Suchergebnis: Katalogdaten im Frühjahrssemester 2019
Biologie Bachelor | ||||||
2. Studienjahr, 4. Semester | ||||||
Wahlmodule | ||||||
Biologische Chemie | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
---|---|---|---|---|---|---|
551-1174-00L | Systembiologie | W | 4 KP | 2V + 2U | U. Sauer, K. M. Borgwardt, J. Stelling, N. Zamboni | |
Kurzbeschreibung | Ausgehend von biologischen Fragen und Phänomenen unterrichtet der Kurs zur Beantwortung notwendige Konzepte von Modellierungen und Datenanalysen. In den Übungen erhalten die Studenten erste praktische Erfahrungen in einfacher Programmierung eigener Modelle und Analysen. | |||||
Lernziel | Wir unterrichten kein oder nur wenig neues biologisches Wissen oder experimentelle Analysemethoden, sondern nutzen aus dem Studium bekanntes Wissen (z. B. Enzymkinetik, Regulationsmechanismen oder analytische Methoden). Unser Ziel ist es biologische Probleme aufzuzeigen, die aus dynamischen Interaktionen molekularer Elemente entstehen und mit Hilfe von Computermethoden gelöst werden können. Spezifische Ziele sind: - Verständnis der Limitationen intuitiver Argumentation in der Biologie - Ein erster Überblick über Computermethoden in der Systembiologie - Übersetzen biologischer Fragestellungen in computerlösbare Probleme - Praktische Erfahrungen in Programmierung mit MATLAB - Erste Erfahrungen in der Computerinterprätation von biologischen Daten - Verständnis typischer Abstraktionen in der Modellierung molekularer Systeme | |||||
Inhalt | Während der ersten 7 Wochen konzentrieren wir uns auf mechanistische Modellierungen. Ausgehend von einfachen Enzymkinetiken betrachten wir zunächst die Dynamik von kleinerer Stoffwechselwegen und enden mit stöchiometrischen Modellen mittlerer Netzwerke. In der zweiten Kurshälfte konzentrieren wir uns auf die Analyse von typischen biologischen Omics Datensätzen. Wir starten mit multivariaten statistischen Methoden wie z. B. Clustering und Principal Component Analysis und enden mit Methoden um Netzwerke aus Daten zu lernen. | |||||
Skript | No script | |||||
Literatur | Der Kurs wird nicht mit einem bestimmten Lehrbuch unterrichtet, aber 2 Bücher werden zur Unterstützung empfohlen: - Systems Biology (Klipp, Herwig, Kowald, Wierling und Lehrach) Wiley-VCH 2009 - A First Course in Systems Biology (Eberhardt O. Voight) Garland Science 2012 | |||||
529-0222-00L | Organic Chemistry II | O | 3 KP | 2V + 1U | J. W. Bode, B. Morandi | |
Kurzbeschreibung | Die Vorlesung vermittelt, aufbauend auf der Veranstaltung Organische Chemie I bzw. Organische Chemie II für D-BIOL, fortgeschrittene Konzepte und Mechanismen organischer Reaktionen. Neben einer Einführung in pericyclische Reaktionen und in den Bereich der metallorganischen Chemie, wird gezielt das Planen und Entwickeln von Syntheserouten komplexer organischer Moleküle erlernt. | |||||
Lernziel | Die Vorlesung setzt sich zum Ziel, neben der Vertiefung grundlegender organischer Reaktionen, fortgeschrittene Transformationen organischer Verbindungen (z.B. Mitsunobu Reaktion, Corey-Chaykovsky Epoxidation, Stetter Reaktion etc.) zu vermitteln. Des Weiteren, werden Grundkenntnisse in pericyclischen Reaktionen (z.B. Diels-Alder Reaktion, Claisen Umlagerung etc.) sowie im Bereich der metallorganischen Chemie (z.B. Kreuzkupplungsreaktionen) erworben. Ein wesentlicher Fokus wird dabei auf das ausgeprägte Verständnis von Reaktivität und Reaktionsmechanismen gelegt. Darüber hinaus werden neue Konzepte, wie beispielsweise die FMO Theorie, zur Vorhersage über den Verlauf und Ausgang einer Reaktion eingeführt. Aufbauend auf dem erlernten Repertoire an neuen organischen Reaktionen und dem besseren Verständnis für die Reaktivität organischer Moleküle werden retrosynthetische Analyseansätzen von komplexen organischen Molekülen und Naturstoffen vermittelt. Das anschließende Endziel der Vorlesung ist die eigenständige Planung und Entwicklung mehrstufiger Syntheserouten zur Herstellung komplexer organischer Moleküle. | |||||
Inhalt | Oxidation und Reduktion organischer Verbindungen, redoxneutrale Reaktionen und Umlagerungen, fortgeschrittene Transformation funktioneller Gruppen und Reaktionsmechanismen, kinetische und thermodynamische Kontrolle von organisch-chemischen Reaktionen, Reaktivitäten von Carbenen und Nitrenen, Frontier Molekular Orbital (FMO) Theorie, Cycloadditionen und pericyclische Reaktionen, Einführung in die metallorganische Chemie, Kreuzkupplungsreaktionen, Einführung in die Peptidsynthese, Schutzgruppenchemie, Grundlagen der retrosynthetischen Analyse von komplexen organischen Molekülen, Planung mehrstufiger Synthesewege. | |||||
Skript | Das Vorlesungsskript sowie zusätzliche Beilagen mit ausführlichem und ergänzendem Inhalt zur Vorlesung werden als PDF Datei kostenlos online aufgeschaltet. Link: Link | |||||
Literatur | Clayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012. | |||||
529-0430-00L | Praktikum Physikalische Chemie (für Biol./Pharm.Wiss.) | O | 3 KP | 4P | E. C. Meister | |
Kurzbeschreibung | Praktische Einführung in wichtige und grundlegende experimentelle Methoden der physikalischen Chemie. Untersuchung qualitativer und quantitativer Zusammenhänge zwischen physikalisch-chemischen Grössen in den beobachteten Systemen. | |||||
Lernziel | Praktische Einführung in die Experimentiertechnik der physikalischen Chemie. Kennenlernen wichtiger Messmethoden und Geräte. Auswertung der Messdaten unter statistischen Gesichtspunkten und kritische Beurteilung der erhaltenen Resultate. Umgang mit Computern. Abfassen von ausführlichen Versuchsberichten. | |||||
Inhalt | Experimente aus den Gebieten der chemischen Thermodynamik und Kinetik, der Elektrochemie, der Viskosität und der optischen Spektroskopie. Simulation physikalisch-chemischer Phänomene mit Computern. | |||||
Skript | Erich Meister, Grundpraktikum Physikalische Chemie: Theorie und Experimente, 2. Auflage, vdf Hochschul-Verlag an der ETH, Zürich, 2012. Weitere Unterlagen zu einzelnen Versuchen werden abgegeben. | |||||
376-0152-00L | Anatomie und Physiologie II | W | 5 KP | 4V | M. Ristow, K. De Bock, M. Kopf, L. Slomianka, C. Spengler | |
Kurzbeschreibung | Kenntnis der Grundlagen der Anatomie und Physiologie des Verdauungstraktes, der endokrinen Organe, des Harnapparates, und des Geschlechtsapparates. Kenntnis elementarer pathophysiologischer Zusammenhänge. Studium sämtlicher Gewebe und ausgewählter Organsysteme des Menschen anhand von histologischen Schnitten. | |||||
Lernziel | Kenntnis der Grundlagen der Anatomie und Physiologie des Menschen und Kenntnis elementarer pathophysiologischer Zusammenhänge. | |||||
Inhalt | Die Vorlesung gibt einen kurzgefassten Überblick über Humananatomie und -physiologie. 3. Semester: Grundbegriffe der Gewebelehre und Embryologie. Anatomie und Physiologie: Nervensystem, Muskel, Sinnesorgane, Kreislaufsystem, Atmungssystem. 4. Semester: Anatomie und Physiologie: Verdauungstrakt, endokrine Organe, Stoffwechsel und Thermoregulation, Haut, Blut und Immunsystem, Harnapparat, zirkadianer Rhythmus, Reproduktionsorgane, Schwangerschaft und Geburt. | |||||
Literatur | Anatomie: Martini, Timmons, Tallitsch, "Anatomie", Pearson; oder Schiebler, Korf, "Anatomie", Steinkopff / Springer; oder Spornitz, "Anatomie und Physiologie, Lehrbuch und Atlas für Pflege-und Gesundheitsfachberufe", Springer Physiologie: Thews/Mutschler/Vaupel: Anatomie, Physiologie, Pathophysiologie des Menschen, Wissenschaftliche Verlagsgesellschaft, Stuttgart oder Schmidt/Lang/Thews: Physiologie des Menschen, Springer-Verlag, Heidelberg | |||||
Voraussetzungen / Besonderes | Der Besuch der Anatomie und Physiologie I - Vorlesung ist Voraussetzung, da die Anatomie und Physiologie II - Vorlesung auf dem Wissen der im vorangegangenen Semester gelesenen Anatomie und Physiologie I - Vorlesung aufbaut. | |||||
3. Studienjahr, 6. Semester | ||||||
Konzeptkurse | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
529-0732-00L | Proteins and Lipids | W | 6 KP | 3G | D. Hilvert | |
Kurzbeschreibung | An overview of the relationship between protein sequence, conformation and function. | |||||
Lernziel | Overview of the relationship between protein sequence, conformation and function. | |||||
Inhalt | Proteins, structures and properties, (bio)synthesis of polypeptides, protein folding and design, protein engineering, chemical modification of proteins, proteomics. | |||||
Literatur | General Literature: - T.E. Creighton: Proteins: Structures and Molecular Properties, 2nd Edition, H.W. Freeman and Company, New York, 1993. - C. Branden, J. Tooze , Introduction to Protein Structure, Garland Publishing, New York, 1991. - J. M. Berg, J. L. Tymoczko, L. Stryer: Biochemistry, 5th edition, H.W. Freeman and Company, New York, 2002. - G.A. Petsko, D. Ringe: Protein Structure and Function, New Science Press Ltd., London, 2004. Original Literature: Citations from the original literature relevant to the individual lectures will be assigned weekly. | |||||
551-0324-00L | Systems Biology | W | 6 KP | 4V | R. Aebersold, B. Christen, M. Claassen, U. Sauer | |
Kurzbeschreibung | Introduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects. | |||||
Lernziel | - obtain an overview of global analytical methods - obtain an overview of computational methods in systems biology - understand the concepts of systems biology | |||||
Inhalt | Overview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology. | |||||
Skript | no script | |||||
Literatur | The course is not taught by a particular book, but some books are suggested for further reading: - Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005 | |||||
551-0320-00L | Cellular Biochemistry (Part II) | W | 3 KP | 2V | Y. Barral, R. Kroschewski, A. E. Smith | |
Kurzbeschreibung | This course will focus on molecular mechanisms and concepts underlying cellular biochemistry, providing advanced insights into the structural and functional details of individual cell components, and the complex regulation of their interactions. Particular emphasis will be on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes. | |||||
Lernziel | The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterization of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain how different molecules and signaling pathways can be integrated during complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, and cell division. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer or during cellular infection. | |||||
Inhalt | Spatial and temporal integration of different molecules and signaling pathways into global cellular processes, such as cell division, cell infection and cell motility. Emphasis is also put on the understanding of pathologies associated with defective cell physiology, such as cancer or during cellular infection. | |||||
Literatur | Recommended supplementary literature (review articles and selected primary literature) will be provided during the course. | |||||
Voraussetzungen / Besonderes | To attend this course the students must have a solid basic knowledge in chemistry, biochemistry, cell biology and general biology. Biology students have in general already attended the first part of the "Cellular Biochemistry" concept course (551-0319-00). The course will be taught in English. In addition, the course will be based on a blended-learning scenario, where frontal lectures will be complemented with carefully chosen web-based teaching elements that students access through the ETH Moodle platform. | |||||
551-0314-00L | Microbiology (Part II) | W | 3 KP | 2V | W.‑D. Hardt, L. Eberl, H.‑M. Fischer, J. Piel, J. Vorholt-Zambelli | |
Kurzbeschreibung | Advanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Lernziel | This concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Inhalt | Advanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||
Skript | Updated handouts will be provided during the class. | |||||
Literatur | Current literature references will be provided during the lectures. | |||||
Voraussetzungen / Besonderes | English | |||||
551-0326-00L | Cell Biology | W | 6 KP | 4V | S. Werner, M. Bordoli, R. Henneberger, W. Kovacs, M. Schäfer, U. Suter, A. Wutz | |
Kurzbeschreibung | This Course introduces principle concepts, techniques, and experimental strategies used in modern Cell Biology. Major topics include: neuron-glia interactions in health and disease; mitochondrial dynamics; stem cell biology; growth factor action in development, tissue repair and disease; cell metabolism, in particular sensing and signaling mechanisms, cell organelles, and lipid metabolism. | |||||
Lernziel | -To prepare the students for successful and efficient lab work by learning how to ask the right questions and to use the appropriate techniques in a research project. -To convey knowledge about neuron-glia interactions in health and disease. - To provide information on different types of stem cells and their function in health and disease -To provide information on growth factor signaling in development, repair and disease and on the use of growth factors or their receptors as drug targets for major human diseases -To convey knowledge on the mechanisms underlying repair of injured tissues -To provide the students with an overview of mitochondrial dynamics. -Providing an understanding of RNA processing reactions and their regulations. -To provide a comprehensive understanding of metabolic sensing mechanisms occurring in different cell types and organelles in response to glucose, hormones, oxygen, nutrients as well as lipids, and to discuss downstream signaling pathways and cellular responses. -To provide models explaining how disturbances in complex metabolic control networks and bioenergetics can lead to disease and to highlight latest experimental approaches to uncover the intricacies of metabolic control at the cellular and organismal level. -Providing the background and context that foster cross-disciplinary scientific thinking. | |||||
551-0318-00L | Immunology II | W | 3 KP | 2V | A. Oxenius, M. Kopf, S. R. Leibundgut, E. Slack, weitere Dozierende | |
Kurzbeschreibung | Einführung in die zellulären und molekularen Grundlagen des Immunsystems und die Immunreaktionen gegen verschiedene Pathogene, Tumore, Transplantate, und körpereigene Strukturen (Autoimmunität) | |||||
Lernziel | Die Vorlesung soll ein grundlegendes Verständnis vermitteln über: - die Interaktion der verschiedenen Immunzellen auf zellulärer und molekularer Ebene? - Erkennung und Abwehr ausgewählter Viren, Bakterien, und Parasiten. - Abwehr von Tumoren. - Mechanismen der Toleranz für körpereigene Moleküle. - Funktion des Immunsystems im Darm und warum kommensale Bakterien keine Immunantwort auslösen. - Immunpathologie und entzündliche Erkrankungen. | |||||
Inhalt | Ziel dieser Vorlesung ist das Verständnis: > Wie Pathogene vom unspezifischen Immunystem erkannt werden > Wie Pathogene vom Immunsystem bekämpft werden > Immunantworten der Haut, Lung, und Darms > Tumorimmunologie > Migration von Immunzellen > Toleranz und Autoimmunität > das Gedächtnis von T Zellen | |||||
Skript | Die Vorlesungsunterlagen der Dozenten sind verfügbar in Moodle | |||||
Literatur | Empfohlen: Kuby Immunology (Freeman) | |||||
376-0209-00L | Molecular Disease Mechanisms | W | 6 KP | 4V | C. Wolfrum, H. Gahlon, M. Kopf | |
Kurzbeschreibung | In this course the mechanisms of disease development will be studied. Main topics will be: 1. Influence of environmental factors with an emphasis on inflammation and the immune response. 2. Mechanisms underlying disease progression in metabolic disorders, integrating genetic and environmental factors. 3. Mechanisms underlying disease progression in cancer, integrating genetic and environment | |||||
Lernziel | To understand the mechanisms governing disease development with a special emphasis on genetic and environmental associated components | |||||
Skript | All information can be found at: Link The enrollment key will be provided by email | |||||
551-0307-01L | Molecular and Structural Biology II: From Gene to Protein D-BIOL students are obliged to take part I and part II as a two-semester course. | W | 3 KP | 2V | N. Ban, F. Allain, S. Jonas, M. Pilhofer | |
Kurzbeschreibung | This course will cover advanced topics in molecular biology and biochemistry with emphasis on the structure and function of cellular assemblies involved in expression and maintenance of genetic information. We will cover the architecture and the function of molecules involved in DNA replication, transcription, translation, nucleic acid packaging in viruses, RNA processing, and CRISPER/CAS system. | |||||
Lernziel | Students will gain a deep understanding of large cellular assemblies and the structure-function relationships governing their function in fundamental cellular processes ranging from DNA replication, transcription and translation. The lectures throughout the course will be complemented by exercises and discussions of original research examples to provide students with a deeper understanding of the subjects and to encourage active student participation. | |||||
Inhalt | Advanced class covering the state of the research in structural molecular biology of basic cellular processes with emphasis on the function of large cellular assemblies. | |||||
Skript | Updated handouts will be provided during the class. | |||||
Literatur | The lecture will be based on the latest literature. Additional suggested literature: Branden, C., and J. Tooze, Introduction to Protein Structure, 2nd ed. (1995). Garland, New York. | |||||
Blockkurse Anmeldung zu Blockkursen muss zwingend über die website Link erfolgen. Anmeldung möglich von 17.12.2018 - 07.01.2019 | ||||||
Blockkurse im 1. Semesterviertel Von 19.2.2019 13:00 - 13.3.2019 17:00 | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
551-0360-00L | Applied Plant Biotechnology Findet dieses Semester nicht statt. Number of participants limited to 8. The enrolment is done by the D-BIOL study administration. | W | 6 KP | 7G | W. Gruissem | |
Kurzbeschreibung | The APB covers multidisciplinary aspects of green biotechnology. Students will acquire knowledge about transgenic crops in the world, processes to generate transgenic plants as well as strategies to engineer plants resistant to biotic and abiotic stresses. Development of new tools for plant biotechnology will be performed in the lab. Social aspects of green biotechnology will also be presented. | |||||
Lernziel | The complete field of Plant Biotechnology shall be introduced in order to provide an overview over the diversity of this discipline, its connections with other disciplines, and its historical context. A major focus of the block course will be the potential of genetic modification as a tool for gene function in basic science as well as for agronomic and/or commercial application dealing with benefit and risk. Basic methods will be handled in practical experiments, lectures will provide the theoretical background including issues beyond the scientific scene like patent issues, ethical considerations, or legal regulation. The goal of this teaching unit is to educate interested students such that they overlook the discipline, are able to understand the basic methodical and intellectual approaches, understand and critically interpret the literature on this field and are able to further follow the development in this field after finishing their studies. Finally, the students should learn to develop own research projects and follow them including communication of their work to the public or the media. | |||||
Inhalt | The following theoretical topics will be presented: - Plant tissue culture (N. benthamiana, cereals, cassava, cell cultures, somatic embryogenesis, regeneration) - Methods for genetic transformation (Agrobacterium) and Molecular analysis of genetically modified (GM) plants (copy number, inheritance of transgenes etc) - Selection systems (antibiotic and herbicide resistance, phosphor-mannose isomerase, marker-free systems, visible markers) - Inducible promoters, tissue specific promoters - Silencing and its application in plant biotechnology - Biotechnological tools for crop improvement (the case of cassava and rice) - Application potential (herbicide tolerance, pest and pathogen resistance, biofuel etc.) - Public interest (ethical issues, patenting of GM-plants, GM food, public outreach). Lectures will have a special focus on the contribution of biotechnology to the improvement of tropical crops such as cassava and rice. A visit to the greenhouse facilities is also planned to give the opportunity to discuss the different project performed at the ETH Plant Biotechnology Lab. For the practical part of the blockcourse, students will perform their own research project. It will aim at the development of new promoters for green biotechnology. Students will clone the specific promoters from different plant species and subsequently produce transgenic plant cells using the methods presented during the course. Project to identify new plant resistance genes from genetically diverse set of rice lines will also be carried out as part of the practicals. | |||||
Skript | Scripts will be distributed in the course for the practical parts and/or on Moodle platform. | |||||
Literatur | Literature will be provided in the course | |||||
Voraussetzungen / Besonderes | Lectures of APB are given in English. | |||||
551-0342-00L | Metabolomics Number of participants limited to 15. The enrolment is done by the D-BIOL study administration. | W | 6 KP | 7G | N. Zamboni, U. Sauer | |
Kurzbeschreibung | The course covers all basic aspects of metabolome measurements, from sample sampling to mass spectrometry and data analysis. Participants work in groups and independently perform and interpret metabolomic experiments. | |||||
Lernziel | Performing and reporting a metabolomic experiment, understanding pro and cons of mass spectrometry based metabolomics. Knowledge of workflows and tools to assist experiment interpretation, and metabolite identification. | |||||
Inhalt | Basics of metabolomics: workflows, sample preparation, targeted and untargeted mass spectrometry, instrumentation, separation techniques (GC, LC, CE), metabolite identification, data interpretation and integration, normalization, QCs, maintenance. Soft skills to be trained: project planning, presentation, reporting, independent working style, team work. | |||||
551-0339-00L | Molecular Mechanisms of Cell Dynamics Number of participants limited to 13. The enrolment is done by the D-BIOL study administration. | W | 6 KP | 7G | E. Dultz, Y. Barral, U. Kutay, M. Peter, K. Weis | |
Kurzbeschreibung | Application of current strategies to study complex and highly regulated cellular processes during cell division and growth. | |||||
Lernziel | The students learn to evaluate and to apply the current strategies to study complex and highly regulated cellular processes during cell division and growth. | |||||
Inhalt | During this Block-Course, the students will learn to (1) describe the main regulators and the mechanics of cell division and growth, (2) perform standard lab techniques and quantitate dynamic cellular processes during cell division and growth, (3) evaluate and compare experimental strategies and model systems, (4) independently search and critically evaluate scientific literature on a specific problem and present it in a seminar, and (5) formulate scientific concepts (preparation and presentation of a poster). Students will work in small groups in individual labs on one research project (8 full days of practical work; every group of students will stay in the same lab during the entire course). The projects are close to the actual research carried out in the participating research groups, but with a clear connection to the subject of the course. | |||||
Literatur | Documentation and recommended literature (review articles and selected primary literature) will be provided during the course. | |||||
Voraussetzungen / Besonderes | This course will be taught in english. | |||||
551-1516-00L | Neuron-Glia Interactions and Myelination in Health and Disease Number of participants limited to 15. The enrolment is done by the D-BIOL study administration. | W | 6 KP | 7G | U. Suter | |
Kurzbeschreibung | The course provides general basic insights and new perspectives in the development, plasticity and repair of the nervous system. The focus is on molecular, cellular and transgenic approaches. | |||||
Lernziel | Through a combination of practical work with lectures, discussions, project preparations and presentations, the students learns basic principles of neural plasticity and repair in health and disease. The course is closely linked to ongoing research projects in the lab to provide the participants with direct insights into current experimental approaches and strategies. | |||||
551-0914-00L | Science and Society and Research Ethics Findet dieses Semester nicht statt. Number of participants limited to 25 The block course will only take place with a minimum of 10 participants. The enrolment is done by the D-BIOL study administration. | W | 6 KP | 7G | E. Hafen | |
Kurzbeschreibung | This introductory course addresses the need to improve the dialogue between researchers and society and to deepen the understanding of ethical questions related to research. It provides an opportunity to recognize and discuss the social and ethical aspects of science. | |||||
Lernziel | The learning objectives of the course are to: -begin to explore the roles and responsibilities of the modern scientist; -help you to gain insights as a scientist into the social and ethical aspects of scientific research; -provide opportunities for you to debate on the social and ethical aspects of science, either from the point of a scientist or as a citizen. | |||||
Inhalt | Scientists are increasingly demanded to discuss and communicate social and ethical issues that arise from their work. Understanding these issues is also part of developing science and technology responsibly. However, the formal education system often requires scientists to focus on core science subjects at the expense of learning about the social and ethical implications of their work. In this course, we provide opportunities for practicing scientists to recognize social and ethical aspects of their work, and to develop knowledge and skills to discuss them with confidence. | |||||
Literatur | The course is not taught by a particular book, but recommended literature (review articles and selected primary literature) will be provided during the course. Members of the course will use twitter @DSS131 and #DSS15 | |||||
551-0118-00L | Plant Cell Biology Number of participants limited to 12. The enrolment is done by the D-BIOL study administration. The course «551-0118-00L Plant Cell Biology» must be booked as «BIO 281 Plant Cell Biology» in the block course tool. | W | 6 KP | 7G | C. Sánchez-Rodríguez, J. Vermeer | |
Kurzbeschreibung | The course is a collaboration of the Plant Cell Biology groups of ETHZ and UZH. The students will learn key concepts related with the remarkable ability of plants to adapt to challenges provided by their environment (both biotic, such as pathogens, and abiotic, like nutrient deficiencies). A multidisciplinary approach including molecular genetics, cell biology, biochemistry and bioinformatics tool | |||||
Lernziel | In this course, students will get cell biological and molecular genetics insights into the developmental plasticity of plants to adapt to their environmental conditions using the model plant Arabidopsis thaliana. With this aim, they will actively participate in ongoing research projects tutored by doctoral students. | |||||
Inhalt | Students will be engaged in research projects aimed to understand the specialized mechanisms evolved by the plants to grow under challenging environments. In a lecture series, the theoretical background for the projects and their interrelationship is provided. Students will design and perform experiments, evaluate experimental results, present their projects, and discuss recent publications to understand the relevance of their work in the context of the current state of plant development and stress response. | |||||
Skript | No script | |||||
Literatur | The recommended literature and list of individual reading assignments will be provided during the course | |||||
Voraussetzungen / Besonderes | All general lectures will be held at ETH Centrum (LFW building). Students will be divided into small groups to carry out experiments at ETH (Central; LFW) and UZH (Botanical Garden) | |||||
Blockkurse im 2. Semesterviertel Von 14.3.2019 8:00 - 4.4.2019 17:00 | ||||||
Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |
376-1346-00L | Study of Epigenetic Mechanisms in Mental Health Number of participants limited to 8 The enrolment is done by the D-BIOL study administration. | W | 6 KP | 7G | I. Mansuy | |
Kurzbeschreibung | This block course is focused on the study of the epigenetic mechanisms that regulate complex brain functions and behavior. It provides an overview of molecular methods used in experimental mice or in human samples to investigate epigenetic processes that control genome activity and gene expression, and are associated with cognitive functions and behavioral responses. | |||||
Lernziel | The purpose is to learn the principles of major methods in epigenetics that allow examine genome activity at the level of DNA, RNA or protein, in the context of complex brain functions. | |||||
Inhalt | 4 independent projects for 3 students each covering various aspects of epigenetic mechanisms. It will focus on state-of-the-art techniques to measure or manipulate gene expression and gene activity in the adult brain or in cell culture, and analyse the effects in vitro or in vivo using omics analyses, molecular and biochemical tools and behavioral testing. | |||||
Skript | Provided at the beginning of the practical. | |||||
551-0352-00L | Protein Analysis by Mass Spectrometry Number of participants limited to 12. The enrolment is done by the D-BIOL study administration. | W | 6 KP | 7G | L. Gillet, B. Collins, P. Picotti | |
Kurzbeschreibung | Protein-Analyse durch Massenspektrometrie Die folgende Thematik wird abgedeckt: Grundlagen der biologischen Massenspektrometrie einschliesslich Instrumentation, Datenaufnahme und -bearbeitung; Anwendung zur Identifizierung und Charakterisierung von Proteinen; Probevorbereitung; Proteomic-Strategien einschliesslich quantitative Analysen. | |||||
Lernziel | Probenvorbereitung fuer die MS Analyse (Trypsin Verdau, C18 Aufreinigung) Prinzipien LC-MS basierter Datenaquisition (QTOF und/oder Ion Trap Instrumenten) Qualitative Proteom Analyse (Protein Identifizierung mit Hilfe von Mascot und/oder Sequest Software) Quantitative Proteom Analyse (unmarkierte und Isotopen markierte Strategien) Analyse und Auswertung von Datensätzen zur Detektion von hoch- bzw. runter-regulierten Proteinen |
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