fraction of the western world population over 65 years of age will double in the next 25 years, an urgency in the global biomedical arena exists to better understand how to optimize complex tissue development under physiologically-relevant mechanical environments for purposes of regenerative medicine and tissue engineering.
Skriptn/a
LiteraturTopical Scientific Manuscripts
376-1400-00LTransfer of Technologies into Neurorehabilitation Belegung eingeschränkt - Details anzeigen W3 KP2VC. Müller, R. Gassert, R. Riener, H. Van Hedel, N. Wenderoth
KurzbeschreibungThe course focuses on clinical as well as industrial aspects of advanced technologies and their transfer into neurorehabilitation from both theoretical and practical perspectives. The students will learn the basics of neurorehabilitation and the linkage to technologies, gain insight into the development within the medtech field and learn applications of technologies in clinical settings.
LernzielThe students will:
- Learn basics and principles of clinical neuroscience and neurorehabilitation.
- Gain insight into the technical basics of advanced technologies and the transfer into product development processes.
- Gain insight into the application, the development and integration of advanced technologies in clinical settings. This includes the advantages and limitations according to different pathologies and therapy goals.
- Get the opportunity to test advanced technologies in practical settings.
- Learn how to transfer theoretical concepts to actual settings in different working fields.
InhaltMain focus:
- Neurobiological principles applied to the field of neurorehabilitation.
- Clinical applications of advanced rehabilitation technologies.
- Visit medical technology companies, rehabilitation centers and labs to gain deeper insight into the development, application and evaluation of advanced technologie
SkriptTeaching materials will be provided for the individual events and lectures.
- Slides (pdf files)
- Information sheets and flyers of the visited companies, labs and clinics
376-1614-00LPrinciples in Tissue EngineeringW3 KP2VK. Maniura, M. Rottmar, M. Zenobi-Wong
KurzbeschreibungFundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
LernzielUnderstanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed.
InhaltThis class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed.
SkriptHandouts provided during the classes and references therin.
LiteraturThe molecular Biology of the Cell, Alberts et al., 5th Edition, 2009.
Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002
227-0948-00LMagnetic Resonance Imaging in MedicineW4 KP3GS. Kozerke, M. Weiger Senften
KurzbeschreibungIntroduction to magnetic resonance imaging and spectroscopy, encoding and contrast mechanisms and their application in medicine.
LernzielUnderstand the basic principles of signal generation, image encoding and decoding, contrast manipulation and the application thereof to assess anatomical and functional information in-vivo.
InhaltIntroduction to magnetic resonance imaging including basic phenomena of nuclear magnetic resonance; 2- and 3-dimensional imaging procedures; fast and parallel imaging techniques; image reconstruction; pulse sequences and image contrast manipulation; equipment; advanced techniques for identifying activated brain areas; perfusion and flow; diffusion tensor imaging and fiber tracking; contrast agents; localized magnetic resonance spectroscopy and spectroscopic imaging; diagnostic applications and applications in research.
SkriptD. Meier, P. Boesiger, S. Kozerke
Magnetic Resonance Imaging and Spectroscopy
752-1300-00LIntroduction to ToxicologyW3 KP2VR. Eggen, S. J. Sturla
KurzbeschreibungIntroduction to how chemical properties and biological interactions govern the disposition and influences of toxicants.
LernzielThe objectives are for the student to establish a framework for examining adverse effects resulting from exposures to toxicants by understanding key mechanisms that give rise to toxic responses and disease processes.
InhaltThis course will introduce mechanisms governing the chemical disposition and biological influences of toxicants. The course is geared toward advanced bachelors students in food science, environmental science, and related disciplines, such as chemistry, biology and pharmaceutical sciences. Examples of topics include: dose-response relationships and risk assessment, absorption, transport, and biotransformation of xenobiotic chemicals; Carcinogenesis; DNA damage, repair, and mutation; Immunotoxicity; Neurotoxicity; and modern toxicity testing strategies. These fundamental concepts in Mechanistic Toxicology will be integrated with examples of toxicants relevant to food, drugs and the environment.
LiteraturCasarett & Doull's Toxicology, The Basic Science of Poisons. Seventh Edition. Editor: Curtis D. Klaassen, 2008, McGraw-Hill. (available on-line)
Voraussetzungen / BesonderesBasic knowledge of organic chemistry and biochemistry is required.
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