Suchergebnis: Katalogdaten im Frühjahrssemester 2021

Biomedical Engineering Master Information
Vertiefungsfächer
Biomechanics
Kernfächer der Vertiefung
Während des Studiums müssen mindestens 12 KP aus Kernfächern einer Vertiefung (Track) erreicht werden.
NummerTitelTypECTSUmfangDozierende
227-0391-00LMedical Image Analysis
Basic knowledge of computer vision would be helpful.
W3 KP2GE. Konukoglu, M. A. Reyes Aguirre
KurzbeschreibungIt is the objective of this lecture to introduce the basic concepts used
in Medical Image Analysis. In particular the lecture focuses on shape
representation schemes, segmentation techniques, machine learning based predictive models and various image registration methods commonly used in Medical Image Analysis applications.
LernzielThis lecture aims to give an overview of the basic concepts of Medical Image Analysis and its application areas.
Voraussetzungen / BesonderesPrerequisites:
Basic concepts of mathematical analysis and linear algebra.

Preferred:
Basic knowledge of computer vision and machine learning would be helpful.

The course will be held in English.
376-1392-00LMechanobiology: Implications for Development, Regeneration and Tissue EngineeringW3 KP2GG. Shivashankar
KurzbeschreibungThis course will emphasize the importance of mechanobiology to cell determination and behavior. Its importance to regenerative medicine and tissue engineering will also be addressed. Finally, this course will discuss how age and disease adversely alter major mechanosensitive developmental programs.
LernzielThe goal of this course is to provide an introduction to the emerging field of “Mechanobiology”.
InhaltWe will focus on cells and tissues and introduce the major methods employed in uncovering the principles of mechanobiology. We will first discuss the cellular mechanotransduction mechanisms and how they regulate genomes. This will be followed by an analysis of the mechanobiological underpinnings of cellular differentiation, cell-state transitions and homeostasis. Developing on this understanding, we will then introduce the mechanobiological basis of cellular ageing and its impact on tissue regeneration, including neurodegeneration and musculoskeletal systems. We will then highlight the importance of tissue organoid models as routes to regenerative medicine. We will also discuss the impact of mechanobiology on host-pathogen interactions. Finally, we will introduce the broad area of mechanopathology and the development of cell-state biomarkers as readouts of tissue homeostasis and disease pathologies. Collectively, the course will provide a quantitate framework to understand the mechanobiological processes at cellular scale and how they intersect with tissue function and diseases.

Lecture 1: Introduction to the course: forces, signalling and cell behaviour
Lecture 2: Methods to engineer and sense mechanobiological processes
Lecture 3: Mechanisms of cellular mechanosensing and cytoskeletal remodelling
Lecture 4: Nuclear mechanotransduction pathways
Lecture 5: Genome organization, regulation and genome integrity
Lecture 6: Differentiation, development and reprogramming
Lecture 7: Tissue microenvironment, cell behaviour and homeostasis
Lecture 8: Cellular aging and tissue regeneration
Lecture 9: Neurodegeneration and regeneration
Lecture 10: Musculoskeletal systems and regeneration
Lecture 11: Tissue organoid models and regenerative medicine
Lecture 12: Microbial systems and host-pathogen interactions
Lecture13: Mechanopathology and cell-state biomarkers
Lecture14: Concluding lecture and case studies
Skriptn/a
LiteraturTopical Scientific Manuscripts
376-1397-00LOrthopaedic Biomechanics Information Belegung eingeschränkt - Details anzeigen
Number of participants limited to 48.
W3 KP2GR. Müller, J. Schwiedrzik
KurzbeschreibungThis course is aimed at studying the mechanical and structural engineering of the musculoskeletal system alongside the analysis and design of orthopaedic solutions to musculoskeletal failure.
LernzielTo apply engineering and design principles to orthopaedic biomechanics, to quantitatively assess the musculoskeletal system and model it, and to review rigid-body dynamics in an interesting context.
InhaltEngineering principles are very important in the development and application of quantitative approaches in biology and medicine. This course includes a general introduction to structure and function of the musculoskeletal system: anatomy and physiology of musculoskeletal tissues and joints; biomechanical methods to assess and quantify tissues and large joint systems. These methods will also be applied to musculoskeletal failure, joint replacement and reconstruction; implants; biomaterials and tissue engineering.
SkriptStored on Moodle.
LiteraturOrthopaedic Biomechanics:
Mechanics and Design in Musculoskeletal Systems

Authors: Donald L. Bartel, Dwight T. Davy, Tony M. Keaveny
Publisher: Prentice Hall; Copyright: 2007
ISBN-10: 0130089095; ISBN-13: 9780130089090
Voraussetzungen / BesonderesLectures will be given in English.
376-1712-00LFinite Element Analysis in Biomedical Engineering Information W3 KP2VS. J. Ferguson, B. Helgason
KurzbeschreibungThis course provides an introduction to finite element analysis, with a specific focus on problems and applications from biomedical engineering.
LernzielFinite element analysis is a powerful simulation method for the (approximate) solution of boundary value problems. While its traditional roots are in the realm of structural engineering, the methods have found wide use in the biomedical engineering domain for the simulation of the mechanical response of the human body and medical devices. This course provides an introduction to finite element analysis, with a specific focus on problems and applications from biomedical engineering. This domain offers many unique challenges, including multi-scale problems, multi-physics simulation, complex and non-linear material behaviour, rate-dependent response, dynamic processes and fluid-solid interactions. Theories taught are reinforced through practical applications in self-programmed and commercial simulation software, using e.g. MATLAB, ANSYS, FEBIO.
Inhalt(Theory) The Finite Element and Finite Difference methods
Gallerkin, weighted residuals, discretization

(Theory) Mechanical analysis of structures
Trusses, beams, solids and shells, DOFs, hand calculations of simple FE problems, underlying PDEs

(Application) Mechanical analysis of structures
Truss systems, beam systems, 2D solids, meshing, organ level analysis of bones

(Theory and Application) Mechanical analysis of structures
Micro- and multi-scale analysis, voxel models, solver limitations, large scale solvers

(Theory) Non-linear mechanical analysis of structures
Large strain, Newton-Rhapson, plasticity

(Application) Non-linear mechanical analysis of structures
Plasticity (bone), hyperelasticity, viscoelasticity

(Theory and Application) Contact analysis
Friction, bonding, rough contact, implants, bone-cement composites, pushout tests

(Theory) Flow in Porous Media
Potential problems, Terzhagi's consolidation

(Application) Flow in Porous Media
Confined and unconfined compression of cartilage

(Theory) Heat Transfer and Mass Transport
Diffusion, conduction and convection, equivalency of equations

(Application) Heat Transfer and Mass Transport
Sequentially-coupled poroelastic and transport models for solute transport

(Theory) Computational Biofluid Dynamics
Newtonian vs. Non-Newtonian fluid, potential flow

(Application) Computational Biofluid Dynamics
Flow between micro-rough parallel plates
SkriptHandouts consisting of (i) lecturers' script, (ii) selected excerpts from relevant textbooks, (iii) selected excerpts from theory manuals of commercial simulation software, (iv) relevant scientific publications.
Voraussetzungen / BesonderesFamiliarity with basic numerical methods.
Programming experience with MATLAB.
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